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    Acetone Purity

    Uploaded by

    wael
    ISO 20483

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Acetone Purity

    Uploaded by

    wael
    0 views2 pages
    ISO 20483

    Copyright

    © © All Rights Reserved

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    PDF, TXT or read online from Scribd

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    ISO 20483

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    0 views2 pages

    Acetone Purity

    Uploaded by

    wael
    ISO 20483

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    ACETONE

    Prepared at the 51st JECFA (1998), published in FNP 52 Add 6 (1998)


    superseding earlier specifications prepared at the 14th JECFA (1970),
    published in NMRS 48B (1971) and republished in FNP 52 (1992). ADI
    "limited by GMP", established at the 14th JECFA in 1970.

    SYNONYMS Dimethylketone, propanone

    DEFINITION
    Chemical names Propan-2-one

    C.A.S. number 67-64-1

    Chemical formula C3H6O

    Structural formula CH3COCH3

    Formula weight 58.08

    Assay Not less than 99.5% (w/w)

    DESCRIPTION Clear, colourless, volatile, highly flammable liquid with a characteristic


    odour; free from sediment and suspended matter

    FUNCTIONAL USES Extraction solvent, flavouring agent (see "Flavouring agents" monograph,
    JECFA no. 139)

    CHARACTERISTICS
    IDENTIFICATION

    Solubility Miscible in all proportions with water and with ethanol

    Specific gravity (Vol. 4) d2020: 0.790 - 0.793

    Refractive index (Vol. 4) n20D: 1.358 - 1.360

    PURITY

    Distillation range (Vol. 4) 55.5 - 57.0o

    Non-volatile residue Not more than 0.001% (w/w)


    (Vol. 4)

    Acidity Not more than 0.002% (w/w) (calculated as acetic acid)


    See description under TESTS

    Phenol Not more than 0.001% (w/w)


    Place 3 ml of the sample in a crucible and evaporate to dryness at 60o,
    add 3 drops of a solution of 0.1 g sodium nitrite dissolved in 5 ml of
    sulfuric acid and allow to stand for 2-3 min. Carefully add 3 ml 2 N sodium
    hydroxide. No colour is produced.

    Readily oxidizable 30 ml of the sample does not discolour 0.1 ml of 3% m/v freshly prepared
    substances aqueous potassium permanganate solution when shaken and allowed to
    stand at 20o for 15 min.

    TESTS
    PURITY TESTS

    Acidity Place 100 ml of freshly boiled and cooled distilled water (neutralized to
    phenolphthalein TS) and a few antibumping granules in a 500 ml conical
    flask of boro-silicate glass and boil gently for 5 min to eliminate carbon
    dioxide. Cool slightly and add 100 ml of the sample. Boil gently for a
    further 5 min. Then seal the flask with a stopper carrying a soda-lime tube
    and allow to cool. When cold remove the stopper, add 0.5 ml
    phenolphthalein TS and examine for alkalinity: if not alkaline titrate with
    0.1 N sodium hydroxide solution using a micro-burette.
    Calculate the acidity as acetic acid (%, w/w) from

    where
    T = volume (ml) of 0.1 N sodium hydroxide solution consumed
    d = specific gravity of the sample.

    METHOD OF Weigh accurately about 1 g of the sample in a flask containing 20 ml of


    ASSAY water, and add water to 1,000 ml. Place 10 ml of the solution in a glass
    stoppered flask, add 25 ml of sodium hydroxide TS, and allow to stand for
    5 min. Add 25 ml of 0.1 N iodine, stopper, allow to stand in a cold and dark
    place for 10 min, and add 30 ml of 1 N sulfuric acid. Titrate the excess
    iodine with 0.1 N sodium thiosulfate, using starch TS as the indicator.
    Perform a blank test in the same manner as the sample and make any
    necessary correction. Each ml of 0.1 N iodine is equivalent to 0.9675 mg
    of C3H6O.

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