PSW 475: Pharmacology, Medicinal Chemistry, and Toxicology III – Spring 2021

PSW 475: Pharmacology, Medicinal Chemistry, & Toxicology III Course Syllabus

COURSE INFORMATION
Class Location: Online Credit Hours: 7.0
Class Times: MTuWTh, 11:10 AM-12:25 PM; F, 1:30-2:45 PM

*** Note: The contents of this syllabus may be subject to change! If this occurs, an addendum to
the syllabus will be placed on Blackboard. Due to Holidays preempting regular class times,
Contingency Blocks will be used on multiple instances as indicated on the class schedule at the
end of the syllabus. Plan for them as you would with regular class days. ***

COURSE COORDINATORS/INSTRUCTORS
Carolyn Friel, R.Ph., Ph.D.
Prof. of Medicinal Chemistry
Office Hours: M,W,R 12:30 – 1:30 PM
Email: carolyn.friel@mcphs.edu

Paul Kaplita, Ph.D.

Assoc. Prof. of Pharmaceutical Sciences
Office Hours: by appointment
Email: paul.kaplita@mcphs.edu

COURSE INSTRUCTORS
Matthew Metcalf, Pharm.D, Ph.D.
Asst. Prof. of Medicinal Chemistry
Office Hours: M,W,F 12:30 – 1:30 PM
Email: matthew.metcalf@mcphs.edu

Alok Sharma, Ph.D.

Assoc. Prof. of Pharmaceutical Sciences
Office Hours: M,W 9:30 – 11:00 AM
Email: alok.sharma@mcphs.edu

Prashant Mandela, Ph.D.

Asst. Prof. of Pharmaceutical Sciences
Office Hours: M,W,R 12:30pm- 1:30pm
Email: prashant.mandela@mcphs.edu

Chase Smith, Ph.D.

Prof. of Medicinal Chemistry
Office Hours: T, R 12:30 – 1:30 PM or by appointment
Email: chase.smith@mcphs.edu

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 PSW 475: Pharmacology, Medicinal Chemistry, and Toxicology III – Spring 2021
COURSE DESCRIPTION
 This course is the third in the Pharmacology, Toxicology, and Medicinal Chemistry series and it
involves a coordinated approach for learning mechanism of drug action, structure-activity relationships,
and toxicity profiles for selected classes of drugs. Emphasis is on drugs used to treat infectious
diseases, cardiovascular and pulmonary disorders, pain, anesthesia, heavy metal toxicity, drug abuse,
and use of radionuclide therapies.

COURSE MATERIALS
Required:
 Pharmacology: Goodman and Gilman’s The Pharmacological Basis of Therapeutics 13th ed, McGraw
Hill, eds. Brunton, Chabner and Knollman. 2018. Available online at: https://accessmedicine-
mhmedical-com.ezproxymcp.flo.org/book.aspx?bookid=2189
 Medicinal Chemistry Textbook: Foye’s Principles of Medicinal Chemistry, Roche VF, Zito SW,
Lemke TL, Williams DA. 8th edition. Wolters Kluwer; 2020. https://pharmacy-lwwhealthlibrary-
com.ezproxymcp.flo.org/book.aspx?bookid=2728
 TurningPoint App (on a smartphone, laptop and/or tablet device) and an active license.
Recommended:
 Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th edition. Philadelphia:
Golan, Armstrong, & Armstrong. Lippincott Williams & Wilkins. 2017. Available online at:
http://pharmacy.lwwhealthlibrary.com/book.aspx?bookid=1765
 Lippincott’s Illustrated Reviews: Pharmacology, 6th edition. Philadelphia: Clark, Finkel, Rey, & Whalen.
Lippincott Williams & Wilkins, 2015. ISBN-13: 978-1451175622.
 Review of Organic Functional Groups: Introduction to Medicinal Organic Chemistry, 5th edition by
Thomas L. Lemke. ISBN 978-1-60831-016-6. 2012. Available online:
http://pharmacy.lwwhealthlibrary.com/book.aspx?bookid=824
 Supplemental readings/materials as assigned.

