OR2J3

OR2J3
Identifiers
Aliases	OR2J3, 6M1-3, C3HEXS, HS6M1-3, OR6-16, OR6-6, OR6.3.6, ORL671, olfactory receptor family 2 subfamily J member 3
External IDs	OMIM: 615016; MGI: 2177520; HomoloGene: 128270; GeneCards: OR2J3; OMA:OR2J3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	29,114,770 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	38,618,461 bp
RNA expression pattern
	Top expressed in
	testicle; ; sural nerve; ; left testis; ; right testis;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; olfactory receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	442186
	258481
	ENSG00000204701
	ENSMUSG00000054940
	O76001
	Q8VFC2
	NM_001005216
	NM_146488
	NP_001005216
	NP_666699
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 2J3 is a protein that in humans is encoded by the OR2J3 gene.^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Genetic variation

A pair of two single-nucleotide polymorphisms, both in the OR2J3 gene, strongly reduce sensitivity to the odorant cis-3-hexen-1-ol, which has a "cut grass" smell.^[6]

Ligands

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000204701 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054940 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OR2J3 olfactory receptor, family 2, subfamily J, member 3".
^ ^a ^b McRae JF, Mainland JD, Jaeger SR, Adipietro KA, Matsunami H, Newcomb RD (September 2012). "Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol". Chemical Senses. 37 (7): 585–93. doi:10.1093/chemse/bjs049. PMC 3408771. PMID 22714804.
^ Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.

External links

OR2J3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000204701 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054940 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OR2J3 olfactory receptor, family 2, subfamily J, member 3".

[McRae2012-6] McRae JF, Mainland JD, Jaeger SR, Adipietro KA, Matsunami H, Newcomb RD (September 2012). "Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol". Chemical Senses. 37 (7): 585–93. doi:10.1093/chemse/bjs049. PMC 3408771. PMID 22714804.

[7] Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.

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OR2J3

Genetic variation

Ligands

See also

References

Further reading

External links

pFad - (p)hone/(F)rame/(a)nonymizer/(d)eclutterfier! Saves Data!