Chapter One Notes Psyb55
Chapter One Notes Psyb55
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➔ Violation of Norms
Behaviour that violates social norms or threats or makes anxious
➔ Personal Suffering
Behaviour is abnormal if it creates great distress and torment in the person experiencing it.
- Personal distress fit many forms of abnormality
➔ Disability or Dysfunction
Disability – impairment in some important area of life
o Substance- use disorders are defined in apart of the social or occupational
disability created by substance abuse and addiction
o Phobia can produce distress and disability.
➔ Unexpectedness
Distress and disability are considered abnormal when they are unexpected responses to
environment stressors
- Psychiatrist; holds an MD degree and has had postgraduate training; residency, in which
he or she has received supervision in the practice of diagnosis and psychotherapy. (they
can also function as physicians)
- Psychoanalyst; received specialized training at a psychoanalytic institute.
- Social Worker; obtains an M.S.W (master of social work) degree. Programs for
counselling psychologist are somewhat similar to graduate training in clinical psychology
- Counselling psychologist are similar to graduate training in clinical psychology but
usually have less emphasis on research and the more severe forms of psychopathology.
History of Psychopathology
→ Early Demonology ;The doctrine that an evil being, such as the devil, may dwell within a
person and control his or her mind and body is called demonology. This type of thinking are
found in the records of the early Chinese, Egyptians, Babylonians, and Greeks.
It’s treatment was often exorcism, the casting out of evil spirits by ritualistic chanting or torture.
o This typically took the form of elaborate rites of prayer, noisemaking, forcing the
afflicted to drink terrible-tasting brews, and extreme measures such as flogging
and starvation, to render the body uninhabitable to devils.
o Trapanning of skulls (the making of surgical opening in a living skull by some
instrument) by Stone Age or Neolithic.
▪ It was presumed that the individual would return to a normal state by
creating an opening through which evils spirits could escape.
▪ One popular theory is that it was a way of treating conditions such as
epilepsy, headaches, and psychological disorders attributed to demons
within the cranium.
▪ This most common in Peru and Bolivia, 3 aboriginal specimens have been
found in Canada, all on the Pacific coast in British Columbia.
→ Somatogensis
- In the fifth century, Hippocrates rejected the prevailing Greek belief that gods sent
serious physical diseases and mental disturbance as punishment and insisted instead that
such illnesses had natural causes and hence should be treated like other, more common
maladies, such as colds and constipation.
- The brain is the organ of consciousness, of intellectual life and emotional; thus, he
thought that deviant thinking and behaviour were indications of some kind of brain
pathology
o Somatogenesis; the notion that something is wrong with the soma, or physical
body, disturbs thought and action
o Psychogensis; in contrast, is the belief that a disturbance has psychological
origins
- Hippocrates classified mental disorders into three categories: mania, melancholia and
phrenitis (of brain fever)
- Hippocrates’s physiology was rather crude, he conceived of normal brain functioning,
and therefore of mental health, as dependent on delicate balance among four humours:
blood, black bile, yellow bile and phlegm.
o Those who were accused of witchcraft were to be tortured if they did not confess;
those convicted and penitent were to be imprisoned for life; and those convicted
and unrepentant were to be handed over to the law for execution.
Development of Asylums
→ Bethlehem and Other Early Asylums
- Bedlam; a contraction and popular name for this hospital, became a descriptive term for
a place of scene of wild uproar and confusion.
o This became one of London’s great tourist attractions, by the eighteenth century
rivalling both Westminster Abbey and the tower of London.
- In the Lunatics’ Tower constructed in Vienne in 1784, patients were confined in the
spaces between inner square rooms and the outer walls, where they could be viewed by
passersby.
- Medical treatment were often crude and painful.
- Benjamin Rush, who began practising medicine in Philadelphia in 1769, he believed that
mental disorder was caused by an excess of blood in the brain.
o He favoured treatment was to draw great quantities of blood
o He also believed that many “lunatics “could be cursed by being frightened.
→ Moral Treatment
- Philippe Pinel considered a primary figure in the movement for humanitarian treatment
of the asylums.
o He began to treat patients as sick human beings rather than beasts.
o Pinel did for people with mental illness, he was not a complete paragon of
enlightenment and egalitarianism. The more humanitarian treatment he reserved for
the upper classes; patients of the lower classes were still subjected to terror and
coercion as a means of control
- Quaker, William Tuke was shocked by the conditions at York Asylum in England,
proposed to the Society of Friends that it found its own institution.
o It was a country estate, providing mentally ill people with a quiet and religious
atmosphere in which to live, work and rest.
o Patients discussed the moral treatment offered at the York Retreat as a form of
affective conditioning informed by “benevolent theory” steeped in religious ethics.
o He believed that a central aspect of moral treatment was restoring a patient’s sense
of self- esteem by letting her or him demonstrate self-restraint.
- This is known as the moral treatment, patients had close contact with the attendants, who
talked and read to them and encouraged them to engage in purpose activity residents led as
normal lives as possible and in general took responsibility for themselves within the
constraints of their disorders.
- Ironically, the efforts of the Dorothea Dix, a crusader for improved conditions for people
with mental illness, helped effect this change.
→ Asylums in Canada
- LaJeunesse documented how attempts at moral treatment in Alberta in the early twentieth
century were undercut by Primer Arthur Sfiton’s decision to focus on larger institutes ,
where patients were crowded into building with inadequate space
- Dr. Henry Hunt Stabb made heroic efforts to institute moral treatment and non- restraint
at the Lunatic Asylum in St, Johns Newfoundland.
- Mentally ill people were admitted to hospital in Quebec as early as 1714, but psychiatric
asylums emerged in the decade following 1840, and eventually there was a network of
asylums.
- The process began with humane intentions as part of a progressive and reformist
movement, which attempted to overcome neglect and suffering.
- Alberta was the last province to open an asylum for the insane
- Asylum superintends were British-trained physicians who modelled the asylums after
British Forms of structure, treatment, and administration, although Barlett,
- “Dangerously overcrowded” and lamented the fact that this overcrowding was responsible
for striking increase in the death list and for the impaired general health of the inmates.
- Almost 20% of the inmates died while in the institution, a large number due to the “general
paresis of the insane” and to a condition called “phthisis”.
- There are concerns that exist today that Canada has developed a two-tier medial system in
which the wealthy have more opportunity for, and quick access to, superior quality care.
o In 1853 the legislature passed the Private Lunatic Asylums Act to accommodate
the wealthy in alternatives to the public asylums.
- This history of development of institutions of the mentally disordered in Canada can be
characterized in terms of two distinctive trends
o Provincial psychiatric hospitals; is “tertiary” that is they provide specialized
treatment and rehabilitation services for individuals whose needs for are too
complex to be managed in the community.
o Community treatment orders; a legal tool issued by a medical practitioner that
establishes the conditioned under which a mentally ill person may live in the
community, including requirements for compliance with treatment.
o The consequence for a patient of failing to follow the CTO is being returned to a
psychiatric faculty for assessment.
- Transinsitutionalization; phenomena where inmates released from one therapeutic
community move into other institutions, either as planned move or as an unforeseen
consequence
→ Psychogenesis
- Some investigators considered mental illnesses to have an entirely different origin. Various
psychogenic points of view, which attributed mental disorders to psychological
malfunctions, were fashionable in France and Austria
→ Anti-Stigma Campaigns
A preventive intervention developed by Stuart sought to reduce stigma in high school students
through a video-based about learning program (the schizophrenia society of Canada’s reaching out
program) that chronicled the challenges of actual people with schizophrenia.
o Exposure to the program results in increased knowledge of schizophrenia and its
treatment and less social distancing.
o Female students showed greater gains in understand than males.
A group called Wait Time Alliance concluded in 2014 that no significant progress has occurred
in terms of reducing wait times.
- Reports of wait times from at least 3 months to over a year have surfaced and seem far too
common.
-
In the twin method, both monozygotic (MZ) twins and dizygotic (DZ) twins are compared.
- MZ, or identical, twin develop from a single fertilized egg and typically they are genetically
the same. Always the same sex
o A growing number of studies have identified MZ twins who differ both genetically
and epigenetically in terms of developmental changes in gene expression.
- DZ, fraternal pairs develop from separate eggs and are on average only 50% alike
genetically, no more alike than any other two siblings. Can be either the same sex or
different.
- When the twins are similar diagnostically, they are said to be concordant. To the extent
that a predisposition for a mental disorder can be inherited, concordance for the disorder
should be greater in genetically identical MZ pairs than in DZ pairs.
- Research using the adoptees method study children with abnormal disorders who were
adopted and reared apart from their parents.
→ Molecular Genetics
It tries to specify the particular gene or genes involved and the precise functions of these genes
- Genetic Polymorphism is the variability that occurs among members of the species. It
involves differences in the DNA sequences that can manifest in very different forms among
members in the same habitat.
- Linkage analysis is a method in molecular genetics used to study people.
o They collect diagnostic information and blood samples from affected individuals
and their relatives and use the blood samples to study the inheritance pattern of
characteristics whose genetics are fully understood, referred to as genetic markers.
o Both serotonin and dopamine are neurotransmitters in the brain; serotonin may
be involved in depression, and dopamine in schizophrenia.
o Another important brain transmitter is GABA, which inhibits some nerve impulses
and is implicated in anxiety disorders.
o Classical Conditioning
This was discovered by Ivan Pavlov (1849-1939).
- In this experiment, because the meat powder automatically elicits salivation with no prior
learning, the powder is termed an unconditioned stimulus and the response to it,
salivation, an unconditioned response.
- When the offering of meat powder is preceded several times by the ringing of a bell, a
neutral stimulus, the sound of the bell alone (the conditioned stimulus) is able to elicit the
salivary response (conditioned response)
- Extinction is what happens to the CR when the repeated sounding of the bell are later not
followed by meat powder; fewer and fewer salivations are elicited, and the CR gradually
disappears.
A famous experiment conducted by John Watson and Rosalie Rayner discovered that classical
condition could work with fear.
- Little Albert experiment. A loud noise would play in the presence of a rat.
- This study suggests the possible association between classical conditioning and the
development of certain emotional disorder, including phobias.
- Contemporary research in abnormal psychology has continued to implicate classical
conditioning in the development of anxiety disorders.
o Operant Conditioning
It applied to behaviour that operates on the environment.
- B.F. Skinner reformulated the law of effect by shifting the focus form the linking of
stimuli and responses to the relationships between responses and their consequences or
contingencies.
- Skinner distinguished two types of reinforcement that influence behaviour.
o Positive reinforcement is the strengthening of a tendency to respond by virtue of
the presentation of a pleasant event, called a positive reinforcer.
o Negative reinforcement also strengthens a response, but it does so via the removal
of an aversive event, such as the cessation of electric shock.called such
consequences negative reinforcers.
- He was responsible for the study of operant behaviour and the extension of this approach
to education, psychotherapy, and society as a whole.
o Modelling
We learn by watching and imitating others
- Experimental work by Albert Bandura and others
- They used a modelling treatment to reduce the fear of dogs in children. After witnessing a
fearless model engage in various activities with a dog, initially fearful children became
more willing to approach and handle a dog.
- Modelling may explain the acquisition of abnormal behaviour.
- Children of parents with phobias or substance-abuse problems may acquire similar
behaviour patterns, in part through modelling.
Albert Bandura developed social learning and cognitive self-regulation theories that influenced
the development of both learning and cognitive paradigms.
- Research on Social Learning is about children who witnessed an adult being aggressive
with a plastic Bobo doll.
- These variations led Bandura to conclude that there are four key processes in observational
learning; attention (noticing the model’s behaviour); retention (remembering the model’s
behaviour); reproduction (personally exhibiting the behaviour); and motivation
(repeating imitated behaviours if they received positive consequences)
- His more recent work is a cognitive self-regulation theory known as social cognitive
theory that focuses on the concept of human agency and self-efficacy, an individual’s
perceived sense of being capable.
o Self-Regulation is a multi-stage process that involved self- observation, self-
judgment by comparing personal achievements and behaviours with standards and
goals, and self-response in the form of self-reinforcement and praise or self-
punishment and criticism.
- The general goal of Beck’s therapy is to provide clients with experiences, both inside and
outside the consulting room, that will alter their negative schemas and dysfunctional beliefs
and attitudes.
Because this approach focused on the role of dysfunctional thoughts and beliefs, the main emphasis
of therapy is replacing these thoughts with more adaptive thoughts.
Neurotic Anxiety
When one’s life is in jeopardy, one fells objective (realistic) anxiety – the ego’s reaction,
according to Freud, to danger in the external world.
- neurotic anxiety a feeling of fear that is not connected to reality or to any real threat.
- Moral Anxiety that drives the supergo – namely the perfection principle.
→ Psychoanalytic Therapy
Classical psychoanalysis is based on Freud’s second theory of neurotic anxiety is the reaction of
the ego when a previously punished and repressed id impulse presses for expression.
- Psychoanalytic therapy is an insight therapy. It attempts to remove the earlier repression
and help the client face the childhood conflict, gain insight into it, and resolve it in the light
of adult reality.
- Psychotherapy is a social interaction in which a trained professional try to help another
person, the client or patient, behave and feel differently.
- London categorized psychotherapies as insight therapies or action (behavioural)
therapies.
o Insight therapies assume the behaviour, emotions and thoughts become disordered
because people do not understand what motivates them, especially when their needs
nad drives conflict.
- Dream analysis, in sleep, ego defences are relaxed, allowing normally repressed material
to enter the sleeper’s consciousness.
- Transference; the client’s responses to the analyst are not in keeping with the analyst-
client relationship but seem instead to reflect relationships with important people in the
client’s past.
- Countertransference; is the analyst’s feeling towards the client. Analyst must be away of
their own feelings so that they can see the client clearly.
Ego analysis
→ Brief psychodynamic therapy
- This shorter form was developed to meet the expectations of the many clients who prefer
therapy to be fairly short term and targeted to specific problems in their every lives.
o Interpersonal therapy
This a contemporary variation of brief psychodynamic therapy that has grown in popularity and
impact.
