Gyne Smle MCQ 2023
Gyne Smle MCQ 2023
Gyne Smle MCQ 2023
A. Bacterial vaginosis
B. Candida
C. N gonorrhea
Q3- 21 year old patient did cervical screening ( Pap smear)for last
5yrs and it was normal, now she did it again and was normal, when
is the next time for screening ?
A. 6months
B.1year
C.2years
D.3years
They can cause symptoms such as heavy menstrual bleeding, pelvic pain,
and pressure.
Progesterone-only therapy can help to control the bleeding associated
with myomas and may also help to shrink the size of the tumors.
- Progesterone-only therapy can be given in the form of oral tablets
injections, or intrauterine devices (IUDs).
It is safe for women who wish to become pregnant as it does not affect
fertility, and it may even help to improve fertility in some cases.
- NSAIDs and combined oral contraceptive pills (OCPs) can also be used
to control bleeding associated with myomas.
However, they are not suitable for women who want to become
pregnant as they can reduce fertility.
on the other hand, there is evidence that the use of OCPs may be
associated with a slight increase in the risk of breast cancer.
However, this risk appears to be small and is largely limited to women
who use OCPs for more than ten years.
- The use of OCPs does not increase the risk of ectopic pregnancy.
In fact, OCPs are often prescribed to women who are at high risk of
ectopic pregnancy, as they can help to regulate the menstrual cycle and
reduce the risk of ovulation occurring in the fallopian tubes.
- In summary, the use of OCPs has been associated with a decreased risk
of ovarian and endometrial cancer, a slight increase in the risk of breast
cancer (with long-term use), and no increase in the risk of ectopic
pregnancy.
- During pregnancy, there are several changes that occur in the respira-
tory system
including in women with asthma. These changes include:
-A. Increased respiratory rate (RR): During pregnancy, there is an in-
crease in oxygen
demand, which causes an increase in RR to meet the increased metabolic
demands of the mother and fetus.
- B. Increased tidal volume: Tidal volume is the amount of air that is
breathed in and out during a normal breath. During pregnancy, tidal vol-
ume increases to meet the increased oxygen demand.
- C. Increased residual volume: Residual volume is the amount of air that
remains in the lungs after a maximal exhalation. During pregnancy, re-
sidual volume increases due to the relaxation of the smooth muscles in
the airways, which can make it more difficult to breathe for women with
asthma.
- D. Increased functional residual capacity: Functional residual capaci-
ty is the amount of air that remains in the lungs at the end of a normal
breath. During pregnancy
functional residual capacity decreases due to the upward displacement
of the diaphragm by the growing uterus, which can also make it more
difficult to breathe for women with asthma.
Q261- Patient with irregular period and and infertility husband se-
men analysis in normal what is the diagnosis?
A. Ovulatory dysfunction
B. Endometriosis
C. Falopian tube problem
- Subserosal fibroids are located on the outer surface of the uterus and
typically do not affect fertility unless they are very large or located in a
specific area that can interfere with implantation or blood flow to the
uterus. A 2 cm fibroid is considered relatively small and is unlikely to in-
terfere with fertility.
- Myomectomy, which involves the surgical removal of the fibroid while
preserving the uterus, may be considered in cases where the fibroid is
causing significant symptoms or if the patient is trying to conceive and
the fibroid is in a location that may interfere with implantation or blood
flow. However, since the patient in this scenario is asymptomatic and
the fibroid is small, myomectomy is not necessary.
- Hysterectomy, which involves the removal of the uterus, is only con-
sidered as a last resort in cases where other treatments have failed or
if there is a significant risk of cancer or other serious conditions. It is
not appropriate in this scenario as the patient is asymptomatic and con-
cerned about fertility.
- The patient should be advised that the fibroid is unlikely to affect her
fertility and that she can continue to try to conceive naturally.
If she experiences any symptoms in the future, she should seek medical
attention.
- Based on research, the most likely time for an increase in domestic vio-
lence is C. Holidays.
- The holiday season can be a stressful time for many people, with added
financial pressures, family obligations, and other stressors.
- This stress can exacerbate existing tensions in relationships and
increase the likelihood of domestic violence.
- Additionally, alcohol consumption may increase during the holiday sea-
son, which can also contribute to violent behavior.
- While domestic violence can occur at any time, studies have shown
that rates of domestic violence tend to increase during holiday periods,
such as Christmas, New Year’s Eve, and Thanksgiving.
- However, it is important to note that domestic violence can occur at
any time, and all instances of domestic violence should be taken
seriously and addressed promptly.
Q14- Pregnancy on tube 5cm patient lives far away absolute contra-
indications of methotrexate
A. Distance from hospital?
B. Obesity
C. Ultrasound
D. BCG 3500
- The low hemoglobin and high MCV in a pregnant woman with emesis
for two weeks suggest a possible folate deficiency. Therefore, option B
(Folate) is the correct answer.
- Folate (vitamin B9) is essential for the synthesis of DNA and red blood
cells, and it is
particularly important during pregnancy for the growth and develop-
ment of the fetus.
