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    Preparation 13: Calcium Hydroxide Topical Solution

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    Danielle De Guzman
    The document describes the preparation of calcium hydroxide topical solution. Calcium hydroxide is slaked by adding water, then filtered and dissolved in purified water to form a clear, colorless topical solution. The solution is used in dermatological preparations as an astringent and protector in lotions. Proper storage in tightly sealed containers is needed to prevent absorption of carbon dioxide.

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    Preparation 13: Calcium Hydroxide Topical Solution

    Uploaded by

    Danielle De Guzman
    1K views60 pages
    The document describes the preparation of calcium hydroxide topical solution. Calcium hydroxide is slaked by adding water, then filtered and dissolved in purified water to form a clear, colorless topical solution. The solution is used in dermatological preparations as an astringent and protector in lotions. Proper storage in tightly sealed containers is needed to prevent absorption of carbon dioxide.

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    Pharmaceutical dosage preparation 13,14 and 15

    Original Title

    DFL E-13,14,15

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    The document describes the preparation of calcium hydroxide topical solution. Calcium hydroxide is slaked by adding water, then filtered and dissolved in purified water to form a clear, colorless topical solution. The solution is used in dermatological preparations as an astringent and protector in lotions. Proper storage in tightly sealed containers is needed to prevent absorption of carbon dioxide.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    1K views60 pages

    Preparation 13: Calcium Hydroxide Topical Solution

    Uploaded by

    Danielle De Guzman
    The document describes the preparation of calcium hydroxide topical solution. Calcium hydroxide is slaked by adding water, then filtered and dissolved in purified water to form a clear, colorless topical solution. The solution is used in dermatological preparations as an astringent and protector in lotions. Proper storage in tightly sealed containers is needed to prevent absorption of carbon dioxide.

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    You are on page 1of 60

    PREPARATION 13

    CALCIUM HYDROXIDE TOPICAL SOLUTION

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Solution
     Liquid preparation that contain
    one or several soluble chemical
    substance dissolve in suitable
    solvent or mixture of mutual
    miscible liquids

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     2 Components
     Solute
     One that is being dissolved

     Solvent
     one that dissolves

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Method of Preparation
    1. Simple Solution
     prepared by dissolving the
    solute in a suitable solvent
     Examples: NaCl solution, Strong
    Iodine Solution

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Method of Preparation
    2. Solutions by Chemical Reaction
     prepared by reacting two or
    more solute with each other in a
    suitable solvent
     Examples: Aluminum subacetate
    solution, Magnesium citrate
    solution, Sulfurated lime solution
    By: Nelson T. Tubon
    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Method of Preparation
    3. Solution by Distillation
     if the solute is a volatile oil

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Method of Preparation
    4. Solution by Extraction
     Drug or pharmaceutical
    necessities of vegetable or
    animal origin
     Also called extractives

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

    Methods of Extraction
     Maceration
     Percolation
     Digestion
     Infusion
     Decoction

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Category
     Topical Solution

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Synonyms
     Lime water

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Description of Final Product


     Clear, colorless solution with
    an alkaline taste

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Use/s
     employed with other ingredients
    in dermatological solution and
    lotion
     as protector in lotion preparation
    and an emulsifying agent

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Formulation
    Ingredients OA CA

    Calcium Hydroxide 3g

    Purified water, qs ad 1000 mL 30 mL

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Computations

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Procedure
     Slake CaO (addition of water with the
    liberation of heat to form a crumbly material in
    mortar/beaker) covered with watch glass
    Xg 0.09 g
     CaO + H2O  Ca(OH)2 + CO2  CaCO3
     MW 56g/n MW 74g/n

     xg : 56g/n:: 0.09g: 74g/n X= 0.07 g CaO

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Procedure
     Let stand for 5 minutes
     Add cold water and agitate for 1
    hour to dissolve completely the CaO
     Filter collect only the supernatant
    liquid.

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Procedure
     Add sufficient amount of cold
    water up to the brim of the
    container (no bubbles inside)
     A clear, colorless solution should
    be achieved

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Label
     Red Label

     Container
     30 mL flint bottle

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Remarks
     The method preparation was simple
    method
     Undissolved portion is not suitable for
    preparation of additional quantity of
    Ca(OH)2 soln. to ensure saturated
    soln.
     Bottle should be filled up to the brim

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Remarks
     The solution should be stored in well-
    filled, tightly stoppered containers
    to deter the absorption of CO2 and
    should be kept in a cool place to
    maintain an adequate concentration of
    dissolved solute.

