Otany Notes

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fATTY ACID BIsYNTHCSIS

when
Jhe dii lay anino
ammo acids and oxlehydaale
Consumed in erceAs Can Je Conveated
acida and the
OccuKA
The acids

liven adipeae timue and


rmammay
gland, the
material
CoA Benve

TCA
COoH
fkckyt-oA
Chain Prsureer
acid A a
leg Fot

ith COOH
tydacconten the
alome
the BOUNCe % onbon
NAOPH and
a cidi nlhile

A7P
biognthuu.
acids procurtion
the cell
axe docaled
(anbon olom
cach

he chom
atBoche d Jo
aaid ia 6- Canbon
End paodd o atty
Which knon 06 alniteleid.
NADPH CIential acid

biesgyntes Or Acid
3 Steps

fatty acid
(2) ConvesiCn
mitochondkia to
|Heetyl CoA nto Qcid
yto plasm
|malenyl- Con
CONDENSAMON
REDUGTaN

DeHYDRAICNN

(RoDucTION)
mitachondxa

Glucose
FATY
RCn
BosNTHESIS 4/13

NADPH+Ht Motu.
Malatc
NAep
Malate Mitochondstal
NAD Malate

NADH +H Daiydngae "acetate

ADP+.Axaloacetate
Acakyl CoR citxate

CofsH
ATP
Citate
Catnatee Citaate
Transpkhen
CITRATE SHUTTLE
the oKIdalionm

Pyuate acud1 . degradolen conbon po«t


amino acida and
from ketone odieu. iochondial
membranc inpenmeabk to alyl Co-h. & # Can
nol
but cilxale i
penmeable Hcelsl oA Condenses ilh Oxolo acelate
to form citrale in mitochondxia
Meleosed nto
Once citxate

CiHnate
ylorlaun /glool tth the help o
itnale
transportex then cituate is cleaved
and Oxalo acelate.
fux ltex Oraloacetate Convéxted fo ma late
Nith the
heh o Uym malate
deigdnagne Convert
in the
malate
ytoploorn. Hnd Malate

Used
acid yntheais
2 CoNVEASIQN OF Actyl CoA into
MalonylCoA
to

Coatanglae
Step This tep MeguiNCo fox and
biotih as
prosthet goup
H-t-SCoA
)

Biotin
ADP+B
00G- CH,-i-SCoA
Malony Cof
akbouylou
3 FATTY AaD BIOSYN THESIS BY
AN 6/13
yrnthast
* FA Synthase Compler B-ketoayl
-keioagf Mulonyt
Heyks ranafexase
7 cub - rib
transforia AT
bhon Eroy' ER RCP ) KRHegl
tgune Out Heductau Cahien
protein
2 unit
ACP Uehydratye heioay
ks" (B keto aoyl kat Cayl canséu protein )' Reductaue
Cnd
Synt
havng iai)
6H ctiy
9x0up padipala
altached to e)m
Faty Acid Synthase.

Condersation Dehydnatiod Reduction


Reduction
^H H
KS KS
ACP (ACP
-scOA o--cH--s
Coh
HceiulCoA malony

"007HC-C
H
HS @ GONDENSATIN
B- ketoo-AcP
Bu thase
ACP
ACP
acyl aid dythast
Conple? chaxqd nh an
ñ Cnd amalorgl q
ACP
NADH+ H

REDUCTION Fketoacyl - ACP Meductose


NAD
OH

RCP
Pgdogal-ACP
ODGHYDRATION

He-HC= HC--

Trans- AcP

Trans-enol ACP
NADPH +H Enoyl ACP Meduchase

NADP
REDUGTION
C

npasdpuaua

thiostexase

HC-cH- (Ch- co0


Palmitate (I6c )
Nad naacdionfor Faty Acid Biogmtheis I4H*
(1 Hcalyl CoR +7-malony! Coh)+ 14JNADPH +
falmtic Acid 7Co, +8 CoA +14 NADP+ 6H0
(a) Condensahon In
hit step. aratyt ACPC
CONNeN potein) and malonyd RCP
tendenses to fonm
Qnd
one HCp
This
ACP
bytthase.
Hc--s o--HÇ-t-s B-kelcacgt
c
+
(ACP)
HC (ACP) (AcP)
Malony er Co, B- ketoaay l-Acr
cb) Reduion
Heductase HCduce
(at acctooety! -AcP) to
ACP.
C
OH
Hf-c-He-cC-$ Bketaarul- ACaducka-HG-He-C-S
(ACP) NADPH
NADP* (ACe)
B- ketooyl ACP
F-Hydaenyaayl A
10/13
e(C) Dehydration
and produtes
bons enoyl ACP malecale of waten s eliminated
and double bond is- Utoodued bethseen d- and, 9
Canbons

HC-H-i--s hyeonyey-ACP dehgleta


HC-HC=HC---5
(ACP) HO
Tan enoy! AcP
td) Reduction
Trans enoyl ACP Heductase Meduces ACP to
butyy! - ACe. Jhee steps ane uepeated than 6
times n each
Cyde fathy actd chain
by 2- unit (obtained Jengthaned
end
malongt Co-A) A he
the acd
and a I6-C satnated Compieke
acid ( Palrnitie
pxodued ). Ac is ndeased aud-Ae)
thotoase.

1/13
Jummang q Pamitate Syathesia.
th 16-C
pabitale
Ond nest ol H-Ci au deaivd
CoR, hch is also producnd prom
CoA

fATTY AcID BioSYNTHESIS IMORTANCE


katty acid biurtesi is cucial for Loxioul bologial
proceses. These molecules sere a block
(a))
Gell Membxanes , eneng atot Cin the foxn
(6) noles in
(c) Additianal acids aHe
esential Components
lalhich vital
the structuna and cells
functon
acid is

e86ential fox oexall cellulan heath and


implicaded in vanous phasdgia and pabeiogil
Conditons. metabelie dioorde.
Cell tembrane Stnuctuxe
FatBy acdi esertial Componenla tm -he
he basic shuctuxe
o cell membrane

EnegyFattySb
acids Contuibule to enengg stoxage in the
a Condrtraled and

ranterengy sounte

Cendein acids act pectteiora to

mOLetales vaxious cellulan pxOceses and

Lipid Synthesis
blocks fpr he sgnt
Foty diprd acida aHe

,crucial ox mau tain ing celtular tr. junctiern.


tiyuitogiad Regalaben
celtulau heallh and Lmked to metabolic
proceses.
fathological Tmplicateru
Dynagulalien fatly acid biaymhu
Vouous metatolie dioxdext and health Condition.

13/13

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