Untitled
Untitled
Untitled
Sr.
Item Details
No.
1. Name & Address of the M/s. OC Specialities Pvt. Ltd.
Project Plot No. E-18, Tal. Mohol, Chincholi MIDC Area, Solapur, Maharashtra
2. Name of the applicant & Mr. Vikas M. Shah
Designation Director
3. Type of Project Proposed Fine Chemical Intermediates Manufacturing Unit
4. Capacity of Project Manufacturing set-up shall be for production of 21 products.
5. Land acquired • Total Land – 8450 Sq. M.
• Built - Up Area – 3149.8 Sq. M.
• Open Space Available – 3647.2 Sq. M.
• Green Belt Area in MIDC plot – 2166.85 Sq. M. (59.40 % of open space)
6. Cost of the Project Total Investment – Rs. 5.14 Crores.
7. Production Capacities
Sr. Name of the Product Quantity Uses
No. (MT/M)
1. Sodium Bromide Soln. Oil Drilling Additive &
OR 390 Water treatment
Sodium Bromide 232 chemicals
Powder
Zinc Hydroxy OR 106 Additive in Natural
Zinc Oxide 74 Rubber
2. Di Isopropyl Ethyl Amine Pharma Intermediate
18.18
(DIPEA)
3. Methyl-2-Chloro Phenyl Pharma Intermediate
10.3
Acetate
4. 4 Methoxy Phenyl Pharma Intermediate
10
Acetone
5. Pharma & Diamide
2,3 Dichloro Pyridine 10
Intermediate
6. 2-Amino-2-Phenyl Pharma Intermediate
6.5
Butyric Acid
7. Ortho Hydroxy Phenyl Cosmetic Intermediate
15
Acetic Acid
8. 2 Coumaranone 12.4 Pharma Intermediate
9. 3-Isochromanone 12 Pharma Intermediate
10. 2,6 Dichloro Benzoyl 22.1 Intermediate for
Chloride Fungicide
11. Methyl-2-Dimethylamino- Pharma Intermediate
10
2-Phenyl Butyrate
12. 2-Dimethylamino-2- Comestics Intermediate
3.01
Phenyl Butanol
13. P-Bromonisole / 4-Bromo Pharma Intermediate.
16.5
Anisole
14. Para Bromo Pharma Intermediate.
Phenetole/4- 14.5
Bromophenetole
15. 2,4 - Dichloro phenyl Intermediate for
39.75
acetyl Fungicide.
16. 2,5 – Dimethyl phenyl Intermediate for
32.5
acetyl chloride Insecticide.
Sr.
Item Details
No.
17. Indoline 36.25 Cosmetics Intermediate
18. Ethyl Phenyl Glyoxalate Cosmetics Intermediate
28.42
(EPG)
19. Ethyl – 1- Hydroxy Pharma Intermediate
33
cyclohexane carboxylate
20. Ethyl – 1- Hydroxy cyclo Pharma Intermediate
35.25
pentane carboxylate
21. 3 – chloro – 2 - 36 Polymer synthesis.
hydrazinylpyridine
Name of the Byproduct
1. Sodium sulphite 182.07 Detergent Soap
soln.25%
2. HCl 30% 75.59 Reused for Chlorination
3. Sodium Nitrite soln.30% 30.42 Reused
4. Distillation residue of P- 3.6 Solvent
xylene
5. Ammonium Chloride 36 Used as buffer solution
8. Air Pollution Control A D.G. Set of 200 KVA capacity would be installed. HSD would be used as
Measures fuel and the consumption rate would be about 75 Lit./Hr. The D.G. Set
would be operated only during power failure.
Sr.
Description Specifications
No.
(a) Stack Number (s) 1 1
(b) Attached to Boiler TFH DG Set
(c) Capacity 3 TPH 6 Lakhs 200 KVA
Kcal/Hr
(d) Fuel type Coal/Biomass Coal/Biomass HSD
(e) Fuel quantity 18 MT/Day/ 100 Kg/Hr / 75 Lit. / Hr.
36 MT/Day 220 Kg/Hr
(f) Material of RCC M.S
construction
(g) Shape Round Round
(round/rectangular)
(h) Height, m (above 30 M 3M
ground level)
(i) Diameter/size, in 0.5 M 0.1 M
meters
(j) Ash Content % Coal - 5 % / Biomass – 3 % 0.1 %
(k) Sulphur content % Coal - 1 % 1%
(l) Control equipment Multicyclone Multicyclone --
preceding the stack Dust Dust
Collector Collector
(MDC) (MDC)
followed by followed by
Bag Filter Bag Filter
Sr.