    By: Nelson T. Tubon


    PREPARATION 13
    CALCIUM HYDROXIDE TOPICAL SOLUTION

     Remarks
     The solution is categorized as an
    astringent.
     For this purpose it is generally
    employed in combination with
    other ingredients in dermatologic
    solutions and lotions to be
    applied.
    By: Nelson T. Tubon
    PREPARATION 14
    STRONG IODINE SOLUTION

    By: Nelson T. Tubon


    PREPARATION 14
    STRONG IODINE SOLUTION

     Category
     Topical Solution

    By: Nelson T. Tubon


    PREPARATION 14
    STRONG IODINE SOLUTION

     Synonyms
     Lugol’s solution
     Iodine Potassium Iodide
     Liquor iodi
     Aqueous Iodine Solution

    By: Nelson T. Tubon


    PREPARATION 14
    STRONG IODINE SOLUTION

     Description of Final Product


     A liquid with a deep brown
    color and odor of iodine

    By: Nelson T. Tubon


    PREPARATION 14
    STRONG IODINE SOLUTION

     Use/s
     treatment of thyrotoxicosis
     antigoiterogenic
    Germicidal and fungicidal
     antiseptic
     keratolytic

    By: Nelson T. Tubon


    PREPARATION 14
    STRONG IODINE SOLUTION

     Formulation
    Ingredients OA CA

    Iodine 50 g

    KI 100 g

    Purified water, qs ad 1000 mL

    By: Nelson T. Tubon


    PREPARATION 14
    STRONG IODINE SOLUTION

     Computations

    By: Nelson T. Tubon


    PREPARATION 14
    STRONG IODINE SOLUTION

     Procedure
     Dissolve KI in 3mL of water
     Add iodine to the mixture
     Add sufficient amount of water

    By: Nelson T. Tubon


    PREPARATION 14
    STRONG IODINE SOLUTION

     Label
     Red Label

     Container
     30 mL amber bottle

    By: Nelson T. Tubon


    PREPARATION 14
    STRONG IODINE SOLUTION
     Remarks
     The method of preparation
    used was simple solution
     In weighing the iodine crystals,
    use porcelain spatula instead of
    stainless because it reacts with
    metal
     KI is used as solubilizing agent
    By: Nelson T. Tubon
    PREPARATION 15
    MAGNESIUM CITRATE

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE

     Category
     Saline Cathartic

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE
     Synonyms
     Citrate
     Citrate of magnesia
     Magnessi citralis
     Lemonada purgante

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE

     Description of Final Product


     It is a colorless to slightly
    yellow, clear effervescent liquid
    having a sweet acidulous taste
    and a lemon flavor.

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE

     Use/s
     saline cathartic

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE

     Formulation
    Ingredients OA CA

    MgCO3 15 g

    Anhydrous Citric acid 27.4 g

    Syrup 60 mL

    Talc 5 .0 g

    Lemon oil 0.1 mL

    KHC03 2.5 g

    Purified water qs ad 350.0 mL 50 mL


    PREPARATION 15
    MAGNESIUM CITRATE

     Computations

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE

     Procedure
     Calibrate the bottle first (Mark the
    level of 50mL distilled water)
     Dissolve citric acid in 21 mL water
     Mix (MgCO3)4 . Mg(OH)2 . 5H2O in
    14 mL of water (another container)

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE

     Procedure
     Mix (MgCO3)4 . Mg(OH)2 . 5H2O solution
    with citric acid. (2 & 3) Stir until it is totally
    dissolved
     (MgCO3)4 . Mg(OH)2 . 5H2O 
    Magnesium Carbonate

    C6H8O7  Mg3(C6H5O7) + 4CO2 + 11 H2O


    Citric acid Magnesium Citrate

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE

     Procedure
     Add syrup as a sweetening agent
    and heat mixture to boiling (1-2
    minutes)

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE

     Procedure
     Mix lemon oil with talc
     Mix 6 and 5
     Filter the preparation while hot
    into the sterilized and calibrated
    bottle

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE

     Procedure
     Add water until it becomes 50 mL
     Stopper using cotton. Let it cool in
    running water
     Add KHCO3

     3KHCO3 + C6H8O7  K3C6H5O7 + 3CO2 + 3H2O

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE

     Procedure

     Stopper with cork right away to


    trap the gas. Let the bottle lie down
    to wet and expand the cork.