Folate deficiency can lead to megaloblastic anemia, which is character-
ized by a high mean corpuscular volume (MCV) and low hemoglobin lev-
els.
- Pregnant women are at an increased risk of folate deficiency due to the
increased
demand for folate by the developing fetus and placenta. Nausea and vom-
iting during pregnancy can also contribute to folate deficiency by reduc-
ing oral intake and increasing losses through vomiting.
- Vitamin B12 deficiency (option A) can also cause megaloblastic anemia,
but it is less likely to be the cause in this case because the high MCV is
suggestive of folate deficiency. Vitamin B12 deficiency is more common-
ly associated with neurological symptoms and is less common in preg-
nant women who consume adequate amounts of animal products.
- In summary, in a pregnant woman with emesis for two weeks, a low
hemoglobin and high MCV suggest a possible folate deficiency.
- Abdominal pain and mass in a young female can be due to various un-
derlying pathologies.
- However, given the normal pregnancy test and the absence of signs of
shock, ectopic pregnancy is less likely. Cystic rupture may present with
abdominal pain and tenderness, but a palpable mass is not a typical find-
ing.
- Ovarian torsion occurs when the ovary twists around its blood supply,
leading to ischemia and infarction of the ovarian tissue.
- It can present with sudden onset abdominal pain, lower quadrant or
right abdominal pain, and often a palpable mass.
- Since torsion can potentially lead to the loss of the ovary and fallopian
tube, prompt diagnosis and management are necessary.
- Diagnostic tests for ovarian torsion include pelvic ultrasound, which
may show an enlarged ovary and a “whirlpool” sign with decreased blood
flow, and diagnostic laparoscopy may be required for diagnosis and fur-
ther management.
B. Ectopic pregnancy:
- Ectopic pregnancy occurs when the fertilized egg implants outside the
uterus, commonly in the fallopian tube. It can cause abdominal pain, pel-
vic pain, vaginal bleeding, and a positive pregnancy test. Ectopic preg-
nancy can also cause signs of shock, such as tachycardia, dizziness, and
hypotension. However, in this case, since the pregnancy test is negative
and there were normal vitals, the possibility of an ectopic pregnancy is
less likely.
C. Cystic rupture:
- Ovarian cysts are fluid-filled sacs that commonly occur during a wom-
Dr.Ali Balharith MD, MACP, FRCPC 18
an’s reproductive years. They can be asymptomatic or may cause abdom-
inal pain, bloating, and irregular menstruation.
- The rupture or torsion of an ovarian cyst can cause sudden onset, se-
vere lower abdominal pain. A palpable mass is not a typical feature of a
ruptured cyst.
- A ruptured cyst can also lead to internal bleeding and can cause symp-
toms such as lightheadedness, dizziness, and low blood pressure.
- However, a cyst rupture is less likely in this case because a palpable
mass was reported.
Q25- Female newly married was on ocps even before marriage, now
wanting to continue but her husband want her to stop ?
A. Patient consent is enough
B. Both should be consented
C. Her consent should be taken after discussion with her husband
- In this case, the patient presented with right knee pain that has not
been relieved by rest, ice, or NSAIDs. Additionally, the pain has
worsened with activity, frequent catching of the joint, and persistent
edema.
- These symptoms suggest an injury to a knee structure, likely the medial
meniscus.
- The medial meniscus is a common site of injury, especially in patients
who have a history of twisting or pivoting injuries to the knee, such as
in the case of hiking.
- On examination, the patient has tenderness along the medial joint line,
and reproduces her pain with flexion and extension of the knee with ex-
ternal rotation of the tibia.
- These findings are consistent with an injury to the medial meniscus,
which may cause pain and causing catching or locking in the knee joint.
- Anterior and posterior drawer testing is negative, which makes it less
likely that the patient has an ACL or PCL injury.
- Similarly, the absence of significant valgus or varus stress on examina-
tion makes it less likely that the patient has an MCL or LCL injury.
- Therefore, in this case, the most likely structure injured is the medial
Dr.Ali Balharith MD, MACP, FRCPC 25
meniscus, which is a common site of injury in patients presenting with
these symptoms.
Q35- 25year old w/ metabolic vaginal discharge, four weeks ago the
patient had a forceps assisted vaginal birth with a prolonged second
stage of labor. The delivery was complicated by a third-degree
laceration, postpartum endometritis, which was treated. During
the pregnancy, the patient was diagnosed with vulvovaginal
candidiasis. Her history includes irritable bowel syndrome.
examination shows small, red, velvety area on the posterior vaginal
wall with foul smelling brown discharge. Which of the following is
the most likely diagnosis in this patient?
A. Rectovaginal fistula
B. Incisional abscess
C. Anal incontinence
D. Retained vaginal gauze
The other answer choices are not as likely to be the diagnosis in this pa-
tient.
