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    Anthelmintics: Namita S. Girhepunje

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    Vaishnavi Bendale
    This document discusses anthelmintic drugs, which are drugs used to treat worm infections. It defines anthelmintics and provides examples such as piperazine, mebendazole, and diethylcarbamazine. The document then classifies anthelmintics based on the type of worms they treat such as tapeworms, flukes, and roundworms. It provides details on the structures, properties, uses, and formulations of several specific anthelmintic drugs including piperazine, mebendazole, diloxanide furoate, and diethylcarbamazine. The document also briefly discusses antimalarial drugs for treating malaria and provides classifications and examples of these drugs.

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    Anthelmintics: Namita S. Girhepunje

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    Vaishnavi Bendale
    29 views37 pages
    This document discusses anthelmintic drugs, which are drugs used to treat worm infections. It defines anthelmintics and provides examples such as piperazine, mebendazole, and diethylcarbamazine. The document then classifies anthelmintics based on the type of worms they treat such as tapeworms, flukes, and roundworms. It provides details on the structures, properties, uses, and formulations of several specific anthelmintic drugs including piperazine, mebendazole, diloxanide furoate, and diethylcarbamazine. The document also briefly discusses antimalarial drugs for treating malaria and provides classifications and examples of these drugs.

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    28.Anthelminics

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    This document discusses anthelmintic drugs, which are drugs used to treat worm infections. It defines anthelmintics and provides examples such as piperazine, mebendazole, and diethylcarbamazine. The document then classifies anthelmintics based on the type of worms they treat such as tapeworms, flukes, and roundworms. It provides details on the structures, properties, uses, and formulations of several specific anthelmintic drugs including piperazine, mebendazole, diloxanide furoate, and diethylcarbamazine. The document also briefly discusses antimalarial drugs for treating malaria and provides classifications and examples of these drugs.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    29 views37 pages

    Anthelmintics: Namita S. Girhepunje

    Uploaded by

    Vaishnavi Bendale
    This document discusses anthelmintic drugs, which are drugs used to treat worm infections. It defines anthelmintics and provides examples such as piperazine, mebendazole, and diethylcarbamazine. The document then classifies anthelmintics based on the type of worms they treat such as tapeworms, flukes, and roundworms. It provides details on the structures, properties, uses, and formulations of several specific anthelmintic drugs including piperazine, mebendazole, diloxanide furoate, and diethylcarbamazine. The document also briefly discusses antimalarial drugs for treating malaria and provides classifications and examples of these drugs.

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    You are on page 1of 37

    AnTHELMINTICS

    By
    Namita S. Girhepunje, Lecturer
    Dadasaheb Balpande College of Diploma in
    Pharmacy,
    Besa, Nagpur

    E-mail:namita.tilgule71@gmail.com
    Learning Outcomes
    After watching this video,You will be able to:

     Understand the defination of AnTHELMINTICS

     identify the various therapeutic uses of


    AnTHELMINTICS

     Draw the structure of AnTHELMINTICS


    AnTHELMINTICS
     Drug used to treat helminth or worm
    infections or to destroy the parasite worms
    or remove them from infected host.
     Antimony sodium tartarate
     Pramomycine
     Dicholorphen
     Piperazine
     Mebendazole
     DEC
    Classification of Anthelmintic drugs

    Cestodes tape worm infection(lives in intestine ribbon line body)


    Diclorophen, paramomycine

    Trematodes Fluke worm (The adult (mature) flukes are found in the
    bile ducts and liver of infected people and animals)
    Antimony sodium tartarate

    Nematodes round worm, thread worm, whip worm(whipworm is one


    of the four most common intestinal parasites of dogs. )
    a) Antifilarial : diethyl cabamazepine citrate

    b) Intestinal nematode infection( like round worm or thread worm)


    Piperazine, mebendazole
    Structure of Anti –AnTHELMINTICS
    piperazine

     Physical properties
    Colourless and glassy with deliquescent crystals
    having faint characteristic odour.
     Freely soluble in water and alcohol
     very slightly soluble in ether
    Piperazine
    Uses

     Used to treat Pinworm infection.