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE

     Label
     white Label

     Container
     120 mL wide mouth flint bottle

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE
     Remarks
     The method of preparation
    used was chemical reaction
     Sterilizing the bottle is done to
    prevent the growth of
    microorganism

    By: Nelson T. Tubon


    PREPARATION 15
    MAGNESIUM CITRATE
     Remarks
     Magnesium citrate soln. has always been a
    troublesome because it has a tendency to
    deposit a crystalline solid upon standing. This is
    due to the formation of some almost insoluble
    normal Mg citrate.
     The cause of the problem has largely attributed
    to the indefinite composition of the official
    MgCO3 which by definition is a basic hydrated
    MgCO3 or a normal hydrated MgCO3.
    (equation on p. 351 – Ansel).
    By: Nelson T. Tubon
    PREPARATION 15
    MAGNESIUM CITRATE
     Remarks
     The solution provides an excellent medium for
    the growth of molds, and any mold spores
    present during the manufacture of the solution
    must be killed it the preparation is to remain
    stable.
     for this reason: during the preparation  liquid
    is heated to boiling (prior to carbonation); boiled
    water is employed to bring the solution to its
    proper volume; boiling water is used to rinse the
    final container; final solution maybe sterilized
     Sterilize the bottle  to prevent contamination
    By: Nelson T. Tubon
    PREPARATION 15
    MAGNESIUM CITRATE
     Remarks
     Mg citrate solution is stored in a
    cold place, preferably in a
    refrigerator, keeping the bottle on its
    side so the cork or rubber liner of the
    cap is kept moist or swollen, thereby
    maintaining the airtight seal between
    the cap and the bottle

    By: Nelson T. Tubon


    PREPARATION 15
    DAKIN’S SOLUTION

    By: Nelson T. Tubon


    PREPARATION 15
    DAKIN’S SOLUTION

     Category
     Solution

    By: Nelson T. Tubon


    PREPARATION 15
    DAKIN’S SOLUTION
     Synonyms
    Sodium Hypochlorite Solution

    By: Nelson T. Tubon


    PREPARATION 15
    DAKIN’S SOLUTION

     Description of Final Product


     It is clear, light yellow solution
    with the characteristic odor of
    chlorine

    By: Nelson T. Tubon


    PREPARATION 15
    DAKIN’S SOLUTION

     Use/s
     disinfectant
     antiseptic

    By: Nelson T. Tubon


    PREPARATION 15
    DAKIN’S SOLUTION

     Formulation
    Ingredients OA CA

    Chlorox 5.25% 95 mL

    Sodium Bicarbonate 27.4 g

    Clear Tap water, qs ad 946 mL

    By: Nelson T. Tubon


    PREPARATION 15
    DAKIN’S SOLUTION

     Computations

    By: Nelson T. Tubon


    PREPARATION 15
    DAKIN’S SOLUTION

     Procedure
     Measure 30 mL of tap water
     Boil for 15 minutes in a water
    bath. (The container must be
    half closed)
     Add 0.1 g of NaHCO3

    By: Nelson T. Tubon


    PREPARATION 15
    DAKIN’S SOLUTION

     Procedure
     Add 3 mL of bleach
     Place solution in a sterile container.
    Close the lid tightly and cover the
    entire container with aluminum foil to
    protect from light

    By: Nelson T. Tubon


    PREPARATION 15
    DAKIN’S SOLUTION

     Label
     red Label

     Container
     sterile narrow mouth amber
    bottle covered with aluminum
    foil
    By: Nelson T. Tubon
    PREPARATION 15
    DAKIN’S SOLUTION
     Remarks
     The expiry date of the solution is
    30 days after it has been
    compounded
     The solution must be discarded
    48 hours after it has been opened
     It must be stored at room
    temperature
    By: Nelson T. Tubon

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