Q39- A 29 year old woman who can’t get pregnant she has been men-
struating every other month and has a milky discharge from the
nipples, prolactin level 334 and pituitary adenoma 0.5cm in MRI,
which therapeutic options is most appropriate at this time?
A. trial of a dopamine agonist
B. transsphenoidal pituitary surgery
C. no treatment
D. radiation therapy
Q41- Healthy young lady just delivered a baby 4 months ago. Howev-
er, she tells you that she does not want to get pregnant for the next
2 years. What method of contraception will you recommend?
A. Combined OCP
B. Depo Provera injection
C. Vaginal ring
D. Transdermal patch
Q44- Female in 20’s with multiple fibroids, best way to preserve her
fertility
A. Myomectomy
B. OCP
C. Progesterone
Fetal demise is the death of a fetus in utero. It can occur at any time
during pregnancy, but is most common in the third trimester. The cause
of fetal demise is often unknown, but it can be due to a variety of factors,
including placental abruption, umbilical cord accidents, and maternal
infections.
Missed abortion is a condition in which the fetus has died, but the body
has not yet expelled it. This can happen for a variety of reasons
including chromosomal abnormalities, infections, and placental
abruption.
Incomplete abortion is a condition in which the fetus has been expelled,
but some of the products of conception (such as the placenta) have
remained in the uterus. This can lead to infection and bleeding.
In this case, the patient is 28 weeks pregnant and has had a positive preg-
nancy test. She has also had mild bleeding and loss of fetal movement.
The ultrasound shows a pregnancy of 18 weeks and no heartbeat. This
indicates that the fetus has died. Therefore, the most likely diagnosis is
fetal demise.
The patient should be offered counseling and support. She may also need
to be hospitalized for monitoring and treatment.
Pregnancy related murmurs are common and are usually benign. They
are caused by the increased blood flow and changes in the heart that
occur during pregnancy. The murmurs are usually heard best over the
left side of the chest and may radiate to the neck or carotid arteries.
Aortic stenosis is a narrowing of the aortic valve, which can cause
a systolic murmur. Mitral stenosis is a narrowing of the mitral valve,
which can cause a diastolic murmur. Aortic regurgitation is a backflow of
blood from the aorta into the left ventricle, which can cause a diastolic
murmur.
Pregnancy related murmurs are usually not associated with any
symptoms. However, if the murmur is loud or associated with other
symptoms, such as chest pain or shortness of breath, it should be evalu-
ated by a doctor.
Q48- Pregnant woman, high gravida (forgot the number) and known
previous caesareans, has metastatic cancer. Doctor advised for ter-
mination of pregnancy but her husband is refusing?
A. you need both consent from her and husband
B. Only need her consent
C. Only her consent and she should inform her husband
D. Consent of representative
In the United States, a woman has the right to make her own decisions
about her healthcare, including whether or not to terminate a pregnan-
cy. This right is protected by the Constitution and by state law. The hus-
band’s consent is not required.
However, it is important to have a conversation with the husband about
the situation. He may be feeling scared, angry, or confused. It is import-
ant to listen to his concerns and to answer his questions.
The doctor can also offer support and resources to the husband.
In some cases, the husband may be able to provide emotional support to
the woman during the pregnancy termination process.
In other cases, the woman may prefer to have a support person who is
Dr.Ali Balharith MD, MACP, FRCPC 46
not her husband. It is important to respect the woman’s wishes.
If the woman is not sure what she wants to do, the doctor can offer her
more information about the risks and benefits of continuing the
pregnancy or terminating it. The doctor can also refer the woman to
a counselor or therapist who can help her make a decision.
Ultimately, the decision of whether or not to terminate a pregnancy is
up to the woman. The doctor can provide information and support, but
the woman has the right to make her own decision.
Q49- Increasingly heavy vaginal bleeding and fatigue over the past
6 months, fm hx for myocardial infarction, Abdominal exam shows
firm, palpable mobile mass just blew the umbilicus, on pelvic ex-
amination, and there is a moderate amount of old, clotted blood
coming from the cervical OS, hematocrit of 24% and hemoglobin
is low, which diagnostic test is most cost effective in confirming a
diagnosis?
A. Transvaginal US
B. Hysterosalpingogram
C. Abdominal and pelvic CT
D. Diagnostic laparoscopy
Having a family history of breast cancer is the greatest risk factor for
developing breast cancer.
Dr.Ali Balharith MD, MACP, FRCPC 48
The risk of developing breast cancer increases if a woman has a first
degree relative (mother, sister, or daughter) who has been diagnosed
with breast cancer.
The risk is even higher if the relative was diagnosed with breast cancer
before the age of 50.
The other options are not as significant risk factors for breast cancer.
* *Age at first pregnancy:* Women who have their first child at an older
age are at an increased risk of developing breast cancer.
However, the risk is still relatively low, and it is not as significant as
a family history of breast cancer.
* *Duration of breastfeeding:* Breastfeeding can slightly lower the risk
of developing breast cancer. However, the effect is small, and it is not as
significant as a family history of breast cancer.
