Pioneered Products of Sabinsa - Sep 16, 2011

National Seminar Pharma Eminence 2011
A presentation from Sami Labs Ltd. / Sabinsa Corp.

By: Dr. Muhammed Majeed
Group Chairman, Sami & Sabinsa Group of Companies
Presented by: Dr. S. Natarajan Executive Vice President, R&D Sami Labs Ltd., Bangalore
Date: September 16, 2011
Sabinsa Corporation 2011|
Global Presence and Group Companies

Edkal Corporation India / USA AFIs USA Sabinsa USA NJ & Utah
Sabinsa Europe (Germany)
Sami Direct India
Sabinsa Japan
ClinWorld Inc. India / USA
SAMI LABS
INDIA
Sabinsa China
Organica Aromatics India Sabinsa South Africa Sabinsa Philippines

Sabinsa Australia
Hanbury FZE U.A.E.
Sabinsa Vietnam
BioPerine is a patented standardized extract obtained from black pepper, containing not less than 95% Piperine. A clinically proven natural bioavailability enhancer for U.S. PATENTS nutrients1
# 5536506 (1996), # 5744161 (1998) # 5972382 (1999),# 6054585 (2000)
INTERNATIONAL PATENTS: European Patent # EP 0810868 (2001) Japan: # JP 3953513 (2007) 1 Summaries of clinical studies are available2247467 (2007) Canada: # CA at: www.bioperine.com
(Mercy Medical Centre, NY) Sabinsa Corporation 2011|
BioPerine increased the absorption of co-administered beta-carotene in human volunteers

(Mercy Medical Centre, NY)
Efficacy of BioPerine (5 mg) on the bioavailability of Vitamin B6 absorption in human volunteers

Mean serum CoQ10 values during supplementation of 120 mg of CoQ10 with and without 5 mg of piperine
BioPerine Enhances Bioavailability of ResveratrolUniversity of Wisconsin Study

BioPerine significantly improves the bioavailability of Resveratrol Plasma exposure for Resveratrol increses by 255% Cmax for Resveratrol increases by a phenomenal 1544% Economic impact of such findings very substantial in bringing down the cost of nutrients precipitously Studies Directed at Neuroendocrine cancer inhibition by Resveratrol Phase I studies are underway at University of Wisconsin Findings have an impact on other nutrients such as Silbinol
Molecular Nutr Food Res., 2011, 55, In Press
L(+)-SELENOMETHIONINE (USP)
O Se H3 C NH2 OH
www.seleniumselect.com
10
L(+)-Selenomethionine : Stereospecific natural form of bioavailable selenium Sami Labs - Received Basic Drugs Award (1994) for pioneering manufacture in India; is the largest manufacturer of L(+)-Selenomethionine.
NATIONAL QUALITY AWARD (BASIC DRUGS, 1994)
11
SELENIUM IN HEALTH
FDA allowed qualified health claim:
Selenium may reduce the risk of certain types of cancers
Supplemental selenium daily dose is generally : 50-200 mcg High dose selenium (L(+)-Selenomethionine) is being studied as a treatment for various types of cancer.
12
Potential Role in Clinical Practice

Cancer Prevention Arthritis/inflammator y diseases Cardiovascular Health
Selenium
Immunity & Resistance to Infections Beneficial effects in HIV infection
Diabetes Support
13
SelenoForce
Source of selenium with greater efficacy in breast cancer prevention

US Patent # 7014874 (2006)
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METHYL SELENOCYSTEINE
Naturally found in garlic and cruciferous vegetables Sami Labs manufactures the stereospecific L natural form
US Patent 6794537 - Sami Labs (2004) - Process Patent US Patent 6982273 - Sami Labs (2006) -Human & veterinary use patent
15
Selenium Containing Peptides
US Patent 8003614- Sami Labs (2011)-Dipeptides Containing SeleneiumBioavailabilityPharma-Cosmeceuticals Applications
16
Setting the Standard.
17
(Coleus forskohlii Extract) Role in enhancing lean body mass

and in the treatment of mood disorders
US 5804596 (1998) EP 0977564 (2005) CA 2281562 (2008)
CH3
CH3
OH O
CH O CH2 OCOCH3
OH H3C H CH3 OH
Forskolin
18
Achievements & Recognitions

