Witnessing an extreme degree of anguish and resilience surely rearranges your emotional DNA.

This debate causes me a lot of anguish.

His stillness screams and reveals so much anguish.

He will be under no illusions about the size of the job in front of him as he placed his head in his hands in anguish after yet another damaging and deeply revealing defeat.

This final stretch of the film is its most profoundly moving, evoking human anguish and perseverance in equal measure through abstract sights to communicate with the viewer on a cellular level.