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customized Drug Delivery System

The document discusses customized drug delivery systems, emphasizing personalized medicine tailored to individual patient needs. It covers various tools such as 3D printing, telepharmacy, and bioelectronic systems that enhance drug delivery and patient care. The advantages of these systems include improved drug efficacy, reduced clinical trial costs, and better patient-drug matching.

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kingkrishi20
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8 views

customized Drug Delivery System

The document discusses customized drug delivery systems, emphasizing personalized medicine tailored to individual patient needs. It covers various tools such as 3D printing, telepharmacy, and bioelectronic systems that enhance drug delivery and patient care. The advantages of these systems include improved drug efficacy, reduced clinical trial costs, and better patient-drug matching.

Uploaded by

kingkrishi20
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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CUSTOMIZED DRUG

DELIVERY SYSTEM
KRISHI PATEL 24MPH010
DEPT. OF PHARMACEUTICES, NIRMA UNIVERSITY
CONTENT
◦ Customized drug delivery
◦ 3D printing of pharmaceuticals
◦ Tele pharmacy
◦ Bioelectronic system
◦
CUSTOMIZED DRUG DELIVERY
◦ It is also termed Personalized drug delivery systems (PDDS).
◦ Personalized medicine is the tailoring of medical treatment to the individual
characteristics of each patient.
◦ Drug delivery system that are designed to release the drug as per the need of the
individual or specific patient.
◦ Therapy with the right drug at right dosing in the right patient.
◦ Ability to look at a patient on an individual basis will allow for a more accurate
diagnosis and specific treatment plan.
◦ Customized medicines is prepared based on each patients medical history, needs,
genetic, health condition and other factors.
◦
CUSTOMIZED DRUG DELIVERY
Personalized Medicine Is...
◦ Personalized medicine is a multi-faceted approach to patient care that not only
improves our ability to diagnose and treat disease but offers the potential to detect
disease at an earlier stage when it is easier to treat effectively.
◦ Risk assessment
• Prevention
• Detection
• Diagnosis
• Treatment
• Management
Advantages of customized drug
delivery system
◦ Better matching patients to drugs instead of "trial and error".
◦ Eliminate life-threatening adverse reaction.
◦ Reduce cost of clinical trials by quickly identifying total failures and favourable
response for particular backgrounds.
◦ Improved efficacy of drugs.
◦ Dosage can be controlled for the patients who need lower doses or with the needs of
each individual patient.
TOOLS TO CUSTOMIZED DRUG
DELIVERYSYSTEM

◦ 3D PRINTING
◦ TELEPHARMACY
◦ BIOELECTRONIC DEVICES
3D PRINTING
3D PRINTING
◦ The process of making three-dimensional solid object from a digital file by layer-to-layer
fabrication.
◦ It include wide variety of manufacturing technologies which are all based on digitally
controlled depositing of materials to create free-form geometries.
◦ This method extensively used in field of biomanufacturing(specially for bone and tissue
engineering).
◦ 3D printing can be used for personalized or unique dosage forms, more complex drug
release profile, and printing living tissue.
ADVANTAGES OF 3D PRINTING
◦ High production rate due to its fast-operating systems.
◦ Ability to achieve high drug loading with much desired precision and accuracy
especially for potent drugs that are applied in small doses.
◦ Reduction of material wastage which can save the cost of production.
◦ An ability to broad types of pharmaceutical active ingredients including poorly water
soluble, peptides and proteins, as well as drug with narrow therapeutic windows.
Current 3D printing technologies
INKJET PRINTING THERMAL INKJET PRINTING FUSED DEPOSITION
MODELING
◦
TELE PHARMACY
◦ Tele pharmacy is the delivery of pharmaceutical care via
telecommunications to patients.
◦ Tele pharmacy service includes drug monitoring therapy, patient counselling, authorize
for prescription drugs.
◦ Also used for video conferencing in Pharmacy for providing education, training, to
pharmacy staff
◦ Remote dispensing of medications by automated packaging and labelling systems
can also be through of as an instance of tele pharmacy.
◦ Tele pharmacy services can be delivered at retail pharmacy sites.
TYPES OF TELE PHARMACY
1. INPATIENT (remote order entry review)
Inpatient tele pharmacy refers to a pharmacist at a remote location performing
remote order-entry services for an inpatient pharmacy at a hospital. The remote
pharmacist reviews medication orders before the hospital staff administers the
drugs to the patient.