- an important goal is to examine these past influences in terms of how they have an impact
on and contribute to current relationships.
involved the expected adverse reaction to negative experience by also positive reaction to
positive experiences.
→ Validity
The extent to which a measure fulfills its intended purpose.
o Eg. If a questionnaire is intended to measure a person’s hostility.
It is important to note that validly is related to reliability: unreliable measure will not have good
validity because unreliable measure does not yield consistent results, an unreliable measure will
not relate very strongly to other measure.
o Eg. Unreliable measure of coping is not likely to relate well to how a person adjusts
to a stressful life experience.
- Content validity is the extent to which a measure adequately samples the domain of
interest.
Psychological Assessment
→ Clinical Interviews
Pays attention to how the respondent answer – or does not answer – questions.
- Both reliability and validity may indeed be low for a single clinical interview that is
conducted in an unstructured fashion.
→ Structured Interviews
Questions are set out in a prescribed fashion for the interviewers.
- SCID is a branching interview; that is, the client’s response to one question determine the
next questions that is asked.
- There are many other structured interviews and the use of such interviews is a major factor
in the improvement of diagnostic reliability.
→ Psychological Tests
Standardized procedures designed to measure a person’s performance on a particular task or to
assess his or her personality, or thought, feelings and behaviour.
o Standardization- statistical norms for the test can thereby be established as soon
as sufficient data have been collected.
o Test Norms are standards that are used to interpret an individual’s score because
the score by itself of an individual is meaningless without a comparison context.
▪ These are usually expressed in terms of the mean score obtained by specific
groups and the distribution or variability of score within a population.
- Personality Inventories
The person is asked to complete a self-report questionnaire indicating whether statements
assessing habitual tendencies apply to him or her.
→ Intelligence Tests
Alfred Binet, a French psychologist, originally constructed mental tests to help the Parisian school
board predict which children were in need to special schooling.
An intelligence test, referred as an IQ test, is a standardized means of assessing a person’s current
mental ability.
- Individually administered test, such as the Wechsler Adult Intelligence Scale (WAIS),
the Wechsler Intelligence Scale of Children (WISC), and the Standford-Binet, are all
based on the assumption that a detailed sample of an individual’s current intellectual
functioning can predict how well he or she will preform in school.
o As part of neuropsychological evaluations.
- IQ tests are highly reliable and have a good criterion validity.
- Race norms – one solutions that is used to rely, revised norms for various racial or
cultural groups
Biological Assessment
→ Brain Imaging “seeing” The Brain
- Types of Brain Imaging
o Computerized axial tomography, the CT scan, helps to assess structural brain
abnormalities. A mobbing beam of X-rays passes into a horizontal cross-section of
the client’s brain, scanning it through 360 degrees; the moving X-ray detector on
the other side measure the amount of radioactivity that penetrates, thus detecting
subtle differences in tissue density.
▪ A computer used the information to construct a two-dimensional. Detailed
image of the cross-section, giving it optimal contrast.
o Newer computer-based devices for seeing the living brain include magnetic
resonance imaging, has been developed that allows researchers to take MRI
pictures so quickly that metabolic changes can be measured, providing a picture of
the brain at work rather than of its structure alone.
o Functional magnetic resonance imaging (fMRI) has been developed that allows
researchers to take MRI pictures so quickly that metabolic changes can be
measured, providing a picture of the brain at work rather than of its structure alone.
o PET scan, more expensive and invasive procedure, allows measurement of brain
function.
Neuropsychological Assessment
- Neurologist is a physician who specializes in medical diseases that affect the nervous
system
- Neuropsychologist is a psychologist who studies how dysfunctions of the brain affect the
way we think, feel, and behave .
o They are trained as a psychologist – as such is interested in thought, emotion, and
behaviour – but one with a focus on how abnormalities of the brain affect behaviour
in deleterious ways.
Seidman and Bruder summarized the goals of neuropsychological testing as follows:
1. To measure as reliably, validly, and completely as possible the behavioural correlates of
brain functions
2. to identify the characteristic profile associated in the neurobehavioral syndrome
Psychophysiological Assessment
- Psychophysiology is concerned with the bodily changes the accompany psychological
events or that are associated with a person’s psychological characteristics.
- Each heartbeat generates spreading changes in electrical potential, which can be recorded
by an electrocardiograph, or on a suitably tuned polygraph, and graphically depicted in an
electrocardiogram.
- A second measure of autonomic nervous system activity is electro dermal responding, or
skin conductance.
o Conductance is typically measured by determining the current that flows through
the skin when a known small voltage derived from an external source is passed
between two electrodes on the hand.
→ Criticisms of Classification
- Some information must inevitably be lost. What matters is whether the information lost is
relevant, the relevance depends on the purposes of the classification system
- Any classification is designed to group together objects sharing a common property and to
ignore differences in the objects that are not relevant to the purposes at hand.
- The second contentious issue is the inclusion of a new disorder for children called
disruptive mood dysregulation disorder. This criteria for this new disorder involved
displays three or more times a week of severe temper tantrums that are out of proportion
with the situations and not in keeping the child’s developmental level.
- The third contentious issue with DSM-5 is the removal of the bereavement exclusion from
the diagnostic criteria for major depressive disorder.
- The fourth issue is that last-minute decision of the DSM-5 group examining personality
disorders to revert to a categorical approach when it appeared that a dimensional approach
was about to be implemented.
o The four categories are identifying, self-direction, empathy, and intimacy.
o Five personality trait domains are evaluated
Negative affectivity vs. emotional stability
▪ Detachment vs. extroversion
▪ Antagonism vs. agreeableness
▪ Disinhibition vs. conscientiousness
▪ Psychoticism vs. lucidity
- Allen Frances chaired the process of creating the DSM-IV and has argued that the changes
in DSM-5 will medicalise and pathologies normal behaviours
o He has argued for a return to the cautious approach used in DSM-IV, and he
contended that proposed changes will result in many conditions being classified as
abnormal when they merely reflect normal or typical behaviour.
Chapter 4: Research Methods in the Study of Abnormal Behaviour
- Qualitative research - similar to case study research in that the focus is on the unique and
rich experiences of a small group of people who are studied in depth.
o Subject to some of the same criticisms that apply to case study accounts, but well-
done qualitative research can illuminate important phenomena that seem to reflect
issues and themes that matter to people and are central to understanding them.
o A study led by Christine Kurtz Landy from the School of Nursing at York
University examines the life experience of socio-economically disadvantaged post-
partum women
▪ Themes that emerged were
• The significant struggles associated with becoming a mother and
feeling out of control during the instance period right after giving
birth
• The sense of burden superimpose on this life transition due to the
context of living a life of poverty.
- Quantitative research – subjective emphasis on the individual are the focus.
→ Epidemiological Research
Epidemiological research focuses on determining three features of a disorder
1. Prevalence – the proportion of a population that has the disorder at a given point of
period of time (often lifetime)
2. Incidence – the number of new cases of the disorder that occur in some period, usually
a year
3. Risk Factor – conditions or variable that, it present, increase the likelihood of
developing the disorder
→ Measuring Correlation
The first step in determining a correlation is to obtain pairs of observations of the variables in
question, such as height and weight, for each member of a group of participants.
- Correlation coefficient – denoted by the symbol r.
→ Statistical Significance
A statistically significant correlation is one that is not likely to have occurred by chance.
- In psychological research, a correlation is considered statistically significant if the
likelihood or probability that it is a chance finding is 5 or less in 100.
→ Applications to Psychopathology
When the correlational method is used in research on psychopathology, one of the variables is
typically diagnosis.
o Eg. Whether the participant is diagnosed as having an anxiety disorder or not.
- Variables such as having an anxiety disorder or not are called classificatory variables.
→ Problems of Causality
The Experiment
→ Basic Features of Experimental Design for Groups of Participants
1. The researcher typically begins with an experimental hypothesis
2. The investigatory chooses an independent variable that can be manipulated
3. Participants are assigned to two conditions by random assignment so that each participant
has an equal chance of being in each condition
4. The researcher arranges for the measurement of depend variable, something that is
expected to depend on or vary with manipulations of the independent variable.
5. When differences between groups are found to be a function of variations in the
independent variable, the researcher is said to have produced an experimental effect.
o The placebo effect is an improvement in a physical or psychological condition that
is attributable to a client’s expectations of help rather than to any specific active
ingredient in a treatment.
o The double-blind procedure is when neither the research or the clients are aware
of who has been placed in the treatment and placebo controls.
- Internal Validity
In contrast research has internal validity when the effect can be confidently attributed to the
manipulation of the independent variable.
- External Validity
The extent to which results can be generalized beyond the immediate study. If investigators have
demonstrated that a particular treatment helps a group of clients, they will undoubtedly want to
conclude that their treatment will be effective in administering to their clients, at other times, and
in other places.
o Determining the external validity of the results of a psychological experiment is
difficult.
- Analogue Experiments
Investigators attempt to bring a related phenomenon – that is, an analogue – into the laboratory for
more intensive study.
→ Mixed Designs
- Experimental and correlational research techniques can be combined.
- Participants from two or more discrete and typically non-overlapping populations are
assigned to each experimental condition.
- In interpreting the results of mixed designs, we must also be aware of the fact that one of
the variables is not manipulated but is instead a classificatory or correlational variable.
Two disorders with the earliest median age of onset (15 – 17 years old) were the phobias
(including specific phobia, agoraphobia, and social phobia) and separation anxiety.
The disorders with the latest median age of onset (23-30 years old) included two anxiety
disorders (panic and generalized anxiety disorder), as well as major depression.
Separation anxiety is the anxiety that results from not having contact or the possibility of losing
contact with attachment guides.
- SAD has a high comorbidity rate with other disorders and often occur in conjunction with
generalized anxiety disorder, specific phobias, panic disorder, avoidant personality
disorder, and mood disorder
- In children, this is often co diagnosed with selective mutism is often characterized by the
failure to speak at school when a child is able to speak at home, and recent research supports
the classification of selective mutism as an anxiety disorder in DSM-5.
Cognitive Theories
Focus on how thought processes can serve as a diathesis on how thoughts can maintain a phobia
or anxiety.
- Anxiety is related to being more likely to attend to negative stimuli, to interpret ambiguous
information as threatening, and to believe that negative events are more likely than positive
ones to occur in the future.
- Cognitive processes are strongly implicated in the etiology and maintenance of SAD.
Socially anxious people are more concerned about evaluation than are people who are not
socially anxious and they are highly aware of the image they present to others.
o Socially anxious people’s hypersensitivity to social cues is reflected by a tendency
to be cognitively preoccupied with situation in which they were treated negatively
by others.
o SAD is also linked with excessive self-criticism.
o Socially anxious people tend to view themselves negatively even when they have
actually preformed well in social interaction and they are less certain about their
positive self-views and relative to people without SAD, they see their positive
attributes as being less important
o Experimental data suggest that people with SAD have a cognitive bias toward being
more attentive visually to negative faces than to positive faces, but no such bias is
evident among people with OCD or in control participants
- Socially anxious people also seem to fear having a negative impact on other people; that
is, they are worried about causing discomfort in other people.
- Cognitive models of SAD link social anxiety with the following key characteristics
o Attentional bias on focus on negative social information and interpret ambiguous
situations as negative
o Perfectionistic standards for accepted social performances
o A high degree of public self-consciousness
o Those high in social anxiety are more likely to ruminate and less likely to distance
themselves as a way of coping with a threatening social event.
o Children with SAD show a pattern of fewer positive thoughts and a greater number
of negative thoughts following a social evaluation experience.
o Negative PEP contributes to data with university student indicates the socially
anxious students who are induced into a state of high self-focus, compared with
those instructed to focus on the other people during a conversation, report the next
day a higher level of negative PEP thoughts but not a lower level of positive
thoughts.
o Overall, there are cognitive elements that are seen to play a role in the development
and maintenance of social anxiety disorder.
Biological Theories
Current work is focused extensively on the role of the amygdala, which is a cerebral structure of
the brain’s temporal lobe.
- Functional MRi and PET studies of specific phobia and SAD have examined response
across three conditions: negative emotion, positive emotion and neutral condition
o Results of meta-analyses show conclusively that people with these disorder,
relative to comparison participants, have greater activity in two areas associated
with negative emotional responses: the amygdala and the insula.
o Exposure-based therapy for clients with specific phobias leads to decreased
activation in some of the same areas of the brain.
o The various anxiety disorder may reflect a complex array of biological factors and
process
o Research in two areas seems promising, the automatic nervous system and genetic
factors
→ Genetic Factors
Linkage analyses seek to identify the specific genes implicated in these disorders
Psychoanalytic Theories
According to Freud, phobias are a defence against the anxiety produced by repressed id
impulses.
- This anxiety is displaced from the feared if impulse and moved to an object or situations
that has some symbolic connection to it.
- These objects of situations- then become the phobic stimuli.
- The phobia is the ego’s way of warding off a confrontation with the real problem, a
repressed childhood conflict.
Panic Disorder
A person suffers a sudden and often inexplicable attack of a host of jarring symptoms: laboured
breathing, heart palpitations, nausea, and chest pain; feelings of choking and smothering;
dizziness, sweating and trembling; and intense apprehension, terror, and feelings of impending
doom.
Depersonalization feeling of being outside one’s body, derealisation, a feeling of the world’s not
being real, as well as fears of losing control, of going crazy, or going crazy, or even of dying, may
beset and overwhelm the person.
- Panic attacks may occur frequently, perhaps once a week or more often; they usually last
for minutes, rarely for hours; and they are sometimes linked to specific situations, such as
driving a car
o They are referred to as cued or expected panic attacks when they are associated
strongly with situational triggers.
o The exclusive presence of cued attacks most likely reflects the presence of a
specific phobia.
▪ Eg. A person with a specific phobia of dogs may always have a panic attack
when in the presence of dogs.
- Panic attacks can also occur in seemingly benign states, such as relaxation or sleep, and in
unexpected situations; in these cases, they are referred to as uncued attacks.
- Recurrent unexpected attacks and either worry about having attacks in the future or a
change in behaviour as a result of the attacks are required for the diagnosis of panic
disorder.
