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Figure 1-NITROSAMINES - CONTAMINATION

The document compares the chemical structures of various angiotensin II receptor blockers (ARBs) that either contain or do not contain tetrazole groups. It notes that several ARBs without tetrazole groups, such as olmesartan, irbesartan, and candesartan, have been found to contain nitrosamine impurities linked to cancer. The document also lists other non-ARB drugs that have been found to contain nitrosamine contamination, including ranitidine, metformin, and varenicline.

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24 views

Figure 1-NITROSAMINES - CONTAMINATION

The document compares the chemical structures of various angiotensin II receptor blockers (ARBs) that either contain or do not contain tetrazole groups. It notes that several ARBs without tetrazole groups, such as olmesartan, irbesartan, and candesartan, have been found to contain nitrosamine impurities linked to cancer. The document also lists other non-ARB drugs that have been found to contain nitrosamine contamination, including ranitidine, metformin, and varenicline.

Uploaded by

د. وليد الشريف
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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ARB’s with Tetrazole ARB’s without Tetrazole

HN N O
HN N O
N N HN O
N N N HO
S
HO O OH
O
N N N N O
OH O
N OH O N N
Cl AZILSARTAN EPROSARTAN
LOSARTAN VALSARTAN
HN N HN N
N N N
N N
OH N N
O
N
HO
N O N O
O TELMISARTAN
N
N
Nitrosamines
IRBESARTAN CANDESARTAN
HN N
N O O O
N N O N N O
N N N N N N
OH

NMBA NDPA NDPA CPNP


O
N
N O O O O O O
O N N NN N N N N N N N
OH O O
NDMA NDEA NEIPA NDIPA NMP
OLMESARTAN

Other drugs with nitrosamine contamination

N HN O NH NH OH
O S N+ - HOOC
N O N N NH2 COOH2N
H H OH
RANITIDINE METFORMIN VARENICLINE tartrate
HO
S NO2
N
N S
N N OH O NH O NH
H H OH OH OH
NIZATIDINE O O HO OH OH
O N
O O N N
N O NH O N
O OH N O OH N
O O O
S
PIOGLITAZONE RIFAPENTIN RIFAMPIN

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