Item Details
No.
9. Water Requirement
Sr. No. Description Water Consumption
(M3/Day)
#
1. Domestic 5
($4 + #1)
2. Industrial
#
a. Processing 17
b. Washing *3
c. Cooling *8
d. Boiler Feed *8
e. Scrubber *2
38
Industrial Total
(#17 + *21)
3. Other (Gardening) *2
• 45
Grand Total
(#18 + *$27)
Note: Out of the total water consumption, 23 CMD (57%) is DEE
Condensate to be recycled, 0.5 CMD for Ash quenching.
#
MIDC Water Source, * Use of the condensate water from the DEE and
$
Rain water
A] REACTION:
B] BRIEF PROCESS:
Charge:
• 4800 Ltrs water, add under stirring.
• 1600 Kg Sodium Hydroxide Flakes stirred to dissolve completely.
Add:
6000 Kg Zinc Bromide Solution (70%) from top in 3 Hrs, stir well for 1 Hrs & centrifuged
washed with 100 Ltrs water.
Output:
• Sodium Bromide 40 % solutions 9750 Kg.
• Zinc Hydroxide (wet Cake 30% moisture content) 2650 Kg.
69
2. DI ISOPROPYL ETHYL AMINE [DIPEA]
A] REACTION:
C3H7
C3H7
2NH + (C2H5)2SO4 + NaOH 2N C2H5 + NaHSO4 + H2O
C3H7
C3H7
B] BLOCK DIAGRAM:
Aqueous
Layer 2940
Kg
C] BRIEF PROCESS: 150 Kg Pitch
Charged Isopropyl Ethyl Amine & Diethyl Sulphate stirred well, then slowly added from
the top caustic solution after completion of addition, heated for 3 Hrs. allow it to settle.
Separate aqueous layer & organic layer. Organic layer is taken for recovery of DIPA &
fractional distillation of DIPEA
70
3. METHYL-2-CHLORO PHENYL ACETATE
A] REACTION:
CH2COOH CH2COOH
Cl H2SO4 Cl
+ CH3OH
B] BLOCK DIAGRAM:
Methanol
Recovered 300
Sodash Solution (15 Kg) Kg (Recycled)
Methanol 500 Kg
Methyl-2-
2-Chlorophenyl Acetic Acid 1000 Kg Chlorophenyl
Esterification
Acetic Acid
Distillation 1030 Kg
Sulphuric Acid (98% 50 Kg) Pure
99.5%
180 Kg
71
C] BRIEF PROCESS:
Charged Methanol, 2-Chlorophenyl Acetic Acid & Sulphuric Acid. Start heating,
maintain reflux temperature for 4 Hrs. Start recovery of excess of Methanol which is
recycled in the next batch. Allow it to settle. Separate aqueous Sulphuric Acid then add
Sodium Carbonate solution to neutralize the mass, separate aqueous
layer. Organic material taken for distillation.
CH3
A] REACTIONS:
CH C COOH3
1) H3CO O
CH
CHO NaCOH3 H3CO
+ CH3 CH COOH3 + NaCl +CH3OH
Sodium
Methoxide
M.W. = 122.5
Sodium
Para Methyl-2-Chloro Epoxy Ester Methanol
Chloride
Anisaldehyde Propionate M.W. = 222 M.W. = 32
M.W. = 58.5
M.W. = 136 M.W. = 122.5
2)
CH3 CH3
CH C COOH3 CH C COONa
O O
H3CO H3CO
+ NaOH + CH3OH
H3CO H3CO
2 + H2SO4 2X + Na2SO4
CH3
H3CO H3CO
2X 2X + CO2
B] BLOCK DIAGRAM:
2- Chloromethyl
Propionate Decarboxylation &
975 Kg Epoxidation Hydrolysis of Separation of Distillation
Ester Aqueous Layer 4-Methoxy
Phenyl
Acetate
Sodium Methoxide 440 Kg Pitch 200 Kg 1000 Kg
Aqueous Pure 99%
Layer 2827 Kg
C] BRIEF PROCESS:
2-Chloromethyl Propionate is charged along with Para-Anisaldehyde under stirring.
Reaction mass is cooled & Sodium Methoxide is charged lot-wise. After completion of
addition stirred for 3-4 Hrs till reaction is completed. Add Caustic Soda solution &
material is heated to reflux. Dilute sulphuric acid is added slowly till pH is 2. Reaction
mass is maintained at reflux temperature till completion of reaction. Allow it to settle to
remove aqueous layer. Organic layer is taken for distillation to get pure 4-Methoxy
Phenyl Acetone.