- A person with panic disorder can have both unexpected and expected panic attacks; the
important point is the unexpected attacks are required for a diagnosis of panic disorder.
o When people are worried about future attacks, it is usually because they are
concerned that the symptoms really mean they are having a heart attack or they
have some other physical health condition.
o They may also be concerned that others will notice the panic symptoms and judge
them.
o They have cognitive symptoms such as a fear of “going crazy” as part of their panic
attack experience, this particular fear may extend beyond the actual panic attack’
their worry about future attacks may be because they view the panic attacks as a
sign of “going crazy”
- Panic disorder has been linked with a wide range of conditions, including depression,
generalized anxiety disorder, alcohol and drug use, and personality disorders.
o Panic disorder is also linked with physical conditions such as asthma, and in
people suffering form both, it is believed that the panic exacerbates the asthma and
vice versa.
o More than 80% of people diagnosed as having one of the other anxiety disorders
also experience panic attacks.
o The 12-month prevalence of panic attacks was 6.4%. Panic attacks were related to
numerous psychological and physical function variables, including poor overall
functioning, suicidal ideation, psychological distress, activity restriction, chronic
physical conditions, and self-rated physical and mental health.
▪ The authors concluded that panic attacks may be a marker of severe
psychopathology independent of a diagnosis of panic disorder.
▪ Research such as this study has led to a diagnosis would be “social anxiety
disorder with panic attacks.”
Agoraphobia
A cluster of fears centring on public places and being unable to escape or find help should one
become incapacitated.
- To be diagnosed, a person would have to be anxious about at least two types of situations
out of the following five: public transportation, open spaces, enclosed spaces, line/crowds,
and being out of the house alone.
- When panic disorder or other anxiety disorder are present, they most often precede the
development of agoraphobia.
- Depressive and substance use disorders often develop after the onset of agoraphobia
→ Noradrenergic Activity
Panic is caused by over activity in the noradrenergic system.
o One version of this theory focuses on a nucleus in the pons called the locus ceruleus.
o Stimulation on the locus ceruleus causes monkeys to have what appears to be a
panic attac, suggesting that naurally occurring
o Yohimbine, is a drug that stimulates the nucleus coeruleus and has been linked
with causing panic attacks.
o Panic disorder may result from a problem in GABA neurons that inhibit
noradrenaline activity
▪ A PET study found fewer GABA receptor binding sites in those with panic
disorder.
▪ Improvement involves changes in GABA receptors for both anxiety and
depression.
→ Cholecystokinin (CCK)
- This is a peptide that occurs in the amygdala, hippocampus, cerebral cortex and
brainstem induces anxiety like symptoms in rats.
o This effect can be blocked with benzodiapenzines.
o Changes in cholecystokinin produces changes in the development of panic.
o Panic disorder is associated with hypersensitivity in CCK.
o CCK-4 injections show how amygdala activation is associated with the subjective
perception of anxiety.
o CCK is a key modulator of the fear network. It induces panic attacks in people
and has a genetic link to panic disorder diagnosis.
Psychological Theories
- The fear of fear hypothesis: agoraphobia is not necessary a fear of public places, but a
fear of having panic attack in public places.
Psychogenic illness or mass hysteria: a mass outbreak of conversion disorder among many
individuals usually due to prolonged exposer to stress in a Le Roy residence in New York
o these individuals suffered from a conversion (functional neurological symptom disorder)
disorder, which is a form of somatoform disorder.
o This disorder could have been exacerbated by the attention they received on social
media
o There was a train derailment near Le Roy that dumped TCE chemical that has not been
cleaned up. This chemical has been shown to cause neurological symptoms.
o Test failed to show an environmental cause for this mass hysteria.
o The ability to accept the conversion disorder hypothesis that this was caused by stress is
more common when we focus on the group instead of the individual
o A somatoform disorder is considered in the absence of no physical or medical cause.
Another cause of mass hysteria: 5 Amish girls experienced an outbreak of conversion disorder
symptoms that were common among them all. These symptoms were deemed to be related to
stressors and psychosocial pressures
o These are physical problems that reflect psychological adjustment problems.
o Challenge for physicians: are the physical symptoms due to medical explanations or
psychological problems.
o Until the most recent DSM revision, a somatoform disorder was ruled out if it was not
conclusive that there was no medical explanation. This has been removed in DSM-5
o In DSM-5 somatoform disorder was changed to somatoform symptom disorder.
o All these disorders are related to anxiety, they were all subsumed under the heading of
neuroses because anxiety was considered the predominant factor
o In DSM-III classification was based on observable traits, not ethology. Anxiety is not
necessarily observable in the somatoform and dissociative disorders.
Somatoform Disorders: individual complains of bodily symptoms that suggest a physical defect
or dysfunction- sometimes rather dramatic in nature- but for which no physiological basis can be
found
o A physical disorder that is unexplained and reflects psychological factors.
o Reflect the mind-body connection that physiological and psychological factors are linked.
o 9.5% of students had a somatoform disorder and ¼ of them had an anxiety disorder.
Illustrating the connection between body and mind.
o Predictors of a somatoform disorder also include depression and impairment in daily
activities.
Conversion Disorder
Somatization Disorder
o Assumed to be linked to psychological factors, such as anxiety
o Two types of somatoform disorders: conversion disorders and somatization
disorder.
o Pain disorder and hypochondriasis are no longer distinct disorders in DSM-5.
o Little is known about these somatoform disorders.
- The DSM-5 requires the presence of only one symptom to be diagnosed with somatic
symptom disorder.
- The old DSM required 13 symptoms to be diagnosed. There is a change in prevalence of
this disorder due to change in criteria.
▪ Criterion B use to involve the presence of somatic symptoms, but now
involves determining the presence or absence of psychological features.
→ Cognitive factors seen in people with conversion disorder are consistent with
cognitive interpretations, including the tendency to discount the importance of
psychological factors contributing to the physical compliances.
→ Research is also looking at the role of cognitive mechanisms.
- When children and adolescences with a conversion disorder were evaluated with a test
battery of neurocognitive functioning, they were linked with deficits in attention, working
memory and executive functioning.
→ Biological Factors in Conversion Disorder
- The research that exist suggest that conversion disorder has no genetic basis.
- Some studies point to some brain structures involved in conversion disorder.
- Conversion disorder symptoms are more common on the left side of the body than on the
right side of the body, controlled by the left brain.
- Connectivity between the amygdala and motor areas is enhanced.
- Stimulation of a numbed hand or foot did not activate the somatosensory region of the
brain, however stimulating the non-numbed hand or foot did activate it.
o An individual with hysterical mutism (nonvocalization) showed impaired
connectivity between speech related brain regions and brain networks that
regulate anxiety.
o These pieces of evidence may only tell us about how the conversion disorder
occurs and not why it occurs.
o These differences in the brain could be consequences of conversion disorder
rather than a cause.
Biopsychosocial Account of Conversion Disorder
- People with somatoform disorders define their problems in physical terms, so they
interpret a referral to a psychologist as an indication the doctor thinks the illness is all in
their head.
- Somatoform disorders are expensive and difficult to treat, and they are less durable and
lasting than treatments for other mental illnesses.
- Cognitive and behavioral therapist believe the high levels of anxiety linked to
somatization disorder are associated with specific situations.
Dissociative Disorders
- Characterized by a change in a persons sense of identity, memory or consciousness.
- Dissociative trance: a narrowing or lose of awareness showing unresponsiveness or
insensitivity to environmental cues.
Dissociative Amnesia
- Unable to recall important personal information, usually after some type of stressful
event.
- Information is not permanently lose, but it cannot be retrieved during episode of amnesia.
- The memory loss involves all events during a limited period of time following the
traumatic experience.
- The memory lose may cause some disorientation and wandering.
- With total amnesia the person loses knowledge of friends and family.
- The episode may last for several hours to years and it has complete recovery and only a
small chance of reoccurrence.
- People with dissociative amnesia show reduced glucose (hypometabolism) in the left
inferolateral prefrontal cortex, where this region is associated with autobiographical
memory.
Dissociative Fugue
- Memory loss is more extensive in dissociative fugue.
- The person becomes amnesic and leaves home and work and assumes a new identity.
- The person may even establish a complex social life
- Fugues typically occur after a person experiences a stressful event.
- Recovery is usually complete
Depersonalization/ Derealization Disorder
- Persons perception is experience of the self is disconcertingly and disruptively altered.
- Involves no disturbance of memory, instead it involves a sense of self triggered by self
- DSM-5 retains this disorder, but also included derealization: a fogginess or sense of
detachment from the situational context and things in the situation.
o Fantasy model of dissociation: People who develop DID are very prone to
engage in fantasies.
Therapies for Dissociative Disorders
- People in these disorders behave in ways that are indicative of forgetting earlier parts of
life.
- These individuals may be unaware of their repressed thoughts.
- Psychoanalytic treatments try to lift repressions.
- There are links between treatment for DID and PTSD as they are often comorbid.
- Age regression: the individual is hypnotized and asked to think back to events in early
childhood
- The primary goal for individuals with DID is integration of several personalities.
Treatment can be enhanced by helping the client cope better with present day challenges.
- Treatment took almost 2 years and up to 500 hours per client in one case
- There is a 3-stage process to treatment:
o Safety, stability and symptom reduction
o Working directly and in depth with traumatic memories.
o Identity integration and rehabilitation.
Two major mood disorders are in DSM-5: major depressive disorder and bipolar disorder.
Diagnosis of Depression
DSM-5 diagnosis requires of presence of at least 5 of these symptoms for 2 or more weeks and
one of the symptoms must be depressed mood or loss in pleasure or interest in doing things:
o Change in sleep
o Sad depressed mood most of the day nearly everyday
o Loss of pleasure or interest in all or almost all activities
o Shift in activity level becoming lethargic or agitated. Psychomotor agitation or
retardation.
o Change in appetite
o Negative self-concept, self-reproach and blame, feelings of worthlessness and
guilt
o Complaints or evidence of loss of concentration
o Recurrent thought of death or suicidal
o Loss of energy, fatigue nearly every day
- Persistent depressive disorder (a depressive disorder that combines major depressive
disorder and dysthymia).
o Predictors of chronic depressive disorder include a co-morbid diagnoses, a
younger age of onset and a history of more frequent bouts of depression.
o The predictors for persistent depressive disorder include: being female, never
married, two or more medical conditions, limits on activity and reduced
contact with family.
o MDD is currently the second leading cause of disability.
Focus on Discovery 8.1
- The gender differences between males and females can be traced back to adolescence as
girls are more likely than boys to have certain risk factors for depression.
o Females are more likely than males to engage in ruminative coping, while males
are more likely to engage in distractive activities.
o Males focus more on a more adaptive form of reflective pondering whereas
females focus more on maladaptive rumination or brooding (moody pondering)
- An interpersonal form of rumination known as co-rumination in which friends discuss
their problems with each other has been linked with depression in females, but this also
fosters strong friendships.
- Females are more likely to engage in silencing the self-a passive style of keeping upsets
and concerns to oneself to maintain important relationships.
- Another theory is the objectification theory based on the tendency to be viewed as objects
and this has a greater influence of women than men.
- Theories propose that women and girls are more likely than boys and men to take a more
active role in generating stress for themselves. However, studies failed to show this.
Diagnosis of Bipolar Disorder
- Bipolar I involves episodes of mania or mixed episodes that involve symptoms of both
mania and depression.
- A diagnosis of a manic state requires an elevated or irritable state and abnormally and
persistent increase goal directed activity or energy plus 3 additional symptoms, four if
irritable.
- The symptoms must be sufficiently severe to impair social and occupational functioning.
o Increased in goal directed activity
o more talking than usual
o flight of ideas or subjective impression that thoughts are racing
o less than usual amount of sleep needed
o elevated self-esteem and feeling like you have special powers and talents
o distractibility
o excessive involvement in pleasurable activities that have reckless
consequences
- Violent behaviors can occur during severe manic episodes.
Heterogeneity with the Categories
- Melancholia refers to a specific pattern of depressive symptoms.
o No pleasure in any activity (anhedonia)
o Depressed mood is worse in the morning
o They awaken two hours t0o early
o Loss appetite and weight
o Are lethargic or extremely agitated
- Peripartum/postpartum depression: both manic and depressive episodes may occur
during pregnancy or within four weeks of childbirth.
- Both bipolar and unipolar depression can be sub diagnosed as seasonal if there is a
regular relationship between the depressive episode and a particular season of the year.
- The most common is winter depression or seasonal affective disorder
o Linked to the decrease in daylight hours.
- Seasonal subtype is found in 11% of individuals diagnosed with depression
- Some individuals are subsyndromal (have fewer symptoms than those that meet DSM
criteria)
- Decreased sunlight caused decreases in activity in the serotonin neurons of the
hypothalamus and these neurons regulate sleep.
- Cyclothymic disorder: the person has frequent periods of depressed mood and
hypomania, which may be mixed with or alternated with normal mood for a period of two
months.
o Have paired sets of symptoms in their periods of depression and hypomania.
o Do not experience full-blown episodes of mania, hypomania or depression.
o To be diagnosed they need to experience periods of hypomania and
depression at least half the time for at least 2 years.
Psychological Theories of Mood Disorders
Psychoanalytic theories of depression
- The potential for depression is created during early childhood.
- During the oral stage, the child’s needs are oversatisified or undersatisified and they
become fixated in this stage and dependent of instinctual gratifications association with
it.
- The person in adulthood may now become dependent on others for maintenance of self-
esteem
- When a love one dies early in childhood, the mourner incorporates or introjects the loss
person. We then unconsciously harbour hate for those we love, and this person becomes
the object of hate and angry.
- The period of introjection is followed by a period of mourning work, the mourner recalls
memories of the lost one and separates themselves from the person who died. This can go
wrong and develop into self-blame, self-abuse and depression.
o The mourners resentment towards the lost love one is directed inward.
Canadian Perspective 8.2
Cognitive perspective: Depression is associated with two personality styles: sociotropy and
autonomy
- Sociotropic individuals are dependent on others. They are concerned with pleasing
others, avoiding disapproval and avoiding separation.
