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    Meaney Et Al (1988)

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    tanya
    The study aimed to determine the effect of stress hormones on memory in rats. Researchers assigned newborn rats to either a treatment group, which received simulated grooming for 15 minutes daily, or a control group with no handling. As adults, the rats were tested on their ability to navigate a water maze. The treated rats performed better, having less hippocampal cell loss and memory deficits. The findings suggest that early life stress from lacking maternal care can impair brain development and cognition long-term by elevating stress hormone levels.

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    Meaney Et Al (1988)

    Uploaded by

    tanya
    145 views2 pages
    The study aimed to determine the effect of stress hormones on memory in rats. Researchers assigned newborn rats to either a treatment group, which received simulated grooming for 15 minutes daily, or a control group with no handling. As adults, the rats were tested on their ability to navigate a water maze. The treated rats performed better, having less hippocampal cell loss and memory deficits. The findings suggest that early life stress from lacking maternal care can impair brain development and cognition long-term by elevating stress hormone levels.

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    Meaney et al (1988)

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    The study aimed to determine the effect of stress hormones on memory in rats. Researchers assigned newborn rats to either a treatment group, which received simulated grooming for 15 minutes daily, or a control group with no handling. As adults, the rats were tested on their ability to navigate a water maze. The treated rats performed better, having less hippocampal cell loss and memory deficits. The findings suggest that early life stress from lacking maternal care can impair brain development and cognition long-term by elevating stress hormone levels.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    145 views2 pages

    Meaney Et Al (1988)

    Uploaded by

    tanya
    The study aimed to determine the effect of stress hormones on memory in rats. Researchers assigned newborn rats to either a treatment group, which received simulated grooming for 15 minutes daily, or a control group with no handling. As adults, the rats were tested on their ability to navigate a water maze. The treated rats performed better, having less hippocampal cell loss and memory deficits. The findings suggest that early life stress from lacking maternal care can impair brain development and cognition long-term by elevating stress hormone levels.

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    Study Description Evaluation

    Aim:  To determine the effect of glucocorticoids (stress Strengths:


    Meaney et al (1988) hormones) on memory - Showed a cause-effect relationship between
    stress and the effect on memory.
    -led to new theories of the role of stress on
    cognitive functioning
    Method:  Rats randomly allocated to one of two Limitations:
    conditions/situations

    Treatment group:
    -questionable to what extent we can
    - Newborns handled daily by researchers, for 3 generalize the findings from rats to
    weeks human beings
    - Day of birth, until day of weaning -Meany did not yet understand the role of
    - During this time, taken away from their mothers epigenetics in explaining the results.
    for 15 mins per day -study was artificial - lacking ecological
    - Placed in a plastic container lined with a paper
    towel validity
    - Brushed for an intense 15 minutes --> simulated -to measure hippocampal volume in rats,
    grooming of mother rat the animals had to be killed. There are
    - Nurtured ethical concerns about the killing of
    animals in research.
    Control group: - Even though the cause and effect was
    - Taken away from mother
    - No handling established, it did not explain the exact
    - Therefore impoverished process of what was happening

    - To test the effect of elevated stress hormones


    over their lifetime, 2yr old rats put in pool of milky
    water
    - Platform in the pool
    - Rats tried to reach the platform, to escape the
    water - based on their memories of previous
    attempts.
    - Route of the rats was tracked
    Result: Evaluation:
    - High levels of glucocorticoids - stress -questionable to what extent we can generalize
    hormones - in the early life of a rat, resulted in the findings from rats to human beings
    changes that affected the rats in old age -research demonstrates lower levels of
    - Increased exposure to adrenal acetylcholine and higher levels of
    glucocorticoids (control group) accelerated glucocorticoids in Alzheimer's patients
    hippocampal neuron loss and cognitive -Meany did not yet understand the role of
    impairments in aging epigenetics in explaining the results.
    - Rats in control group took more circuitous -study was artificial - lacking ecological
    route to reach platform when they reach old validity
    age -led to new theories of the role of stress on
    - Hippocampal cell loss and pronounced cognitive functioning
    spatial memory deficits came with age in -to measure hippocampal volume in rats, the
    neglected rats animals had to be killed. There are ethical
    - Almost absent in rats groomed by concerns about the killing of animals in
    researchers research.

    Conclusion: Ethical considerations: To measure hippocampal


    - Appears that extra stroking/grooming led to activation volume in rats, the animals had to be killed.
    of genes responsible for reaction to stress response There are ethical concerns about the killing of
    - The genes helps the young rate manage stress
    animals in research
    - Leads to better memory, and a longer and healthier
    life
    - This study demonstrates the function of
    glucocorticoids,
    Study Description Evaluation
    Marmot (1990)

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