5. 2, 3-DICHLORO PYRIDINE
A] REACTIONS:
Cl
N N
NH2 N NCl
Cl Cl
2HCl
+ NaNO2 + + 2H2O + NaCl
0-5°C
N N
Diazonium
3-Amino-2- Sodium Salt Water Sodium
Chloropyridine Nitrite M.W. = 18 Chloride
M.W. = 128.56 M.W. = 69 M.W. = 58.5
74
B] BLOCK DIAGRAM: Hydrochloric N2 gas
Acid (30%) 74 Kg
400 Kg 2, 3-Dichloropyridine
210 Kg Water
+ wet 320 Kg
NaNO2 194 Kg Cupric +
Chloride Caustic Soda Water 1875 Ltrs.
42 Kg 835 Kg (Recycled)
420 Kg
Hydrochloric Acid (30%) Water
Sulphuric Water Isopropyl Alcohol
2500 Kg
Acid 1570 Kg 75 Kg
(80%)
3-Amino Crystallization
Pyridine Steam of 2, 3-
250 Kg Chlorination Diazotisation Decomposition of
Distillation Dichloro-
Diazonium Salt
pyridine 300 Kg
3-Amino Pyridine is treated with Hydrochloric Acid [35% - 37% w/w] and Hydrogen
Peroxide [50% w/w].
Diazonium Salt is further reacted with previously heated solution of salt and acid. The
evolved Nitrogen gas is scrubbed. On addition of (40% w/w) caustic solution to adjust
pH 7-7.5 pass stream and product 2, 3-dichloropyridine starts distillating out along with
steam water.
75
A] REACTION:
B] BLOCK DIAGRAM:
Water
Caustic Soda Water 500 Kg
5 Kg 1500 Kg
Acidification by
HCl 30%
200 kg
P - Hydroxy
Benzoic Acid Aqueous effluent
200 kg 2165 Kg
C] BRIEF PROCESS:
Para Cresol along with catalyst and water is fed continuously to the oxidation reactor and air
is passed at desired temperature. After maintaining period, material is continuously
withdrawn from the oxidation reactor at fixed interval. The material is further treated with
dilute Caustic Soda Solution to remove p-Hydroxy Benzoic Acid. The slurry is fed to
centrifuge washed & dried to get p-Hydroxy Benzaldehyde. The alkali aqueous layer is
neutralized with Hydrochloride acid 30% and precipitated
p-Hydroxy Benzoic Acid is centrifuged, washed & dried.
76
6. 2-AMINO-2-PHENYL BUTYRIC ACID
A] REACTIONS:
HN
1) O O C C O
II
C – C2H5 C2H5 C NH
+ HCl + NaCl
77
B] BLOCK DIAGRAM:
Acetic Acid
135 Kg
Ammonium Bicarbonate
660Kg 1000 Kg 5-Phenyl
Autoclave Neutralization -5-Ethyl Hydention
Sodium Cyanide Centrifuging
225 Kg 7.75 Autoclave
Water
500 Ltrs Aqueous
Layer
STAGE – II 2070 Kg
Water
HCl 30% 200 Ltrs
2000 Kg Water Vapour
150 Kg
650 Kg Dry
Drying 800 Kg 2 –Amino, 2- Phenyl
Neutralization Centrifuging 2 –Amino, 2- Phenyl Butyric Acid
7.0 Butyric Acid
Aqueous
Layer
4600 Kg
C] BRIEF PROCESS:
78
7. ORTHO HYDROXYL PHENYL ACETIC ACID /
2-HYDROXY PHENYL ACETIC ACID
A] REACTIONS:
1)
CH2COOH CH2COONa
Cl ONa
+ 3NaOH + NaCl + 2H2O
2)
CH2COONa CH2COONa
ONa ONa
+ 2 HCl + 2NaCl
3)
79
B] BLOCK DIAGRAM:
Hydrochloric
Acid (30%)
2200 Kg
Water Vapour
150 Kg
HCL 30% 650 Kg
2 chlorophenyl
Water 200 Kg
Acetic Acid 1000 Kg
Caustic Soda
Flakes 940 Kg Ist Neutralize nd
II Neutralize
Autoclave Solution Solution Drying Wet cake
Centrifuging
Water Pressure pH 2.0 900 Kg
2000 Ltrs 14-16 Kg 6.5 to 7.0
C] BRIEF PROCESS:
In autoclave charge water, caustic Soda flakes, Copper Sulphate.7H2O and Orthochloro
Phenyl Acetic Acid and heated till desire pressure is reached.
