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    Naproxen

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    Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, and inflammation. It works by inhibiting prostaglandin synthesis. It is indicated for conditions like arthritis, tendinitis, and dysmenorrhea. Common side effects include nausea, diarrhea, rash, and dizziness. Serious side effects can include gastrointestinal bleeding, renal impairment, and anaphylaxis. It interacts with lithium and certain lab tests. Nursing considerations include monitoring for side effects, taking with food to reduce gastrointestinal upset, and arranging eye exams during long-term use.

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    Naproxen

    Uploaded by

    api-3797941
    2K views3 pages
    Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, and inflammation. It works by inhibiting prostaglandin synthesis. It is indicated for conditions like arthritis, tendinitis, and dysmenorrhea. Common side effects include nausea, diarrhea, rash, and dizziness. Serious side effects can include gastrointestinal bleeding, renal impairment, and anaphylaxis. It interacts with lithium and certain lab tests. Nursing considerations include monitoring for side effects, taking with food to reduce gastrointestinal upset, and arranging eye exams during long-term use.

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    Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, and inflammation. It works by inhibiting prostaglandin synthesis. It is indicated for conditions like arthritis, tendinitis, and dysmenorrhea. Common side effects include nausea, diarrhea, rash, and dizziness. Serious side effects can include gastrointestinal bleeding, renal impairment, and anaphylaxis. It interacts with lithium and certain lab tests. Nursing considerations include monitoring for side effects, taking with food to reduce gastrointestinal upset, and arranging eye exams during long-term use.

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    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    2K views3 pages

    Naproxen

    Uploaded by

    api-3797941
    Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, and inflammation. It works by inhibiting prostaglandin synthesis. It is indicated for conditions like arthritis, tendinitis, and dysmenorrhea. Common side effects include nausea, diarrhea, rash, and dizziness. Serious side effects can include gastrointestinal bleeding, renal impairment, and anaphylaxis. It interacts with lithium and certain lab tests. Nursing considerations include monitoring for side effects, taking with food to reduce gastrointestinal upset, and arranging eye exams during long-term use.

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    naproxen

    (na prox' en)

    naproxen
    Apo-Naproxen (CAN), EC-Naprosyn, Naprelan, Naprosyn, Naxen (CAN),
    Novo-Naprox (CAN)

    naproxen sodium
    Aleve, Anaprox, Anaprox DS, Apo-Napro-Na (CAN), Synflex (CAN)

    Pregnancy Category B (first and second trimesters)


    Pregnancy Category D (third trimester)

    Drug classes
    NSAID
    Analgesic (nonopioid)

    Therapeutic actions
    Analgesic, anti-inflammatory, and antipyretic activities largely related to inhibition of
    prostaglandin synthesis; exact mechanisms of action are not known.

    Indications
    • Mild to moderate pain
    • Treatment of primary dysmenorrhea, rheumatoid arthritis, osteoarthritis,
    ankylosing spondylitis, tendinitis, bursitis, acute gout
    • OTC use: Temporary relief of minor aches and pains associated with the common
    cold, headache, toothache, muscular aches, backache, minor pain of arthritis, pain
    of menstrual cramps, reduction of fever
    • Naproxen only: Treatment of juvenile arthritis

    Contraindications and cautions


    • Contraindicated with allergy to naproxen, salicylates, other NSAIDs; pregnancy;
    lactation.
    • Use cautiously with asthma, chronic urticaria, CV dysfunction; hypertension; GI
    bleeding; peptic ulcer; impaired hepatic or renal function.