COURSE OBJECTIVES
 The knowledge and skills taught in this course are consistent with the Center for the Advancement of
Pharmacy Education (CAPE) Educational Outcomes 2013. A current list of our adapted CAPE 2013
curricular outcomes is on the SOP W/M Blackboard site. To view the goals and objectives for this
course please refer to the document titled “Course Objectives” posted on Blackboard in the Course
Information content area.
 After successful completion of this course the student should be able to:
1. Describe the pharmacologic and therapeutic class of a compound given its generic name or
chemical structure.
2. Describe the molecular, biochemical and pharmacological mechanisms of action, pharmacokinetic
properties, physiochemical properties, pharmacogenomic (where appropriate) and therapeutic
and/or adverse effects of a compound, given its generic name or chemical structure.
3. Characterize the pharmacological or toxicological activity a set of compounds on the basis of
Structure Activity Relationships.
4. Predict likely drug-drug, drug-environmental chemical and/or drug-food interactions based on the
chemical properties and/or the mechanism of action of the compounds involved.
5. Describe current concepts and molecular principles underlying the mechanisms of drug actions.
6. List examples of drugs that alter cardiovascular function, pulmonary function, pain, anesthesia, drug
abuse, radionuclide therapy, heavy metal toxicity, and microbial diseases and identify their
mechanism of action, side effects, drug interactions, and their toxicity and treatment.
7. Describe the mechanisms of action, pharmacokinetics, therapeutic indications, adverse effects,
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 PSW 475: Pharmacology, Medicinal Chemistry, and Toxicology III – Spring 2021
contraindications, and drug interactions of drugs acting on cardiovascular function, pulmonary
function, pain, anesthesia, drug abuse, radionuclide therapy, heavy metal toxicity, and
microbial/viral diseases.
8. List the classes of drugs, and their names, used to treat cardiovascular function, pulmonary
function, pain, anesthesia, drug abuse, radionuclide therapy, heavy metal toxicity, and
microbial/viral diseases, and describe the molecular, biochemical and pharmacological mechanisms
for therapeutic and/or adverse effects each drug.
9. Identify the appropriate drug for a patient in a given hypothetical patient case scenario.
10. Identify the problem with a drug class/combination of drugs in a given hypothetical patient case
scenario.

ATTENDANCE
 Class attendance is part of a student’s professional obligation. Attendance may be taken using
various methods, including but not limited to the TurningPoint App and/or unannounced in-class
assessments, which may occur at any time during a class and could occur more than once during
a class. Class attendance may be recorded and may be shared with the Dean of Students or their
campus designee, and the Dean of the SOP-W/M.

UNIVERSITY POLICIES AND PROCEDURES

 Students must abide by the Academic Policies and Procedures set forth in the current MCPHS
University Catalog and Student Handbook available online. Important information regarding
Documented Student Absence Requests, Office of Student Access and Accommodations (OSAA),
Academic Honesty and Plagiarism and other academic policies is set forth in the Academic and
University Policies and Procedures sections of these documents.

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 PSW 475: Pharmacology, Medicinal Chemistry, and Toxicology III – Spring 2021
EXAMS
 Examinations are designed to determine the extent of students’ understanding of basic principles and
concepts of medicinal chemistry, pharmacology and toxicology, and will require integration of these
basic principles and concepts.
 All exams for PSW 475 will use ExamSoft / Examplify electronic testing.
o Refer to the ExamSoft/Examplify Student Guide for specific details.
 Examinations will take place during regular class times or during one of the available Contingency
Blocks.
 Examinations will follow the School of Pharmacy Worcester/Manchester (SOP-W/M) Course, Exam,
and Grading Policies and Procedures, which can be found on the Blackboard School of Pharmacy
Worcester/Manchester – Student Site. Note: This also includes the specified penalties for not following
or violating the School of Pharmacy Worcester/Manchester (SOP-W/M) Course, Exam, and Grading
Policies and Procedures.