80
8. 2-COUMARANONE
A] REACTION:
CH2COOH
CH2
OH
C
+O 2 + H 2O
O
2-Hydroxy Phenyl 2-Coumaranone Water
Acetic Acid M.W. = 134 M.W. = 18
M.W. = 152
B] BLOCK DIAGRAM:
30 Kg Pitch
C] BRIEF PROCESS:
Ortho Hydroxy Phenyl Acetic Acid is charged into reactor and heated to 150° C to distilled
out water of reaction. Vacuum is applied and crude 2-Coumanone is distilled to get pure
2-Coumanone
81
9. 3- ISO CHROMANONE
A] REACTIONS:
1) CH3 CH2 Cl
CH2OOH CH2OOH
+ Cl2 + HCl
2)
CH2 Cl
CH2OOH CH2
O
+ NH4OH + NH4Cl
C O
CH2
82
B] BLOCK DIAGRAM:
Hydrochloric
Acid (30%)
210 Kg
N2 Toluene 600 Kg
C] BRIEF PROCESS:
Charge into glass lined reactor 2-Methyl Phenyl Acetic Acid, Mono Chlorobenzene and
Catalyst .chlorine is pass at 900C till desire conversion is obtained. The evolved
hydrochloric acid is scrubbed in to water. After completion of reaction nitrogen is purged
to remove HCl from the system. Material is cooled to 250C and ammonia solution is
added till pH 6.5 -7. After reaching pH 6.5 -7 organic layer is separated & washed with
water, unreacted 2-Methyl Phenyl Acetic Acid is recovered by acidification of aqueous
layer. Organic layer is distilled to recovered MCB. The bottom left material 3-IC is distilled
under high Vaccum and further crystallized in Toluene. Toluene is recovered from mother
liquor by distillation.
83
10. 2, 6- DICHLORO BENZOYL CHLORIDE
A] REACTIONS:
1)
CHO COOH
Cl Cl Cl Cl
+ HNO3 + HNO2
+ NaOH + H 2O
2, 6
Dichlorobenzaldehyde
900 Kg
Neutralization Acidification
Oxidation Centrifuging 2, 6 DCBA pH 6.5-7.0
Nitric Acid 60% 980 Kg
w/w 1350 Kg
1030 Kg Nitric
Acid 48%
Recycled
SO2 390 Kg
Thionyl
Water Water
Chloride HCl 215 Kg Thionyl
150 Kg 30 Kg Chloride
500 Kg
Recycled
Centrifuging Pure 2,
2, 6 DCBA Drying 6
2, 6 DCBA Distillation Dichloro
wet cake 950 Kg Benzoyl
950 Kg
980 Kg Chloride
Pitch
190 Kg
1505 Kg
Aqueous
to ETP
C] BRIEF PROCESS:
2, 6 Dichloro Benzaldehyde is treated with nitric acid 60%.The evolved nitric acid is
Scrubbed into caustic soda solution to get sodium nitrite solution which is sold in the
market. The 2, 6 Dichloro Benzoic acid formed is cooled & centrifuged. It is further
neutralized with caustic soda solution, clarified and neutralized with Hydrochloric acid
30%. The Precipitated 2, 6 Dichloro Benzoic acid is centrifuge, washed with water &
dried.
Step – II
The dry 2, 6 Dichloro Benzoic acid is further treated with Thionyl Chloride. The
evolved gas of Sulphur Dioxide is scrubbed in to caustic soda solution and Hydrogen
Chloride gas is scrubbed in to water scrubber. After completion of reaction excess
Thionyl Chloride is distilled & recycled and bottom material is Vaccum distilled to get
pure 2, 6 Dichloro Benzoyl Chloride.
