Ischemic Heart Disease PW
Ischemic Heart Disease PW
Ischemic Heart Disease PW
is a disease characterized by ischemia (reduced blood supply) of the heart muscle, usually due to coronary artery disease (atherosclerosis of the coronary arteries). condition caused by a reduced amount of blood supplying the heart muscle. It can be caused by cholesterol and other lipids building up on the inner walls of arteries that supply the heart, forming a thick plaque that can reduce the amount of blood carrying nutrients and oxygen to heart tissue.
most common in older individuals. Males are affected more often than females however the rates equalize between men and women following menopause.
Pathophysiology
The arteries become "furred up" by fat-rich deposits in the vessel wall called plaques. Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood. When plaque builds up in the arteries, the condition is called Atherosclerosis. Stable angina is due to inability to supply the myocardium (heart muscle) with sufficient blood in situations of increased demand for oxygen, such as exertion.
Unstable angina, STEMI ("ST segment elevation myocardial infarction,") and NSTEMI (NON ST segment elevation myocardial infarction,") are attributed to "plaque rupture", where one of the plaques gets weakened, develops a tear, and forms an adherent blood clot that either obstructs blood flow or floats further down the blood vessel, causing obstruction there.
Risk Factors:
Family history of coronary artery disease Diabetes high blood pressure or atherosclerosis Smoking Poor nutrition Overweight Hypertension birth control pills physical inactivity stress
Lab. Findings:
The laboratory tests of value in confirming the diagnosis may be divided into four groups: (1) ECG (2) serum cardiac biomarkers (3) cardiac imaging (4) nonspecific indices of tissue necrosis and inflammation.
During the initial stage, total occlusion of an epicardial coronary artery produces ST-segment elevation. Most patients initially presenting with STsegment elevation ultimately evolve Q waves on the ECG. However, Q waves in the leads overlying the infarct zone may vary in magnitude and even appear only transiently, depending on the reperfusion status of the ischemic myocardium and restoration of transmembrane potentials over time.
Management
Medications used to treat ischemic heart disease
Drug therapy is commonly used for treatment of ischemic heart disease and includes:
QUIZ!
1. Ischemic Heart Disease is common in what individuals? 2. It is made up of fat, cholesterol, calcium, and other substances found in the blood. 3. What do you call the condition when plaque builds up in the arteries? 4. What is the main symptom of Angina pectoris? 5. STEMI stands for?
15. procedure to remove plaque and restore blood flow in clogged arteries
16. procedure that helps restore blood flow to the heart by routing the flow through transplanted arteries