‫مىــبرة التعلــيم الصــيدلي فـــي مصــر ومحيطــهب اإلقليـــمي‬

‫أول كلية صيدلة معتمدة مه الهيئة القىمية لضمبن جىدة التعليم واالعتمبد‬

‫ﻧﻣﺎذج أﺳﺋﻠﺔ ﻣﻘررات اﻟﻣﺳﺗوى اﻟراﺑﻊ‬

‫‪Kasr El-Ainy Street, Cairo 11562, Egypt‬‬ ‫شبرع قصر العيىي – القبهرة ‪ – 66511‬جمهىرية مصر العربية‬

‫‪Tel.\Fax: (00202) 3628426‬‬ ‫ت‪/‬فبكس‪)00101(3114811:‬‬

 ‫مىــبرة التعلــيم الصــيدلي فـــي مصــر ومحيطــهب اإلقليـــمي‬
‫أول كلية صيدلة معتمدة مه الهيئة القىمية لضمبن جىدة التعليم واالعتمبد‬

Pharmacology iv POC704
The following is true about sucralfate EXCEPT:

a. It can be used alone for treatment of peptic ulcer

b. It is preferred over H2 antagonists as it acts through a physical

mechanism of action
c. It cannot be taken with antacids

d. The presence of food significantly reduces its effectiveness

2-……….Is the DMARD of choice for RA patients with hepatitis C

a. MTX
b. Hydroxychloroquine
c. Infliximab
d. Sulfasalazine
e. B or D
3- …….. is preferred for prophylaxis of menstrual associated migraines
a. Galcanezumab
b. Frovatriptan
c. Valproate
d. Propranolol
e. Any of the above

4- …….. is the preferred contraceptive for a hypertensive female:

a. Injectable medroxyprogesterone acetate
b. Oral EE and levonorgestrel
c. Transdermal EE and etenogestrel
d. Vaginal EE and etenogestrel

5. Which of the following topical β-blockers causes less exacerbation of

pulmonary disease?
a. Betaxolol
b. Carteolol
C. Tomolol
D. Levobunolol

Kasr El-Ainy Street, Cairo 11562, Egypt ‫ – جمهىرية مصر العربية‬66511 ‫شبرع قصر العيىي – القبهرة‬

Tel.\Fax: (00202) 3628426 )00101(3114811:‫فبكس‬/‫ت‬

 ‫مىــبرة التعلــيم الصــيدلي فـــي مصــر ومحيطــهب اإلقليـــمي‬
‫أول كلية صيدلة معتمدة مه الهيئة القىمية لضمبن جىدة التعليم واالعتمبد‬

Medical Microbiology PMC704

T/F
Viruses can infect human, animal and plant cells.
All viruses have an envelope made of phospholipid membrane for extra protection.
Catheters can increase the risk of urinary tract infections.
Leptospira spread to humans from animals carrying the spirochete.
It is very difficult to establish a vaccine for HIV.
Streptococcus mutans is present as normal flora in central nervous system.
All hepatitis viruses belong to the same family.
Diagnosis of kissing disease is based on the presence of abnormally enlarged cells “Owl’s eye”.
The prodromal period is a short time of generalized, mild symptoms that precedes illness.
Detection of IgM antibody indicates a current infection.

MCQ
To dissolve blood clots and spread to new locations, Staphylococcus aureus
produce
A Coagulase B Hyaluroindase
C Staphylokinase D Lipase
E Beta-Lactamase

Fungal infections known as ring worm or tinea can occur in

A Scalp B Nails
C Groin and buttocks D A and B
E A, B and C

Neisseria gonorrhoeae has all of the following except

A Fimbriae B Spores
C Capsule D Endotoxin
E Protease

Lyme disease, during its latter phase, is treated with:

A Antibacterial drugs. B Antiviral drugs.
C Anti-inflammatory drugs. D Nucleotide analogs.