85
11. METHYL – 2 – DIMETHYL AMINO – 2 – PHENYL BUTYRATE
A] REACTIONS:
1)
COOH COOCH3
Toluene
+ (CH3)2SO4 + H2SO4
2)
COOCH3 COOCH3
86
B] BLOCK DIAGRAM:
CO2 490 kg
Toluene 1600 Kg
Recycled
Vaccum 1000 Kg
Methyl-2-Dimethyl
Distillation Amino-2-Phenyl
Butyrate
Pitch
40 Kg
C] BRIEF PROCESS:
87
12. 2- DIMETHYL AMINO – 2 – PHENYL BUTANOL
A] REACTION:
COOCH3 CH2OH
7% Vitride
B] BLOCK DIAGRAM:
Sodium Hydroxide Water 2000 Kg Toluene (R) 870 Kg
280 Kg recycled
Toluene 720 Kg
Methyl-2-Dimethyl 2-(Dimethyl
Toluene Amino)-2-Phenyl
Amino-2-Phenyl
Butyrate 550 Kg Reduction Recover Butanol 430 Kg
C] BRIEF PROCESS:
88
13. 4 – BROMO ANISOLE
6. Water 500
A] REACTION:
OCH3 OCH3
Br
Anisole Hydrobromic Hydrogen P. Bromo Water
M.W. = 108 Acid Peroxide Anisole M.W = 2 X 18
M.W. = 81 M.W. = 34 M.W = 187 = 36
B] BLOCK DIAGRAM:
Anisole 1000 kg
Distillation of
Hydrobromic Acid
Bromination Crude P. Bromo 1820 kg
48% 1625 kg
Anisole Crude P.
Hydrogen Peroxide
1845 Kg Bromo Anisole
30%
1250 kg
89
C] BRIEF PROCESS:
In the glass lined reactor anisole and Hydrobromic Acid (48%) is charged. The materials are
cooled to 50C and then add slowly Hydrogen peroxide (30%) solution. Reaction is
exothermic. Chilling is required. Temperature is controlled between 10-120C throughout
the addition of Hydrogen peroxide solution after completion of reaction. Material is stirred at
10-150C for 1 hr check completion of reaction. conversion repeated is above 99%. If it is less
then stirred 1 hr more. After completion of reaction material allowed to settle. Separate out
bottom organic material for aqueous layer. Organic material recharged and washed with 5%
sodium Thiosulphate solution till colour changes to light yellow. Material is allowed to settle.
separate Organic layer for aqueous layer and taken for Vacuum distillation to get pure form.
14. 4 - BROMOPHENETOLE
A] REACTION:
OC2H5 OC2H5
Br
Phenetole Hydrobromic Hydrogen Water
M.W. = 122.17 Acid Peroxide Para – Bromo M.W. = 2 X 18
M.W. = 81 M.W. = 34 Phenetole = 36
M.W. = 201.06
90
B] BLOCK DIAGRAM: 10 Kg
Sodium thiosulphate Water
solution (5% w/w) 525 Kg Vapour
C] BRIEF PROCESS:
In a glass lined reactor, Phenetole and Hydrobromic acid (48 %) are charged. The
material is cooled to 50C and then add slowly Hydrogen Peroxide (30 % w/w) solution.
Reaction is exothermic. Chilling is required. Temperature controlled between 10-120C
throughout the addition of Hydrogen peroxide solution. After completion of reaction
material is stirred at 10-150C for 1 hr. Check completion of reaction. Conversion
expected is above 99%. If it is less than that stirred 1hr more. After completion of reaction
material is allowed to settle. separate out bottom organic material from aqueous layer.
Organic material is recharged and washed with 5% w/w sodium thiosulphate solution. Till
colour changes to light yellow material is allowed to settle. Separate organic layer from
aqueous layer and taken for vacuum distillation to get pured form.
91
A] REACTIONS:
Stage I: Cyanation
Cl CN
Cl Cl
water,TEA
+ NaCN Toluene
+ NaCl
Cl Cl
(2,4-dichlorophenyl)acetonitrile,MW=186 Sodium Chloride,MW=58.5
2,4-Dichloro benzyl chloride,MW=195.5 sodium cyanide,MW=49
Cl Cl
NaOH,Toluene + NH 3
Cl Cl
(2,4-dichlorophenyl)acetonitrile,MW =186 (2,4-dichlorophenyl)acetic acid sodium Am m onia,MW =17
salt,MW =227
HCl
COOH
Cl
+ NaCl
Cl
(2,4-dichlorophenyl)acetic acid,MW =205 Sodium Chloride,MW =58.5
COOH
COCl
Cl
Cl
SOCl2 + HCl(g) + SO2(g)
Cl
Cl
Hydrochloric acid,MW=36.5 Sulfur dioxide,MW=64
(2,4-dichlorophenyl)acetic acid,MW=205 (2,4-dichlorophenyl)acetyl chloride,MW=223.5
92
B] FLOW CHART:
Stage I :Cyanation
1)Toluene(1000 Kg)
Cyanation
2)2,4-dichloor benzyl chloride(2000 Kg)
Crude
7)Pitch(150 kg)
93
Stage II (Hydrolysis)
5)HCl(1800 Kg)
Isolation
Distillation
Crude
94
C] BRIEF PROCESS:
Stage I : Cyanation
2,4 dichloro benzyl chloride is coverted into cyanide by using sodium cyanide and toluene as
a solvent and triethyl amine as a base.The product is isolate by layer separation.The organic
layer is distilled out to recover toluene followed by fractional distillation gives pure product
stage I as (2,4-dichlorolphenyl)acetonitrile.The aqueous layer contains extra sodium cyanide
is destroyed by using sodium hypochlorite as a oxidizing agent.