# of # of
Exam Date % Course Value
Points Questions
1 Feb 1 112.5 45 14.75%

2 Feb 16 100 40 13.11%

3 Mar 1 100 40 13.11%

4 Mar 15 100 40 13.11%

5 Mar 31 100 40 13.11%

6 Apr 15 112.5 45 14.75%

Smith
assignment 12.5 1.64%
TBD
Smith
assignment 25 3.28%
TBD
FINAL TBD 100 40 13.11%
TOTAL: 762.5 100%

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 PSW 475: Pharmacology, Medicinal Chemistry, and Toxicology III – Spring 2021
REMEDIATION
 The MCPHS SOP W/M Faculty are committed to student success. Academic remediation is one
strategy to use in order to ensure students achieve competency in this required course.
 Exams given after the first exam may include remediation questions. These will test specific learning
objectives from prior exams, thereby allowing students to demonstrate their understanding of the
previously covered material. Faculty will post specific lecture objectives to guide student learning before
any exams, which include bonus remediation questions. Points earned from correct answers to these
questions will be bonus points, only added to the numerator of the total exam points.

GRADING SCALE
Grade % Letter Grade
93-100 A
90-92 A-
87-89 B+
83-86 B
80-82 B-
77-79 C+
73-76 C
70-72 C-
60-69 D
< 60 F

SOP-W/M COURSE, EXAM AND GRADING POLICIES AND PROCEDURES

 Students must abide by the School of Pharmacy Worcester/Manchester (SOP-W/M) Course, Exam,
and Grading Policies and Procedures. Important information is provided regarding course policies that
includes but is not limited to: Attendance, Absence, Tardiness, Student Conduct, Academic Honesty
and Plagiarism, Class Participation, Class Recordings, Course Communication, Distance Education
Outages, Personal Lecture/Class Recordings, School Closures.
 Important exam and grading information provided in these policies includes but is not limited to: Student
Conduct During Exams, Academic Honesty During Exams, Exam Supplies, Entering Exam Rooms,
Exam Completion, Exiting Exam Rooms, Absence from Exams, Exam Review Guidelines, Exam
Scores and Grading, Absence from Examinations, and Final Course Grades.
 To view the SOP–W/M policies and procedures mentioned above please refer to the documents posted
on the Blackboard School of Pharmacy Worcester/Manchester – Student Site.

COURSE SPECIFIC POLICIES AND PROCEDURES

 Make-up exams will only be administered upon administrative notification to the course coordinator of
an official excused absence according to the guidelines outlined in the Student Handbook. Make-up
examination will be scheduled at the discretion of the instructor(s). The format of the make-up exam is
at the discretion of the instructor(s) and may take any form (electronic or paper) that may include, but
not limited to: multiple choice, short answer, structure or mechanism drawing, essay and oral question
components.
 Students are responsible for having access to the TurningPoint App. Technical problems with the App

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 PSW 475: Pharmacology, Medicinal Chemistry, and Toxicology III – Spring 2021
or not having a device to run the App is not a legitimate excuse for being unable to participate in any in-
class assessments. Students who click in remotely (or ask another student to click in for them), for
either Attendance or to answer a Clicker Question, represents a violation of the Academic Honesty
Policy and the Student Code of Conduct. Violators will receive a penalty of 25 points subtracted from
the final course grade and will lose all points associated with clicker questions for the class. The
student will also be reported to the Dean of Students and the Dean of the SOP W/M for Academic
Dishonesty.
 In the event that an Extra Credit opportunity is offered during a class session, only students in
attendance at the time of the assignment will receive extra credit. Make-up opportunities will not be
offered whether an absence is either excused or unexcused.
 All assignments are to be turned in no later than the due date and time indicated on (Blackboard,
course outline, etc.). Unless prior approval has been received by the instructor, late assignments will
result in a grade of zero (0). If you anticipate that you will not be able to turn in an assignment on the
due date you must contact the instructor before the due date/time.
 All in-class assessments/assignments must be turned in at the time indicated by the instructor. Anyone
continuing to work on in-class assessments after time is called will receive a grade of zero (0) for that
assessment.
 Grades for each assessment will be posted in the Blackboard grade center.
 Any situations not addressed by the policies and procedures above will be handled at the discretion of
the instructor(s) or course coordinator(s).
 Students must read, understand, and comply with all University, SOP-W/M, and course-specific policies
and procedures.

