The Ventricular System and CSF (Cerebrospinal Fluid)
The Ventricular System and CSF (Cerebrospinal Fluid)
The Ventricular System and CSF (Cerebrospinal Fluid)
(Cerebrospinal Fluid)
The entire surface of central nervous system is bathed by a clear, colorless fluid
called cerebrospinal fluid (CSF). The CSF is contained within a system of fluid-filled
cavities called ventricles. The ventricles are shown in blue on the following
midsagittal section of the brain.
The Ventricles
CSF is produced mainly by a structure called the choroid plexus in the lateral, third
and fourth ventricles. CSF flows from the lateral ventricle to the third ventricle
through the interventricular foramen (also called the foramen of Monro). The third
ventricle and fourth ventricle are connected to each other by the cerebral aqueduct
(also called the Aqueduct of Sylvius). CSF then flows into the subarachnoid space
through the foramina of Luschka (there are two of these) and the foramen of
Magendie (only one of these).
Flow of CSF:
Lateral Ventricle 3rd Ventricle (through the interventricular foramen) 4th
Ventricle (connected to the 3rd Ventricle by the cerebral aqueduct or aqueduct of
sylvius) Subarachnoid space (through the foramina of Luschka (2 of these) and
foramen of Magendie) absorbed through blood vessels back in the blood
stream
Absorption of the CSF into the blood stream takes place in the superior sagittal sinus
through structures called arachnoid villi . When the CSF pressure is greater than the
venous pressure, CSF will flow into the blood stream. However, the arachnoid villi
act as "one way valves"...if the CSF pressure is less than the venous pressure, the
arachnoid villi will NOT let blood pass into the ventricular system.
1. Protection: the CSF protects the brain from damage by "buffering" the brain.
In other words, the CSF acts to cushion a blow to the head and lessen the
impact.
2. Buoyancy: because the brain is immersed in fluid, the net weight of the brain
is reduced from about 1,400 gm to about 50 gm. Therefore, pressure at the
base of the brain is reduced.
3. Excretion of waste products: the one-way flow from the CSF to the blood
takes potentially harmful metabolites, drugs and other substances away from
the brain.
4. Endocrine medium for the brain: the CSF serves to transport hormones to
other areas of the brain. Hormones released into the CSF can be carried to
remote sites of the brain where they may act.