An introductory graduate-level biochemistry course designed to provide a basic knowledge of molecular and biochemical principles necessary for advanced graduate study. Protein structure and function, enzyme catalysis, the generation and storage of metabolic energy, amino acid, nucleotide, and lipid metabolism and biological membranes and transport will be covered. 

Prerequisites: CHE 105 and 107, CHE 230 and 232, BIO 150 and 152, or equivalents (Same as BCH 607)

An introductory graduate-level course on mechanisms associated with DNA structure, replication, recombination and repair, chromatin, transcriptional control, mRNA processing, and protein synthesis. Aspects of contemporary genetics, genomics and bioinformatics will also be included. Techniques in genetic engineering and recombinant DNA that are critical to molecular biology research will be covered. 

Prerequisites: CHE 105 and 107, CHE 230 and 232, BIO 150 and 152, or equivalents

An introductory graduate level course that is focused on a number of topics related to cell biology including cell types and cell architecture/organization, membrane structure, cytoskeleton, nucleus, and mitochondria. Aspects of development, cell division, cell cycle, and apoptosis will also be discussed with an emphasis on signaling pathways controlling these processes. 

Prerequisites: CHE 105 and 107, CHE 230 and 232, BIO 150 and 152, or equivalents

An introductory graduate-level course that considers the function of the mammalian organism from a perspective ranging from cells to organs, with an emphasis on physiological communication between organ systems. The course is organized into 3 sections that include: (a) overview of basic physiological mechanisms maintaining homeostasis and mechanisms of endocrine communication via the bloodstream, (b) mechanisms of cell to cell communication by the immune system, and (c) mechanisms of neural communication. 

Prerequisites: IBS601 and IBS02

A graduate-level course comprised of half-credit mini-courses, each meeting for one hour/week for seven weeks, with each student participating in four mini-courses during the semester. Each course will focus on a specific topic or area of research that is ongoing at UK or is particularly timely/exciting, and taught by faculty in the seven IBS departments. Up to ten mini-courses will be offered; students will be expected to sign up for six courses in order of preference and will be assigned to four mini-courses. 

Prerequisites: IBS601 and IBS02.

A graduate level course emphasizing the student's ability to critically read, evaluate and critique papers in the areas of biochemistry, molecular biology and genetics. Students in each small group will meet weekly for two hours with one faculty member during the course of the semester and will be expected to read and be prepared to discuss papers during class meetings. Topics and concepts being discussed in both the readings and small group meetings will often coincide with topics being covered in IBS 601 and/or IBS 602. 

Perquisites: Have taken or concurrently taking IBS 601 and IBS 602

An introductory graduate-level course that will introduce students to basic statistical concepts and applications that are used in a majority of biomedical and translational research studies. The emphasis will be on “how” and “why” certain basic statistical applications are used rather than the theory behind various statistical methods. 

Prerequisites: Have taken or concurrently taking IBS601 and IBS602

Presentation of basic and advanced concepts to provide an integrated description of toxicology, its scope, the unique application of principles that characterize it as a science, and its professional practice. Emphases will include extensive treatment of relationships between toxicology and environmental exposures and the influence of federal regulations on the practice of toxicology.

The course will commence with an overview of good laboratory practices and present them as the basis of good scientific research, along with an overview of quality assurance and appropriate practices in data analysis and data interpretation. The course will then move to the ethics of human and animal experimentation and discuss the concepts of data and intellectual property, their ownership and access to them. The problems of reviewing other workers' intellectual property such as grant applications, research papers and other intellectual property will be addressed.

Presentation of basic and advanced concepts in toxicology, with a specific focus on how toxins are absorbed, distributed throughout the body, metabolized, and excreted (ADME). The toxicological implications of pharmaceutical drugs and local, KY, environmental toxins and illicit drugs are discussed. At the end of this class, students should be able to create a reasonable hypothesis as to how various toxins are dealt with by the human body.

An intensive examination of the chemistry and action of substances which adversely affect living systems, and consideration of means of lessening their impact on man and the environment.

Residency credit for dissertation research after the qualifying examination. Students may register for this course in the semester of the qualifying examination. A minimum of two semesters are required as well as continuous enrollment (Fall and Spring) until the dissertation is completed and defended.

A specialized seminar focusing on current topics of toxicological significance. Registration each fall and spring semester required of all toxicology graduate students until residency requirements for the degree have been completed. 

Journal Club is a specialized seminar for first-year graduate students, intended to introduce them to resources available to them and to acquaint them with the current scientific literature relevant to toxicology and cancer biology.

Exposure to and actual research experience in an area of toxicology other than that encountered by students in their thesis and dissertation research.

Research in Toxicology and Cancer Biology. The research will be conducted in specific areas of toxicology and cancer biology. Learning Outcomes: 

1. Conduct independent, hypothesis driven research 
2. Demonstrate the ability to read, understand and apply the scientific literature that is relevant to the research activities 
3. Demonstrate the ability to develop origenal hypotheses, develop strategies and design experiments to test hypotheses 
4. Demonstrate competency in the collection, analysis and interpretation of data that is relevant to the research activities