ForsLean, manufactured by a proprietary process.
It is a standardized extract from the roots of the Coleus forskohlii Forskolin. Nutracon Award, 2001
plant,
the
only
known plant source of the
19
Achievements & Recognitions
US Patent # 5804596, won the Thomas Alva Edison Patent Award (R & D Council, NJ USA) on November 11, 2004
20
Clinical Studies
1. Open field study (8 weeks) with 6 overweight women subjects. Dr. A. Conte, USA 2. Open-field study (6 months) with sixteen obese subjects: Dr. Asano, Japan 3. Pilot clinical efficacy and safety study, 19 women subjects, randomized , double blind placebo controlled : University of Memphis TN, USA 4. Preclinical toxicology evaluation - CBPRC, Bombay 5. 60 subject clinical efficacy study CBPRC, Bombay 6. 24 subject body composition evaluation and body weight Northern Michigan University, USA 7.Double-blind placebo controlled study, 30 obese/overweight subjects Kansas State University, USA 8. 60 subject clinical efficacy study Completed at Manipal 9. 6 month feeding/toxicity study- Completed 10. Micronuclei and dose effects studies- Completed 11. Bone Density and Hormonal Levels Study (3months) with 24 women subjects Completed Dr. Pankaj Gandhi Hospital, Mumbai 12.Hormonal Study (3months) with 30 male subjectsCompleted Kasturba Medical College,Manipal
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LEAN BODY MASS

Lean Body Mass refers to the sum of the weight of your bones, muscles and organs... basically the sum of everything other than fat in your body Measurable A Better Conditions
Description
of
Obesity
22
Effects on Body Weight, Body Fat and Lean Body Mass

Open field study, 6 overweight women subjects, 500 mg ForsLean corresponding to 50 mg forskolin/day for 8 weeks
10 8 6 4 % 2 0 -2 -4
Before After 4 weeks After 8 weeks
10 8 6 4 lbs 2 0 -2 -4 -6 -8 -10
Majeed et al, Nutracos, Feb 2006, Page 2
Mean weight loss (lbs)
Mean body fat (%)
-6 -8 -10
Mean lean body mass (%)
N=6 23
Sabinsa Corporation 2011 |
Exercise, Supplements and Obesity
24
Anti Cancer Application
The Ohio State University Comprehensive Cancer Center is conducting a study on Forskolins effect on Chronic Myelogenous Leukemia (CML). Early results on CML patient cells both in culture and in mice showed that forskolin reduced the cancer cells ability to grow up to 90 percent.
25
CURCUMIN C3 COMPLEX
Source: (Turmeric) Curcuma longa
Active components: Curcuminoids Antioxidant, Anti-inflammatory support, Immune support. Plant part used: Roots
U.S. PATENT US 5861415 (1999) European Patent EP 0839037 (2002)
26
27
The first book to comprehensively list the medicinal claims of Curcuminoids was published by SABINSA in 1993
28
Therapeutic potential of Curcumin

Cardiovascular diseases Multiple sclerosis Diabetes
Cholesterol, platelet aggregation, inhibition of smooth muscle cell proliferation
Alzheimer disease Chemotherapeutic Chemopreventive

Skin, liver, colon, stomach
Nephrotoxicity Antioxidant
Gall-stones formation Cataract formation
Curcumin C3 Complex
Antiangiogenic Anti-inflammatory
Arthritis Lung fibrosis
Cardiotoxicity Wound healing
HIV Replication HIV replication
Adopted from Dr.Bharat Aggarwal, MD Anderson Cancer Research Center, Texas
29
Curcumin and its Multi-targets
www.curcuminresearch.org
30
Curcumin potentiates the effect of paclitaxel by suppressing the metastasis of the human breast cancer to the lung in mouse xenograft model
Clinical Cancer Research 2005 Oct 15;11(20):7490-8