- Autonomy is an achievement related construct that focuses on self-critical goal striving,
distress for solitude and freedom from control.
o This predicts recurrence of depression even after controlling for the history of
depression.
- Psychoanalytic approach: depression is associated with introjected and anaclitic
personality traits
- Anaclitic orientation involves excessive dependency on others.
- The introjected orientation involves excessive levels of self-criticism.
o There is a strong link between dependency and depression.
o This is linked to the dimension of perfectionism. Depressed individuals have
higher levels of self-oriented high personal standards and socially prescribed
perfectionism.
- Congruency hypothesis: reflects stress approach
o If a non-depressed person with a certain personality trait(diathesis) experiences a
stressful event congruent with their diathesis they will become depressed
Cognitive Theories of Depression
→ Beck’s Theory of Depression
- Depressed individuals feel as they do because their thinking is bias towards negative
interpretations.
- In childhood depressed individuals acquire a negative schema-a tendency to see the world
negatively
- Negative schemata fuel and are fueled by negative biases.
- Negative cognitions include dysfunctional attitudes that bias the interpretation of
events.
- Depression and martial discord frequently co-occur. Critical comments by spouses are a
significant predictor of recurrence of depression.
→ Psychological Theories of Bipolar Disorder
- People with bipolar disorder have higher levels of dysfunctional attitudes.
o Also have problems with autobiographical memory and the ability to generate
solutions to task.
- Manic phase is seen as a defense against a psychological state. Manic states serve a
protective function.
Biological Theories of Mood Disorder
The evidence that certain neurotransmitters in drug therapies help to treat mood disorders
provides evidence that mood disorders have biological factors associated with them
→ Genetic Vulnerability
Genetic factors do not determine when manic symptoms will occur
- There is evidence for certain genes playing a role in bipolar disorder
o Bipolar disorder results from a dominant gene on the 11th chromosome
o Attempts to replicate the results above have however had mixed success.
→ Neurochemistry, Neuroimaging and Mood Disorders
- Low levels of norepinephrine and dopamine led to MDD and high levels led to
mania.
- In the 1950s, two other drugs, tricyclic and monoamine oxidase inhibitors were found
effective in relieving depression.
- Tricyclic drugs (imipramine and Tofranil) are a group of antidepressant medications
named because their molecular structure is characterized by three fused rings.
o They prevent norepinephrine, serotonin and dopamine reuptake so that more
neurotransmitter is left in the synapse and can be transmitted to the next neuron.
- Monoamine oxidase inhibitors (tranylcypromine and parnate) are named because they
keep monoamine oxidase from deactivating the neurotransmitters.
- Newer antidepressant drugs called selective serotonin reuptake inhibitors (SSRIs)
(fluoxetine and Prozac)
o Specifically inhibit the reuptake of serotonin.
- Researchers have also looked at the metabolites of these neurotransmitters found in the
urine.
o The problem is that these levels of neurotransmitter are not direct measurements
of the levels of neurotransmitters in the brain.
- Another line of research focuses on how antidepressants alter the chemical messengers
that a postsynaptic receptor sends to a postsynaptic neuron.
o If receptors are overly sensitive, they should respond to low amounts of
neurotransmitter
o Drugs that increase dopamine levels have been shown to cause manic episodes in
individuals with bipolar depression, suggesting dopamine receptors are overly
sensitive.
- In a study a diet was used to reduce the levels of serotonin in those in remission from
depression by lowering levels of tryptophan.
o 67% of individuals experienced a return in their depressive symptoms.
- In another study with non-depressed individuals with a positive or negative family history
of depression had their tryptophan levels lowered.
o Those with a positive family history of depression experienced a depressed mood
when their tryptophan levels were lowered.
- Many functional activation studies have been conducted on mood disorders to determine
how depression relates to brain activity.
o Amygdala, hippocampus, anterior cingulate and prefrontal cortex are main brain
structures involved in MDD and bipolar disorder.
o Hyperactivity in the amygdala and hypoactivity in the prefrontal cortex is
related to diminished cognitive appraisal and depression.
o Both recurrent depression and long-duration untreated depression are related to
decreased hippocampal volume.
- A study examined whether monoamine oxidase levels are elevated during untreated
depression.
o There are elevated MAO-A levels in postpartum mothers during the period
associated with post partum blues.
- Neurobiological mechanisms for bipolar disorder have also been examined.
o Neurobiological mechanisms for bipolar disorder are still unclear and debated.
There are many reasons for these inconsistent results across studies:
▪ Small sample sizes (creates difficulty replicating)
▪ Different equipment used across studies
▪ Different patient characteristics.
→ The Neuroendocrine System
The hypothalamic pituitary adrenocortical (HPA) axis may play a role in depression
- The limbic system is linked to emotions and effects the hypothalamus.
- The HPA axis is thought to be overactive in depression because it produces disturbances
in sleep and eating.
Cortisol levels are high in depressed individuals because of the excess release of
tryptophan by the hypothalamus.
o This excess release of cortisol from the adrenal gland causes an enlargement of
the adrenal gland.
o These high levels of cortisol have led to biological test for depression-
>dexamethasone suppression test.
▪ Dexamethasone suppresses cortisol secretion. But when given at night,
those with depression do not experience lower or suppressed cortisol
secretion.
▪ The failure of dexamethasone to suppress cortisol levels suggest
overactivity in the HPA axis in depressed individuals.
- Combines mindfulness meditation to increase awareness in the body and mind with
cognitive intervention
- MBCT has also been shown to be effective in reducing symptoms of depression in those
with chronic recurrent depression with a history of suicide ideation
- MBCT is effective in treating anxiety and depression, however one limitation is that there
is limited studies with credible controls.
- CBT and MBCT work because they increase metacognitive awareness and by reducing
the tendency to ruminate.
- MCBT reduces the over generality of autobiographical memory effect.
o When asked to recall past events, depressed individuals usually tend to recall
broad, categorically events lacking in specificity, instead of specific detailed
events.
o This over generality effect reflects the negative schema described by Beck
- Another approach relative to the prevention of relapse is preventive cognitive therapy
delivered to clients after CT.
o This helps individuals who have experienced more than 3 depressive episodes
stay well longer.
Student Perspective 8.1
- The prevalence of depression among students is elevated. There is a 12% prevalence rate
in college and university students age 19 to 25.
- The three most common disorders among university women were generalized anxiety
disorder, depression and nicotine dependence.
- Both CBT and relaxation training have been found to be useful
o Perfectionism is associated with depression. An online intervention that combined
CBT with stress management to manage dysfunctional perfectionism was
beneficial in reducing depression and anxiety associated with perfectionism.
o Males students are highly underrepresented when it comes to prevention
measures. There needs to be more prevention measures developed for males.
Psychological Treatment of Bipolar Disorder
- A CBT intervention targeted at thoughts that go away when individuals go through a
manic episode has been shown to be effective in treatment bipolar disorder.
- It is difficult to get bipolar clients to take their medication regularly because they often
lack insight it the destructive nature of their behavior.
o Education about bipolar disorder and its treatment can improve adherence to its
treatments.
o Education about bipolar disorder may also improve social support from family
and friends.
▪ Individuals with bipolar disorder are more likely to relapse if they return
after treatment to an environment with hostility and over involvement
(expressed emotion)
- Common features of psychological treatment for relapse prevention in bipolar disorder
include the following:
o Psychoeducation
o Promotion of medication adherence
o Promotion of daily routines and sleep
o Monitoring of mood
o Detection of early warnings of relapse
o Coping strategies and problem-solving techniques.
- Evidence continues to be mixed on whether structural psychological interventions are
beneficial in relapse prevention.
o One meta-analysis concluded that only psychoeducation is useful and only in
specific conditions
o Another meta-analysis suggested that CBT, group psychoeducation and family
treatment are beneficial on top of pharmacotherapy.
- About 1/3 of those with bipolar disorder seek psychotherapy and those that seek it score
higher on illness severity.
Biological Therapies
→ Electroconvulsive Therapy (ECT)
- Introduced in the early 20th century.
- Cerletti, was interested in epilepsy and sought a means to induce seizures. He saw
seizures induced in animals by electrical shocks administered to the head in animals.
- He used shock administered to the side of a human head to treat depression and
schizophrenia.
- ECT treatment is restricted today to profoundly depressed individuals.
- ECT is being used frequently in Canada and elsewhere because when it works it is faster
than psychotherapy and antidepressants.
- ECT entails the induction of a momentary seizure and unconsciousness by passing a
current of 70 to 130 volts through a clients head.
- Previously electrodes were placed on both sides of the head, so the current flew through
each hemisphere, which is known as bilateral ECT.
o In bilateral ECT the person was usually awake and this triggered contortions of
the body
- In unilateral ECT the current passes through the non-dominant (right) cerebral cortex
o Client is now given a short acting anaesthetic and then a strong muscle relaxant
o It reduces metabolic activity and blood circulation to the brain and may inhibit
aberrant brain activity.
o ECT leads to improvements in problem-solving and this lead to changes in brain
activity.
- Unilateral ECT was compared to ultra brief pulse ECT
o Ultra brief pulse was evaluated because it may result in less cognitive deficits.
o Some research has suggested that brief pulse ECT is more effective with no
difference in side effects.
▪ Given the study limitations it is premature to conclude this.
- One issue with ECT is the high relapse rate.
o ECT was effective in treating both unipolar and bipolar depression, but the
remission rate was 51.5%.
- Many groups protest against ECT
o They suggests that ECT is inhumane, pose considerable risk and is not effective.
o Prior clients believe that ECT has led to permanent damage.
o There is variability in outcomes experienced, as other people believe ECT saved
their lives.
o Reports conclude ECT is effective but that safeguards such as informed consent
are needed to protect the rights of the clients.
o Concerns have been raised about certain people receiving a large number of
treatments.
Deep brain stimulation and repetitive transcranial magnetic stimulation
- Deep brain stimulation is used for treating treatment resistant depression once ECT,
psychotherapy and medication have failed.
o Treatment is based on the observation that the subgenual cingulate cortex is
overactive in tre atment resistant depression.
o This treatment disrupts focal limbic-cortical circuits by stimulating the subgenual
cingulate cortex believed to be involved in treatment resistant depression.
▪ Has been shown to be effectively safe in treating unipolar and bipolar
depression.
▪ Has also been shown to be effective in treating OCD, substance abuse
traumatic brain injury, anorexia nervosa and dementia
- The limitations of deep brain stimulation is that it can cost up to 250000 per person
- Repetitive transcranial magnetic stimulation is a non-invasive method of brain
stimulation using brief magnetic pulses to stimulate the brain
o This elicits a treatment response in those with depression and pain and may be as
effective as ECT.
o Elevations in glutamate levels were shown in adolescents treated with transcranial
magnetic stimulation.
Drug Therapy for Depression
- Drugs are the most commonly used treatment for mood disorders
- The use of antidepressants has increased exponentially.
- Antidepressants do not work for everyone and side effects are sometimes serious. It is
difficult to find personal characteristics that might predict treatment response.
- There are three major categories of antidepressants:
o Monoamine oxidase inhibitors: Parnate
o Tricyclic antidepressants: Tofranil and Elavil
o Selective serotonin reuptake inhibitors (SSRIs): Prozac and Zoloft
- SSRIs were the most commonly used antidepressant for those who had a major
depressive episode in the past year
- Antidepressant medication is often used with some form of psychotherapy.
▪Fact: Most people who contemplate suicide are ambivalent about their
own deaths
o The motives for suicide are easily established
▪ Fact: we actually do not understand why people commit suicide
o All who commit suicide are depressed
▪ Fact: many people who take their own lives are actually not depressed and
may even be at peace with themselves
o Improvement in emotional state means a lessened risk of suicide
▪ Those who commit suicide especially those who are depressed usually do
so after their energy begins to rise.
→ Suicide and Psychological Disorders
- 15% of those who have been diagnosed with MDD actually commit suicide.
- Depressive symptoms of suicide include weight or appetite loss, insomnia, feelings of
worthlessness and recurrent thoughts of death or suicide intention.
- Individuals with MDD that report more suicide attempts have more current general
medical conditions, more current alcohol and substance abuse, more report of suicide
ideation and 9 year earlier onset of depression compared to individuals with MDD that
have not had suicide attempts.
- Comorbid anxiety disorders also increase risk of death by suicide in depressed
individuals.
- In individuals with bipolar disorder, hopelessness predicted depression during depressive
phases, whereas a subjective rating of severity of depression and younger age predicted
suicide attempts in mixed episodes.
- Females, but not males who perceive themselves as rejected were more likely to make a
suicide attempt.
- Individuals with borderline personality disorder usually make attempts at suicide and
succeed
- The suicide rate for male alcoholics is greater than for the general population of males.
Disinhibition during intoxication may make individuals less able to resist their thoughts
of suicide.
- The number of completed suicides among those with schizophrenia is comparable to the
number of completed suicides in those with depression
- Of males who complete suicide, 78% screened positive for psychopathology at the age of
8. Self-reports of depression did not predict suicide outcome.
- Outcome of suicide was predicted by conduct and internalizing problems
- Female suicide was not predicted by any of the factors at age 8.
→ Perspectives of Suicide
→ Durkheim’s sociological Theory
- Egoistic Suicide: is committed by people who have few ties to the family, society or the
community. These individuals feel isolated from others.
- Altruistic suicide: viewed as a response to societal demands. People feel apart of a group
and sacrifice themselves for what they take to be the good of suicide
o This has been implemented in the role of suicides of NFL players and marines
- There may be genetic factors as well for suicide risk
o Monozygotic twins have a higher risk for suicide than dizygotic twins.
o Cluster B personality and aggressive-impulsive behavior mediate the relationship
between familial predisposition and suicide.
o Low level of 5-HIAA have been found in individuals in several diagnostic
categories who committed suicide.
Preventing Suicide
- SUPRE-MISS is used to prevent suicide. SUPRE refers to suicide prevention and MISS
refers to multi-site intervention study on suicide behaviors.
- The four themes for suicide prevention include
o Health and empowered individuals
o Clinical and community preventive services
o Treatment and support services
o Surveillance, research and evaluation.
Treating the underlying mental disorder
- Most people that attempt to kill themselves are suffering from a treatable mental disorder
- When Beck’s cognitive approach reduces depression, it also reduces suicide risk.
- Efforts to prevent suicide should focus on the underlying psychological disorder
Treating suicidality directly
- Reduce the intense psychological pain and suffering
- Lift the blinders-help the individual see other options other than the option to take their
own life
- Encourage the person to pull back from the self-destructive act.
Suicide prevention centres
- Staffed by non-professionals controlled by psychologists and psychiatrists.
- Initial contact is made by phone and that phone number is widely known in the
community.
- The person tries to access the probability that the caller will make a suicide attempt and
tries to dissuade the caller from doing so.
- Staffers are taught to adopt a phenomenological stance: to view the suicidal persons
situation as the way they see it. This empathy for suicidal people is referred to as turning
in.
Cultural and Ethical Issues in dealing with suicide
→ Therapist responsibility
- The suicide of a therapist client is grounds for a malpractice lawsuit
→ Physician Assisted Suicide
- This is a highly charged issues
- This topic is of current interest in Canada due to the case in 2012 of Gloria Taylor who
petitioned for an assisted suicide to end her case of Lou Gehrig disease
- On February 6th, 2015 the Supreme Court of Canada ruled that the laws against assisted
suicide are unconstitutional.
→ C-14 bill passed by the house of commons allows for assisted suicide in
medical competent adults in the advance stages of a serious illness where
death is foreseeable.
- 60% of physicians were in favour of the legalization of assisted suicide.
→ Physicians had more positive views if they provided care to HIV patients.
→ Another factor was location. More favourable views came from Canada, British
Columbia and Quebec.
→ Caring for the suicidal client
- Must be prepared more energy and time than usual.
- The therapist should be prepared that they will become an essential figure in this persons
life and that they will be a source of dependency, but also hostility and resentment when
they try to offer help.
- CBT and IPT combined with depression had efficacy in reducing suicide intention.
- There is evidence that new antidepressants play a role in falling suicide rates.
- Lithium plays a role in reducing suicide in those with bipolar disorder and unipolar
depression
- Clozapine plays a role in reducing suicide in those with schizophrenia.
Anorexia Nervosa
- Anorexia means loss of appetite and nervosa indicates that it is for an emotional reason.
- The term is a misnomer because most with anorexia do not loss their appetite for food,
they are preoccupied with food.
- There are four criteria for be diagnosed with anorexia nervosa and they include:
o The person must refuse to maintain a normal weight and weights less than 85% of
what is considered normal for their age and height
▪ DSM-5 has modified this criteria and no longer refers to the 85%
guideline- their revised version involves restriction of energy intact
resulting in a low body weight.
o The person has an intense fear of gaining weight and this fear cannot be reduced
by weight loss
o The person has a distorted sense of their body shape.
o In females it can cause amenorrhea, the loss of their menstrual period.
▪ This criteria has been eliminated from DSM-5 because many adolescence
and women who have anorexia nervosa and do not meet this criteria are
still similar to those who meet all four criteria for a diagnosis.
- The self-esteem of those with anorexia nervosa is closely linked to maintaining thinness.
- Anorexia nervosa typically begins in the mid-to-late teenage years after dieting and
exposure to stress.
- Co-morbidity is high. Those with anorexia are also prone to depression, social phobia and
panic disorder.
Physical Changes in Anorexia Nervosa
- Self-starvation and the use of laxatives produce undesirable consequences.
- Blood pressure falls, nails become brittle, mild anemia may occur and the skin dries out.
- Some individuals loss hair from their scalp and may develop Laguna, a fine soft hair on
their bodies
- Levels of electrodes are lowered, and this can cause tiredness, weakness and cardiac
arrhythmias.
- Brain size declines and neural abnormalities are common.
o White matter deficits are restored in the brain upon recovery from anorexia
nervosa.
o Deficits in grey matter are irreversible
Prognosis
- About 70% of those with anorexia nervosa eventually recover.
- Recovery often takes 6 or 7 years and relapse is common before a stable pattern of weight
is maintained
- Changing the distorted views of themselves is extremely difficult
- Anorexia nervosa is a life-threatening illness.
o Death rates are 10 times higher than the general population and two times higher
than for those with other psychological disorders.
o No other disorder that has equal mortality rates
o A shorter time to death was associated with chronicity, later age of onset and not
being in a relationship.
o Suicidality was not linked to a shorter death in those with anorexia nervosa,
BUT it was in those with bulimia nervosa.
Focus on Discovery 10.1
- The tendency to engage in intentional self-harm and self-injury is very common and it
increases the risk for subsequent suicide attempts.
- Intentional self-injury is associated with expericing eating disorders and the vulnerability
to eating disorders.
o This is high among those high in impulsivity
- In one study about 17% of youth between 14 and 21 engaged in non-suicidal self-injury
o Mean age of onset was 15 years old
o The main forms were cutting, scratching and self-hitting
o More self-injury was linked to depression and difficulties regulating attention and
impulsivity.
o Self-harm among young women was related to body shame and a history of
parental criticism.
- There are four reasons why self-harm may occur, they include:
o Interpersonal reasons
o To suppress an unwanted social stimulus (social negative reinforcement)
o To suppress negative emotions (automatic negative reinforcement)
o To generate feelings (automatic positive reinforcement)
- One factor that could account for self-injury is the internet self-injury message boards.
o This was referred to as the virtual cutting edge.
o Online social interaction provides support for those with a history of self-harm,
but they also normalize and encourage further acts of self-injury.
- The strongest predictors of self-injury were prior history of self-harm, higher
hopelessness and personality disorders with dramatic and erratic symptoms.
Bulimia Nervosa
- Bulimia means ox hunger and nervosa means for an emotional reason.
- This disorder involves rapid consumption of a large amount of food followed by
compensatory mechanisms, such as vomiting, fasting or excessive exercise to prevent
weight gain.
- DSM-5 defines a binge as eating an excessive amount of food with a defined period of
time (2 hours)
→ This binge must also include a sense of lack of control over the behavior.
→ Binge-eating and compensatory behavior must occur atleast once a week for a
period of three months.
- Bulimia nervosa is not diagnosed if the bingeing and purging only occur in the context of
anorexia nervosa. The diagnosis in this case would be anorexia nervosa, binge-eating-
purging type.
- Represents a discrete category that differs qualitatively from normality.
- Binges occur in secret and may be triggered by stress and the negative emotions it brings.
- Stressors that involve negative social interactions are potent elicits for bingeing
o Bulimics have high levels of interpersonal sensitivity, as reflected by self-
criticism following social interactions.
- DSM-5 criteria requires that the self-evaluation by influenced by body shape or body
weight.
- Binge episodes followed by lower self-concept, mood state and social perception.
- The person engaged in bingeing often feels a lack of control over the amount of food
being consumed.
- Binges are not always as large as the DSM implies and there is a lot of variation in the
calorie intact consumed by individuals with bulimia nervosa during binges.
- They report losing control during binges to the point of a dissociative state and they feel
ashamed of their binges.
- After the binge is over, disgust, feelings of discomfort and fear of weight gain led to
purging- induced vomiting and excessive exercise to undo the calorie intact.
- In the DSM-5 there needs to be bingeing once a week for a period of 2 months.
- A morbid fear of fat is an essential criteria for a diagnosis of bulimia nervosa because:
o It is the core psychopathology of bulimia nervosa
o It makes the diagnosis more restrictive
o Makes the syndrome closely related to anorexia nervosa.
- Fat talk is the tendency of female friends to take turns disparaging their bodies to each
other.
- Typically begin in late adolescence and early adulthood. There are different
developmental trajectories:
o One group has high steady symptoms, and another has increasing behaviors.
- Many females do not meet diagnostic criteria but show risk of subsequent vulnerability to
problems.
o The vulnerability for an eating disorder can be detected at a high age
o For females as their body mass increased, their body dissatisfaction decreased.
- For many people with BN they are overweight before the diagnosis and the binge eating
often starts after dieting.
- There is diagnostic crossover: more than 18% with AN develop BN, while 7% with BN
develop AN.
o Mortality is much less common in BN than AN however.
Student Perspective 10.1
- Fat talk reflects a conversional norms that it is somewhat excepted for people to express
negative opinions about their bodies as a way of fitting in.
- Fat talk reflects a highly defensive and negative sense of self
o Engaging in fat talk is associated with body shame, greater body self-
consciousness, a lower sense of empowerment and maladaptive eating attitudes.
o It is linked to increases in body dissatisfaction, negative affect, disordered eating
and more frequent checking of one’s body.
Biological Factors
Genetic Factors
- A role of genetics is suggested because both AN and BN run in families.
- Females with a relative with AN are 4 times more likely to develop the disorder
themselves.
- There is higher identical twin than fraternal twin concordance rates for AN and BN.
- Some genetic variants have been identified but have not achieved genome wide
significant
- The genetic basis for the internalization of the ideal thin suggest a genetic basis between
psychology and biology for why some people are more susceptible to body image issues.
Eating Disorders and the Brain
- The hypothalamus regulates eating and hunger
- Individuals with lesions to the lateral hypothalamus loss weight and have no appetite.
- The hypothalamus and the paraventricular nucleus have both been implicated in AN.
o Some hormones such as cortisol, which are regulated by the hypothalamus are
low in those with AN
o These low levels of hormones do not cause the disorder, the occur as the result of
self-starvation.
- The weight loss of animals with hypothalamus lesions does not parallel anorexia.
o Those with anorexia starve themselves despite being hungry
o The hypothalamus does not account for body-image disturbance or fear of
becoming fat.
o Therefore, the hypothalamus is not a highly likely factor in AN.
- Endogenous opioids are substances produced by the body that reduce pain sensations,
enhance mood and suppress appetite
- The differences in eating disorders across cultures suggests the importance of culture
presenting realistic or unrealistic views of ones body.
- In china, the fear of fat criteria for those with AN, may not been seen in anorexic females
in China.
- A subtype of bulimia known as the herbal purgative class was seen in Fiji, characterized
by the use of herbal purgatives.
Cognitive-Behavioral Effects
- Cognitive behavioral roles emphasize fear of fatness and body-image distortions as the
motivating factors in starvation and weight-loss.
- Behaviors that achieve thinness are negatively reinforcers for the anxiety about being fat.
- Dieting and weight-loss may be positively reinforced by the sense of control they create.
- Perfectionism and a sense of personal inadequacy may make a person more likely to
develop an eating disorder.
- Even brief exposure to images of young models can install negative mood in young
women.
- Chronic dieters feel thinner after looking at images of the thin body and this motivates
them to diet (thinspiration effect). This can cause distress when the individual is not able
to meet this unrealistic thin.
- Another strong drive for thinness is criticism from peers and parents about being
overweight.
o Girls aged 10 to 15 were evaluated twice within a 3-year period.
o Obesity at the first assessment was related to being teased by peers.
o At the second obesity was linked to body dissatisfaction, which was into
symptoms of an eating disorder.
- Bingeing results frequently when diets are broken. A lapse that occurs in diet for
someone with AN is likely to cause a binge.
Psychodynamic View
- The core cause in eating disorders lies in disturbed parent-child relationships
- The core personality traits of low self-esteem and perfectionism are found in those with
an eating disorder.
- The eating disorder fulfills some need, such as the need to increase one’s personal
effectiveness or to avoid growing up sexually.
- Early psychodynamic theories interpreted AN as arising from a conflict drive, but create
views view it as associated with a deficit drive, which is a way to compensate for deficit
in the self.
- Some psychodynamic theorist view AN as an attempt by children raised by ineffective
parents to ward off feelings of helplessness and powerlessness.
Family Systems Theory
- The symptoms of an eating disorder are best understood by considering both the afflicted
person and how their symptom are embedded in a dysfunctional family structure.
- The child is seen as physiological vulnerable and the child’s family has key features that
promote the development of an eating disorder.
- The child’s disorder plays a role in helping the family members avoid other conflicts.
- The families of individuals with eating disorders have the following characteristics:
o Enmeshment: overinvolvement and intimacy in which parents speak for the
children
o Overprotectiveness: family members have an extreme level of concern for others
welfare
o Rigidity: families try to maintain the status quo and do not deal effectively with
events that require change.
o Lack of conflict resolution: avoid conflict or are at a state of chronic conflict.
Characteristics of Families
- Results on characteristics in families that result in eating disorders have been variable
because of the different methods used.
- Self-reports usually reveal high levels of conflict within the family
- Parents of clients with eating disorders report higher levels of isolation and lower levels
of mutual involvement and support.
o These characteristics could however be the result of an eating disorder and not the
cause of it
Child Abuse and Eating Disorders
- Self-reports of sexual abuse are higher for those with eating disorders
- 25% of women with an eating disorder reported a history of sexual abuse.
- The presence and severity of abuse predicts more extreme psychopathologies.
- Both sexual and physical abuse are linked to an eating disorder. Having endured all 3
types of abuse amplifies the risk of an eating disorder.
Personality and Eating Disorders
- Trait negative emotionality and perfectionism have achieved risk status for the
development of an eating disorder
- Six personality factors have been linked consistently with an eating disorder: avoidance
motivation, lower extroversion and self-directedness, neuroticism, perfectionism and
sensitivity to social rewards.
- When looking at the role of personality it is important to remember that the eating
disorder could have caused the personality and not the other way around.
- In a study for six weeks, men volunteered to only eat 1500 calories a day and all lost
about 25% of their body weight.
- Narcissism has also been focused on in AN and BN studies.
o Perfectionism consists of two factors: self standards and external pressures
imposed on the self.
o Self-oriented perfectionism (setting high standards for the self) and socially
prescribed perfectionism are both high in those with eating disorders.
o The CBT challenges irrational beliefs to help them develop normal eating
patterns.
o The client and therapist learn that situations that trigger a binge and than learn
more adaptive ways to cope with this situation.
- CBT is the most commonly used and empirically supported treatment for body
disturbance issues.
o However, although CBT is effective about half the clients relapse after 4 months
and this is predicted by less motivation to change and higher initial levels of food
intake.
o IPT has fared well with CBT in treatment effectiveness.
▪ 2/3 of those who were treated with CBT achieved remission, whereas 1/3
of those treated with IPT achieved remission.
- If CBT took the form of schema-focused CBT it would be more effective. This would
focus on:
o Identify and modify the core beliefs that create negative schema.
Negative Symptoms
- Consists of behavioural deflicts, such as avolition, algoia, anhedonia, flat. Affect, and
asociality, all of which are described below.
- Attentional deficits contribute to clear reductions and impairments in woring memory.
- These sympotoms tend to endure beyond an acute episode and have profound effects on
people’s lives.
- It is important to distinguish among negtavie symptoms that ar truly symptoms of
schizophrenia and those that are due to some other factor.
→ Avolition
Lack of energy and seeming absence of interst in or an inability to persist in wha ar eusaly
touritne activies.
- Clients may become inattentive to grooming nad personal hygeien, with uncombed hari,
dirty naisl and disheveled clothes.
→ Alogia
In poverty of speech, the sheer amount og speech is greatly reduced. In poverty o content of
speech, illustrated in the following excerpt, the amount of discourse is adequate, but it converys
little information and tends to be vague and repetitive.
→ Anhedonia
- In inability to experiences pleasure. It is manifested as a lac of interest in recreational activites,
failture ot develop close relationship with other people, and lac of interest in sex.
→ Asociality
Severly impaired social reltionahips.
- They have few friends, poor social sills, and little interst in being with toher people.
- Many reported childhood “social troubles”.
Other Symptoms
→ Catatonia
Defined by several motole abnormalities.
- Catatonic Immobility- clients adopt unusal postures and maintain them ofr very long
periods of time.
- Waxy flexiblitiy- an other peopon can move the persons’ limbs into strange postions that
they maintain for extended periods.
→ Anappropriate Affect
The emotinals response of these indivdials are out of contect; for exmaples the clien may laugh
on hearing that his or her mother just died or become enraged when asked a simple question
about how a new garment fits.
- The sumptoms of schizophrenia have profound effect on people’s leives, as well as the
lives of theif families and friends.
- Delusions and hallucinations may cause considerable distress, compounded by the fact
that hopes and dreams have been shattered.
- Cogntivie impariemtns and avolition make stable eplousemd difficult, with
improverishement and ofter homelessness the restuls
- Strange behaivour and social-skills deficits leads to loss of friendsand a solitary existene.
o With age of onset and deteriorating course no longer considered definfinf features
of the disorder, Bleuler faced a conceptual problem.
- The metaphorical concept that he adopted for this purpose was the “breaking of
associative threads”/
o Goal-directed, efficient thinking nad communication were possible only when
these hypothetical strucutres were intact.
o The notion that associative threads were disrupted in people with schizophrenia
could then account for other problmes.
o Bleuler viewed attentional difficulites, for example as might result from a loss of
purposeful direction in thought – as the cuase of passive repsones to objects and
people in the immediate surroundings.
- They amay have flat effect or experience osntat shifts of emtion, breaking into
inexplicable fits of laughter and crying
- Their behaviour is generally disorganized and not god directin
- Clinet sotmies deteriorate to the point of incontinence, voiding anywhere and at any time,
and complete neglect their appearance, never bathing or combing hair.
→ Catatonic Schizophrenia
- Clinets typsically alternate between catatonic immobility and wild excitement, but one of
thes symptoms may predominante.
- These clients resist instrucutions nd suggestions and often echo (repeat back) the speech
of tohers
- The onset of catatoni reation may be more sudden than the onset of other forms os
chizphgrnai, although the person is linkely to have previously shown some apthay and
withdrawal form reality.
→ Paranoid Schizophrenia
This is assigned to a substantial numbero f recently admitted clinets to spychitartic hosptials .
- The key to this diagnosis is the presence of prominent delusions
Grandoise delusions
- They have exaggerated sense of their own important, power, knowledge, or identiy
Delusional Jealousy
- The unsubstantiated belif that their partner is unfaithful.
- The other delusison described earilyer, such as the sense of beign persecuted of psied on,
may also be evident
Ideas of reference
- They incorporate unimportant events within a delusions framework and read personal
signifnace into the trivival acitivies of others
- Individuals with parniod schizophrenia are agitated, argumentative, angry and sometimes
vilent.
- They remain emotionally responsive, although they may be somewhat stilted, formal and
intense with tohers.
- They are also more alert and verbal than are people with other types of schizophrenia
→ Twin Studies
The analyses suggested that negative sympomts havea s tonger genetic component than do
positive ones
→ Adoption Studies
- the sutudy of children whose mothers had schizophrenia but who wre reared form early
infancy by non-schizophrenic adoptive parents has provided more-conclusion
information on the roel of genes in schizophrenia by eliminating the possible effects of a
deviant environment.
- Children reared without contact with their so-called pathogenic mothers were still more
likely to become schizophrenia than were the control participants.
→ Molecular Genetics
Thanker noted that the hung for schizophrenia-related genes turned out to be more difficult than
expected for several reasons
- The hung of schizophrenia-related genes turned out to be more difficult thatn expected
for several reasons
o Lack of preciseness in defining the boundaries of the clinical phenotype
o Absence of biological test that confirm diagnostic categorization
o Clinical heterogeneity and the complex nature of schizophrenia
- They have focused on five disorders that appear to share a common genetic vulnerabitliy:
schizophrenia, major depressive disorder, bipolar disorder, autism specturn disorder, and
attention-deficit/hyperactive disorder.
Biochemical Factors
→ Dopamine Activity
- The dopamine hypothesis is the longest standing biologically based theory of
schizophrenia and it has predominated for over four decaded.
- The hypothesis that schixophrenia is related to excess activity of dopamine is based
principally on the knowledge that drgus effective in treatgin schizophrenia reduce
dopamine activity.
- Antipsychotic drugs- being useful in treating some symptoms of schizophrenia, produce
side effects resembling the symptoms of Parkinson’s deisease.
- Parkinsonism is known to be casued in part of low levels of dopamine in particular
nerve tract of the brain.
o it has been confirmed that becauseo f the structural similarities to dopamine
molecule, molecules of anitpyschotic drugs fit into and thereby block postsynaptic
dopamine receptors.
o The dopamine receptes tha are blocked by first-generation or converntional
anitpsychotics are called D2 receptors.
- There are several subclasses of dopamine recepts that differ I the specific of how they
signal the postsynaptic neuron.
- The action of the drgus that help people with schizophrenia, it is but a short inductive
leap to view schizophrenia as reuslitng from excess actibity in dopamine nerve tracts.
- Dopamine theory
o Came from the literature on amphetamine psychosis.
o Amphetamines can produce a state that closely resembles paranoid schizophrenia,
and they can exacerbrate the symptoms of schizophrenia.
o Amphetamines casue the release of catecholamins, including norepinephrine and
dopamine, into the synaptic cleft and prevent their inactivation.
o Additional evidence fro the dopamine hypothesis came for post-mortem studies of
people with schizophrenia.
o A key piece of evdicne is the link btween more potent antipsychotic drugs and
dopamine D2 receptors.
o Based on data just reviewed, researched at first assumed that schizohphrenia was
caused by a dopamine excess. But as other studies progressed this assumption did
not gain support.
▪ Major metabolic of dopamine, homovanilic acid (HVA) was not found in
greater amount in people with schizophrenia.
▪ Some post-mortem studies of brains of schizophrenic people, as well as
PET scans of schizophrenic people, have reveals that dopamine receptos
are greater in number of are hyper-senstivie in some people with
schizohphrnia.
o The key change involved the recognition of differences among the neural
pathways that use dopamine as a transmitter
▪ The excess dopamine activity that is thought to be most relevant to
schizophrenia is localized in the mesolimbic pathway and the therapeutic
effects of antopsychotics on postivie symptoms occur by blocking
dopamine receptors there, thereby lowering activity in this neural system.
o The mesocortical dopamine pathway begin in the same brain region as the
mesolimbic, but it projects to the prefrontal cortex.
▪ The prefrontal cortex also projects to limbic areas that are innervated by
dopamine.
▪ These dopamine neurosn in the prefrontal cortex may be underactive and
ths fial to exert inhibitory control over the dopamine neurons in the limbic
area, with the result that there is overactivity I nthe mesolimbic dopamine
system.
▪ This proposal has the advantage of allowing the simultaneous preence of
postivie and negative symptomsi n the same person with schizophrenia.
o Because anitpsychotics do not have major effects on the dopamine neurson in the
prefrontal cortex, we would expect them to be relatively ineffective as treatments
for negative symptoms, and they are.
- Schizophrenia has widespread symptoms covering percepton, cogntivition, motor active
and social behaivour.
→ Other Neurotransmitters
Dopamine neurons generally modulate the activity of other nueral systems; for example, in the
prefrontal cortex, they regulate BAG neurons.
- Serotonin neurson regulate dopamine neurosn in the mesolimbic pathway
- Glutamate, a transmitter that is widespread in the human brain, may also pkay a role.
o Low levels of glutmate have been found in cerebrospinal fluid of people with
schizohphrenia.
Schizophrenia and the Brain: Structure and Function
→ Enlarged Ventricles
- Structural problmes in subcortical temporal-limbic areas, such as the hippocampus and
the basal ganglisa, and the prefrontal and temporal cortex
- A reduction in crotical grey matter in both the temporal and frontal regions and reduced
volume in basal ganglia and limbic strucutres suggesting deterioration and atrophy of
brain trissue.
- Large ventric la in people with schizphrnia are correlated with impaired performance on
neuropsychological tests. Poor adjustment prior to the onset of the disorder, and poor
response to drug treatment.
o Large ventircel are no specific to schizphrniea as they are also evidcnet I nthe CT
scans of people with toher psychoses usch as psychosis such as bipolar disorder.
→ The Prefrontal Cortex
- The prefrontal cortex is known to play a role in behaivours such as speech, decision-
making and willed action, all of which are disrupted in schizophrenia. A
- Auditory halluciotn result when the prefrontal corte is accompanied by activity I nthe
termporal gyrus
- Lack of illness awareness is related to poorer neuropsychological performance more
often in clients with schizophrenia than in biopolar participants, supporting the
hypothesis that lack of awareness is related to defective frontal-lobe function.
- Glucose metabolism in the prefrontal cortex has also been studied while clients are
preforming neurospychoglical testsof prefrontal function.
- Failure to shoe frontal activation has also been detected bythe fMRI conducted a meta-
analysis of functional imgagin studies that contrasted peple with schizphrnia and
“healthy” volunteers specifc araes relative to comparison participatns, suggesting that
“cogntii e controls deficits strongly contribute to epxisode memory impairment in
schizophrenia
- The frontal hypoactivation is less pronoused in the non-schizphrnie twin of discorand MZ
pairs, again suggesting that this brain dysfunction may not have a genetic origin.
- fMRI to test the hypothesis the violet people with schizophrenia and comorbid anti-social
personality and substance use disroders show a different pattern of prefrontal fucnitoning
than seriously vilent peope with schizophrenia only.
- Cortical development is in critical stage of growth during the second trimerst- nerons are
being produced in the rudimentary brain called the neural tube.
- Post-mortem analyses of neurons in the brains of individuals with schizophrenia have
shown reduced number of cells in the outer layed of the cortex in both the prefrontal and
the temporal areas
- A widespread thinning of the cortx of people with schizophrenia has been reported,
apparently resulting fro mloos of dendrites and axons nad neurons in the frontal cortex
have been shown to be smaller than normal in people with schizophrenia
- The brains of people with schizophrenia are damaged early in development.
o An injury to this area may remain silent until the period of development when the
prefrontal cortex begins to play a larger role in behaviour.
→ Related Research
- Recognizing that the symptoms implicate many areas of the brain, research has moved
away fro mtrying to find some highly specific “lesion” and is examining neural systems
and the way different areas of the brain interact with one another.
- This work calls attention to the possible role of a wider ranger of brain stuctures in
schizophrenia.
- The extent of a more broad-bsed cognitive impairment needs to be examined with respect
to the heterogenetiy of schizophrenia
- A growing body of work suggests the schizophrenia is related to dysfunction of
functionally and anatomically connected netwroks of brain regions.
o The authors conclude that white matter pathology plays a critical role in the
cognitive impariemtns seen in schizophrenia.
o In future we can expect to learn more about toher important developemtns in our
understaidn of brain strcutre and function in people with schizophrenia
- The degrading treatment a person receives from tohers, the low level of education, and
the lack of rewards and opportunity taken together may make membership I nthe lowest
social class cu has stressful expericne that an individual – at least one who is predisposed
– develop schizophrenia.
- Social-selction theory – the reverses the direction of causality between social class and
schizophrenia.
- During the course of their developing psychosis, people with schizophrenia may drift into
the poverty-ridden areas of the city.
- One way of resvolign the conflict between these opposing theories is to study the social
mobility of poepe with schizophrenia.
o Consistent with the social-selection theory, some studies found that people with
schizophrenia are downardly mobilr in occupational status.
o This approach has not resovled the isse.
o This could be considered evidence in favour of the sociogenic yptoehsis that
lower-class status is conducie to schizophrenia.
- A subsequent study in Isreal employed a new metholody, simultaneously investigating
both social class and ethnic backgorun.
- The rates of schizophrenia were examine in Isreali Jews of European ethnic background
and in more recent immigrants to Isreal from North Africs and the Middle East.
- The datt are more supportive of the social-selection theory that of the sociogenic
ypothesis. n
→ the Family and Schizophrenia
- Etiology and the role of the family
Early theorists regarded family relationships, especially those between a mother and her son, as
crucial in the development of schizophrenia.
o Schizophrenogenic mother was coined to describe the supposedly cold and
dominiant, conflict0inducing parent who was said to produce shcizphrenia in her
offspring.
o These mothers were characterized as rejecting, overprotective, selc-sacrificng,
impervious to the feelings of other, rigid and moralisti about sex and fearful of
intimacy- a very destructive view sine it basically blamed the moterh for a sever
psychiatric disorder in a child.
o Some findsin suggest that the faulty communicatiosn of paretns play a riel in the
etiology of schizophrenia.
o Further evdicen favouring some role for the family comes from an adoption study
by Tienari and his colleages.