     Enterobiosis
     infestation with or disease caused by pinworms (genus
    Enterobius, especially E. vermicularis) that occurs especially in
    children.

     Round worm infestation ascariasis


     This can happen when hands or fingers that have
    contaminated dirt on them are put in the mouth, or by eating
    vegetables or fruits that have not been carefully peeled,
    washed, or cooked.
    Stability and Storage
     Stored in tightly closed container, light resistant
    containers.

    Official Preparation
    Piperazine citrate elixirs
    Piperazine citrate tablets
    syrup

    Brand Name
    Antepar, Helmacid, Wormicid
    Mebendazole
     Physical Properties

    White to slightly Yellow amorphous powder.

    Odourless, Bitter saline taste .

    It is practically insoluble in water, chloroform and ether.

    Freely soluble in formic acid.


    Uses

     Anthelmintic effective against threadworm, roundworm, whipworm


    and hookworm.

     Used in the t/t of capillariaris and also effective against tapeworm.


    Capillariasis is a parasitic disease in humans caused by two
    different species of capillarids: Capillaria hepatica and Capillaria
    philippinensis. C. hepatica is transferred through the fecal matter of
    infected animals and can lead to hepatitis.

     River blindness, is a disease caused by infection with the parasitic


    worm Onchocerca volvulus. Symptoms include severe itching,
    bumps under the skin, and blindness.

     Guinea worm infection GWD is spread by drinking water containing


    Guinea worm larvae. Larvae are immature forms of the worm.
    Stability and Storage
     Stable under normal conditions of tem., light and moisture.
    Stored in tightly CLOSED containers.

    Official Preparation

    Mebendazole tablet chewable


    Oral Suspension
    Syrup, tablets

    Brand Name
    Mebex, Wormin , Mebendacin, Nemasole
    Diloxanide Furoate
     Physical Properties

    White or almost white crystalline powder.

    Odourless, tasteless.

    It is very slightly soluble in Chloroform.


    Stabilty and storage
     It is stored in well closed , tightly closed

    containers, light resistant containers.

     Uses

     Used in intestinal amoebiasis.


     Used in amoebic dysentry.
     Used in combination with chloroquine and tetracycline in
    amoebic dysentry and in t/t of hepatic amoebiasis.
    Official Preparation

    Diloxanide furoate IP, BP


    Diloxanide furoate tablet IP, BP

    Brand Name
    Furamide, Amibactin,Tiniba D. F.
    Diethylcarbamazine DEC
     Physical Properties

    White crystalline powder.

    Odourless, bitter taste

    It is soluble in water

    Insoluble in choloroform and ether.


    DEC

    N,N Diethyl, 4 methyl piperazine 1 carboxamide


    Stability and storage
     It is stored in well closed , tightly closed
    containers.

     Uses

     Round worm infestation ascariasis.


     Filarial infection. Onchocerciasis river blindness, lymphatic filariasis. a
    parasitic disease caused by microscopic, thread-like worms
     Loiasis a tropical African disease caused by infestation with eye worms,
    Tropical eiosinophilia.
    Official Preparation

    Diehylcarbamazine Injection
    Diethylcarbamazine tablet

    Brand Name
    Filazine, Hetrazen, Bonocide forte.
    Antimalarial Drugs
    Chemical agents or drugs which prevents or cure the infectious
    disease malaria caused by protozoan plasmodium, characterised by
    chills, fever, sweating and body pain.

    Malaria is a protozoal infection caused by p. vivax, p.falciparum, p.


    malarial, p. ovale

    Atovaquone and proguanil (Malarone)


    Quinine sulfate (Qualaquin)
    doxycycline (Vibramycin, Monodox)
    Mefloquine.
    Primaquine phosphate.
    Chloroquine (Aralen, Lariago)
    Antimalarial Drugs
    Classification
    Cinchona alkaloid
    Quinine

    4-amino Quinoline
    Chloroquine, Amodiaquine

    8-amino Quinoline
    Primaquine

    9-amino Acridine
    Mepacrine
    Antimalarial Drugs
    Biguanide devt
    Proguanil

    Pyrimidine devt
    Pyrimethamine,Trimethoprime

    Misc
    Dapsone
    Quinine
     Physical Properties

    white or faintly yellow crystalline powder.