• With inpatient tele pharmacy, remote pharmacists are able to provide 24/7 coverage
to strengthen pharmacy.
• Remote order-entry review in a health system serves as an extension of the in-
house pharmacy.
2. Remote dispensing (retail/outpatient/discharge)
A remote-dispensing site, or retail community tele pharmacy, is a licensed brick-and-
mortar pharmacy staffed by a certified pharmacy technician. A pharmacist supervises
the technician, reviews prescriptions and performs his or her duties from a remote
location via technology.

• Typically used in retail community pharmacy and outpatient/ discharge pharmacy


settings, tele pharmacy gives patients convenient access to a pharmacist and
prescription medication.
• Remote dispensing allows healthcare organizations to open retail tele pharmacy sites
in areas where a traditional pharmacy would not be feasible by sharing the cost of a
pharmacist across multiple stores.
3. Remote counselling
Remote- patient counselling equates to pharmacists providing patient counselling and
interactive video session, or by some means through telecommunications.

• Remote-patient counselling allows pharmacists to consult and provide a variety of


pharmacy-care services to patients via secure, live video calls. Beyond being
beneficial to retail independents, community, clinic and hospital-based pharmacies.
• Remote counselling also provides opportunities for discharge counselling and various
clinical interactions with pharmacists.
BIOELECTRONIC
SYSTEM
Bioelectronic is the application of
electronic devices to living organisms
for clinical testing diagnosis and
therapy.
DEFINITION
◦ Bio electronic medicines are a tiny
implanted device treating disease by
changing the electric pulses in nerves to
and from specific organs.
◦ The vision for bio electronic medicines is
one of miniature, implantable devices
that can be attached to individual
peripheral nerves.
◦ Such devices will be able to decipher and
modulate neural signalling patterns,
achieving therapeutic effects that are
targeted at single functions of
specific organs.
HEART PACEMAKER
◦ A pacemaker is a small, battery-powered device that
prevents the heart from beating too slowly. You need
surgery to get a pacemaker. The device is placed
under the skin near the collarbone.
◦ The heart's electrical system typically controls the
heartbeat. Electrical signals, called impulses, move
through the heart chambers. They tell the heart when
to beat.
◦ A pacemaker only works when it senses trouble with the
heartbeat. For example, if the heart beats too slowly,
the pacemaker sends electrical signals to correct the
beat.
◦ Some pacemakers can increase the heartbeat as
needed, such as during exercise.
◦
ASTHMA
The device is attached to
a pulmonary nerve to
potentially block the
signals that cause the
lungs to constrict.
REFERENCES
◦ 3d printing of pharmaceuticals edited by Abdul w. Basit, Simon Gaisford Advances in
the pharmaceutical science series 31 springer publication
◦ 3D printing & pharmaceutical Manufacturing Opportunities & challenges International
Journal of Bioassays
◦ Assraa H., Jassim J., Moses O. "3D Printing Technology in Pharmaceutical Drug Delivery:
Prospects and Challenges." Journal of Biomolecular Research and Therapeutics.
4(4);2-6.
◦ Stratified, personalised or P4 medicine: a new direction for placing the patient at the
centre of healthcare and health education.
◦ Birmingham K., Gradinaru V., Anikeeva P., Warren m., Pikov V. "Bioelectronic medicines:
a research roadmap." Nature reviews/Drug discovery 2014. vol 13:339-400.
THANK YOU

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