ASSESSMENT OF STUDENT LEARNING AND TEACHING EFFECTIVENESS

 The material in this course will be team taught by pharmaceutical sciences faculty. Material covered on
an exam or in an assessment will be material covered in class and/or from assigned readings or as
detailed by the instructor.
o Potential Portfolio Materials: This course does not include portfolio materials.
o Interprofessional Education (IPE) Activities: This course does not include IPE activities.
o Pharmacists’ Patient Care Process (PPCP):
o This course includes content relevant to the following checked components of the PPCP:
Collect Assess Plan Implement Follow-up: Monitor and
Evaluate
o To learn more about the PPCP, visit: https://jcpp.net/patient-care-process/

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 PSW 475: Pharmacology, Medicinal Chemistry, and Toxicology III – Spring 2021
CLASS SCHEDULE:
# Date Topic Instructor Reading
1 Jan 19 Antimicrobial Therapy Dr. Kaplita G&G, chapter 48
2 Jan 20 Sulfonamides/Quinolones Dr. Kaplita G&G, chapter 52
3 Jan 21 Beta-lactams Dr. Kaplita G&G, chapter 53
4 Jan 22 Cell wall/membrane inhibitors Dr. Kaplita G&G, chapter 55
5 Jan 25 Sulfonamides/Quinolones Dr. Friel Foye, chapter 33
6 Jan 26 Beta-lactams Dr. Friel Foye, chapter 33
7 Jan 27 Beta-lactams Dr. Friel Foye, chapter 33
8 Jan 28 Protein synthesis inhibitors Dr. Friel Foye, chapter 33
9 Jan 29 Protein synthesis inhibitors Dr. Kaplita G&G, chapter 55
Feb 1 Exam 1 (lectures 1-9) 9
10 Feb 2 Aminoglycosides Dr. Kaplita G&G, chapter 54
11 Feb 3 Antimycobacterials Dr. Friel Foye, chapter 33, 36
12 Feb 4 Antimycobacterials Dr. Friel Foye, chapter 33, 36
13 Feb 5 Antimycobacterials + Antifungals Dr. Kaplita G&G, chapter 56, 57
14 Feb 8 Antivirals Dr. Kaplita G&G, chapter 58
15 Feb 9 Antiretrovirals Dr. Kaplita G&G, chapter 59
16 Feb 10 Antifungals Dr. Friel Foye, chapter 35
17 Feb 11 Antivirals + Antiretrovirals Dr. Friel Foye, chapter 38
18 Feb 12 Adrenergic pharmacology Dr. Mandela G&G, chapter 12
Feb 15 HOLIDAY: President’s day
Feb 16 Exam 2 (lectures 10-17) 8
19 Feb 17 Hypertension Dr. Mandela G&G, chapter 27
20 Feb 18 Hypertension Dr. Mandela G&G, chapter 27
21 Feb 19 Hypertension Dr. Mandela G&G, chapter 27
22 Feb 22 Hypertension Dr. Metcalf Foye, chapter 24
23 Feb 23 Ischemia Dr. Metcalf Foye, chapter 21, 23
24 Feb 24 Ischemia Dr. Mandela G&G, chapter 27
25 Feb 25 Ischemia Dr. Mandela G&G, chapter 27
26 Feb 26 Heart failure Dr. Metcalf Foye, chapter 21, 23
Mar 1 Exam 3 (lectures 18-25) 8
27 Mar 2 Heart failure Dr. Mandela G&G, chapter 28
28 Mar 3 Heart failure Dr. Mandela G&G, chapter 28
29 Mar 4 Dyslipidemia Dr. Sharma G&G, chapter 31
Mar 5 NO CLASSES
30 Mar 8 Dyslipidemia Dr. Sharma G&G, chapter 31
31 Mar 9 Dyslipidemia Dr. Sharma G&G, chapter 31
32 Mar 10 Dyslipidemia Dr. Smith Foye, chapter 25
33 Mar 11 Coagulation Dr. Mandela G&G, chapter 30, 31
34 Mar 12 Coagulation Dr. Mandela G&G, chapter 30, 31
Mar 15 Exam 4 (lectures 26-31 and 33-34) 8
35 Mar 16 Coagulation Dr. Mandela G&G, chapter 30, 31
36 Mar 17 Coagulation Dr. Smith Foye, chapter 26
37 Mar 18 Coagulation Dr. Smith Foye, chapter 26
38 Mar 19 Arrhythmia Dr. Mandela G&G, chapter 29

