Pipoxizine

Pipoxizine
Clinical data
ATC code	None;
Identifiers
	IUPAC name 2-(2-{2-[4-(Diphenylmethylene)-1-piperidinyl]ethoxy}ethoxy)ethanol;
CAS Number	55837-21-3;
PubChem CID	68750;
ChemSpider	61995;
UNII	B9A98D632Z;
CompTox Dashboard (EPA)	DTXSID30866510 ;
Chemical and physical data
Formula	C24H31NO3
Molar mass	381.516 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1ccc(cc1)C(=C2CCN(CC2)CCOCCOCCO)c3ccccc3;
	InChI InChI=1S/C24H31NO3/c26-16-18-28-20-19-27-17-15-25-13-11-23(12-14-25)24(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-10,26H,11-20H2; Key:SCMPXORBOTWFTI-UHFFFAOYSA-N;

Pipoxizine (INNTooltip International Nonproprietary Name) is a first-generation antihistamine as well as serotonin antagonist of the diphenylmethylpiperazine group related to hydroxyzine.^[1]^[2] It was investigated as a bronchodilator but was never marketed.^[1]^[3]^[4]

References

^ ^a ^b Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1619–. ISBN 978-0-412-46630-4.
^ World Health Organization (1988). International Nonproprietary Names (INN) for Pharmaceutical Substances. W.H.O. ISBN 9789240560369.
^ Brunner A, Gartmann J, Studler H. "Pipoxizine, a New Bronchodilator". Lung. 154 (2): 143.
^ Neukirch F, Korobaeff M, Verdier F, Timsit G, Fay M, Drutel P (1978). "[Effect of a histamine aerosol in 20 subjects with histamine hyperreactivity. Application to a study of the protective properties of pipoxizine]". Revue de l'Institut d'Hygiene des Mines (in French). 33 (4): 191–195. PMID 45187.

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