Stage II : Hydrolysis
Stage II i.e 2,4-dichloro phenyl acetic acid is converted into acid chloride using thionyl
chloride as a chlorinating agent.the liberated and hydrochloric acid gas is scrubbed into
water and sulphur dioxide gas into alkali scrubber which converts into sodium sulfite .The
product is isolated by fractional distillation gives pure product as 2,4-dichloro phenyl acetyl
chloride.
95
16. 2,5 – DIMETHYL PHENYL ACETYL CHLORIDE
A] REACTIONS:
Stage I: Chloromethylation
CH3
CH3
+ HCHO + HCl
Cl
n + H2O
CH3
CH3
p-Xylene,MW=106 p-formaldehyde,MW=30 2-(chloromethyl)-1,4-dimethylbenzene,MW=154.6 water,MW=18
Stage II : Cyanation
CH3 CH3
Cl CN
+ NaCl
+ NaCN
H2O,Toluene
CH3 CH3
2-(chloromethyl)-1,4-dimethylbenzene,MW=154.6 Sodium cyanide,MW=49 (2,5-dimethylphenyl)acetonitrile,MW=145 Sodium Chloride,MW=58.5
96
Stage III: Hydrolysis
CH3 CH3
CN COONa
NaOH,H2O
+ NH3
CH3 CH3
(2,5-dimethylphenyl)acetonitrile,MW=145 (2,5-dimethylphenyl)acetic acid sodium,MW=186 Ammonia,MW=17
HCl,MW=36.5,Toluene
CH3
COOH
+ NaCl
CH3
(2,5-dimethylphenyl)acetic acid,MW=164 Sodium Chloride,MW=58.5
COOH COCl
SOCl2
+ HCl + SO2(g)
CH3 CH3
(2,5-dimethylphenyl)acetic acid,MW=164 (2,5-dimethylphenyl)acetyl chloride,MW=182.6 Hydrochloric acid,MW=36.5 Sulfur dioxide,MW=64
B] FLOW CHART:
97
Stage I : Chloromethylation
1)p-Xylene(1500 kg)
Condensation
2)Conc. HCl(4665 Kg)
3)p-Formaldehyde(1110 Kg)
8)Recovered xylene
Organic layer
450 kg
9)Pitch
Crude stage I
145 kg
1425 kg
Pure stage I
98
Stage II : Cyanation
1)Toluene(712 kg)
Cyanation
2)Stage I(1425 Kg)
Crude
7)Pitch(150 Kg)
99
Stage III : Hydrolysis
5)HCl(1430 Kg)
Isolation
100
Stage IV : Chlorination
NaOH scrubber
Distillation
Sodium sulfite
Crude
HCl(275 Kg)
Packing
1300 kg
C] BRIEF PROCESS:
Stage I : Chloromethylation
P-xylene is chloromethylated using p-formaldehyde and concentrated hydrochloric acid and zinc
chloride as a catalyst.The product is isolated by separating organic layer, followed by sodium
carbonate washing to remove excess acidity.The organic layer is distilled out to remove p-xylene
followed by fractional distillation gives pure product stage I as 2-(chloromethyl)-1,4-dimethylbenzene
Stage II : Cyanation
Stage I 2-(chloromethyl)-1,4-dimethylbenzene is coverted into cyanide by suing sodium cyanide and
toluene as a solvent.The product is isolate by layer separation.The organic layer is distilled out to
recover toluene followed by fractional distillation gives pure product stage II as (2,5-
dimethylphenyl)acetonitrile
Stage IV : Chlorination:
Stage III i.e 2,4-dimethyl phenyl acetic acid is converted into acid chloride using thionyl chloride as a
chlorinating agent.the liberated sulphur dioxide gas and hydrochloric acid gas is scrubbed into
scrubber. The product is isolated by fractional distillation gives pure product as 2,5-dimethyl phenyl
acetyl chloride.