31
Ongoing Clinical Trials with Curcumin

Disease
Multiple myeloma Pancreatic cancer Pancreatic cancer Melanoma Michigan, USA Colon Cancer UK Colon Cancer Michigan, USA Colon Cancer Alzheimers Disease William P Steward, MD Milan Fiala, MD University of Leicester, UK UCLA, USA Dean Brenner, MD University of Ernie Hawk, MD National Cancer Institute,
Investigator
Saroj Raj-Vadhan, MD Razelle Kurzrock, MD Rami Ben Yosef, MD Christopher D. Lao, MD
Institution
UTMDACC, USA UT MDACC, USA Ichilov, Israel University of
Safety Studies Dean Brenner, MD University of Adopted from Dr.Bharat Aggarwal, MD Anderson Cancer Research Center, Texas Sabinsa Corporation 2011| Michigan, USA
32
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BOSWELLIN
Source: Boswellia serrata (Indian frankincense, olibanum) Active components: Boswellic Acids Nutraceutical Supports the inflammation. Beta-
applications: management of
Plant part used: Exudate (gum resin) Form in which supplied: Standardized extract (powder)
34
35
The FOUR major identified pentacyclic triterpenoids in Boswellin are

-Boswellic acid Acetyl- -Boswellic acid 11-keto- -Boswellic acid Acetyl -11 keto -Boswellic acid
Boswellin Chemistry
36
Chemistry of Boswellic Acids

-Boswellic Acid Acetyl--Boswellic Acid
HO HOOC
AcO O HOOC
11-Keto--Boswellic Acid
Acetyl-11-Keto--Boswellic Acid
HO HOOC
Ac O
HOOC
Sabinsa Corporation
37
Salient Features of Boswellin

Sami Labs/Sabinsa Corporation pioneered the introduction of standardized Boswellia serrata extract to global markets Correctly standardized for boswellic acids (method submitted to the United States Pharmacopoeia for monograph development)
38
Anti-inflammatory Applications of Boswellic acids

Promising Clinical trials for the following indications are reported in literature: Rheumatoid arthritis Osteoarthritis Chronic colitis Ulcerative colitis Crohn's disease Bronchial asthma Peritumoral brain edemas*
Ref: Ammon HP. Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases. Wien Med Wochenschr. 2002;152(15-16):373-8. Review. German
European Union: orphan drug application exists for this indication

39
POLICOSANOL
Policosanol is a mixture of fatty alcohols derived from waxy extract of sugarcane. Policosanol is reported to support healthy blood lipid levels and cardiovascular health
Patents: US 7217546 (2007) IN 229695 (2009)
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Clinical Studies
A double-blind placebo controlled study was conducted using Sabinsas Policosanol derived from Indian Sugarcane to investigate the efficacy of Policosanol vs. Atorvastatin for the treatment of Hyperlipidaemia.
41
Decrease in Cholesterol Levels
Details
Mean SEM
Policosanol
%
16.11 1.85
Atorvastatin
19.66 2.59 42
Decrease in Triglyceride Levels
Details
Mean SEM
Policosanol
%
33.74 3.22
Atorvastatin
35.61 4.19 43
Decrease in Cholesterol / HDL Ratio
Details
Mean SEM
Policosanol
%
Atorvastatin
23.87 2.69 44
20.91 3.32
ESR, an early marker of inflammation, significantly decreased with Policosanol but increased by 7.36% with Atorvastatin.
25 20 15 10 5 0 Base Line Final
ESR
Policosanol Atorvastatin Atorvastatin

% Details ESR BASE LINE FINAL VISIT %
Policosanol
Details ESR BASE LINE FINAL VISIT
Mean
SEM
23.10
2.65
16.33
1.60
29.32
4.33
Mean
SEM
17.26
2.67
18.53
4.24
7.36
5.04
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Clinical Trials
Policosanol compared favorably with Atorvastatin at improving the serum lipid profile. Policosanol was well tolerated and no drug-related adverse drug reactions were observed. Policosanol is a safe and effective supplement for lowering of bad cholesterol levels and can be used to lower several cardiovascular disease risk factors.
46
Gugulipid is a patented standardized extract obtained from Commiphora mukul (wightii) gum resin (Guggul), containing not less than 2.5% guggulsterones.
Commiphora mukul tree
Clinically proven to cardiovascular health.
support
Guggul has been traditionally used in Ayurveda in the management of obesity and inflammation. US Patent: US 6436991 (2002)
Summaries of clinical studies are available at: www.gugulipid.com
1
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Potential Roles in Clinical Practice

