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    Adaptive Immunity - 2

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    landpook
    This document discusses key aspects of adaptive immunity and antibodies. It covers CD molecules like CD4 and CD8, factors that influence antigen immunogenicity including foreignness and adjuvants, B-cell and T-cell epitopes, immunoglobulin structure and classes, and antigenic determinants on immunoglobulins. The roles of antibodies include opsonization, complement activation, and antibody-dependent cytotoxicity.

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    Adaptive Immunity - 2

    Uploaded by

    landpook
    22 views13 pages
    This document discusses key aspects of adaptive immunity and antibodies. It covers CD molecules like CD4 and CD8, factors that influence antigen immunogenicity including foreignness and adjuvants, B-cell and T-cell epitopes, immunoglobulin structure and classes, and antigenic determinants on immunoglobulins. The roles of antibodies include opsonization, complement activation, and antibody-dependent cytotoxicity.

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    Adaptive immunity presentation

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    This document discusses key aspects of adaptive immunity and antibodies. It covers CD molecules like CD4 and CD8, factors that influence antigen immunogenicity including foreignness and adjuvants, B-cell and T-cell epitopes, immunoglobulin structure and classes, and antigenic determinants on immunoglobulins. The roles of antibodies include opsonization, complement activation, and antibody-dependent cytotoxicity.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    22 views13 pages

    Adaptive Immunity - 2

    Uploaded by

    landpook
    This document discusses key aspects of adaptive immunity and antibodies. It covers CD molecules like CD4 and CD8, factors that influence antigen immunogenicity including foreignness and adjuvants, B-cell and T-cell epitopes, immunoglobulin structure and classes, and antigenic determinants on immunoglobulins. The roles of antibodies include opsonization, complement activation, and antibody-dependent cytotoxicity.

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    You are on page 1of 13

    ADAPTIVE IMMUNITY - 2

    • CD molecules
    • CD4
    • CD8
    Antigens
    • Immunogenicity versus antigenicity
    Contribution of the immunogen to
    immunogencity
    • Factors that influence immunogenicity
    • Foreignness
    • Molecular size
    • Chemical composition and heterogeneity
    • Susceptibility to antigen processing and
    presentation
    Contribution of biological system to
    immunogenicity
    • Genotype of recipient animal
    • Immunogen dosage and route of
    administration
    • Adjuvants
    B-Cell Epitopes
    • Soluble antigen
    • Hydrophilic mobile peptides containing
    sequential or nonsequential amino acids
    • Chemically there are Protein, polysaccharide,
    lipid
    • Involment of MHC molecule is not required
    • Involes binary complex of membrane Ig and
    Ag
    C-Cell Epitopes
    • Involes ternary complex of T-cell receptor, Ag
    , MHC molecule
    • No binding of soluble antigen
    • Required to display processed antigen
    • there is involvement of MHC molecule to display
    processed antigen
    • the chemical nature of antigen is mostly proteins but
    also some lipids and glycolipids presented on MHC
    molecule
    • there are internal linear peptides produced by
    processing of antigen and aoundto MHC molecule
    Immnoglobulins structure and
    function
    • Heavy-chain
    • Light-chain
    • Constant region
    • Variable region
    Immunoglobulin fine structure
    • Immunoglobluin domains
    • A loop of about 60 amino acids formed
    through intra chain disulfide bond
    • Light chains contain one variable domain and
    one constant domain
    • Heavy chains contain on variable domain 3 or
    4 constant domain
    Variable-Region domains
    • Hyper variable regions(complamentarity
    determining regions)
    • Framework regions
    Immunoglobulin class and biological
    acativities
    • Opsonization
    • Activation of complement
    • Antibody-dependent cell-mediated
    cytotoxicity(ADCC)
    Immunoglobulin classes
    • Immunoglobulin G
    • Immunoglobulin M
    • Immunoglobulin A
    • Immunoglobulin E
    • Immunoglobulin D
    Antigenic determinants on
    immunoglobulins
    • Isotype
    • Allotype
    • Idiotype
    Immunoglobulin superfamily and
    monoclonal antibodies

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