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 PSW 475: Pharmacology, Medicinal Chemistry, and Toxicology III – Spring 2021
39 Mar 22 Arrhythmia Dr. Mandela G&G, chapter 29
40 Mar 23 Arrhythmia Dr. Mandela G&G, chapter 29
41 Mar 24 Arrhythmia Dr. Mandela G&G, chapter 29
Mar 25 NO CLASSES
42 Mar 26 Somatosensory function and pain Dr. Kaplita G&G, chapter 18, 24
43 Mar 26 Opioids Class during contingency block Dr. Kaplita G&G, chapter 18, 24
44 Mar 29 Opioids Dr. Kaplita G&G, chapter 18, 24
45 Mar 30 Opioids Dr. Metcalf Foye, chapter 20
Mar 31 Exam 5 (lectures 35 and 38-44) 8
46 Apr 1 Opioids Dr. Metcalf Foye, chapter 20
47 Apr 2 Drugs of Abuse Dr. Metcalf Foye, chapter 19
48 Apr 5 Drugs of Abuse Dr. Metcalf Foye, chapter 19
49 Apr 6 General anesthesia Dr. Sharma G&G, chapter 19
50 Apr 7 General anesthesia Dr. Sharma G&G, chapter 19
51 Apr 8 General anesthesia Dr. Friel Foye, chapter 16
52 Apr 9 Local anesthesia Dr. Kaplita G&G, chapter 20
53 Apr 12 Local anesthesia Dr. Friel Foye, chapter 16
54 Apr 13 Nuclear pharmacy Dr. Friel -
55 Apr 14 Heavy metal toxicity Dr. Friel -
56 Apr 15 Exam 6 (lectures 45 – 53) 9
Steroids: Adrenocorticoids Class during contingency
Apr 15 Dr. Metcalf Foye, chapter 28, 39
block
57 Apr 16 Steroids: Estrogens/progestins/androgens Dr. Friel Foye, chapter 40, 41
Apr 19 HOLIDAY: Patriot’s Day

58 Apr 20 Asthma/COPD Dr. Metcalf Foye, chapter 39

59 Apr 21 Pulmonary pharmacology Dr. Mandela G&G, chapter 36
60 Apr 22 Pulmonary pharmacology Dr. Mandela G&G, chapter 36
61 Apr 23 Pulmonary pharmacology Dr. Mandela G&G, chapter 36
Apr 26 FINAL EXAM TBD (lectures 54-61) 8

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 PSW 475: Pharmacology, Medicinal Chemistry, and Toxicology III – Spring 2021
All materials for this course are © 2020 - 2021 Paul Kaplita, PhD; Matthew Metcalf, PharmD, PhD;
Prashant Mandela, PhD; Alok Sharma, PhD; Carolyn Friel, PhD; and Chase Smith, PhD – respectively.
All Rights Reserved. Dissemination of any course materials without express written permission is
prohibited.