Lipid disorders Cardiovascular health Obesity Arthritis and inflammation Thyroid stimulation Acne management support
48
Pharmacology & Clinical Trials

Sabinsa, USA sponsored an IND for Gugulipid. Randomized, Double Blind, Placebo Controlled Trial Evaluating the safety and Efficacy of GUGULIPID in Americans with Hypercholesterolemia. Dept. of General Internal Medicine. University of Pennsylvania 9 Penn Tower, 3400 Spruce St,. Philadelphia, USA. 1st Publication: Gugulipid for the treatment of Hypercholesteremia. A randomized trial. JAMA, August 13, 2003, Vol. 290 No. 6 2nd Presentation: Metabolic Effects of Gugulipid. 10th Annual symposium on Complementary Healthcare, Royal Collage of Physicians, London, UK. Clinical efficacy study: Mercy Medical Center, Bronx, New York Dr. Edward Norkus Double Blind Cross over study-ongoing
49
Role in Cardiovascular Health Summary of results Comprehensive indices of cardiovascular health were measured: Oxidative stress C-reactive protein (CRP) Levels of uric acid Lipoprotein (a)
50
RESULTS OF RANDOMIZED DOUBLE BLIND PLACEBOCONTROLLED CROSSOVER STUDY Active therapy: Gugulipid (75 mg guggulsterones daily dose, 12 weeks, 30 volunteers )
Serum hsCRP (m g/dl)
Pa e o l cb G g lpd u ui i
Serum M DA (m g/dl)
0 . 5
1 . 5
hs-CRP: high-sensitivity C-reactive protein, marker of oxidative stress associated with inflammation MDA: Malondialdehyde, marker of oxidative stress No dermatologic hypersensitivity observed during treatment
(Mercy Medical Center, NY, October 2004)
51
RESULTS OF RANDOMIZED DOUBLE BLIND PLACEBOCONTROLLED PARALLEL DESIGN STUDY ON Lp(a) levels Active therapy: Gugulipid (75 mg (standard dose, SDG) or 150 mg (high dose, HDG) guggulsterones daily, 8 weeks, 42 volunteers with elevated Lp(a) )
Mean percentage change in Lp(a) levels from Baseline of 0.71 micromol/L
SDG HDG Placebo
2 1 0 -1 -2 -3 -4 -5 -6 -7 -8
-5 -7
Szapary, PO et al. JAMA, Aug 13, 2003, 290(6): 765-772

52
Source: Garcinia cambogia (Fam. Clusiaceae) Plant part used: Fruits Active constituents Hydroxycitric acid, Garcinol Nutraceutical benefits: Weight management support
Patents: AU 773081 (2004), NZ 518116 (2005), US 7063861 (2006), EP 1254209 (2006), and JP 4205943 (2008)
(-) (-)HCA,
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Ocufors Eye Drops for Glaucoma

First natural drug to go through full fledged clinical documentation to obtain a drug approval
55
Ocufors from Coleus forskohlii

Application in Glaucoma
Vision of a Glaucoma patient
Normal vision
Same scene as viewed by a person with glaucoma
Patents Granted: USA : US 6960300 (2005); Singapore: SG 121197 (2008) Mexico : MX 260326 (2008); South Africa: ZA Sabinsa Corporation 2011| 2006/01898 (2008)
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Ocufors Eye drop solutions for Glaucoma Treatment