* *Chronological age:* The risk of developing breast cancer increases
with age. However, the risk is still relatively low in women under the age
of 50.
A family history of breast cancer is a much more significant risk factor
than chronological age.
The patient in this case is a 58-year-old woman with a family history of
breast cancer.
Her cousin on the paternal side of her family died of breast cancer.
This is a significant risk factor, and she should be evaluated by a doctor
for early detection of breast cancer.
The following are some additional tips for breaking bad news:
* Be honest and direct.
* Avoid using euphemisms or jargon.
* Allow the patient time to process the news.
* Be patient and understanding.
Dr.Ali Balharith MD, MACP, FRCPC 50
* Offer emotional support.
* Provide information about resources that can help.
Q52- A pregnant lady with swelling in the left leg, diagnosed as DVT,
which of the following is the best management?
A. Duplex and heparin
B. Duplex and heparin and IVC filter
C. Warfarin
Option B (Duplex and heparin and IVC filter) may be considered in cer-
tain cases where there is a high risk of pulmonary embolism, but it is not
the first-line management. Warfarin is contraindicated in pregnancy due
to its teratogenic effects.
Q53- 28 weak still birth with congenital anamoly , how will you know
the Causes ?
A. Placental saming.
B. Cord sampling.
C. Fetus sampling
Fetal sampling is the most likely to help determine the cause of a still-
birth with congenital anomaly. The placenta and umbilical cord can also
be sampled, but they are less likely to provide as much information.
Fetal sampling can be performed in a number of ways, including:
* *Amniocentesis:* This involves inserting a needle through the mother’s
abdomen and into the amniotic sac to remove a small amount of amni-
otic fluid. The fluid contains cells from the fetus, which can be examined
for genetic abnormalities or structural defects.
* *Chorionic villus sampling (CVS):* This involves inserting a needle
Dr.Ali Balharith MD, MACP, FRCPC 51
through the mother’s abdomen and into the placenta to remove a small
amount of tissue from the placenta. The tissue contains cells from the
fetus, which can be examined for genetic abnormalities or structural de-
fects.
* *Fetal blood sampling:* This involves inserting a needle through the
mother’s abdomen and into the umbilical cord to remove a small amount
of blood from the fetus. The blood can be examined for genetic abnor-
malities or infections.
Fetal sampling is a relatively safe procedure, but it does carry some
risks, such as infection and bleeding. The risks of fetal sampling should
be weighed against the potential benefits of obtaining information that
could help prevent future stillbirths.
Q54- Young female presented with heavy vaginal bleeding has been
diagnosed with uterine fibroid. Her hemoglobin is 7. What is the
most appropriate next step?
A. Myomectomy
B. Correct the anemia
C. Combined Oral Contraceptive Pills
D. blood transfusion
The most appropriate next step for a young female presented with heavy
vaginal bleeding, diagnosed with uterine fibroid, and hemoglobin of 7
is to *correct the anemia*. This can be done with a blood transfusion or
iron supplements. Once the anemia is corrected, the patient can then be
evaluated for further treatment of the uterine fibroids.
Here are the reasons why the other options are not the best choice:
* *Myomectomy:* This is a surgical procedure to remove uterine fibroids.
It is not the best option for a patient with severe anemia, as it would re-
quire general anesthesia and could lead to further blood loss.
* *Combined oral contraceptive pills (COCPs):* COCPs can help to con-
trol heavy menstrual bleeding, but they are not effective in treating ane-
Dr.Ali Balharith MD, MACP, FRCPC 52
mia. They can also increase the risk of blood clots, which is a concern for
a patient with severe anemia.
* *Blood transfusion:* This is the most immediate way to correct the
anemia. However, it is not a long-term solution. The patient will need to
be evaluated for further treatment of the uterine fibroids to prevent the
anemia from recurring.
If a pregnant woman has a high TSH level, constipation, and cold intol-
erance, the most appropriate medication to give would be thyroxine (B).
Thyroxine is a synthetic form of the thyroid hormone that can help reg-
ulate the body’s metabolism. In pregnant women, hypothyroidism (low
thyroid hormone levels) can cause a range of complications, including
miscarriage, preterm delivery, and developmental delays in the fetus.
Propylthiouracil (A) is a medication used to treat hyperthyroidism (over-
active thyroid), which is the opposite of hypothyroidism. It is not appro-
priate for a pregnant woman with high TSH levels.
Therefore, the correct answer is B. Thyroxine.
In a patient who is allergic to both sulfa and penicillin and presents with
dysuria, the recommended antibiotic treatment option is nitrofurantoin,
option B. Nitrofurantoin is an antibiotic that is commonly used to treat
urinary tract infections and is not related to the sulfa or penicillin anti-
biotic classes. However, it is important to confirm the diagnosis of a uri-
nary tract infection through urine culture and sensitivity testing before
initiating antibiotic treatment. The choice of antibiotic treatment may
also depend on the severity of the infection, patient factors, and local
resistance patterns.
In a woman who has delivered and lost 1000cc of blood after delivering
the placenta, with a firm uterus, and who is alert and stable, the likely
diagnosis is uterine atony, option A.
Uterine atony is a common cause of postpartum hemorrhage and is
defined as the inability of the uterus to contract effectively after
delivery.
This can lead to excessive bleeding and requires prompt management,
including uterine massage, administration of uterotonic medications,
and potentially surgical interventions such as a hysterectomy or uterine
artery embolization. Coagulopathy, retained products of conception, and
genital tract trauma are other potential causes of postpartum
hemorrhage that should also be considered and ruled out through appro-
priate evaluation and management
Q63- A 40 year old women G4P4 , her last daughter age 8 And LMP
before 6 month , what u will check ?
A. FSH
B. TSH
FSH is a hormone released by the pituitary gland that plays a crucial role
in regulating the menstrual cycle and promoting the growth and
development of ovarian follicles.
In this case, the patient’s age and history suggest that she may be
experiencing perimenopause or menopause, and checking FSH levels
can help to confirm the diagnosis and assess her ovarian function.
In a 40-year-old woman with a history of DVT, the best option for birth
control would be option A - Condom.
The use of these forms of birth control can increase the risk of blood
clots, which may lead to the development of DVT or even more severe
complications such as pulmonary embolism.
Explanation:
- Premenstrual pain is a common symptom in women that occurs before
or during menstruation. Exercise has been shown to be effective in re-
ducing premenstrual pain.
- Aerobic exercise, in particular, can help release endorphins, which are
natural painkillers that can help relieve discomfort. Additionally, regular
exercise can help reduce stress and improve overall health.
- Decaf coffee does not have any direct effect on premenstrual pain and
therefore is not an effective treatment option.
None of the options provided would be the most appropriate next step
for a stable patient with an open wound fracture who has already
received antibiotics.
The most appropriate next step in the management of an open wound
fracture in a stable patient who has already received antibiotics is
surgical debridement of the wound. This will involve removing any
debris or necrotic tissue from the wound and irrigating it thoroughly to
prevent infection and promote healing. This can be performed in the
operating room under local or general anesthesia.
Closed reduction with casting or open reduction with intramedullary
nailing are interventions that may be necessary in the management of
certain types of fractures, but they are not appropriate as the next step
for an open wound fracture in a stable patient who has already received
antibiotics.
Therefore, the most appropriate option for this case scenario would be
to perform surgical debridement of the wound.
D. Debridement with intramedullary nail is the appropriate next step.
Explanation:
- An open wound fracture is a serious injury that requires prompt treat-
ment to prevent infection and promote healing.
- The first step in the management of an open wound fracture is to
administer antibiotics to prevent infection.
- The next step is to perform a thorough debridement of the wound to
remove any foreign material or dead tissue that could harbor bacteria
Dr.Ali Balharith MD, MACP, FRCPC 64
and prevent healing.
- Intramedullary nailing is a surgical technique used to stabilize the bone
and promote healing after debridement.
- Closed reduction with above or below knee cast is not appropriate for
an open wound fracture, as it can increase the risk of infection and delay
healing.
- Therefore, debridement with intramedullary nail fixation is the most
appropriate next step in the management of an open wound fracture.
Explanation:
Explanation:
In a 70-year-old female with a prosthetic heart valve who is on warfarin,
conservative management is recommended for pelvic organ prolapse
(POP). While surgical management may be an option, the risks of surgery
in this patient population are high due to the increased risk of bleeding
and other complications associated with anticoagulant therapy.
A pessary is a non-surgical option for the management of POP. It is a
small, removable device that is inserted into the vagina to support the
prolapsed pelvic organs. Pessaries are available in different shapes and
sizes and can be fitted to the patient’s individual needs.
Sacrocolpopexy is a surgical procedure that is used to correct POP by
attaching a surgical mesh to the sacrum and the anterior vaginal wall
to provide support to the pelvic organs. However, due to the risks asso-
ciated with anticoagulant therapy, surgery would not be the preferred
option in this case.
Le Fort technique and hysterectomy are surgical procedures that are not
typically used for the management of POP.
Therefore, pessary would be the safer and more appropriate manage-
ment option for this patient with a prosthetic heart valve on warfarin.
Explanation:
- Anterior and posterior colporrhaphy is a surgical procedure that in-
volves repairing and tightening the walls of the vagina to correct pro-
lapse and reduce the size of the vaginal opening.
- This procedure is appropriate for women who have had a hysterectomy
and are sexually active, as it does not involve the use of mesh or other
materials that could cause complications or discomfort during sexual ac-
tivity.
- Sacrospinous fixation is a surgical procedure used to correct prolapse of
the uterus, cervix, or vaginal vault, but it is not typically used to correct
prolapse of the vaginal walls.
- Manchester repair is a type of vaginal hysterectomy that involves the
removal of the uterus and the repair of the vaginal walls, and it is not
typically performed in women who have already had a hysterectomy.
