Biotin

SAFETY DATA SHEET
1. PRODUCT
1.1 Product identifiers

Name: (+)-Biotin N-hydroxysuccinimide ester
CAS-No.: 35013-72-0
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
2. HAZARDS IDENTIFICATION
2.1 Classification of the substance or mixture

Not a hazardous substance or mixture.
2.2 GHS Label elements, including precautionary statements

Not a hazardous substance or mixture.
2.3 Hazards not otherwise classified (HNOC) or not covered by GHS

No data available
3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1 Substances
Synonyms: d-Biotin NHS ester
NHS-Biotin
BNHS
Biotinyl-N-hydroxy-succinimide
N-Succinimidyl D-biotinate
N-Hydroxysuccinimidobiotin
(+)-Biotin N-succinimidyl ester
Formula: C14H19N3O5S
CAS-No.: 35013-72-0
No components need to be disclosed according to the applicable regulations.
For the full text of the H-Statements mentioned in this Section, see Section 16.
4. FIRST AID MEASURES
4.1 Description of first aid measures
General advice
No data available
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
In case of skin contact
Wash off with soap and plenty of water.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.2 Indication of any immediate medical attention and special treatment needed
1
no data available
5. FIREFIGHTING MEASURES
5.1 Extinguishing media
Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture

Carbon oxides, nitrogen oxides (NOx), Sulphur oxides
5.3 Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information

no data available
6. ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing vapours, mist or gas.
For personal protection see section 8.
6.2 Environmental precautions

Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up

Sweep up and shovel. Keep in suitable, closed containers for disposal.
6.4 Reference to other sections

For disposal see section 13.
7. HANDLING AND STORAGE
7.1 Precautions for safe handling

Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: -20 °C
Store under inert gas. Air sensitive. Keep in a dry place.
7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1 Control parameters
Components with workplace control parameters

Contains no substances with occupational exposure limit values.
8.2 Exposure controls
2
Appropriate engineering controls
General industrial hygiene practice.
Personal protective equipment

Eye/face Use equipment for eye protection tested and approved under appropriate government standards such as
protection NIOSH (US) or EN 166(EU).
Skin Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without
protection touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after
use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Body Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and
Protection to the specific work-place., The type of protective equipment must be selected according to the concentration
and amount of the dangerous substance at the specific workplace.
Respiratory Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type
protection N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under
appropriate government standards such as NIOSH (US) or CEN (EU).
Control of Do not let product enter drains.
environmen
tal
exposure
9. PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on basic physical and chemical properties

Appearance Form: powder
Colour: off-white
Odour no data available
Odour Threshold no data available
pH no data available
Melting point/freezing point Melting point/range: 212 - 214 °C (414 - 417 °F)
Initial boiling point and boiling range no data available
Flash point no data available
Evaporation rate no data available
Flammability (solid, gas) no data available
Upper/lower flammability or explosive limits no data available
Vapour pressure no data available
Vapour density no data available
Relative density no data available
Water solubility no data available
Partition coefficient: n-octanol/water no data available
Auto-ignition temperature no data available
Decomposition temperature no data available
Viscosity no data available
Explosive properties no data available
Oxidizing properties no data available
9.2 Other safety information
no data available
10. STABILITY AND REACTIVITY
10.1 Reactivity
no data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
no data available
3
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5
11. TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
Acute toxicity
no data available
Inhalation: no data available
Dermal: no data available
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by ACGIH.
NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a
known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by OSHA.
Reproductive toxicity
no data available
no data available
Specific target organ toxicity -single exposure
no data available
Specific target organ toxicity -repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: Not available
12. ECOLOGICAL INFORMATION
12.1 Toxicity
no data available
12.2 Persistence and degradability
no data available
12.3 Bioaccumulative potential
no data available
4
12.4 Mobility in soil
no data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Other adverse effects
no data available
13. DISPOSAL CONSIDERATIONS
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.
14. TRANSPORT INFORMATION
DOT (US)
Not dangerous goods
IMDG
Not dangerous goods
IATA
Not dangerous goods
15. REGULATORY INFORMATION
SARA 302 Components

SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components

SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the
threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards

No SARA Hazards
Massachusetts Right To Know Components

No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components
Component CAS-No. Revision Date
Biotin N-hydroxysuccinimide ester 35013-72-0
New Jersey Right To Know Components
Component CAS-No. Revision Date
Biotin N-hydroxysuccinimide ester 35013-72-0
California Prop. 65 Components
This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other
reproductive harm.
5
16. OTHER INFORMATION
HMIS Rating
Health hazard: 0
Chronic Health Hazard:
Flammability: 0
Physical Hazard 0
NFPA Rating
Health hazard: 0
Fire Hazard: 0
Reactivity Hazard: 0

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SAFETY DATA SHEET

1.1 Product identifiers

2.1 Classification of the substance or mixture

2.2 GHS Label elements, including precautionary statements

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS

4. FIRST AID MEASURES

4.1 Description of first aid measures

5.1 Extinguishing media

Suitable extinguishing media

5.2 Special hazards arising from the substance or mixture

5.3 Advice for firefighters

5.4 Further information

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures

For personal protection see section 8.

6.2 Environmental precautions

6.3 Methods and materials for containment and cleaning up

6.4 Reference to other sections

7. HANDLING AND STORAGE

7.1 Precautions for safe handling

For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Recommended storage temperature: -20 °C

Store under inert gas. Air sensitive. Keep in a dry place.

7.3 Specific end use(s)

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters

Components with workplace control parameters

8.2 Exposure controls

Personal protective equipment

9. PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties

9.2 Other safety information

10. STABILITY AND REACTIVITY

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

10.5 Incompatible materials

Strong oxidizing agents

10.6 Hazardous decomposition products

Other decomposition products - no data available

In the event of fire: see section 5

11. TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects

12. ECOLOGICAL INFORMATION

12.2 Persistence and degradability

12.3 Bioaccumulative potential

12.5 Results of PBT and vPvB assessment

12.6 Other adverse effects

13. DISPOSAL CONSIDERATIONS

13.1 Waste treatment methods

14. TRANSPORT INFORMATION

15. REGULATORY INFORMATION

SARA 302 Components

SARA 313 Components

SARA 311/312 Hazards

Massachusetts Right To Know Components

Chronic Health Hazard: