Scribd
Upload
28 views22 pages

Molecule of The Month

Uploaded by

Prajna B
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
28 views22 pages

Molecule of The Month

Uploaded by

Prajna B
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
You are on page 1/ 22

SHORT FILM PREMIERING NOW IN GUEST

HOUSE, STRUCTURAL BIOLOGY CLASS!

MOLECULE OF THE MONTH


(JULY 2019):
AMPA Receptor
bY Aditi upadhyay
21151
LET’S MEET OUR MAIN CHARACTERS!!
Neurotransmitters!!
Serotonin?

Adre
n a l ine
? ?
i n e
p a m
do

Neurotransmitters!!
when we talk of neurotransmitters..
what comes to your mind?
But did you know that
Did you know?
glutamate is also a
neurotransmitter?
GLUTAMA
Our brain's intricate communication network relies on neurotransmitters, including glutamate, which plays a

TE
pivotal role in carrying excitatory signals between neurons. Glutamate achieves this by binding to specific
receptors, such as the AMPAreceptor, influencing various cognitive processes and memory formation.
AMPA
RECEPTORS
AMPA Receptor: The
Key Player in Glutamate
Signaling
AMPA
RECEPTORS
AMPA Receptor: The
Key Player in
Glutamate Signaling
AMPA
RECEPTORS
AMPA Receptor: The
Key Player in
Glutamate Signaling
AMPA
RECEPTORS

THE TETRAMER IS ASSEMBLED FROM A PAIR OF GLUA1/GLUA2


HETERO-DIMERS.
MECHANISM
OF AMPA RECEPTORS
MECHANISM
OF AMPA RECEPTORS
MECHANISM
OF AMPA RECEPTORS
MECHANISM
OF AMPA RECEPTORS
MECHANISM
OF AMPA RECEPTORS
OTHER GLUTAMATE RECEPTORS
UMM.. OKAY, BUT WHAT MAKES
AMPA SO SPECIAL?
• AMPA GLUTAMATE RECEPTORS OPERATE AT AN
EXTRAORDINARY SPEED, MAKING THEM ONE OF THE
FASTEST RECEPTORS FOUND THROUGHOUT THE
BRAIN.
• A DISTINCTIVE FEATURE OF AMPA RECEPTORS IS
THEIR FAST DESENSITIZATION INDUCED BY THE
AGONIST AMP A.
• AMPA RECEPTORS PLAY A CRUCIAL ROLE IN
SYNAPTIC PLASTICITY, BEING INVOLVED IN LONG-
TERM POTENTIATION (LTP) AND LONG-TERM
DEPRESSION (LTD) OF SYNAPTIC TRANSMISSION
GLOSSARY :
• NEUROPLASTICITY: THE ABILITY OF THE NERVOUS
SYSTEM TO CHANGE ITS ACTIVITY IN RESPONSE TO
INTRINSIC OR EXTRINSIC STIMULI BY REORGANISING
ITS STRUCTURE, FUNCTIONS, OR CONNECTIONS
AFTER INJURIES.
• LONG-TERM DEPRESSION (LTD) OF SYNAPTIC
TRANSMISSION: A PROCESS BY WHICH SYNAPTIC
CONNECTIONS BETWEEN NEURONS BECOME
WEAKER.
• LONG-TERM POTENTIATION (LTP) OF SYNAPTIC
TRANSMISSION: A PROCESS BY WHICH SYNAPTIC
CONNECTIONS BETWEEN NEURONS BECOME
STRONGER THROUGH FREQUENT ACTIVATION.
REFERENCES:
• PAL, M. M. (2021). GLUTAMATE: THE MASTER
NEUROTRANSMITTER AND ITS IMPLICATIONS IN
CHRONIC STRESS AND MOOD DISORDERS. FRONTIERS
IN HUMAN NEUROSCIENCE, 15.
HTTPS://DOI.ORG/10.3389/FNHUM.2021.722323
• JANE, D. (2006). AMPA GLUTAMATE RECEPTOR.
XPHARM: THE COMPREHENSIVE PHARMACOLOGY
REFERENCE, 1-19.
HTTPS://DOI.ORG/10.1016/B978-008055232-3.60374-5
• HTTPS://PDB101.RCSB.ORG/MOTM/235
•texthttps://youtu.be/B7ig6sIwIC8?si=v
eG4DFZBxfpmMPVD
• https://youtu.be/-mHgPfXHzJE?
si=Dw6WmrYnG1TNdbv3
• https://youtu.be/u7Ev9gwSMrw?
si=DDKTXkU1SuQ6hz43
THAN
K YOU
:)

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy