Diseases

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Diseases

Cardiovascular,
Respiratory and Renal Diseases
Cardiovascular disorder (CVD)

• Affects the cardiovascular system


• Ranges from:
• 1. Disturbances of blood vessels or heart valves
• 2. Disruption of blood flow to the heart and brain.
Atherosclerosis
• Thickening or hardening of the arteries caused by a buildup of plaque
in the inner lining of an artery.
• Causes
• High blood pressure
• High cholesterol
• High triglycerides, a type of fat (lipid) in the blood
• Smoking and other sources of tobacco
• Insulin resistance, obesity or diabetes
Atherosclerosis
• Symptoms
• Chest pain.
• Shortness of breath.
• Heart palpitations.
• Weakness or dizziness.
• Nausea.
• Sweating.
Atherosclerosis
Stages of atherosclerosis
• Endothelial cell injury. This is likely the initial factor that begins the
process of atherosclerotic plaque formation. ...
• Lipoprotein deposition. ...
• Inflammatory reaction. ...
• Smooth muscle cell cap formation.
• No cure till now. lowering your low-density lipoprotein (LDL)
cholesterol
Complications caused by atherosclerosis
• Coronary artery disease.
• When atherosclerosis narrows the arteries close to the heart, may
develop coronary artery disease,
• can cause chest pain (angina),
• a heart attack or heart failure.
• A heart attack or heart failure is a chronic or progressive condition.
• It occurs when the muscle of heart becomes stiff and weak
• Heart can not keep up with workload which leads to heart attack.
• Carotid artery disease.
• When atherosclerosis narrows the arteries close to your brain, you
may develop carotid artery disease, which can cause a transient
ischemic attack (TIA) or stroke.
• Stroke occurs when there is lack of blood flow in the brain.
• Occurs due to blood clots in the brain
• Peripheral artery disease. When atherosclerosis narrows the arteries
in arms or legs, may develop circulation problems in arms and legs
called peripheral artery disease.
• This can make less sensitive to heat and cold,
• increasing risk of burns or frostbite.
• poor circulation in your arms or legs can cause tissue death
(gangrene)
• Aneurysms. Atherosclerosis can also cause aneurysms
• An aneurysm is a bulge in the wall of your artery.
• aneurysms have no symptoms.
• Pain and throbbing in the area of an aneurysm may occur and is a
medical emergency.
• If an aneurysm bursts, one may face life-threatening internal
bleeding.
Prevention
• Quitting smoking
• Eating healthy foods
• Exercising regularly
• Maintaining a healthy weight
• Checking and maintaining a healthy blood pressure
• Checking and maintaining healthy cholesterol and blood sugar levels
Respiratory diseases
• Asthma
• Asthma is a long-term disease of the lungs.
• It causes airways to get inflamed and narrow
• it makes it hard to breathe.
• Severe asthma can cause trouble talking or being active.
• Airway blockage, the muscles tighten. It’s harder for air to pass
through.
• Inflammation -Asthma causes red, swollen bronchial tubes in lungs.
• Airway irritability, People with asthma have sensitive airway
Respiratory diseases
• cause symptoms as :
• trouble breathing,
• wheezing, coughing,
• shortness of breath, and
• trouble with normal daily activities.
• immediate medication is necessary if,
• Fast breathing
• Pale or blue face, lips, or fingernails
• The skin around your ribs pulls inward when you breathe in
• Trouble breathing, walking, or talking
Bronchitis
• Bronchitis is an inflammation of the lining of bronchial tubes
• the most common are acute and chronic.
• Symptoms: Fatigue.
• Shortness of breath.
• Slight fever and chills.
• Chest discomfort.
• Causes a cold or flu virus, a bacterial infection,
• exposure to substances that irritate the lungs like tobacco smoke,
dust, fumes, vapors, and air pollution.
Emphysema
• Emphysema is a disease of the lungs that usually develops after many
years of smoking
• is a condition that involves damage to the walls of the air sacs
(alveoli) of the lung.
• Is a COPD(chronic obstructive pulmonary disease)
• Smoking is the number one factor.
• Air pollutants in the home and workplace
• genetic factors (alpha-1 antitrypsin deficiency), and
• respiratory infections can also play a role in causing emphysema.
Symptoms of Emphysema
• Shortness of breath, especially during light exercise or climbing steps
• Ongoing feeling of not being able to get enough air
• Long-term cough or “smoker’s cough”
• Wheezing
• Long-term mucus production
• Ongoing fatigue
Treatment of emphysema
• Once it develops, emphysema can’t be reversed
• Quitting smoking
• Bronchodilator medications
• Anti-inflammatory medication
• Oxygen therapy
• Lung volume reduction surgery
Respiratory diseases

• Lung cancer malignant lung tumor characterized by uncontrolled cell


growth in tissue of lungs.
Tuberculosis
• Tuberculosis a disease caused by Mycobacterium tuberculosis , a
bacteria that releases a toxin called tuberculin.
• The infection destroys patients' lung tissue, causing them to cough up
the bacteria
Tuberculosis
• Pneumonia
• Infection – inflammation of alveoli
• Alveoli is filled with fluid and dead WBC.
• May caused due to Streptococcus pneumoniae
• Pulmonary edema
• Abnormal accumulation of interstitial fluid
• Pulmonary embolism presence of blood clot or foreign substances in
pulmonary arterial vessel that obstruct the circulation in lung tissue.
Renal diseases
• Glomerulonephritis (Bright’s disease)
• Inflammation of glomerulus
• Immune complex disorder
• When bacterial infection occurs in the body, immune system
responds , the antigen antibody complexes clog the filtration
membrane and drops the filtration mechanism.
Renal failure
• When kidney does not perform excretory functions needed for
homeostasis.
• Urine production declines
• Water ion and metabolic wastes are retained in the body.
• Fluid balance , pH and metabolism of the body are disturbed.
• Acute Renal Failure occurs due to renal ischemia, urinary trauma,
exposure to nephrotoxic drugs
• Causes filtration to slow suddenly or stops.
• Chronic Renal failure occurs gradually. Associated problem occurs
over time
• This condition cannot be reversed
• It’s progression can only be slowed down.
• End stage of renal failure can be relieved by hemodialysis.
Renal calculi or Kidney stone
• Occurs when salts of calcium/magnesium or crystals of uric acid
deposits within urinary tract
• Also called as nephrolithiasis
• Caused obstruction in ureter
Other renal disorders
• Urinary tract Infection – microbial infection in urine
• Cystitis – inflammation of the urinary bladder
• Urethritis – inflammation of urethra
• Pyelonephritis – inflammation of kidneys

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