PHAR1015-SomeExtraPracticeSAQs 2021

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PHAR1015 – Applied Clinical Therapeutics for Pharmacy B; Sem 2 - 2021

Additional Short Answer questions preparation


and eTG practice
These questions are not necessarily ‘samples’ of the style in the assessments. They are here
to give you some practice to familiarise you with looking for this information in
‘Therapeutic Guidelines – Antibiotic’. Please open up eTG, you will require it to answer
the following.

Exercise One

Mrs CL is a 90 year old lady who is 165 cm tall and weighs 78 kg. A serum creatinine is
measured for her at 90 micromol/L.

Provide an appropriate dosage adjustment, if required, for the following prescriptions. (If no dose
adjustment is required, then specify so.) (Don’t worry, she’s not taking them all at once!)

Prescribed dose: Amoxicillin 500mg PO QID


Your recommendation:

Prescribed dose: Benzylpenicillin 1.8g 4 hourly


Your recommendation:

Prescribed dose: Ceftriaxone 1g IV daily


Your recommendation:

Prescribed dose: Metronidazole 400mg oral 12-hourly


Your recommendation:

Prescribed dose: Cefazolin 2g IV TDS


Your recommendation:

Prescribed dose: Nitrofurantoin 100mg 12-hourly


Your recommendation:
Exercise 2

This exercise uses an infectious disease you may or may not remember (it was covered in RTI!).
Regardless of the specific infection, don’t panic - the principles of antimicrobial therapy are the
same as what we’ve been talking about in this course.

Mr PP is a 92 year old elderly man who lives in a nursing home. He has a history of stroke,
and as such has difficulty swallowing. He requires his food to be administered in puree
form as his swallowing difficulties present a risk of aspiration - the accidental inhalation of
food. He is 168cm tall and weighs 76kg.

He is sent to hospital one day with a cough, fever, and confusion.

The practitioner seeing him in the emergency department wrote the following notes:
Mr TS, elderly gentleman, lives in N/home due to requiring significant care after a stroke 2
years ago

Presenting Complaint:

Cough, fever, confusion.

Past Medical History:

- Stroke 2 years ago. Requires full time care

Medicines:

- Medicines for the prevention of further stroke.

Allergies:

- Nursing home report mild rash 1 week after starting cefalexin (5 years ago)

History of the Presenting complaint:

Nurses witnessed a significant aspiration of lunch a few days ago. Since then has developed a
cough, fever and confusion.

On examination:

Confused. Abdomen and chest clear. Lungs have one lobe with poor air-entry.
Blood Pressure: 86/60 mmHg, Heart Rate 120 beats/minute, Temperature: 38.7oC.

Lab tests (normal range in brackets):

Sodium 137 mmol/L (135-145)


Potassium 4.0 mmol/L (3.4-4.5)
Chloride 99 mmol/L (95-110)
Bicarbonate 28 mmol/L (22-32)
Urea 6 mmol/L (3-8)
Creatinine 93 micromol/L (50-110 Females, 60-120 Males)

White Cells: 14 x 109 cells per Litre (4-10 x 109)

Assessment:
ASPIRATION PNEUMONIA – ESTABLISHED (NOT RESPONDING TO EMPIRICAL
CAP THERAPY).

Your task:
Identify an appropriate antibiotic regimen, including dose, route and frequency for Mr PP.
Explain and justify your selection, including a comment about the severity of infection.
Exercise 3

Select an appropriate drug, dose, route and frequency for the following situations:

23 year old man, otherwise healthy, with an acute lower UTI. His urine has grown a
culture of Pseudomonas aeruginosa. No adverse drug reactions known. (this one is a
‘tough one’)

33 year old pregnant female with a lower UTI. No organism is grown. No adverse drug
reactions known.

54 year old female, otherwise healthy with Staph cellulitis. No obvious signs of sepsis.
She has had a reaction to penicillin in the past, it caused DRESS.

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