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Important questions in Computational Biology
Unit-1: Cell Biology and Genetics
1. Cell Theory and Organelles: Explain the principles of the cell theory and discuss the significance of its discoveries in the field of biology. Describe the structure and functions of major cell organelles, highlighting their roles in maintaining cellular homeostasis. 2. Cell Division and Tissue Differentiation: Explore the processes of cell replication and division. How do these processes contribute to tissue differentiation in multicellular organisms? Discuss the importance of maintaining a balance in cell division for overall organism health. 3. Stem Cells and Applications: Elaborate on the concept of stem cells and their potential applications in medical science. Discuss the ethical considerations associated with the use of stem cells and the ground- breaking advancements in treating diseases through stem cell research. 4. Genetic Algorithms: Explain the principles of genetic algorithms in the context of biological systems. How can genetic algorithms be applied to study and solve complex biological problems? Discuss the advantages and challenges associated with using genetic algorithms in biology. Unit-2: Basics in Biochemistry 5. Structure and Functions of Biomolecules: Provide a detailed overview of the structure and functions of carbohydrates, lipids, proteins, enzymes, DNA, RNA, and hormones. Explain how each biomolecule contributes to the proper functioning of living organisms. 6. Human Genome Project and Genomics: Discuss the significance of the Human Genome Project and its impact on genomics. How has genomics advanced our understanding of genetic information, and what are the implications for personalized medicine? Unit-3: Structural Biology 7. Protein Synthesis and Structure: Explain the process of protein synthesis and delve into the secondary structure of proteins. Discuss the relationship between protein structure and function, and how advancements in structural biology have contributed to our understanding of complex protein interactions. 8. Structural Databases and Visualization Tools: Explore the role of structural databases and visualization tools in structural biology. How do these tools aid researchers in studying and understanding the three- dimensional structures of biological macromolecules? Unit-4: Neurobiology 9. Neurons and Neural Networks: Provide a comprehensive overview of the basics of neurons and glial cells. Discuss the structure and functions of the brain, highlighting the key components. Compare and contrast artificial neural networks with biological neural networks, emphasizing their respective concepts and differences. 10. Applications of ANN and Machine Learning in Biology: Explore the applications of artificial neural networks, machine learning, and data mining in the field of biology. How do these technologies contribute to advancements in understanding complex biological systems and analysing large-scale biological data? Unit-5: Immunobiology 11. Elements of the Immune System and Immunity: Describe the essential elements of the immune system and distinguish between active and passive immunity. Discuss the mechanisms through which the immune system defends the body against pathogens. 12. Immuno-informatics and Epitope Prediction: Explore the field of immune-informatics and its role in epitope prediction. How do computational tools assist in predicting potential epitopes for vaccine development? Discuss the challenges and future prospects of immune-informatics in the field of immunobiology.