    Odourless, very bitter taste.

    It is very slightly soluble in water, soluble in dilute acid,


    alcohol, dil. Ammonia solution.
    Stabilty and storage
     It is affected by light, stored in air tight closed , protected
    from light.
     Uses
    Used in t/t malaria and caused by p. falciparum.
     Relieve night leg cramp., To treat cerebral malaria.
     Relieve muscle cramp in myotonia congentina. Prolonged
    muscle contraction and slow relaxation.
     As a sclerosing agent in combination with urethane.
     Mild antipyretic and analgesic.
    Quinine
    Official Preparation

    Quinine dihydrochloride injection


    Quinine hydrochloride tab
    Quinine bisulphate tablet
    Quinine Sulphate tab IP, BP

    Brand Name
    Vigotab, Malaria mixture, Flue-foe
    Chloroquine
     Physical Properties

    white or slightly yellowish crystalline powder.

    Odourless, Bitter taste.

    It is very s;lightly soluble in water & alcohol, soluble in


    dilute acid, Chloroform and ether.
    Chloroquine

    7- chloro 4(4 diethyl amino, 1 methyl butyl amino)


    Quinoline
    Stabilty and storage
     It is stored in air tight closed , protected from light .The soln
    for injection are sterilized by autoclaving or by filtration. It is
    used in the form of tablet and injection.

     Uses

     Used in t/t malaria.


     , Amoebic hepatitis, lupus erythromatous.
     Used in the t/t of rheumatid arthritis. In the t/t of giardiasis.
    Chloroquine
    Official Preparation

    Chloroquine BP
    Chloroquine phosphate IP ,BP
    Chloroquine Phosphate tab IP, BP
    Chloroquine Sulphate IP, BP
    Chloroquine sulphate injection IP, BP

    Brand Name
    Aralen, Resochin,Ciplaquine, Malaquin, Lriago
    Amodiaquine

    7- chloro 4(4 hydroxy 3-diethyl amino, 1 methyl


    phenyl) amino Quinoline
    Amodiaquine
     Physical Properties

    yellowish crystalline powder.

    Odourless, Bitter taste.

    It is soluble in water & insoluble in organic solvents like


    Chloroform and ether.
    Stabilty and storage
     It is stored in air tight closed , protected from light .

     Uses

     Used in t/t malaria.

     Kills erythrocytic form of malaria.

     Used in suppression and the t/t of malarial parasite.

     Amoebic hepatitis and Rheumatid Arthritis.


    Amodiaoquine
    Official Preparation

    Amodiaquine Hydrochloride IP ,BP


    Amodiaquine tab IP, BP

    Brand Name
    Camoquin, Basoquin
    Primaquine
     Physical Properties

    Orange red crystalline powder.

    Odourless, Bitter taste.

    It is soluble in water & practically insoluble in alcohol.


    Stabilty and storage
     It is stored in air tight closed , protected from light .

     Uses

     Used in t/t malaria.


     Kills primary erythrocytic form of malaria.
     Used in suppression and the t/t of malarial parasite.
     Radical cure of P. vivax infection in combination with
    chloroquine.
    Primaquine
    Official Preparation

    Primaquin Phosphate IP ,BP


    Primaquine tab IP, BP
    Pyrimethamine

    Brand Name
    Primaquin
    For any queries or any suggestions
    kindly contact at
    Thank You

    Mrs. Namita S. Girhepunje,


    Lecturer
    Dadasaheb Balpande College of
    Diploma in Pharmacy, Besa, Nagpur
    Email: namita.tilgule71@gmail.com
    Mobile: 9764999821

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