Spiny spores are seen with

A Histoplasma capsulatum B Bacillus anthraces
C Streptococcus pneumoniae D All of the above

Kasr El-Ainy Street, Cairo 11562, Egypt ‫ – جمهىرية مصر العربية‬66511 ‫شبرع قصر العيىي – القبهرة‬

Tel.\Fax: (00202) 3628426 )00101(3114811:‫فبكس‬/‫ت‬

 ‫مىــبرة التعلــيم الصــيدلي فـــي مصــر ومحيطــهب اإلقليـــمي‬
‫أول كلية صيدلة معتمدة مه الهيئة القىمية لضمبن جىدة التعليم واالعتمبد‬

Drug Information PPC704

Q1. Choose the correct answer
1) Primary sources of literature include
a) Textbooks b) databases c) research articles d) review articles
2) Causes of research flaws include all of the following except
a) Investigators’ bias b) Investigators’ incompetence c) Pressure to publish d) limited
funding e) none of the above
3) Research can be classified according to its time orientation into
a) Observational or interventional b) descriptive or experimental c) prospective or
retrospective d) all of the above e) none of the above
4) When comparing the means of more than two groups, which statistical test would you
use
a) ANOVA b) unpaired t test c) odds ratio d) Chi square test e) Fisher’s exact test
Q2. Put true or false
1) The abstract is the first part of the research paper and represent its summary ( )
2) Cohort studies start with choosing subjects having the effect of interest ( )
3) Type II error occur while erroneously accepting the null hypothesis ( )
4) Cost utility analysis compares QUALY ( )
Q3. Write short notes about
1) Enumerate the different types of control group in research
Q4. Complete the following
1) The researchers comment on their research findings in the …………… section of the
paper
2) Relative risk= ………………..………÷ ………………………
3) If the 95% CI of proportions contains ………………….. , the difference between study
groups is considered statistically non-significant

Kasr El-Ainy Street, Cairo 11562, Egypt ‫ – جمهىرية مصر العربية‬66511 ‫شبرع قصر العيىي – القبهرة‬

Tel.\Fax: (00202) 3628426 )00101(3114811:‫فبكس‬/‫ت‬

 Sample questions for Medicimal Chemistry 1 (PCC708)

A] Choose one best answer:

1) In the structure of telithromycin, the group responsible for hepatotoxicity is

2) Regarding piroxicam, the ……..moiety represents the acidic moiety essential for COX
inhibition.
a. Enol
b. Sulphonamide
c. Carboxamide
d. Pyrimidine

3) A non-steroidal drug containing triazole ring used to treat estrogen dependent breast
cancer:
a- Letrozole.
b- Tamoxifen.
c- Estramustine NaPO4.
d- DES.
B] Complete the following:

1) Redraw the structure as requested:

OH
a more active anti-TB drug
Br

N OCH3

2) Mention the mechanism of action of the following drug

3) Draw the main active metabolite for the following drug and write its name:
 ‫منــارة التعلــيم الصــيدلي فـــي مصــر ومحيطــها القليـــمي‬
‫أول كلية صيدلة معتمدة من الهيئة القومية لضمان جودة التعليم‬
‫والعتماد‬

Course Code: --PTC 707--------------

Course Name: --ADVANCED CONTROLLED DRUG DELIVERY SYSTEM

Objective Questions
1.Which of the following materials is commonly used in the fabrication of
biodegradable microspheres for drug delivery?

A( Polyethylene glycol
B( Poly)lactic-co-glycolic acid( )PLGA(
C( Polystyrene
D( Polyvinyl chloride
E( Gelatin

2.In the context of nanoparticle drug delivery systems, which characteristic

is most important for cellular uptake?

A( Surface charge
B( Drug loading capacity
C( Molecular weight of the drug
D( Hydrophobicity
E( Color of the nanoparticles

3.What is the primary mechanism of drug release from a hydrogel-based

controlled release system?

A( Erosion of the matrix

B( Diffusion through the matrix
C( Osmotic pressure
D( Chemical degradation
E( Temperature-induced phase transition

Kasr El-Ainy Street, Cairo 11562, Egypt ‫ – جمهورية مصر العربية‬11562 ‫شارع قصر العيني – القاهرة‬
Tel.\Fax: (00202) 3628426 )00202(3628426:‫فاكس‬/‫ت‬
 ‫منــارة التعلــيم الصــيدلي فـــي مصــر ومحيطــها القليـــمي‬
‫أول كلية صيدلة معتمدة من الهيئة القومية لضمان جودة التعليم‬
‫والعتماد‬

Subjective Questions

1.Discuss the advantages and disadvantages of using liposomes as a drug

delivery system. Include at least three points for each.