- Relapse and the role of the family
A study of clients with schizophrenia who returned to live with their famileid after discharge.
o Interviews were conducted with parents of spoursed before discharge and rated
for the number of critical comments made about he client and for expression of
hostility toward or emotional overinvomented with him or her.
Expressed emtion (EE), families ewre divided int o two groups: those revealing a gret deal of
expressed emtion, called high-EE families, and those revealing little called low-EE familes.
o At the end of the follow up, 10% of the client returning to low-EE homes had
relapse.
Research indicaed that both interpretations of the operation of EE – the casucal and the reactice-
may be correct
o The finding were that
▪ The expression of unusual thorughts by the clients elicited higher levels of
crtical comments by family members who had previously been
chractertized as high in EE
▪ The high-EE familes, critical commetns by family members led to
increased expression of unuscla thoughts.
o In this study, ti found that bidirectional relationship: critical comments by mbmers
of high-EE familed elicted the increased expression of unsucal thoguths by
clients, and uncuale thoguhts expressed by clients lef to increased ciritcal coming
in high EE famied.
Biological Treatments
→ Shook and Psychosurgery
- Prefrontal lobotomy – surgical procedure tha destroys the tracts connecting the formal
lobes to lower centres of the bring.
o the initial reports clained high rates of success variations of psychosurgery.
o The lobotomy proceduere was used especially for those who behavior was
violent.
→ Drug Therapies
antipsychotic drugs - theses drugs are also called “neuroleptics” because they produce side
effects similar to the symptoms of a neurotlogical disease
→ First-generation (conventional) antipsychotic drugs
Chlorpromazine (Thorazine) was first used therapurtically in the US and rapidly becasne the
preferred treatment ofr schizophrenia.
- This was not a cure
- Had many side effects, some advacnes have been made in controlly side effects of second
–genration antipsychotics, but now there are emergin concerns of side effects that
enhance the risk of cardiometiabolti dysfunction.
- Clients who responed positively to antipsychotic are kept on socalled maintenance doses
of the drug, just enough to continue the therapeutic effect.
→ Second-generation (atypical) antipsychotics
atypical anitpsychotics relative to antipsychotics in gn=enral, it that at effective dose levels, the
atypical anitpsychotics are less likely to cause side effect.
- Antipsychotic drugs are an indispensable part of treatment for schizophrenia and will
undoubtedly continue to be an improtat compent
-
Psychological Treatments
→ Social Skills Training
- Designed to teach peioke wit schizophrenia behaviorus tha can help the succedd in a wide
variety of interpersonal siutations – disucing their meiaction with their psychiatrist,
ordering meals in a restuarnt, filling out job applicatiosn, saying no to offers to by drus o
n th stress -.
→ Family Therapy and Reducing Expressed Emotion
these therapies have several features in common beyond the overall purpose of calming things
down for the clients by calming things down for the family.
- They educate cient and familes about he biological vulnerablilty that predisposed peope
to schizophrenia, cognitive problmes inherent to schizophrenia, the symptoms of the disorder,
and signs of impending relapse.
- they provide info about and advice on monitorying the effects of antipsycotic medciaotn
- they encourage family members to blame neither themselves not the client for the
disorder and for the difficuatlies all are having it copign with it
- they help improve communcaiotn and probmel-solving skills within the family
- they encourage clients and their fmailed to expand their social contract,s escpially their
support networks
- they instill a degress of hopd that things can improve, including the hope that the client
may not have to return to the hosical
→ Cognitive-Behavioral therapy
Their conceptual model of cognitviton and schizophrenia, suggested that cognitive-behaviorual
therapy can facilitate motivation and engagement in social and vocational activites.
o Other studies have shown that a schizphreani clinet’s ability to recnogised fcaily
affect in other, working memory, and attention can all be improved thorught
congitve training.
Other
→ De stigmatization
there needs to be more worok for destigmatizing the condition of schizophrenia
- This suggests that the assessment and diagnosis of perosnity disorders are enhavned when
the significant others in an indivdial’s life become infomrants.
- Another significant diagnosis challenge is that the substnatioal properiton go licnets are
deemed to have a genral preonlaity disorder as PD nor otherwised specific.
- Although clinical inteviews are preferable when weeking to make a diagnosis,
researchers often realy on the used of self-report measures when assessing personality
disorder symtoms
- Two key issues involeding self-report measures of persnlity disorder need to be
considered
o The various self-report measures differ in their content and are not equivalent
o A general concertn involing self-reprot measures, inciluding PD emaures, is tha
the cut-ff points used with sekf-report response to determin the presence of a
personality disorder often overestimate the number of people who meet diagnostic
criteria for particular disorder
Personality Disorder Clusters: Odd/Eccentric Cluster
Personaly disorder have been groups in to three clusters
- Individauls in cluster A (paranoid, schizoid, schiaotypical) seem odd or eccentric. These
disorder reflect oddness and avoidance of sical contact
- Those in cluster B (borderline, histrionic, narcissistic, and anti-sical) seem dramatic,
emotional, or erractic. Behaviours are extrapunitive hostile.
- Those in cluster C(avoidant, dependent, and obsessive- comppuslive_ appear fs
- The empirical evidence n the validiy of thse clusters is mized, and some evidcne suggest
ath tperhaps a fourth clutster reflection obsession and inhibition should also be considerd.
- The odd/eccentric sluter compises three diagnosis: paranoid, schizoiod, and schizotypai
PDs. The symptoms of these disorders bear some similarity to the symptoms of
schizophrenia, especially to the less sever symptoms of its prodromal and residual phases.
Paranoid Personality Disorder
The indivial with paranoid personliaty disorder is suspicison of other. Peope with this
diagnosis expect to be mistreated or exploited by others and thsu are secretive and always on the
lookout for possible isgns of trickery and abuse.
- Indivdiauls with PPF are preoccupied with unjustified doubts about the trustworthiness or
loyalty of others.
- This diagnosis is idffernt form schizophrenia, parnaiod type, because symptoms usch as
hallucinations are not presnt and these is less impairment in social and occupational
function.
- It differes from delusional disorder because full-blown delusion are not presnt
- PPD occurs most frequently in en and co-occurs most frequently with schizoprypcal
borderline, and avoidant perwonaltiy disoreer.
- Data suggest that iti is one of the more commonly diagnosied personality disorders in
community sampled and that parnodi personltiy disorder is best repestned as a continuous
dimensions rather than a discrete category
Schizoid Personality Disorder
- They do no appear to desire or enoy social reltioanhips and usually have no close friends
- They appear dull, blanc and aloof and haven o warm, tender feelings for others.
- They rarely report strong emotions, haveno interest in sex, epxereinces few pleasureable
acitivyt.
- Comorbidity is highest for schizotypcal, avoidant, and paranoid personality disorder,
most likely because of the similar diagnostic criteria in the four categroeis.
Schizotypal Personality Disorder
- People with schizotypal personality disorder usually have the interpersonal ddiculites of
the schizoid personality and excessive social anxiety that does not dimish as they get to
know others.
- Cogntiive limitations and resctrictions found in schizophrenia are also evidnce in
schizotypal personality disorder.
o Those with schizotypcal persnlity disorder may also have ood beliefs or magical
thinking and recurrent illusions.
o Their speech, may use words in an unusaly and unclear fashion
- A significant problem in the diagnosis of schizotypial perosliaty disorder is its
comorbidity with other personiaty disorder.
- Epidemiolgical data suggest that comorbitiy is higher for schizotypal personality disorder
than for any other persolnity disorder.
- Epidmiolgical dta suggest that comorbidity is higher for schizotypal personality disorder
than for any other personality disorder and the degree other personality disorder nd the
degree of comorbidity with borderline preosnliaty disorder and narcissitic personality
disorder continue to be very high.
Etiology of the Odd/Eccentric Cluster
- Family studies of paranoid personality disorder for the most part find higher than average
rates in the relative of peile with schizophrenia of delusional disorder
- Family studies have shown that the relative of people with schizophrenia are at increased
risk for this disorder.
- Genetic factors paly some role in etiology, but a study of twins in tNormawy found that
the heritabiltis of personalitydisroder were modest and ranged rom 20 to 41%.
- Family studies probide at least some evidnce that persolity disorder of odd/eccentric
cluster are related to schizophrenia.
- People with schizotypai lperosnltiy disorder have dficit in cognitive and neuropsycholgial
fucntions.
greater frequenty of negative life events, both in termso f self- reported and interviewer-
assessed life events.
→ Etiology of Borderline Personality
Object-relations theory
Object-relations theorists hypothesize that peopke react to their wolrd thought the perspective of
people form their past, primarity their parents of other priary cargivers.
- Althoguth people woth BPD have weak egos and needs constant reassuring, they
retainthe capacitrye to test realtiy
- They are intouch with reality be frequently engange in a defene mechanism called
splitting.
o Rthis tendency caused extreme difficulty in regulating emotions because the
person wth BPD sees the wordl, including himself or herself, in black-and-white
terms.
o BPD report a low level of care by their mothers.
o Resrach conducted in Toronto by Links and van Reekum indicates that people
with BPD also frequently report childhood sexual and physical abuse.
Biological factors
Na analysis reported that heritability estimates range across four studies fomr 37% to 69%.
- These same researchers found in their studies tha someone with first-degree relative with
BPD bs someone whitout a first-degree relaive with BPD, had a three to four times
greater likelihood of beign diagnosed with BPD. There are also indications that gentic
factors palya substantioal role while environemtnal factors play a realtively small role.
- Data suggest poor functioning of the frontal lobes, which may plya arole in impulsive
behaviours.
- BPD clients preform poorly on neurolotical tests of frontal-lobe functioning and show
low glusoce metablosim I nthe forntal lobes
- People with BPD have an overactivtion in the insula and posterior cingulate cortex, and
undersactivation across a region that stretch form he amygdala to the dorsolateral
prefrontal cortex.
Linehan’s diathesis – stress theory
Purposes that BPD develops when people with biological diathesis for having difficultiy
controlling thiter meotionals are rasied in a famiy environemtn that is invalidty.
- An invalidtating environemtn is one in whichte prsons wants and feeligns are discounted
and disresptect and effort ot communication one’ feeligns are disregrated or even
puncihsed.
- An extreme form of invalidation is child abuse, sexual nad nonsexual
- A key piece of evidnce supporting Linehan’s theory concerns childhood physical and
sexual abuse.
- The tendency for people to blame themselves for thinks that they ar clearing no responbitl
for and that are well byond their control is due in part to our tendency to need to maintain
“an illusion of control” that is fueled by the fera inherent in realieding that some things
are beyond our control
Histrionic Personality Disorder
The diagnosis of histrionic personality formerly called hysterical personity is applied to
peoplw who are overly dramitc and attention-seeking.
- They often use feautes of their physical appearance, such as unuscal cloth, makeup or
hair colour to draw attention to themselves
- These indivdiauls, alhtought displaying emiton extravangtly are thought to be meotinall
shllow.
- They are self-centred, over concerned with tier attractiveness, and uncomfortable when
not the centre of attention.
- They can be inappropriately sexually provocative and seductive and are eaily influenced
by others
- Htie rspeech is often impressionistncand liackign in deaitl.
→ Etiology of Histronic Personality Disorder
Narcissistic Personality Disorder
- Preoccupied with fantasies of great success.
- They require almost constant attention and excessive admiration and believe that only
high-staute people can understand them
- Their interperosnaly relatioships are disturbed by their alck of empthay, feelingsof envy,
arrogance and their tendency to take advantage of toher.
- Relationship are alos problematic because of their feeligns of entitlement – they expect
others to do special not-to-be-reciprocated favours for them
- Dark riad- consists of the combination of narcissim, psychopathy, and
Machiavellianism.
o People who are narcissictic also tend to have the other elemtns of the triad
o The concept of psychopathy and itsl ink with anti-social tendiecne are describe
belof
o Machiavellianimsis a peronslity style characterized by an extreme willngess to
take advantage of toher when the opportunity presnt itself brcause peope wkth
orientation essentially belive that everyone is out for himself or herself
o Also supplemented with addition of the dimension and sadism and as a reslt now
tcalled the dark tetraed
o Sadism is a tendancy to enhoy cruelty in everyday life
- An important point hta emergy from this reent work ist hat when we foecus on personliy
dimendison in reseahc concentrated on persolniy varibel, there is a tendency to lsoe isgh
of a person-centred apracoha dn the fact that several coreelated dimentions tha relfct
persoliy dysfunction may esixt within the ame person
- The diagnoses invoeld not only certain patterns of anii-socail behiouar byt patterns that
began in childhood
- Other symtoms inclue failure to conform to iscla norem, deceitfulness, impusivity,
irritabliey nad reckless disregard for the safety of self and others
- APD became prominent topic in Cadna as a result of April 2013 inquest exmaing the dath
of ashly smith, the girl who coke herself to death.
o There are many troubling aspects of this case.
→ Charateristics of Psychopathy
Linked closely to the writing of Hervey Cleckly and his classic book. This criteria for
psychopthe refer less to anti-social behaivour per se than to the psychopathic indival’ thoughs nd
feeligns.
- ONe of the key characteristic of psychotpahtys ipovert of emtoions, both psotive nad
ngetaiv.
o Psychopathic peopelw have no senseo f hacne and even their seemingly psotive
feelignso for thers are merely an act.
o The psychopath is superficially charming and manipulates other for personily gian
o They exploit other even if it invoeld the use of violenve and aggereion
o Their lack fo anziety may make it impossible for psychopaths to learn from
theirmistakes, and their lack of positive metion leads tem t bheaviour
irresponsible and oftern cruely otwards others.
