Tissue Biochemistry

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NEELAM MEHTAB

BS 3RD YEAR

Q/A                  BIOLOGICAL MEMBRANE                          DATE: 19-3-2020


1.     Define living artificial cell with properties.
2.     Explain membrane lipid are amphipath etic molecules
3.     Self-assembly of Lipid bilayers
4.     Why the plasma membrane is a selectively permeable barrier
5.     THE FLUID MOSAIC MODEL with special features.
6.     Draw well labeled diagram of FLUID MOSAIC MODEL

ANSWERS
1. In the area of synthetic biology, a "living" artificial cell has been defined as a completely
synthetically made cell that can capture energy, maintain ion gradients, contain
macromolecules as well as store information and have the ability to mutate.

2. All of the lipid molecules in cell membranes are amphipathic (or amphiphilic)—that is,


they have a hydrophilic (“water-loving”) or polar end and a hydrophobic (“water-
fearing”) or nonpolar end. The most abundant membrane lipids are the phospholipids.
These have a polar head group and two hydrophobic hydrocarbon tails.
NEELAM MEHTAB
BS 3RD YEAR

3. composed of a hydrophilic head and two hydrophobic tails. The hydrophilic head group
consists of a phosphate-containing group attached to a glycerol molecule. The hydrophobic
tails, each containing either a saturated or an unsaturated fatty acid, are long hydrocarbon
chains.
 Phospholipid molecules spontaneously form bilayers in aqueous
environments. In this energetically most-favorable arrangement, the hydrophilic heads
face the water at each surface of the bilayer, and the hydrophobic tails are shielded
from the water in the interior.
4. The plasma membrane is a selectively permeable barrier between the cell and the
extracellular environment. Its permeability properties ensure that essential molecules
such as glucose, amino acids, and lipids readily enter the cell, metabolic intermediates
remain in the cell, and waste compounds leave the cell.
5. The fluid mosaic model describes the plasma membrane structure as a mosaic of
phospholipids, cholesterol, proteins, and carbohydrates.
The plasma membrane as a fluid combination of phospholipids, cholesterol, and proteins.
Carbohydrates attached to lipids (glycolipids) and to proteins (glycoproteins) extend from
the outward-facing surface of the membrane.
Cells are surrounded by a continuous phospholipid bilayer in which are embedded
membrane proteins.
 Phospholipids in the bilayer are fluid, able to diffuse laterally within one half of the
bilayer.
 Phospholipids rarely "flip" from one half of the bilayer to the other.
 Some membrane proteins can also diffuse to new locations in the bilayer.
6.
NEELAM MEHTAB
BS 3RD YEAR

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