    Available forms
    Tablets—250, 375, 500 mg; 220, 275, 500 mg (as naproxen sodium); DR tablets—375,
    500 mg; CR tablets—375, 500 mg; suspension—125 mg/5 mL

    Dosages
    Do not exceed 1,500 mg/day (1,375 mg/day naproxen sodium).
    ADULTS
    • Rheumatoid arthritis or osteoarthritis, ankylosing spondylitis:
    Delayed-release (EC-Naprosyn)
    375–500 mg PO bid.
    Controlled-release (Naprelan)
    750–1,000 mg PO daily.
    Naproxen sodium
    275–550 mg bid PO. May increase to 1.65 g/day for a limited period.
    • Acute gout:
    Controlled-release (Naprelan)
    1,000–1,500 mg PO daily.
    Naproxen sodium
    825 mg PO followed by 275 mg q 8 hr until the attack subsides.
    • Mild to moderate pain:
    Controlled-release (Naprelan)
    1,000 mg PO daily.
    Naproxen sodium
    550 mg PO followed by 275 mg q 6–8 hr.
    OTC
    200 mg PO q 8–12 hr with a full glass of liquid while symptoms persist. Do not exceed
    600 mg in 24 hr.
    PEDIATRIC PATIENTS
    • Juvenile arthritis:
    Naproxen
    10 mg/kg/day given in 2 divided doses.
    Naproxen sodium
    Safety and efficacy not established.
    OTC
    Do not give to children < 12 yr unless under advice of physician.
    GERIATRIC PATIENTS
    Do not take > 200 mg q 12 hr PO.

    Pharmacokinetics
    Drug Onset Peak Duration
    Naproxen 1 hr 2–4 hr < 7 hr
    Naproxen sodium 1 hr 1–2 hr < 7 hr

    Metabolism: Hepatic; T1/2: 12–15 hr


    Distribution: Crosses placenta; enters breast milk
    Excretion: Urine

    Adverse effects
    • CNS: Headache, dizziness, somnolence, insomnia, fatigue, tiredness, dizziness,
    tinnitus, ophthalmic effects
    • Dermatologic: Rash, pruritus, sweating, dry mucous membranes, stomatitis
    • GI: Nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence
    • GU: Dysuria, renal impairment, including renal failure, interstitial nephritis,
    hematuria
    • Hematologic: Bleeding, platelet inhibition with higher doses, neutropenia,
    eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis,
    granulocytopenia, aplastic anemia, decreased Hgb or Hct, bone marrow
    depression, menorrhagia
    • Respiratory: Dyspnea, hemoptysis, pharyngitis, bronchospasm, rhinitis
    • Other: Peripheral edema, anaphylactoid reactions to anaphylactic shock

    Interactions
    Drug-drug
    • Increased serum lithium levels and risk of toxicity with naproxen
    Drug-lab test
    • Falsely increased values for urinary 17-ketogenic steroids; discontinue naproxen
    therapy for 72 hr before adrenal function tests
    • Inaccurate measurement of urinary 5-hydroxyindoleacetic acid

    Nursing considerations
    Assessment
    • History: Allergy to naproxen, salicylates, other NSAIDs; asthma, chronic
    urticaria, CV dysfunction; hypertension; GI bleeding; peptic ulcer; impaired
    hepatic or renal function; pregnancy; lactation
    • Physical: Skin color and lesions; orientation, reflexes, ophthalmologic and
    audiometric evaluation, peripheral sensation; P, edema; R, adventitious sounds;
    liver evaluation; CBC, clotting times, renal and liver function tests; serum
    electrolytes; stool guaiac

    Interventions
    • Give with food or after meals if GI upset occurs.
    • Arrange for periodic ophthalmologic examination during long-term therapy.
    • If overdose occurs, institute emergency procedures—gastric lavage, induction of
    emesis, supportive therapy.

    Teaching points
    • Take drug with food or meals if GI upset occurs; take only the prescribed dosage.
    • Dizziness, drowsiness can occur (avoid driving or the use of dangerous
    machinery).
    • Report sore throat; fever; rash; itching; weight gain; swelling in ankles or fingers;
    changes in vision; black, tarry stools.

    Adverse effects in Italic are most common; those in Bold are life-threatening.

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