- Therefore, anterior and posterior colporrhaphy is the most appropriate
procedure to manage prolapse and enlarged vaginal opening in a 70-year-
old woman who is sexually active and has had a hysterectomy.
Explanation:
- HbA1c is a test used to measure a person’s average blood sugar levels
over the past 2-3 months.
- High HbA1c levels in a pregnant woman indicate poor control of blood
sugar levels, which can have adverse effects on fetal development and
increase the risk of complications.
- Congenital malformations are a potential risk for a baby if the mother
has high HbA1c levels during pregnancy, particularly in the first trimes-
ter when the baby’s organs are developing.
- Chromosomal abnormalities, on the other hand, are typically not relat-
ed to the mother’s blood sugar levels during pregnancy.
- Therefore, if a pregnant woman has high HbA1c levels at 20 weeks gesta-
tion, it is important to closely monitor the pregnancy and manage blood
sugar levels to reduce the risk of congenital malformations and other
complications.
Explanation:
- Inheritance of SCD follows an autosomal recessive pattern, which
means that a child must inherit two copies of the abnormal hemoglobin
gene (one from each parent) to develop SCD.
- The man in this scenario has sickle cell trait (one normal hemoglobin
gene and one abnormal hemoglobin gene), which means he can pass ei-
ther the normal or abnormal gene to his offspring.
- The woman in this scenario has no family history of SCD and is pre-
sumed to have two normal hemoglobin genes.
- The Punnett square for this scenario would show a 50% chance of each
offspring inheriting the normal hemoglobin gene from the father and a
50% chance of inheriting the abnormal hemoglobin gene from the father.
- However, since the mother has two normal hemoglobin genes, even if
the offspring inherits the abnormal hemoglobin gene from the father,
they will still be a carrier of sickle cell trait (like the father) and will not
develop SCD.
- Therefore, the risk of having children with SCD in this case is low or nil.
However, genetic counseling may still be recommended for the couple
to discuss their options and potential risks.
B. Semen count and C. Antenatal testing are not appropriate next steps
in the management of primary infertility in this case, and therefore they
are considered incorrect options.
B. Semen count is a test that assesses the number and quality of sperm
in a semen sample. However, since the wife reports a regular menstrual
cycle and the couple has only been trying to conceive for 3 months, it
is not clear whether male-factor infertility is a contributing factor, and
Semen analysis does not guarantee fertility.
C. Antenatal testing aims to screen or diagnose certain conditions or ab-
normalities that may be present in the fetus or the mother during preg-
Dr.Ali Balharith MD, MACP, FRCPC 76
nancy. However, antenatal testing is not a diagnostic tool for infertility,
and it is not typically used in cases of primary infertility.
Explanation:
- Nifedipine is a calcium channel blocker that can be used to relax smooth
muscle, including the smooth muscle of the uterus.
- It is often used to manage preterm labor by reducing the frequency and
intensity of uterine contractions.
- Terbutaline is another medication that can be used to relax the smooth
muscle of the uterus, but it is associated with a higher risk of adverse ef-
fects, such as tachycardia and hypotension, and is typically reserved for
cases in which other medications have failed.
- Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that
can also be used to manage preterm labor, but it is associated with a
higher risk of adverse effects, such as premature closure of the ductus
arteriosus in the fetus, and is typically reserved for cases in which other
medications have failed.
- Corticosteroids may be given to enhance fetal lung maturity in cases
where preterm delivery is imminent, but they are not typically used to
manage uterine contractions.
Dr.Ali Balharith MD, MACP, FRCPC 77
- Therefore, in this scenario, nifedipine is the most appropriate
medication to give to manage uterine contractions and reduce the risk
of preterm delivery.
Correct answer is:C. The uterine muscles fail to contract is the like-
ly source of her bleeding in this scenario.
Explanation:
- Uterine inversion is a rare but serious complication of childbirth in
which the uterus turns inside out after the delivery of the baby and pla-
centa.
- Uterine inversion can be life-threatening and can cause heavy vaginal
bleeding and shock.
- One of the main causes of bleeding in uterine inversion is the failure of
the uterine muscles to contract properly.
- This can be due to a variety of factors, including over-distension of the
uterus, rapid delivery of the placenta, or excessive traction on the umbil-
ical cord.
- Trauma to blood vessels or muscular injury and laceration can also cause
bleeding during childbirth, but in this scenario, the bleeding is likely due
to the failure of the uterine muscles to contract properly, which is a com-
mon cause of bleeding in cases of uterine inversion.
- It is important to quickly manage uterine inversion and control bleed-
ing to prevent further complications and ensure the patient’s safety.
Explanation: Leg swelling and signs of deep vein thrombosis (DVT) along
with shortness of breath (SOB) is concerning for a possible pulmonary
embolism (PE). PE commonly arises from deep vein thrombosis (DVT)
in the legs. Thus, Doppler ultrasound of the lower limb (LLL) is a good
initial test to confirm the presence of DVT in this pregnant lady. CT PA
scan can be considered as the next step if Doppler ultrasound is incon-
clusive or technically difficult. Chest x-ray and V/Q scan are not helpful
in diagnosis of DVT.