Ocufors, a patented ophthalmic solution containing 1-2% forskolin, for the treatment of glaucoma First time the Government of India has approved a product developed from natural sources for use as a pharmaceutical grade drug A stable, water-soluble forskolin solution shown in clinical trials to be 30 % more effective than the most popular glaucoma treatment in the world market today
57
IND # 3305/115 Human Study Completed and drug status granted Summary Data
0 Forskolin Timolol
Intraocular pressure
-3.2
Right eye Left eye
-4.9 -6 -6.4*
-10
*p<0.05
58
First NDA MF 6746 received in 2006 from Drug Control General of India for Forskolin eye drops in the treatment of Open Angle Glaucoma
59
First natural drug to go through full fledged clinical documentation to obtain a drug approval
60
Sornip from Boswellia serrata

(Patented by Sami Labs & marketed by Cipla)
The solution for Psoriasis

An autoimmune disorder with not much therapy in modern medicine
61
The Psoriasis Trial

An open Multicentric Phase III clinical trial to investigate the efficacy and safety of a natural compound formulation for management of Psoriasis - study has been successfully completed and approved by DCGI.
BASELINE VISIT
FINAL VISIT
62
Psoriasi s
Before
After
63
Psoriasis Trial
BASELINE VISIT
FINAL VISIT
Patents Granted: South Africa: ZA 2007/0694 (2007); Singapore: SG 136165(2009); Russia: RU 2366412 (2009); New Zealand: NZ 552027 (2010).
64
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LactoSpore is a lactic acid bacillus preparation in the form of a light colored powder manufactured and distributed by Sabinsa. The source of Lactic acid bacillus was originally known in literature as Lactobacillus sporogenes. It is also known as Bacillus coagulans. Lactobacillus sporogenes produces only L(+) Lactic acid. Sabinsa provides LactoSpore of the following strengths 6 Billion spores/g 15 Billion spores/g LACTOSPOREEC - Under development
66
LactoSpore An ideal probiotic for the following reasons:

Room temperature stable Naturally microencapsulated for stability and ease of processing Proliferates within the GI tract Produces L(+) Lactic acid only Aids in protein, lipid and carbohydrate digestion Compatible with nutrients and antibiotics Not artificially made resistant Japanese FDA approved probiotic
67
LactoWise a Synbiotic, is a proprietary composition comprising of beneficial human intestinal microorganisms and a source of dietary fiber for promoting gastrointestinal health.
The composition includes Bacillus coagulans, a probiotic marketed by Sabinsa Corporation, US under the brand name LactoSpore. Soluble Fenumannans from the dietary fibers FenuFibers, from Sabinsa Corporation US.
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TETRAHYDROCURCUMINOIDS (White Turmeric)

COLOR FREE compounds derived from yellow Curcuminoids extracted from Curcuma longa (turmeric) roots.
Skin lightening effects ( inhibition of melanogenesis) Antioxidant action Anti-inflammatory action

Patents: US 6653327 (2003), EP 1171144 (2007), AU 2006235807 (2008), NZ 514884 (2008), EP 1328263 (2009)
70
Freeze dried Powder from tender green coconut water A natural reservoir of nutrients and growth factors to support healthy cell growth , nutrition, hydration and cell rejuvenation Proprietary process to retain optimum bioPatented: US 7300682 potencyand EP (2007) 1341547 (2006) Affirmed GRAS for Food and Beverage Applications 2011| Sabinsa Corporation
The Nourishment Factor
71 71 71
(Tetrahydropiperi ne)
Prepared by a patented proprietary process from black pepper Acts as a skin permeation enhancer for other active ingredients in formulations Patented: GB 2380675 (2003) US 6849645 (2005) and JP 4098985 (2008)
72
Transdermal Absorption Study with Betamethasone Dipropionate (BMDP)
THP increased permeation of BMDP, when combined with THP as compared to BMDP application alone.
Reference: Research Report, Sami Labs Ltd. (April 2000)
73
Winner of 2005 Thomas Alva Edison Patent Award NJ R&D Council

74
Ayurvedas Original Rasayana ORAC Dense Phytonutrient
75
Recognized in Ayurvedic tradition of Indian medicine, Amalaki or Amla and is known for its traditional used in hair care and skin care. Saberry is a light colored and water soluble powder obtained from the fruits of Emblica officinalis or Amla.
76
Salient Features of Saberry