101
17. INDOLINE
A] REACTION:
NH2
Cl NH2
+ HO
N
H
2-(2-chlorophenyl)ethanamine,MW=155.5 Ethanolamine,MW=61 2,3-dihydro-1H-indole,MW=119
CH4
NH2
HO
NH2 .HCl
+ NaOH HO + NaCl + H 2O
102
B] FLOW CHART:
3)Xylene(2800 Kg)
1) Ethanolamine(2800 Kg)
Cyclization
2)2-chloro phenylethylamine Sodium Hydroxide(515 kg)
(2000 kg)
Bottom layer
Recovered
ethanolamine
Pitch(81 kg) 2750 kg
Crude
Recovered Xylene(2660 kg)
Liquid aqueous waste
(421 Kg)
Fractional distillation
Pure(1450 kg)
95% of theory
C] BRIEF PROCESS:
Brief Process:2-chloro phenyl ethylamine is cyclised to 3-indoline by using ethanolamie as a base.
The product is isolated by extraction in xylene followed by solvent distillation gives crude product
which on fractional distillation gives pure product. The by-product ethanolamine hydrochloride is
basified with sodium hydroxide liberates free base which is used in the next reaction.
103
18. ETHYL PHENYL GLYOXALATE (EPG)
List of Raw materials:
A] REACTION:
COOC2H5
CN
H OH
H OH
NaOCl,MW=74.5
O
O
OC2H5
H2O + NaCl +
Water,MW=18 Sodium chloride,MW=58.5 Ethyl phenyl glyoxalate,MW=178
104
B] FLOW CHART:
Crude EPG
13)Pitch(83 Kg)
Pure EPG
1137 Kg
C] BRIEF PROCESS:
Mandelonitrile is reacted with hydrochloric acid and water and hydrolyzed to acid which is in-situ
esterfied with etyla alcohol to give ethyl mandalate. The excess ethyl alcohol is distilled out and re-
used in the next batchs. After that water and toluene is added ,water layer is separated which
contains ammonium chloride. Organic layer contains product is oxidized with sodium hypochlorite.
The organic layer is separated followed by tolune distillation gives crude ethyl phenyl glyoxalate
which on fractional distillation gives pure ethyl phenyl glyoxalate.
105
19. ETHYL-1-HYDROXY CYCLOHEXANE CARBOXYLATE
A] REACTION:
EtOOC OH
NC OH
HCl,C2H5OH
water,Toluene + H2O + NH4Cl
106
B] FLOW CHART:
10)Recovered toluene
Pure ethyl-1-hydroxy-
cyclohexane carboxylate
1320 Kg
C] BRIEF PROCESS:
1-hydroxy cyclohexane carbonitrile is hydrolyzed with hydrochloric acid and esterifies with ethanol
in-situ gives desired product. The formed product is isolated by adding water followed by toluene
extraction. The aqueous layer is separated contains ammonium chloride and organic layer contains
product. The solvent is distilled out gives crude product which on fractional distillation gives ethyl-1-
hydroxy cyclohexane carboxylate.
107
20. ETHYL-1-HYDROXY CYCLOPENTANE CARBOXYLATE
A] REACTION:
NC OH
EtOOC OH
HCl,C 2 H 5 O H
Toluene + H 2O + NH 4 Cl
1-hydroxycyclopentanecarbonitrile,MW =111 ethyl 1-hydroxycyclopentanecarboxylate,MW -158 water,M W =18 am m onium chloride,MW =53.5
108
B] FLOW CHART:
Pure ethyl-1-hydroxy-
cyclopentane carboxylate
1410 Kg
C] BRIEF PROCESS:
1-hydroxy cyclopentane carbonitrile is hydrolyzed with hydrochloric acid and esterifies with ethanol
in-situ gives desired product. The formed product is isolated by adding water followed by toluene
extraction. The aqueous layer is separated contains ammonium chloride and organic layer contains
product. The solvent is distilled out gives crude product which on fractional distillation gives ethyl-1-
hydroxy cyclopentane carboxylate.