Explanation:
- Oligohydramnios is a condition in which there is a decreased amount of
amniotic fluid surrounding the fetus.
- Amniotic fluid is important for fetal growth and development, and oli-
gohydramnios can lead to complications such as fetal growth restriction,
preterm labor, and fetal distress.
- Placental insufficiency is a condition in which the placenta is unable to
supply the fetus with adequate nutrients and oxygen.
- Placental insufficiency can lead to oligohydramnios because the de-
creased blood flow to the placenta can cause a decrease in fetal urine
Dr.Ali Balharith MD, MACP, FRCPC 80
output and a subsequent decrease in the amount of amniotic fluid.
- Other causes of oligohydramnios include ruptured membranes, fetal
renal abnormalities, and maternal hypertension.
- DM (diabetes mellitus), choriangioma, and duodenal atresia are not typ-
ically associated with oligohydramnios.
The highest possible score on the BPP is 10/10, which indicates a healthy,
active fetus with a sufficient amniotic fluid volume. However, some scor-
ing systems allow for a maximum score of 8/10, or even 6/10, depending
on the specifics of the scoring system. A BPP score of 9/10 is considered
the best score as per the usual scoring system as it indicates that the fe-
tus is doing well and there are no significant risks of fetal compromise or
distress. A score of 8/10 or below may indicate the need for closer mon-
itoring or more extensive testing, depending on the clinical situation. A
score of 12/1 is not a relevant or appropriate score in the context of the
BPP.
Explanation:
- Pregnant women are at an increased risk of developing DVT due to
changes in blood clotting factors and venous stasis.
- Women with a history of previous DVT are at an even higher risk and
require anticoagulation therapy to prevent recurrence.
- Warfarin is contraindicated during pregnancy due to its teratogenic ef-
fects, as it can cross the placenta and cause fetal abnormalities.
- LMWH is the preferred anticoagulation therapy for pregnant women
with a history of DVT, as it does not cross the placenta and has a low risk
of fetal complications.
- LMWH is administered subcutaneously and does not require monitor-
ing of coagulation parameters.
- LMWH can be safely used throughout pregnancy and is typically con-
tinued for 6 weeks after delivery to reduce the risk of postpartum DVT.
- Therefore, in this scenario, LMWH is the recommended anticoagula-
tion therapy for a pregnant woman with a history of previous DVT.
Explanation:
Among the given risk factors of smoking, subfertility, advanced mater-
nal age, and family history of diabetes mellitus in a second-degree rela-
tive, the biggest risk factor for the 34-year-old primigravida is smoking.
Smoking during pregnancy is a significant risk factor for adverse preg-
nancy outcomes, including preterm labor, growth restriction, placental
abruption, stillbirth, and congenital anomalies. Smoking also increases
the risk of maternal complications such as pre-eclampsia, placenta pre-
via, and premature rupture of the membranes.
Subfertility, advanced maternal age, and family history of diabetes melli-
tus in second-degree relatives are also significant risk factors for adverse
pregnancy outcomes, but their impact is generally less severe than smok-
ing. Women with subfertility usually receive medical assistance, and ade-
quate preconception counseling and care should help reduce the risk of
adverse pregnancy outcomes. Advanced maternal age is associated with
increased fetal aneuploidy and increased obstetric complications. Family
history of diabetes mellitus in a second-degree relative increases ante-
natal screening, and adequate glycemic control during pregnancy would
minimize adverse outcomes.
However, since all the mentioned factors can contribute to an increased
risk of adverse pregnancy outcomes, preconception counseling, risk as-
sessment, and individualized care planning are essential to achieve bet-
ter maternal and fetal outcomes. Antenatal care plays a vital role in re-
ducing the impact of risk factors and providing better prenatal care for
Dr.Ali Balharith MD, MACP, FRCPC 85
achieving better fetal outcomes.
In a pregnant patient with sickle cell anemia (SCA), who is G2P1 and in
the 9th week of pregnancy, with a history of two previous admissions
for vaso-occlusive crises (VOC) but asymptomatic at present, the most
appropriate management would be C) Close follow-up.
Fibroids are noncancerous growths in the uterus that are quite common,
especially in women of reproductive age. Many women have fibroids
that do not cause any symptoms or problems. In asymptomatic patients,
conservative management with regular monitoring is the preferred ap-
proach.
Pelvic ultrasound is a non-invasive imaging test that can be used to mon-
itor the size and growth of the fibroid. A yearly pelvic ultrasound (option
A) is appropriate for an asymptomatic patient with a 5-6 cm fibroid, as
this would allow for monitoring of any changes in size or appearance of
the fibroid.
A complete blood count (CBC) is not necessary for routine monitoring of
a fibroid and would not provide useful information in an asymptomatic
patient. Therefore, option B is not the most appropriate management for
an asymptomatic patient with a 5-6 cm fibroid.
In summary, in an asymptomatic patient with a 5-6 cm fibroid, the most
appropriate management would be A) Follow up with pelvic ultrasound
yearly. This allows for regular monitoring of the fibroid without subject-
ing the patient to unnecessary tests or interventions.
Explanation:
The most likely cause of bleeding in this case scenario is uterine atony,
defined as the lack of normal uterine muscle tone and failure of the uter-
us to contract adequately after childbirth.
Postpartum hemorrhage (PPH) is one of the most common causes of
maternal morbidity and mortality worldwide, with uterine atony being
responsible for up to 80% of all cases. It could occur due to a variety of
risk factors, including prolonged labor, multiple gestations, macrosomia,
polyhydramnios, and previous PPH history.
Option B: Coagulopathy, or deficiencies in clotting factors, could also
cause PPH, but typically lead to more severe bleeding and are less likely
in an uneventful delivery as described in the case scenario.
Option C: Retained products of conception could be another possible
cause of PPH, but this would typically manifest with symptoms such as
fever, abdominal pain, or vaginal discharge, which are not mentioned in
this case scenario.
Option D: Genital tract laceration could also cause PPH, but is less com-
mon than uterine atony as the cause of PPH.
Therefore, based on the scenario described, the most likely cause of
bleeding is uterine atony, and prompt management with uterine mas-
sage and/or medication to contract the uterus is essential to prevent po-
tentially life-threatening complications.
Explanation:
During the first trimester of pregnancy, the body undergoes various hor-
monal changes that can cause some alterations in blood chemistry. How-
ever, the blood urea nitrogen (BUN) level, which is produced by the liver
and excreted by the kidneys, remains unchanged during pregnancy. It is
because the glomerular filtration rate (GFR), which is the rate at which
the kidneys filter the blood, increases during pregnancy. This increased
GFR helps the kidneys excrete more waste products efficiently, leading
to a stable BUN level.
Dr.Ali Balharith MD, MACP, FRCPC 106
Option A is incorrect as plasma sodium concentration may decrease due
to hemodilution caused by increased blood volume during pregnancy.
Option B is incorrect because creatinine clearance decreases during the
first trimester of pregnancy, leading to an increase in serum creatinine
level.
Option C is incorrect as BUN may remain unchanged during pregnancy
due to increased GFR and efficient kidney function.
Explanation:
Q110- A 50 year old female with Chronic lower abdominal pain and
bleeding Imaging shows: fibroid What’s the most appropriate man-
agement?
A. Hysterectomy
B. Combined OCP
C. Myomectomy
D. Dilation and curettage
Explanation:
Placenta previa accreta is a pregnancy-related complication where the
placenta abnormally attaches to the uterine wall leading to severe and
persistent vaginal bleeding, putting both mother and fetus at high risk
for significant complications.. In this condition, there is a greater chance
for the development of deep vein thrombosis (DVT) due to blood clots.
Dr.Ali Balharith MD, MACP, FRCPC 111
Uterine rupture (Option A) is an uncommon obstetric emergency that
occurs typically during labor, which can result in vaginal bleeding. How-
ever, it is less likely the cause of the bleeding and DVT in the scenario
described.
Placental abruption (Option B) is another possible cause of vaginal bleed-
ing and DVT, but typically occurs earlier in pregnancy than the given
scenario. It occurs when the placenta separates from the wall before the
delivery of the baby.
In summary, with the presentation of uncontrollable vaginal bleeding
coupled with DVT development during pregnancy, placenta previa ac-
creta could be the likely diagnosis, and urgent intervention by an obste-
trician would be required to ensure both mother and fetus’s safety and
health.
In the given scenario of a patient with amenorrhea and high LH and FSH
levels during the luteal phase, the likely cause of amenorrhea is A - Ovar-
ian dysfunction.
Explanation:
Amenorrhea refers to an absence of menstruation in women of repro-
ductive age, which may be indicative of various underlying causes. As
mentioned in the scenario, the patient has elevated FSH and LH levels,
which suggests ovarian dysfunction. FSH (Follicle-stimulating hormone)
and LH (Luteinizing hormone) are hormones produced by the brain that
regulate the menstrual cycle. High levels of LH and FSH during the lute-
al phase can indicate a lower-than-normal level of estrogen production
by the ovaries.
Ovarian dysfunction can occur due to various causes such as polycystic
ovary syndrome or premature ovarian failure (early menopause). These
Dr.Ali Balharith MD, MACP, FRCPC 113
conditions can prevent the ovaries from functioning normally, leading
to a diminished production of estrogen, a leading cause of amenorrhea.
Asherman Syndrome (Option B) is a rare condition that is character-
ized by the formation of scar tissue inside the uterus, leading to men-
strual abnormalities such as reduced menstrual flow or amenorrhea.
However, this condition is not commonly associated with elevated lev-
els of LH and FSH.
Q116- What is the time interval between ovulation and cleavage in dicho-
rionic diagnostic twins?
A. 0-72 h
B. 4-8 days
C. 9-12 days
D. >12 days