Protein N.2023
Protein N.2023
Protein N.2023
chemistry
Dr. Dalia Mahmoud Dr. Amal Darwish
Lecturers of Medical Biochemistry and Molecular Biology
12/02/2023
Extended Modular Program 1
Proteins
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Amino Acids
Amino Acids are the Building Blocks of
Proteins
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Amino Acids structure
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Amino Acids structure
8
Peptide bond breakage
Inside
Outside body
body
SHARING IS
CARING!
Bonds
Non
Covalent
covalent
Electrostatic Hydrophobic
Peptide Disulfide Hydrogen interaction interaction
Covalent bonds
1. Peptide bond
2. Disulfide bond (-S-S-)
– It occurs between 2 cysteine
amino acids
Non covalent bonds
1. Hydrogen bonds:
• They are weak in comparison to
covalent bonds
Primary
Secondary
Tertiary
Quaternary
Primary structure of proteins
• Refers to sequences of amino acids in the polypeptide
chain, linked by peptide bonds.
• Each protein has specific number, specific types and
specific sequences of amino acids
Secondary protein structure
• It is the local folding of the polypeptide chain to form
certain regular confirmations
• These regular forms of secondary structure include:
1. α- helix
2. β- pleated sheets
• These forms are kept stabilized by interactions of by
hydrogen bonds
α- Helix - pleated sheet
Tertiary structure of proteins
• It is the three dimensional structure of proteins
(protein folding)
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A. Classification of proteins according to
function
Transport : hemoglobin
Regulatory: hormones,
insulin
Catalytic: enzymes
Defense function:
immunoglobulins
In cell membrane
structure
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B. Protein classification According
to the biological value
High biological value Low biological value
proteins proteins
• Contain all essential • Lack one or more
amino acids required essential amino acids
for synthesis of human
tissue proteins.
• Proteins of animal
origin: meat liver, milk,
fish
• Some plant proteins
(beans, lentils) in
combination
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Protein classification According to the
biological value
The pancreatic
When the stomach proteases (proteases=
Pancreatic digestive enzymes that digest
empties its content into
small intestine , the enzymes also, are proteins) are trypsin,
pancreas will secrets secreted as an chemotrypsin,
its digestive enzymes. inactive form. elastase,
carboxypeptidases.
Digestion of protein by enzymes from intestinal
cells
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