Nemia N Verview: By: Silky Ladia

ANEMIA : AN OVERVIEW
BY : SILKY LADIA
Definition of Anemia
 Deficiency in the oxygen-carrying capacity of the blood
due to a diminished erythrocyte mass.
 May be due to:

 Erythrocyte loss (bleeding)
 Decreased Erythrocyte production
 low erythropoietin
 Decreased marrow response to erythropoietin
 Increased Erythrocyte destruction (hemolysis)
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MEASUREMENTS OF ANEMIA
 Hemoglobin = grams of hemoglobin per 100 mL of whole blood (g/dL)
 Hematocrit = percent of a sample of whole blood occupied by intact red blood cells
 RBC = millions of red blood cells per microLt of whole blood
 MCV = Mean corpuscular volume
 If > 100 → Macrocytic anemia
 If 80 – 100 → Normocytic anemia
 If < 80 → Microcytic anemia
 RDW = Red blood cell distribution width
 = (Standard deviation of red cell volume ÷ mean cell volume) × 100
 Normal value is 11-15%
 If elevated, suggests large variability in sizes of RBC

LABORATORY DEFINITION OF ANEMIA
 Hgb:
 Women: <12.0
 Men: < 13.5
 Hct:
 Women: < 36
 Men: <41

SYMPTOMS OF ANEMIA
Decreased oxygenation
 Exertional dyspnea
 Dyspnea at rest
 Fatigue
 Bounding pulses
 Lethargy, confusion
Decreased volume
 Fatigue
 Muscle cramps
 Postural dizziness
 syncope
SPECIAL CONSIDERATIONS IN DETERMINING ANEMIA
Acute Bleed
 Drop in Hgb or Hct may not be shown until 36 to 48 hours after acute bleed (even
though patient may be hypotensive)
Pregnancy
 In third trimester, RBC and plasma volume are expanded by 25 and 50%,
respectively.
 Labs will show reductions in Hgb, Hct, and RBC count, often to anemic levels, but
according to RBC mass, they are actually polycythemic
Volume Depletion
 Patient’s who are severely volume depleted may not show anemia until after
rehydrated

RBC LIFE CYCLE
 In the bone marrow, erythropoietin enhances the growth of differentiation of burst

forming units-erythroid (BFU-E) and colony forming units-erythroid (CFU-E) into
reticulocytes.
 Reticulocyte spends three days maturing in the marrow, and then one day maturing in
the peripheral blood.
 A mature Red Blood Cell circulates in the peripheral blood for 100 to 120 days.
 Under steady state conditions, the rate of RBC production equals the rate of RBC loss.

CAUSES OF ANEMIA --
1) Erythrocyte Loss
 Bleeding
Chronic (gastrointestinal, menstrual)
Acute/Hemodynamically significant:
Gastrointestinal
Retroperitoneal
2) Low Erythropoietin
 Kidney Disease
 Normochromic, normocytic
 Low reticulocyte count
 Frequently, peripheral smear in uremic patients show
“burr cells” or echinocytes
ANEMIA DUE TO DECREASED RESPONSE TO ERYTHROPOIETIN
 Iron-Deficiency
 Vitamin B12 Deficiency
 Folate Deficiency
 Anemia of Chronic Disease
IRON DEFICIENCY ANEMIA

TREATMENT OF IRON DEFICIENCY ANEMIA
 Oral iron salts
 Ferrous sulfate – 325 mg per Day
 Side effects: constipation, black stools, positive
hemmo cult test
 Vitamin C can facilitate iron absorption.

TREATMENT OF VITAMIN B12 DEFICIENCY
 Vitamin B12 – 1000 micrograms intramuscularly monthly
-OR-
 Vitamin B12 – 1000-2000 micrograms po QDaily

TREATMENT OF FOLATE DEFICIENCY
 Folate – 1 to 5 mg po Qday
 Vit. B12 deficiency must be excluded in folate-
deficient patients, because supplemental folate can
improve the anemia of Vit. B12 deficiency but not
the neurologic sequelae.

ANEMIA IS A LABORATORY DIAGNOSIS
Men Women
Hemoglobin (g/dL) 14-17.4 12.3-15.3
Hematocrit (%) 42-50% 36-44%
RBC Count (106/mm3) 4.5-5.9 4.1-5.1
Reticulocytes 1.6 ± 0.5% 1.4 ± 0.5%
WBC (cells/mm3) ~4,000-11,000
MCV (fL) 80-96
MCH (pg/RBC) 30.4 ± 2.8
MCHC (g/dL of RBC) 34.4 ± 1.1
RDW (%) 11.7-14.5%

PHYSICAL EXAMINATION
 Pallor (may be jaundiced– think hemolytic)
 Tachycardia, bounding pulses
 Systolic flow murmur
 Glossitis
 Angular cheilosis
 Decreased vibratory sense/ joint position sense (B12 deficiency, w/

or w/o hematologic changes)
 Ataxia, positive Romberg sign (severe B12/folate deficiency)

PERCENTAGE DISTRIBUTION OF ANEMIC PATIENT IN
RURAL & URBAN INDIA


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ANEMIA : AN OVERVIEW

 May be due to:

 Decreased Erythrocyte production

 Decreased marrow response to erythropoietin

 Increased Erythrocyte destruction (hemolysis)

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 RBC = millions of red blood cells per microLt of whole blood

 MCV = Mean corpuscular volume

 If > 100 → Macrocytic anemia

 If 80 – 100 → Normocytic anemia

 If < 80 → Microcytic anemia

 RDW = Red blood cell distribution width

 = (Standard deviation of red cell volume ÷ mean cell volume) × 100

 Normal value is 11-15%

 If elevated, suggests large variability in sizes of RBC

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 Men: < 13.5

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 In the bone marrow, erythropoietin enhances the growth of differentiation of burst

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 Vitamin B12 Deficiency

 Anemia of Chronic Disease

IRON DEFICIENCY ANEMIA

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 Tachycardia, bounding pulses

 Systolic flow murmur

 Decreased vibratory sense/ joint position sense (B12 deficiency, w/

 Ataxia, positive Romberg sign (severe B12/folate deficiency)

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