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    Serotonin PPT Notes 2023

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    adhi85099
    Serotonin is also known as 5-Hydroxytryptamine. It is synthesized, stored, released, metabolized, and acts by binding to receptors in the body. Serotonin is involved in various physiological processes like vasoconstriction and vasodilation of blood vessels, smooth muscle contraction, intestinal peristalsis, and regulation of mood and sleep. Abnormal levels of serotonin are implicated in several disorders like migraine, nausea and vomiting, and hypertension.

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    Serotonin PPT Notes 2023

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    adhi85099
    183 views20 pages
    Serotonin is also known as 5-Hydroxytryptamine. It is synthesized, stored, released, metabolized, and acts by binding to receptors in the body. Serotonin is involved in various physiological processes like vasoconstriction and vasodilation of blood vessels, smooth muscle contraction, intestinal peristalsis, and regulation of mood and sleep. Abnormal levels of serotonin are implicated in several disorders like migraine, nausea and vomiting, and hypertension.

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    Serotonin is also known as 5-Hydroxytryptamine. It is synthesized, stored, released, metabolized, and acts by binding to receptors in the body. Serotonin is involved in various physiological processes like vasoconstriction and vasodilation of blood vessels, smooth muscle contraction, intestinal peristalsis, and regulation of mood and sleep. Abnormal levels of serotonin are implicated in several disorders like migraine, nausea and vomiting, and hypertension.

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    © All Rights Reserved
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    Download as pdf or txt
    183 views20 pages

    Serotonin PPT Notes 2023

    Uploaded by

    adhi85099
    Serotonin is also known as 5-Hydroxytryptamine. It is synthesized, stored, released, metabolized, and acts by binding to receptors in the body. Serotonin is involved in various physiological processes like vasoconstriction and vasodilation of blood vessels, smooth muscle contraction, intestinal peristalsis, and regulation of mood and sleep. Abnormal levels of serotonin are implicated in several disorders like migraine, nausea and vomiting, and hypertension.

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    SEROTONIN

    • It is also known as 5-Hydroxy Tryptamine/5-HT.


    • The name serotonin is because its action was observed in platelets
    during blood clotting that constricts blood vessels.
    PHARMACOLOGY OF SEROTONIN
    Synthesis
    Storage
    Release
    Metabolism
    Mechanism of action
    Pharmacological actions
    Pathophysiological role
    Therapeutic uses
    SYNTHESIS OF SEROTONIN
    STORAGE & RELEASE
    Storage: In mast cells, serotonin is stored in granules as an inactive
    complex composed of histamine
    STORAGE & RELEASE
    Release of Serotonin from mast cells
    STORAGE & RELEASE
    Release of Serotonin from mast cells
    METABOLISM OF SEROTONIN
    MECHANISM OF ACTION OF SERTONIN
    Serotonin released in response to various stimuli exerts its actions
    by binding to various types serotonin receptors –
    MECHANISM OF ACTION OF SERTONIN
    Serotonin released in response to various stimuli exerts its actions
    by binding to various types serotonin receptors –
    MECHANISM OF ACTION
    Receptor Location and function
    HT1 HT1A-Brain→CNS depression
    HT1B/1D-Cranial blood vessels → Vasoconstriction
    HT2 HT2A/2C- Cranial blood vessels → Vasodilation
    HT2A- Smooth muscle → Contraction
    HT2A- Platelets → Aggregation
    HT2A- Brain → Stimulation
    HT3 HT3-Chemoreceptor Trigger Zone (CTZ) of brain →
    Vomiting
    HT3-GIT → Irritation and Peristalisis
    HT4 HT4- Intestinal smooth muscle → Stimulates peristalisis
    movement
    PHARMACOLOGICAL ACTIONS
    Blood vessels: 5-HT causes vasocontraction & Vasodilation based
    on type of blood vessels.
    Larger blood vessels like arteries and veins get constricted due to
    contraction of smooth muscle layer present blood vessels.
    Smaller blood vessel are relaxed due to release of Nitric oxide
    known as EDRF (Endothelium derived Relaxing Factor).
    The net effect of Serotonin on blood vessel is vasodilatation.
    PHARMACOLOGICAL ACTIONS
    CVS: No marked effect on heart. But larger dose of serotonin
    causes bradycardia and hypotension.
    PHARMACOLOGICAL ACTIONS
    Triple response: Serotonin produces characteristic response on
    the skin which characterized by following
    Flare: Intense red spot
    Flush: redness in affected area
    Whale: Odema in affected space
    PHARMACOLOGICAL ACTIONS
    Smooth muscle: By stimulating 5-HT2 receptors , serotonin causes
    contraction of smooth muscles. Some important examples are
    Bronchio-constriction and asthma
    Contracts intestinal smooth muscle and increases peristalic
    movements
    PHARMACOLOGICAL ACTIONS
    Glands:
    Serotonin suppress acid and pepsin secretion in the GIT and can
    inhibit formation of ulcers.
    PHARMACOLOGICAL ACTIONS
    Afferent nerves:
    5-HT stimulates sensory nerves and increases their sensitization.
    Hence, it increases stimulates all sensations like itching, heat, pain
    and etc
    PHARMACOLOGICAL ACTIONS
    CNS:
    Serotonin produces wakefulness/alertness.
    Hence along with serotonin histamine responsible for the
    regulation of day-night cycle.
    PHARMACOLOGICAL ACTIONS
    Respiration:
    Stimulation of respiration.
    Platelets:
    Serotonin increases activation/aggregation of platelets
    Adrenal Medulla:
    Stimulates secretion of adrenaline.
    PATHOPHYSIOLOGICAL ROLE
    Precursor of melatonin
    Nausea & Vomiting
    Migraine
    Haemostasis
    Variant angina
    Increases intestinal motility
    Hypertension
    THANK
    YOU

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