109
21. 3-CHLORO-2-HYDRAZINYL PYRIDINE
A] REACTION:
Cl
2 +2 NH2NH2 + K2CO3
N Cl
2,3-dichloropyridine,MW=296 Hydrazine ,MW=64 Potassium carbonate,MW=138
n-Butanol
Cl
110
B] FLOW CHART:
3)Potassium carbonate(1840 Kg) 4)Hydrazine hydrate
Cooling,Filtration
5)n-butanol(1000 kg)
Wet Weight
Drying
Mother Liquor
Layer separation
Aqueous layer (5127 Kg)
Organic layer
distillation to ETP
C] BRIEF PROCESS:
2, 3-Dichloro pyridine is reacted with hydrazine hydrate in presence of potassium carbonate
as a neutralizing agent and n-butanol as a solvent. The product is precipitated out during
course of reaction is isolated by filtration followed by n-butanol washing gives final product 3-
chloro-2-hydrazinyl pyridine as a solid. The biphasic mother liquor is separated by layer
separation method. Aqueous layer is sent to ETP for treatment and organic layer is taken for
n-butanol distillation and recovered n-butanol is re-used for next batch. The remaining pitch
after n-butanol distillation is sent for incineration.
111
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exercise of powers eonferred ,by
sub-section (3) of section I of ·tile Maharashtra Industrial Development
A.c~ 1961 (Mah, of 1962) the <1overnment of Maharasbtra liereby appoints rre
17fh May.. 1988 to be the date from which Chapter
+~.;:: 'm"
VI.; __of
••••
the said Act shaH
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¥~ ~ . i{tt~l~ ~ ~~, if ~~ l'~(./~ ~ .~ ;.\~O . [~~"!:l
• take effect in the area mentioned'. in the Schedule annexed hereto. and.
. declares the said area as industrial area under clause (g) of section 2 ,Q! tb~
said Act. '. ,
, .
The said area is more clearly defined in red in ·the maps deposited in. tho
Offi~ of the Chief Executive Officer" Mabarashtra InduStrial Developntent
Corporation. Bombay 400 093,. and the. Special .Land .-Acquisi.tion Offieer,
Solapur Division. Solapur, Dis' let Solapur, and is bounded by the: .~
"as indicated in the said Schedule.' ~
, Schedule
.
.District Solapur, taluka Mohol, vil~ge Ch~holL
'88
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3 67'(} 125 '0 241).
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t tv: (he East by--Gnt Nos. !4,1 5. J 9. 20. 25. 56, 62. 64 pt.. 65 pl ..•
fl(~ rr.. 07 pt., 68 pt., 70 pr., 90. Q2. 94, 95. 98. 104. l05. "'06. of villagr
K~"ndi. -" J
On the West by-Oat Nos. 52,,14'8' pt., ISS, J56•. 151. (58. )83.. 1~
I is\!. J90. 230 pt., 231 Pt.1 233 pt ... of -<jiUage Cbincholi, and Bo,undZl1
l~f Village Sawleshawar.
d" the North by-Boundav of Villaaes Darfal and Akole,
I. .• ow
~ ,.~. '
0" fir S'ltith by-Gat Nos. 1 pt. 4 ft .. 6. 8. 10 pt.. ~I pt .. 12 'fK-.
fJ pt.. 1\.~ ~ pt:, 2~ pt., 25 pt., 28 pt. 29 .pt., J2, 37. 70 pf .. 71 p!.
72 pt., . d 73 pt.. of Village Chincholi and Pune-Solanur Nntion~1
H·I~\;\\'a
L..
:.
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N' •
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'ByQrdct and in' the name of· the Governor0f Me harashtra, .:
M, D~.SARV!.' .•..."r.AR-
-oe~.... om cer.
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"
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SCHI!DVLE
District
-- -' .,-~.-.-.--. -
Oat No.
Aurangabad,
.. _Area_---_
t~Juk;a .Atlrangatx'ld;: village
... ..... - ... "~ ---
Gat No.
WnIQdgaon.
Arca
Ares Ares
e! pt. 02·()
.... _-- -----
69 pt. 01·0
,J" -.-----.--.- -- - - - -_._.-
I .
B-owtdtUies. :
Orr the Nortli by'.-Part of.Gat Nos. 70. 71~ 16. 77.18.
CJr. the SOfith.~.~p~rt of Gal, N~s. 70. 11, 76. 17~78 ~nd 8I.
On {he East b. .~oundary of village Nakashtra wadi.
On tlu: lVestry. -Aurn~i$.d-Ahm.dnagar Road.
. 1 'i! •
;J~s:
On lhe North by.-Part of Gat Nos. 18, 19. 20, 21 and 26.
On .he S~)u'h by.-Part of Gat No~. 18. 19. 20 and 22.
On the East by.~Bou(]dary of village Valadgnqn,
0,. the West bj.-Boundary village Valadgeon. of