2.Explain the concept of "targeted drug delivery" and describe at least two
different strategies employed to achieve targeted delivery in advanced drug
delivery systems.

3. Evaluate the role of polymer-based systems in controlled drug delivery.

Discuss their properties that make them suitable for this application.

4. Evaluate the role of stimuli-responsive materials in drug delivery systems.

Provide examples of different stimuli that can be used and discuss the
potential benefits and challenges associated with these systems.

Kasr El-Ainy Street, Cairo 11562, Egypt ‫ – جمهورية مصر العربية‬11562 ‫شارع قصر العيني – القاهرة‬
Tel.\Fax: (00202) 3628426 )00202(3628426:‫فاكس‬/‫ت‬
 ‫منــارة التعلــيم الصــيدلي فـــي مصــر ومحيطــها اإلقليـــمي‬
‫أول كلية صيدلة معتمدة من الهيئة القومية لضمان جودة التعليم‬
‫واالعتماد‬

Final Exam Sample Questions for

Biopharmaceutics and Pharmacokinetics
Course Code PTC708, PT809, PT609
Question I: Choose the best answer for the following statements.
1. A drug was given as an intravenous bolus to a 70 Kg patient in a dose of 80 mg. The elimination
follows first-order kinetics. Two hours after drug administration, the concentration was found to be
1.48 µg/mL. Four hours after administration, the drug concentration was 0.74 µg/mL. What is the
initial plasma drug concentration directly after the injection?

a) 1.9 µg/mL b) 2.9 µg/mL

c) 3.9 µg/mL d) 4.9 µg/mL e) none of the above

2. A drug was given in an intravenous dose of 2.29 mg/Kg to a 70 Kg patient. The drug follows a
two-compartment model with an equation describing its kinetics as follows:

Cp = 8.2 e -3.45t + 2.5 e - 0.049t

What is the plasma level after 5 hours of the IV dose?

a) 2.368 µg/mL b) 1.968 µg/mL
c) 4.689 µg/mL d) 5.142 µg/mL
e) 10.254 µg/mL

3. Steady state concentration is reached when:

a. The infusion is stopped
b. The rate of infusion equals the rate of elimination
c. Two hours after the infusion is started.
d. The drug has a short half-life.
e. All of the above.

4. Drug A is a weak acid pka 6.4 with a partition coefficient of 2.06. Drug B is also a weak acid pka
6.4 and has a partition coefficient of 0.89
-According to the pH partition hypothesis, which of the following will be true about the absorption of
these two drugs from the stomach
a-absorption of Drug A > drug B
b-absorption of Drug A = drug B
c-Absorption of Drug b< drug a
d-Only drug A will be absorbed from the stomach
e-Neither drug will be absorbed from the stomach
 ‫منــارة التعلــيم الصــيدلي فـــي مصــر ومحيطــها اإلقليـــمي‬
‫أول كلية صيدلة معتمدة من الهيئة القومية لضمان جودة التعليم‬
‫واالعتماد‬

5. Plasma samples from a patient were collected after an oral dose of 10 mg benzodiazepine solution.
The equation that describes the plasma drug concentration was found:
Cp (ng/ml) = 60 (e - 0.1t _ e - 0.3t) Assuming that the drug is 80% absorbed and that first-order rate
constants for absorption and elimination are in hr -1 , Find the time to reach peak plasma concentration
a. 4.59 h
b. 5.97 h
c. 5.49 h
d. 9.54 h
e. 9.45 h

Question II: Complete the following sentence.

1. Lag time appears on the………………………

2. In the simple diffusion……………………is never attained
3. Small molecular weight drugs can diffuse paracellularly into the cell membrane
through………………..
4. ………………… forms a poorly absorbable complex with Phenytoin when it was used as
diluent whereas replacing it with ………………. resulted in an improved bioavailability
of the same drug.
5. Steady state concentration is reached when the rate of infusion is equal…………………