100% Natural New biomarker Glucogallin, in Amla extracts Novel extraction technology to preserve the efficacy International Patent Pending Published in Journal of Agricultural and Food Chemistry, Volume 57(1) 2009 GRAS Affirmed
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BoswellinPS*
In addition to the active Boswellic acids, Boswellin PS* also contains Polysal which contributes to its immediate anti-inflammatory action. Boswellin PS* is standardized to contain: AKBBA 10% Total Identified Boswellic Acids 20% Total Organic Acids 35%
* Patent pending
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CHILITENOIDS
Chilitenoids are Sabinsas standardized extract obtained from dried fruits of Capsicum annuum. Chilitenoids are natural xanthophyll carotenoids with a bright red color. Chilitenoids are available as Soft containing minimum 5% Capsanthin. Sabinsas Chilitenoids are stable. extract
Capsanthi n
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Chilitenoids - Specification
Content of Total Carotenoids 10.0% Content of Capsanthin 5.0% Color value 1.5x105 : Not less than : Not less than : Between 1x105 to
81
Applications
Chilitenoids can find applications As a Nutraceutical, for antioxidant and heart health support As a Natural color in food applications As a Natural color in Color Cosmetics due to its photoprotective potential.
82
OXYRESVENOX Oxyresveratrol
OxyResvenox is the registered trademark of Sabinsas Oxyresveratrol. Oxyresveratrol is the analog of Resveratrol and is of synthetic Origin. Sabinsa's 34th US Patent 7,253,324, specifically protects the process for the synthesis of biologically active polyphenolic compounds like Pterostilbene, Resveratrol, Oxyresveratrol and Gnetol.
OH HO CH CH OH
OH
83
Dose-dependent inhibitory effects on mushroom tyrosinase by Oxyresveratrol, Resveratrol, and Kojic acid.
A Oxyresveratrol
IC50 (M)
B - Resveratrol
C Kojic Acid
Lower the IC50 value Better the activity

84
SabiLize (Natural Preservatives)

A natural proprietary preservative blend, under the brand name SabiLize Helps Stabilize formulations the natural way SabiLize in creams are significantly effective against Staphylococcus aureus (Gram positive bacteria) at 0.5% Escherichia coli (Gram negative bacteria) at 0.5% Candida albicans (Yeast) at 0.5% Aspergillus niger (Filamentous fungi) at 1.0% Ocular and Dermal Irritection Assays classified that SabiLize is, Minimal irritant for ocular irritation potential Non irritant for dermal irritation potential
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3- Hydroxypterostilbene (3HPT)
3-Hydroxypterostilbene is a stilbene isolated from Pterocarpus marsupium, Sphaerophysa salsula and certain types of propolis. It is an analog of Resveratrol and Pterostilbene. 3-HPT is about 30 times more potent antioxidant than Resveratrol, 70 times than vitamin E, 80 times than vitamin C, 90 times than BHT. Potent skin lightening agent. Supports weight management. Supports general health and wellness.
87
Turmerones
Sabinsas Turmerone is a powdered standardized extract from the dried rhizomes of Curcuma longa and contains a minimum of 25% Turmerones. Turmeric root contains 5 -6% of Turmeric oil. The chief components of Turmeric oil are sesquiterpene ketones (50 60%) in the form of Turmerone and ar-Turmerone
Potent anti-inflammatory and anti-arthritis agent.

Ar-Turmerone
88
NUTRACEUTICALS COMMON HEALTH CONCERNS ADDRESSED

Arthritis, joint health, inflammation Osteoporosis Abnormal blood lipid levels Hyperglycemia Cardiovascular health Prostate health Menopausal symptoms Obesity Cancer/chronic disease
prevention
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COSMECEUTICALS COMMON COSMETIC CONCERNS ADDRESSED Skin Lightening

Sunless tanning UV protection Antioxidants & Anti inflammatory Anti Ageing Wound Healing Sebum Regulation Barrier function restoration Anti Cellulite Stretch marks prevention Hair fall prevention
90
Always on the Trail of New Products New Developments..New Applications

