Immunodeficiency Disorders

Immunodeficiency
disorders
Dr. Mehzabin Ahmed

Immuno deficiency Diseases:
Classification
1) Primary immuno deficiency
2) Acquired immuno deficiency

Primary immuno deficiency diseases
 May affect one or multiple components of the immune system

including B cells, macrophages, NK cells and complement
 they are characterized by
 increased susceptibility to infection,
 ↑ incidence of autoimmunity and malignancy.
E.g.: B cells - X- linked agamma globulinemia common variable

deficiency.
T cells - Di George's syndrome
B&T cells - Severe combined immuno deficiency
Complement - Defects in specific complement components.
Acquired immuno deficiency
 A variety of agents including drugs, irradiation, and ultraviolet

light can produce acquired immuno deficiency.
 However, chronic infection with HIV, which causes acquired
immuno deficiency is very important.
 HIV binds to the surface glycoprotein GP 120 on the T helper
cells. The expression of CD4 allows this binding
 entry of virus is facilitated by chemokine receptors such as CCR5
- CCR2
 persistent infection follows and the continuous deletion of CD4+
T cells and accompanying destruction of cytotoxic T lymphocyte
and B lymphocytes results in host becoming more susceptible to
opportunistic infections.
HIV infection
 Mode of spread is by sexual contact, Parental inoculation (infected
syringes & needles) and from mother to child (vertical transmission)
 HIV binds to CD4 receptors on helper T cells.
 It gets internalized and after reverse transcription gets integrated into host
genome and
 may remain latent for months to years or
 may form complete viral particles that may bud off the cell membrane.
 Extensive budding leads to cell death.
 Along with this method of T cells loss, apoptosis of normal or uninfected

CD4+ T cells occurs. Thus there is a rapid T cell depletion.
 In addition to T cells, monocytes and macrophages, which also carry the
CD4 molecules, are infected.
 They serve as reservoirs of the virus and to transport the virus to the
nervous system.
 In the late stages, when T cells numbers decline rapidly, these
macrophages are the sites of continued viral replication.

Stages of HIV infection: 3 stages
1) Acute, viraemic stage:
 Viraemia, and infection of Lymphnodes,
 lasts for 6-12 weeks.
 Virus specific immune response by cytotoxic CD8+ T cells occurs which results
in seroconversion.
2) Chronic, latent phase:
 Virus replication continues along with a gradual decline of CD4+ counts
 may last from 7-10 years.
3) Final, crisis phase:
 Rapid decline of CD4+ T cells weight loss, diarrhoea, opportunistic infections,
and secondary neoplasms.
 patients with CD4+ T cells counts less than 200 /ml. are having AIDS even if
clinical features are not seen.
 Acquired Immuno - deficiency syndrome caused by HIV - I.
 It is characterized by
 profound suppression of T cell - mediated immunity,
 opportunistic infections,
 secondary neoplasms and
 neurologic disease.
AIDS
Opportunistic infections:
 Candida, cytomegalovirus, Mycobacteria, cryptococcus,
Toxoplasma, herpes, histoplasma, and pyogenic bacteria can
cause severe infections in an immunocompromised patient.
Neoplasms:
 Kaposi’s sarcoma and B- Cell, Non-Hodgkin's lymphoma are
found to occur with an increased frequency in these patients.
CNS:
 Acute aseptic meningitis, Myelopathy, Peripheral neuropathy,
Encephalopathy - AIDS dementia complex affected the CNS
function in AIDS patients.
 Year mortality rate in AIDS = 85%
 Longer period - 100%.

Treatment
 Anti-HIV (also called antiretroviral) medications are used to control the
reproduction of the virus and to slow or halt the progression of HIV-
related disease
 Four classes of these anti HIV drugs:
1. Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs), bind to and block
the action of reverse transcriptase, a protein that HIV needs to reproduce.
2. Nucleoside Reverse Transcriptase Inhibitors (NRTIs), are faulty versions of
building blocks that HIV needs to make more copies of itself. When HIV
uses an NRTI instead of a normal building block, reproduction of the virus is
stalled.
3. Protease Inhibitors (PIs), disable protease, a protein that HIV needs reproduce
itself.
4. Fusion Inhibitors, are newer treatments that work by blocking HIV entry into
cells.

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Immunodeficiency

Dr. Mehzabin Ahmed

1) Primary immuno deficiency

2) Acquired immuno deficiency

 May affect one or multiple components of the immune system

E.g.: B cells - X- linked agamma globulinemia common variable

 A variety of agents including drugs, irradiation, and ultraviolet

 Extensive budding leads to cell death.

 Along with this method of T cells loss, apoptosis of normal or uninfected

macrophages are the sites of continued viral replication.

 secondary neoplasms and

 Longer period - 100%.

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