Glucose

5ATP
H2NADH 2 ATP
2xPyruvate

2 NADH 5 ATP

2x Acetyl CoA

2QH2 3 ATP

2 GTP

2 602
 CoA
Oxaloacetate
Hgc E stiff
CoA

gas
qts
Ho affair.ited coo.TT
Ho d coo
is.Acouitate
100
20
malate
catamaran
ii Fumarate
3 NADH
it
IEEE
nrayas.lk
HCCOO
6 Dehydrogenase Isocitrate
a coo
not
d
do sina.go.am
It
f
officoo
igiggy 3

A
Dehydrogenase
d S CoA
CoA SH α ketoglutarate
CO

Succinyl CoA

C C bond formation 6 Dehydration to give FADH

2 attiin
via dehydration 7 Hydration
Iii.fi NADH
Oxidative decarboxylation 8 Dehydration to give
3 4
to 2 NADH
give
5 Substrate level phosphorylation

to give GTP
 Condensation of Acetyl CoA Oxaloacetate

Citrate Synthase

Hoc Ks CoA
CoA CoA SH
Acetyl
o I
Had coo
ooc I CH coo
Oxaloacetate citrate
is

c.it tt sea
an.xE
s
ÉÉ

11
Hac 00
搐h p o
ÉÉ
d 000
Ho
000 A
CoA5H H2O
H coo

ATT
2 Isomerization by Dehydration Rehydration
Aconitase

Coo Coo
HE 00
Hc Hq

4 00 H d coo
Ho
H 00
I HO coo
G H2O H2O
cis Aconitate Isocitrate
Citrate

3 Oxidative Decarboxylation
Isocitrate Dehydrogenase

4 too NADP At Hac 00

Hee too HC Coo

EE
1 NADCP ᵗ iEiiiffifEiii
Isocitrate
a
Carbonyl guttate
Mn
t
helps stabilize open
intermediate which draws
in
from 102
electron density leaving
4 2nd Oxidative Decarboxylation
a Ketoglutarate Dehydrogenase
complex

Hc Coo CoA SH Hac Coo

00 off s coat
α Ketoglutarate

5 Substrate Level Phosphorylation

Succinate CoA Synthetase
GA SH
É
Hac Coo

s.in
I 3
Succinate
Succinyl CoA

Wo
14
at
III
in Ekas
OH

as c.at Has coa

Hey
Coo
Efftle
It 1 0
o

Hac co

his Iq Hd coo
6 Oxidation of an Alkane to Alkene
Succinate Dehydrogenase

FAD FAD 2
Coo H
yooo
ooa.tn
100 Fumarate
Succinate

Connets to complex 11 in ETC QHz

it directly to FAD FAD

Ht FADH
goQ to make QH
then to

7 Hydration Across a Double bond

Fumanase
on
anti
y
IE 0004110
ooo
p
Fumarate L Malate

Fumarate is Symetrical so
either side can gain OH
8 Oxidation of Alcohol to ketone
L Malate Dehydrogenase
Coo
NAD GADH Ht Coo
to

doo

L Malate Oxaloacetate

8
Oxaloacetate citrate

0 Isocitrate
8

to
f
ketoglutarate

Succinyl CoA

Both Carbons released

id not come from
FF lot
Since Succinate is
symmetrical either of
the two sets of 8
Cas on oxaloacetate oxaloacetate
for the next cycle CoA
could be from Acetyl
citrate
y
Isocitrate
p
Either way one c from
Acetyl CoA is lost
as CO2
3
40
intogluterate

8
SuccinylCoA

OR

Oxaloacetate
citrate

Isocitrate
10
8

to
ketoglutarate

SuccinylCoA
 S CoA

2 Malate
f
80 Citrate
8

in.mn
or EgoIsocitrate
Fumarate

FADH 4110
Succinate 88

GTP
81472
succinyl CoA
NADH from Glycolysis in
cytosol needs a way into carob
mitochondria to make ATP
In muscle it gets turned
0005 I pig

to FADH then QH2

thoughs empglymate sat

shuttle
In hurt liver the It's
to malate pumped into a
go
mito matrix this back Eii
into NADH via Malate
Aspartate shuttle
FIFI
Ii if if
NADHCtt NADH mit 2.5 ATP
 Pyruvate
Piri
facti citrate
PEPCarboxykinase
CoA

ETforaioa.tt
calklxytinasen.tt
a ketoglutarate
Aspartate AAs
Eh m
Glutamate Purines
gun ua
pyratmines Pyruvate

Porphyrins

Pyruvate
titods
PDcfiitiistiat.ie
A t succinyl CoA citrate
appH

TIE.ci aty
Isocitrate
aioe

iff.IEgnapHijijfit α ketoglutarate

i oa.am
FAI É Ét
GTF
GlyoxylateCycle Isocitrate Lyase
Branches at step 3 Hec Coo
coo
in TCA te H
Uses 2 mn enzymes 01419 co liteGlyoxylate
Isocitrate lyase Isocitrate sulfite
Malate synthase
Feeds in an extra malate synthase coo
Joints
fi ftbenlrdunyIwo Is coA
He 0
1H
Glyoxylate too
Produces Oxaloacetate Acetyl CoA
that can feed into malate
gluconeogenesis