Broad Institute (Harvard & MIT) discovered Piperlongumine has an unique anticancer mechanism (Nature July 2011, 475, 231-4) Piperlongumine increases Reactive Oxygen Species selectively in cancer cells, thus killing them, compared to normal cells Piperlongumine occurs in Piper longum L Piperlongumine already extracted by Sami Labs in multi-kg quantities M D Anderson Cancer Center in Houston, USA is presently doing studies on anticancer application.
Exploring ways to reduce the burden of diseases

91
Patent Awards
US Patent # 5,804,596, won the Thomas Alva Edison Patent Award (R & D Council, NJ USA) in 2004 for ForsLean
Thomas Alva Edison Patent Award 2005 for THP
Thomas Alva Edison Patent Award 2009 for Garcitrin

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Intellectual Property
U.S. & International Patents issued: 68 Patent Coverage: India, U.S.A., European Patent Office, Sweden, Netherlands, Italy, United Kingdom, Ireland, Luxembourg, Monaco, Portugal, Spain, France, Denmark, Greece, Switzerland, Belgium, Austria, Germany, Japan, Australia, New Zealand, Canada and Russia.
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nnovating for the Future from the Past

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www.sabinsa.com www.samilabs.com
THANK YOU
95

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National Seminar Pharma Eminence 2011

A presentation from Sami Labs Ltd. / Sabinsa Corp.

Sabinsa Corporation 2011|

Sabinsa Corporation 2011|

Global Presence and Group Companies

Sami Direct India

ClinWorld Inc. India / USA

Organica Aromatics India Sabinsa South Africa Sabinsa Philippines

Hanbury FZE U.A.E.

Sabinsa Corporation 2011|

BioPerine increased the absorption of co-administered beta-carotene in human volunteers

Efficacy of BioPerine (5 mg) on the bioavailability of Vitamin B6 absorption in human volunteers

Sabinsa Corporation 2011|

BioPerine Enhances Bioavailability of ResveratrolUniversity of Wisconsin Study

Sabinsa Corporation 2011|

NATIONAL QUALITY AWARD (BASIC DRUGS, 1994)

Sabinsa Corporation 2011|

Selenium may reduce the risk of certain types of cancers

Sabinsa Corporation 2011|

Potential Role in Clinical Practice

Source of selenium with greater efficacy in breast cancer prevention

Selenium Containing Peptides

US Patent 8003614- Sami Labs (2011)-Dipeptides Containing SeleneiumBioavailabilityPharma-Cosmeceuticals Applications

Sabinsa Corporation 2011|

Setting the Standard.

Sabinsa Corporation 2011|

(Coleus forskohlii Extract) Role in enhancing lean body mass

Achievements & Recognitions

known plant source of the

Achievements & Recognitions

Sabinsa Corporation 2011|

LEAN BODY MASS

Effects on Body Weight, Body Fat and Lean Body Mass

Mean weight loss (lbs)

Mean body fat (%)

Mean lean body mass (%)

Sabinsa Corporation 2011 |

Exercise, Supplements and Obesity

Sabinsa Corporation 2011|

Anti Cancer Application

Sabinsa Corporation 2011|

U.S. PATENT US 5861415 (1999) European Patent EP 0839037 (2002)

Sabinsa Corporation 2011|

Sabinsa Corporation 2011|

Sabinsa Corporation 2011|

Therapeutic potential of Curcumin

Alzheimer disease Chemotherapeutic Chemopreventive

Gall-stones formation Cataract formation

Arthritis Lung fibrosis

Cardiotoxicity Wound healing

HIV Replication HIV replication

Sabinsa Corporation 2011|

Adopted from Dr.Bharat Aggarwal, MD Anderson Cancer Research Center, Texas

Curcumin and its Multi-targets

Clinical Cancer Research 2005 Oct 15;11(20):7490-8

Ongoing Clinical Trials with Curcumin

Sabinsa Corporation 2011|

Sabinsa Corporation 2011|

The FOUR major identified pentacyclic triterpenoids in Boswellin are