Anti Anxiety Agents

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ANTI-ANXIETY AGENTS

N O VA S O U T H E A S T E R N U N I V E R S I T Y
ASSAF COLLEGE OF NURSING
NUR 3191: PHARMACOLOGIC BASIS FOR
N U R S I N G I N T E RV E N T I O N S I
NEURONS

• Respond to stimuli

• Conduct electrical impulses

• Release neurotransmitters
LIFE OF
NEUROTRANSMITTER

• Current reaches end of cell;


• Neurotransmitter released;
• Attaches to receptor;
• Stimulates or inhibits activity;
• Separates from receptor destroyed.
NEUROTRANSMITTERS

• Role in human behavior and emotions


• Mechanism of action in most psychotrophic drugs.
• Convey impulses across the synapse.
• Chemical messengers of the brain.
• Many exists in CNS and Peripheral Nervous System (PNS)
ANTIANXIETY AGENTS
(ANXIOLYTICS)

Benzodiazepines Barbiturates Antihistamnes

Beta Blockers Buspirone


MECHANISM OF ACTION
Benzodiazepines:
• Increases neurotransmitters GABA
• Preference for limbic system
• Depresses CNS
• Produces skeletal muscles relaxation
• Anticonvulsant properties
BENZODIAZEPINES

Indications for use:


• Short term treatment of anxiety
• Treatment of seizure disorder
• Useful in the acute stage of panic
BENZODIAZEPINES
• chlordiazepoxide (Librium)
• clonazepam (Klonopin)
• diazepam (Valium Serax)
• oxazepam (Serax)
• clorazepate (Tranxene)
• lorazepam (Ativan)
• prazepam (Centrax)
• alprazolam (Xanax)
ADVERSE EFFECTS

• Central nervous system


• Hypotension
• Paradoxical reactions
• Hyperactivity and aggressive behavior
• Habit-forming and addictive
• Xanax (Alpraolam), Valium (diazepam), and Ativan
(Lorazepam) should only be used short-term. Dependence and
tolerance develop quickly.
• Signs and symptoms of withdrawal
I. Anxiety, tremors, insomnia
II. Grand mal seizures, delirium
III. Respiratory depression and death
TOXICITY AND MANAGEMENT OF
OVERDOSE

• Decontamination of the gastrointestinal system


• Antidote – flumazenil (Romazicon)
BARBITURATES

• Prototype sedative-hypnotic drugs


• Inhibit nerve cells – producing CNS depression
BARBITURATES

Used for extreme cases of insomnia and seizures that are


unresponsive to other drugs.
• phenobarbital (Nembutal sodium)
• secobarbital (Seconal sodium)
• butabarbital (Butisol sodium)
• phenobarbital (Luminal)
ANTIHISTAMINES

Used to treat allergies, dermatologic reactions, motion


sickness, N/V, and drug-induced EPS

• diphenhydramine (Benedryl)
• hydroxyzine (Atarax, Vistaril)
MISCELLANEOUS
BUSPIRONE (BUSPAR)

• Non-benzodiozepine
• Non addicting
• Less sedating
• No physical or psychological dependence
• Can be used for long periods of time
• Useful in generalized anxiety disorder
CONTRAINDICATIONS
OF ANXIOLYTICS
• Severe respiratory depression
• Open angle glaucoma
• History of seizure disorder
• Severe liver or kidney disease
• Hypersensitivity
• Pregnancy
PATIENT TEACHING
• Routine oral dosing given at bedtime
• Avoid alcohol and caffeine
• Caution against driving and machinery
• Do not stop abruptly
• Report sleep pattern changes
• Paradoxical excitation (increased talkativeness, emotional release,
excitement, and excessive movement)
• Observe for therapeutic effects
• Observe for adverse effects
NURSING ASSESSMENT
• Review CBC, electrolytes and kidney function test, if
ordered
• Vitals signs especially BP
• Asses for alertness, orientation, and sensory and motor
functioning
• Complaints of headache, ataxia or neurological abnormalities
• Medication reconciliation
• Allergies
• Mental status
• Drug interactions
PATIENT TEACHING
• Routine oral dosing given at bedtime
• Avoid alcohol and caffeine
• Caution against driving and use of machinery
• Do not stop abruptly
• Report sleep pattern changes
• Paradoxical excitation (increased talkativeness, emotional
release, excitement, and excessive movement)
• Observe for adverse effects
• Observe for therapeutic effects
REFERENCE

Lilley, L. L., Rainforth Collins, S., Harrington, S., & Snyder, J. S. (2017).
Pharmacology and
the nursing process. (8th ed.) St. Louis, MO: Mosby Elsevier.
 

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