John_Sulston
John_Sulston
John_Sulston
Sulston played a central role in both the C. elegans[7] and human genome[26] sequencing projects. He had
argued successfully for the sequencing of C. elegans to show that large-scale genome sequencing projects
were feasible. As sequencing of the worm genome proceeded, the Human Genome Project began. At this
point he was made director of the newly established Sanger Centre (named after Fred Sanger[27]), located
in Cambridgeshire, England.
In 2000, after the 'working draft' of the human genome sequence was completed, Sulston retired from
directing the Sanger Centre. With Georgina Ferry, he narrated his research career leading to the human
genome sequence in The Common Thread: A Story of Science, Politics, Ethics, and the Human Genome
(2002).[28]
He was elected an EMBO Member in 1989[30] and awarded the George W. Beadle Award in 2000.[2] In
2001 Sulston gave the Royal Institution Christmas Lectures on The Secrets of Life. In 2002, he won the
Dan David Prize and the Robert Burns Humanitarian Award. Later, he shared the Nobel Prize in
Physiology or Medicine[31] with Sydney Brenner and Robert Horvitz, both of whom he had collaborated
with at the MRC Laboratory of Molecular Biology (LMB), for their discoveries concerning 'genetic
regulation of organ development and programmed cell death'.
One of Sulston's most important contributions during his research years at the LMB was to elucidate the
precise order in which cells in C. elegans divide. In fact, he and his team succeeded in tracing the
nematode's entire embryonic cell lineage.[8]
In 2004, Sulston received the Golden Plate Award of the American Academy of Achievement.[32] In
2006, he was awarded the George Dawson Prize in Genetics by Trinity College Dublin.[33] In 2013,
Sulston was awarded the Royal Society of New Zealand's Rutherford Memorial Lecture, which he gave
on the subject of population pressure.[34]
He was appointed a Member of the Order of the Companions of Honour (CH) in the 2017 Birthday
Honours for services to science and society.[35]
Sulston was a leading campaigner against the patenting of human genetic information.
Personal life
John Sulston met Daphne Bate, a research assistant in Cambridge.[18] They got married in 1966[18] just
before they left for US for postdoctoral research. Together they had two children. Their first child, Ingrid,
was born in La Jolla in 1967, and their second, Adrian, later in England.[37] The couple lived in
Stapleford, Cambridgeshire where they were active members of the local community: John regularly
volunteered in the local library and in working parties at Magog Down; he was a Trustee of Cambridge
Past, Present and Future.[38]
Although brought up
in a Christian family,
Sulston lost his faith
during his student
life at Cambridge,
and remained an
atheist.[4][19] He was
a distinguished The Sulston Laboratories of the Wellcome Trust Sanger Institute are named in
supporter of Sulston's honour.
[39]
Humanists UK. In
2003 he was one of
22 Nobel Laureates who signed the Humanist Manifesto.[40]
Sulston was in favour of free public access of scientific information. He wanted genome information
freely available, and he described as "totally immoral and disgusting" the idea of profiteering from such
research. He also wanted to change patent law, and argued that restrictions on drugs such as the anti-viral
drug Tamiflu by Roche are a hindrance to patients whose lives are dependent on them.[19]
In December 2010, Sulston backed Julian Assange by acting as a bail surety for him, according to
Assange's attorney Mark Stephens.[41] Sulston forfeited £15,000 of the £20,000 pledged in June 2012, as
Assange had entered the embassy of Ecuador to escape the jurisdiction of the English courts.[42][43]
References
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2. Kimble, J. (2001). "The 2000 George W. Beadle Medal. John Sulston and Robert
Waterston" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461515). Genetics. 157 (2):
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ry.cam.ac.uk/handle/1810/252837). repository.cam.ac.uk (PhD thesis). University of
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4. John E. Sulston (https://www.nobelprize.org/laureate/752) on Nobelprize.org , accessed 11
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Worm" (https://www.nytimes.com/2018/03/15/obituaries/john-e-sulston-75-dies-found-clues-t
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22. Sulston, J.E.; Horvitz, H.R. (1977). "Post-embryonic cell lineages of the nematode,
Caenorhabditis elegans". Developmental Biology. 56 (1): 110–156. doi:10.1016/0012-
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37. Sulston, John (2002). The Common Thread (https://archive.org/details/commonthreadsto00
suls/page/22). Bantam. pp. 22 (https://archive.org/details/commonthreadsto00suls/page/22).
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38. "Our achievements" (https://www.cambridgeppf.org/about/#meettheteam). 10 May 2018.
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41. "Wikileaks' Julian Assange tells of 'smear campaign' " (https://www.bbc.co.uk/news/uk-1201
5140). BBC. 17 December 2010. Retrieved 21 April 2014.
42. Booth, Robert (8 October 2012). "Julian Assange supporters ordered to forfeit £93,500 bail
money" (https://www.theguardian.com/media/2012/oct/08/julian-assange-supporters-ordere
d-forfeit-bail). The Guardian.
43. "Julian Assange's backers lose £200,000 bail money" (https://www.telegraph.co.uk/news/wo
rldnews/wikileaks/9519767/Julian-Assanges-backers-lose-200000-bail-money.html). 4
September 2012.
External links
Freeview Video of Fredrick Sanger in conversation with John Sulston by the Vega Science
Trust (http://www.vega.org.uk/video/programme/18)
John Sulston profile from the Medical Research Council lab for Molecular Biology (https://ar
chive.today/20040118104822/http://www2.mrc-lmb.cam.ac.uk/archive/Sulston02.html)
John Sulston interviewed by Alan Macfarlane 16 September 2008 (video) (https://www.sms.
cam.ac.uk/media/1131145)
John E. Sulston (https://www.nobelprize.org/laureate/752) on Nobelprize.org
The public servant: John Sulston (http://news.bbc.co.uk/2/hi/in_depth/sci_tech/2000/human
_genome/753685.stm)
British Scientists share 2002 Nobel Prize (http://news.bbc.co.uk/2/hi/health/2305733.stm)
John Sulston: One man and his worm (https://www.theguardian.com/g2/story/0,3604,80711
0,00.html) from The Guardian
John Sulston profile (https://sites.google.com/site/staplefordonline/village-people) on the
Stapleford Cambridge website where he lives