→ Controversies with Daignoses of APD and Psychopathy
The two diagnosis – APD and psychoahty- are realted by they are by no means identical
- One study found that only about 20% of people with PD scoared high on he Hare PCL-R.
o Harpur and Hare observed that alsmot allpsychopaths are diagnosed with APd byt
many peaopld diagnosed with APD do not meethe critier for sychopahty of PCL-
R
- Extensice reseach ahs now identified factors nad processed the distinguist APD and
psychopathy.
o Dlear differeince have merged in defencie reactivyt suggesting thst psychopathy
is distingused bya low fear dispotion.
o This deflicit in psychopathis described in more datil below
o Other resaech ahs found that factors bleived to distingus APD and psychopathy
actually do not.
o A study of male prison inatme found tha PD and featues ps psychopathy wer both
associated with a hisotyr of suicide attemps
o It was belied previously tha cognitive control delficts were linked with APd but
psychopathic indivdiuasl had elevated cognitive control, but hera gins, recetn data
indicate tha APD and psychopathy are both assoicaited with delifst in cognitive
control
→ Research and Theory on the Etiology of Anti-Social Personality Disorder and
PScyhoapthy
- Childhood roots of psychopathy
Evidence is accumulaitngo n the nature of psychopathy in children and youth. Research ahs
shown that following
o Genetically influenced psychopathic personality in adolescents is a stonrg
predicotry of adult anit-soicl bheiaovur
o Female youth offenders, realitve to high psychopathy are more likely to have a
histpry psychatir hospticalliatin fi they are high is psychopathy
o Chidlren with psychopathi tratis have abnormal prefonrtla cortex responsiveness
o Tests of regional grey matter volume aong incarcerated male adolescents link
psychopathy with decread grey matter volumes if diuffes paralimbic brain
regions, leading the researched to conldue that psychopath in younger people is
best viewed as a neruodevelopemtnal disorder
o Canadian youth with pre-exisitng elevated levls of psychopathy are more likely to
joing youth gangif they acome fomra neigbourhood of residential instability in
terms of high neighourhood turnover artes
Schemea therpaye for borderline perosilty disorder involed three pahses of treatmen
- Bonding between the clientand therapist and emtoinal regulation
- Schema mode change
- Development of authomuy
Therapy for the Borderlien Personality
→ Dialectical Behaviour therapy
This has three overall goals for borderline indivdials
- Modulate and contrll their extreme emotional and bheiaorus
- Tolerate feleings distressed
- Trust their own throughts and emotionas
Therpay of Psychopathy
The primary reasons for their unsuitability for psychothrepyar is thaty they are unable and
unmotived to form any sort of trusting, honest relatioshp with a therapist
- People who lite almost without knowi, who care little for the feeligns of toher and
understand their own even less, who appear not to realize that hwat they are doing is
morally wrong, who lack any motivation to obey society’s law and moreses, and who
living only fohte prestn, have no concern for the cuture are, all in all, extremel poor
candiated for therapy.
The diagnostic criteria for older adults are basically the same as for younger adutls. The nautrea
nd manifestatiosn of mental disorder are usally assumed to be the same in adulthood and old age,
even though little research supports this assumption.
- Accurate assessment of eldery people for the purposes of establishing diagnosis and
conducting research requires assessment measure tairlored to elderly poel.
- A meaure of cognitive functioning is often included as standard practice inreaserch to
determein whether the elderly respondent has experienced decline in cognitive abilty.
- Researchers often assess cognitive functioning wtihte Mini-Mental State Examination.
- The MMSe is a brief mearue fo an idnvidiual’s cognitive state, assessing “orientation,
memory, and attention .. abitliy to name, follow verbal and written commands, write a
sentene spontaneously and copy a coplex polygon.
- Some elderly people will have diminished attention spans, one goal is to develop short
but reliable mearues suitable for screening purposes.
- A releatiely simple meaure usedto detect demeitan and Alzhimer’s disease is the clock-
drwaing subtest of the Clock Test.
o The clock test was devleopemt by Holly Tuokko of the Univeristy of Vicotiria
and her associated.
o They wer asked to imaging htat htei ciricla is the face of a clock and to put the
numbers on the clock and then draw the hahnd plancement for the time of 11:10.
Up to 25 different types of errots can occur, including omissions, perserverations,
rotaitons, misplacement, distori bing, substitution and addtions.
o This simple test has been found to reliable and valide, thought results vary
depending on the scoring system used.
- Another assesemtn ogald is to create measure whose itme content is toailered directly to
the concernt and symptosm reported by elderly ple , not to those of younger respondents.
- One well-known measure crafted for the elderly is the Geriatir Depression.
- The GDS has acceptable psychometric characteris and is regarded as the sandrad measure
for assessing depression in the elderly.
- The Geriatirc Suicide Ideation Scale is a 31 item meaure that is the first mearue of suidice
ideation created specifically for the elderly.
- Subsequent research with a community sample attested to the psychometric feature of the
GSIS and its subscaled, and it established that high GSIS scaore are associated with
ihigher levels of loneliness and osical hopelessness and lower levels of social support nad
well-being
Rage of Problems
One concertn expressed by the Wolrd Healht Orgnaization (WHO, 2002) is htat elderly people
with a mental disorder may suffer from “double jeopardy”; this is, they suffer the stigmas
associated with being olrder and being mentally ill.
It is important to remember that in addition to a lifetime of exposure to losses and to toher
stressors, olderadults have many positive life experiences, coping mechanism, and wisdom on
which ot draw.
Older adutls who beling to groups that provide meningul, strong roles for them seem to have a
easier time adjusting to gorwing old.
Old Age and Brain Disorders
Althought majoriy of older peoep do no have braind disorder, these pek account ofr more
admission and hospital inpatinet days than any other geriatice condition.
Dementia
Accoridngto the DSM-5, the preferred term instead of “dementia” is “neurocognitive disorder”
to be used in settings where docots and pateitns are famility with the term.
- Sometimes call “senility” is gernal descriptive erm for gradual deterioration of
intellectural abilities to the point that social and occupational funcitons are impaired.
- Difficutly remebefing thigns, escpially recent evens, is the most prominent symtoms and
reported memory probme in people who objectly have normal cogition predict
subsequent dementia.
- People with dementia may leave tasks unfinished because they forget to return to them
after an interruption.
- The people who had started to fill a teakettle a the isnk leaves the water running; a parent
is unable to remember th name of a daughter or son.
- Hygiene may be poor and appearance slovenly because the person forgets to beathe or
how to dress.
- People with dementia also get lost, even in familiar settings.
- Judgement may become faulty, and the person have difficulty comprehending sitautiosn
and making plans or decisions.
- Porple with dementia relinquishe their standards and los control of their impules; they
may be use coarses language, tell inappropriate joeks, pr shoplife.
- The bility to deal with abstract ideas deteriorates, and disturbances in emotions are
common, including symtoms of depression, flatness of affect, and sporadic emotional
outbursts.
- People with demential are likely to show language disturbances as well, such as vague
patterns of speech.
- Although the motor system is intanct, they may have difficulty carrying out motor
activities, such as those involed in curshing teeth or dressing themselves.
- They may also have trouble recognizing familtiy surroudnings or naming common
object.s
- Episode of delirium, a state of great mental confusion may also occur.
o These should be distinguesd from paraphrenia, the term used to describe
schizophrenia htath as its onset during old age .
- Thse course of dementiamat may be progressive, statisc or remitting, depednign on the
cuase,
- Many people with progressive dementia eventually become withdrawn and aptehtic. In
the terminal pahse of the illness, the persontiy loses its sparkle nad integrity.
- Relatives and friends say that the peson is just not himself or herself anymore
- Social involvemtn with tohers keep narrowing.
- The person is obilicious to his or her surroudningd .
- The prevalen ce of dementia increase with advancing age .
- One US study found a prevalence of 13.9% for peope k71 and older and 9.7% prevalcne
of Alzheimer’s disease.
- The prevalence of dementia was 5% for those aged 71-79 years old, but 37.4% for htose
aged 90 years and older.
- This same team eteam of investigators estimated later that another 22.2% of those aged
71 years or older have some form of cognitiveimpairment without dementia
→ Types and Causes of Dementia
Dementias are typically classified into three tyeps. Alzheimer’s diesae is the most common.
Therea re frontal- temporal and frontal-subcortincal dementias, which are define by the area of
the brian that are mot affecte.d
- Alzheimer’s Disease
o The person aften blames other for personaly failigs and may have delusions of
being persecutre
o Meneory continue to deteriorate, and the person comes increasingly disorinetaed
agitated
o Imaging of braing changes show clear signs of decline hta are often beyond a
person’s awareness
o Main physiolgicla change in the brian, evidcent at autopsy, is an atrophy of the
cerebral cortex, firsthe entorhinal cortex and the hippocampus and late the frtonal,
tmeproal and parietal loves
▪ A neurons and synapses are lost, the fissures widen and the ridges became
narrower and flatter.
▪ The ventircles also become enlarged
▪ Plaques- small, round areas making up the remnants of the lost nerurons
and b-amyloid, a waxy protein depostis – are scattered thorught he cortex.
▪ Tangled, abnormal protein filamens - neurofibrillary tangles –
accumulate with the cell bodies of neurosn
• These plaues and tangels are presnt throughouthe cerebral cortex
and the hippocampes
o The cerebellum spinal cord, and motoe and sensory areas of he cortex are less
affected, which is hwy LAzheimer’s suffered fo not appear to have anything
phsycaill wrong with them until late in the disease process.
o People are able to walk around normally, and their over-learned habits, such as
making small talk, remain intact, so that in short encourtners, strangers may not
notice anyting amiss
o There is a very strong evidcen for a gentic basis fro ALzheirm’s.
- Frontal-Temporal Dementias
o It typically beigns in a person’s late fifities.
o The usual cognitive impariemtns of a dementia,frontal-temproal dementias are
marked by extrem behaiovural and personality changes
o Sometiems people are very apthetic and unresponcei to heir environment; at toehr
times, they show an oppite pattern of euphora, overactivye and impulsivity.
o Alzheimer’s dises, frontal-temproal dementias are not closely linked to loss of
cholingerigc neurson.
o Serotonin neruson are most affected , and tehres I swidespreaad loss of neruson in
the forntal and temporal lobers
o Pick’s disease is one cause of frontal-temporal demntia
- Frontal-subcortical Dementias
Both cognition and motor activyt are affecte.d Thypes of rontal-subcortical dementias include
o Huntington’s chorea, now referred to more commonly as Huntington’s disease,
is caused by a single doinnate gene location on chromonse 4 and it diagnosed
prinicaply by neurologists on the basis of genetic testing. Ita major behaivoural
feaure is the present of wrting movements. The best-known person with this
diseas ithe late folk songwriter and signer Woody Hutehr.
o Parknson’ disease ia marked by meucal treoens, muscular rigidity and akinesia
and can elad to dementia
- Given the extene t o which family membrs are relied on the stressors and challenges
facing famileis, issued a call for much greater recognition of the roles paleyd by fmaileis
and greater integration of familes into social system and the removeal of practice and
poicy barriers that lmit the support that famlied recived form psychotolis
- Caring for a personw with Alzhierm’s have been shown to be extremely stressful and
distressing
- Analyses reported by Candain Study of Healht and Agin Workign Group indicate tha
depression is twice as evidcen among caregivers as among on-cargivers.
- Tis CSHA study is improtnat because it is one for the few caregiver studies that began
with a nationally represtative smapel of dinvidal suffering form dementia and their
cargivers
- The link between role-seocif deands of caregivering and burden are migitage by resilitncl
resilsine promotes well-being among cargeivers experinceing signifcnat burer.
- Optimsin the caregive is also protective
Delirium
The term implied being off track of deviating for mthe usual stte.
- Typically described as a “clouded state of consciousnesss”
- The patients has great trouble concentrating and focusing attteniong and conneot atina a
coherent and directed stream of thorught
- The person with delirim is frequently restless, partically at ngiht.
- This sleep-waking cycle beomce disturbed, so that the person is drowys duing the day
and wake restless and agitated during the night
- Vivid dreamsn a nightmare are commonet
→ Causes of Dellrium
- The causes of delirium in order audlrs can be grouped into several genral classes: urg
intocisaiotn and drug-withdrawl, reaction, metabolic, and utritioanl imblances, infectiosn
or fevers, neurological disorder, and the stress of a change I the person’s surrdoung
- This may happen afer srugry most commonly hip replacements.
- Althoguth delirium usualy delvoeps swift, the exact mode of sonnet sepdns on the
underlying cuase
- Resutlingform a rtoxic reaction or consion has a naburtpy onset, whe ninfecitoor metoabi
disorunar underline delirimm the onset of ysmtoms is more gradual
→ Treatment of Deliriu
Comple recovery from delirium is poosibel f ithe synform is idneifit correctly and the udnelrying
cuase promptly treat.
It gnernaly takes on rot four weeks for the condiotn to clear; tit takes longer in older vs. yoiuger
people.
- Primary prevention strategies appear to reduce high rates of delirium, as well as the
duration of delirium episode in hospitalized older audls.
- Oftern- negleict aspect of management of delirium is education the fmaiy of ap erosn
with dementia to distinguish the manifestatison fo dementia and delirium
Social involvemtn
Old Age of Psychological Disroders
Overall Prevalence of Mental Disorders in Late Life
Depression
→ Causes of Depression in Older Adults
- Mnay elderly peoplein poor physical helaht are dpressed and it is often difficult to
ascertain whether the heath problmes arcmae fist and were a results of being depressed
- Thw oversight can lead to worsening of the depression and emidcal condition
- Numerosu findinding point to the improtnace of sica support as a stress buffer for elderly
people faced with life challenges
- Retirement has vee nasusmed to have negative conaueq, the resreach does not suppro this
→ Treatment of Depression
Reminiscence therapy for depression requires inidvidal to reflect o ntheir past and presnt
situation to help achieve a sence of selc- aceetapce ad nreduce self blame.
Anitdepressant can be somewhat useful.
Substance-Realted Disorders
→ Alchol Abuse and Dependence
→ Medication Misuse
Sleep Disorders
→ Causes of Sleep Disorders
Sleep apena
→ Treatment of Sleep Disorders
Pharamacotheprya is most comone fomr of treamten for sleep disorder for people of all ages, but
this epsically ture for the eldery.
→ Suicide
Only a few seek out help. Elderly are neglect whe nit comes ot suidice prevention. One approach
veign evaluated is an intiate.
Treatment and Care of Olde Adults