Papers by Yasunobu Yoshikai
Journal of Immunology, May 1, 1995
International Immunology, Jul 7, 2023
Frontiers in Immunology, Apr 10, 2018
bioRxiv (Cold Spring Harbor Laboratory), Jul 15, 2023
Immunology Letters, Nov 1, 2017
Journal of Immunology, Oct 15, 1994
Journal of Immunology, Jun 15, 1995
Cell Reports, Nov 1, 2019
Journal of Virology, Jun 1, 1994
Journal of Immunology, Oct 15, 2004
Journal of Experimental Medicine, Aug 1, 1991
Journal of Immunology, Sep 1, 1997
International Immunology, Feb 1, 1998
Journal of Immunology, Feb 15, 2020
Infection and Immunity, Dec 1, 2004
Interaction between commensal bacteria and intestinal epithelial cells (i-ECs) via TLRs is import... more Interaction between commensal bacteria and intestinal epithelial cells (i-ECs) via TLRs is important for intestinal homeostasis. In this study, we found that the numbers of CD8� � TCR� � and TCR� � intestinal intraepithelial lymphocytes (i-IELs) were significantly decreased in MyD88-deficient (�/�) mice. The expression of IL-15 by i-ECs was severely reduced in MyD88 �/ � mice. Introduction of IL-15 transgene into MyD88 �/ � mice (MyD88 �/ � IL-15 transgenic mice) partly restored the numbers of CD8�� TCR� � and TCR� � i-IELs. The i-IEL in irradiated wild-type (WT) mice transferred with MyD88 �/ � bone marrow (BM) cells had the same proportions of i-IEL as WT mice, whereas those in irradiated MyD88 �/ � mice transferred with WT BM cells showed significantly reduced proportions of CD8� � TCR� � and TCR� � i-IELs, as was similar to the proportions found in MyD88 �/� mice. However, irradiated MyD88 �/ � IL-15 transgenic mice transferred with WT BM cells had increased numbers of CD8��
Nagoya journal of medical science, 1992
During infection with L.monocytogenes, a facultative intracellular bacteria, TcR gamma/delta T ce... more During infection with L.monocytogenes, a facultative intracellular bacteria, TcR gamma/delta T cells specific for 65 kd hsp precede TcR alpha/beta T cells specific for the listerial antigens in appearance. The gamma/delta T cells provide a first line of defense against the infection by recognizing exogenous and endogenous 65 kd hsp on infected cells and producing cytokines such as gamma IFN. The hsp-specific T cells respond quickly to antigenically diverse pathogens before antigen-specific T cells expand clonally, and they play a role in covering the gap between the phagocytic system and highly evolved immune response. 65 kd hsp-specific T cells play important roles not only in host defense mechanism against infection with various pathogens but also in induction of auto-immune disease. Both 65 kd hsp-specific gamma delta T cells and 65 kd hsp-specific alpha beta T cells abrogate the unresponsiveness of the self-reactive alpha beta T cells and/or B cells by producing IL-2 and contrib...
Mucosal Immunology, 2020
This most comprehensive analysis to date of γδ T cells in the murine uterus reveals them to compo... more This most comprehensive analysis to date of γδ T cells in the murine uterus reveals them to compose a unique local T-cell compartment. Consistent with earlier reports, most cells expressed a canonical Vγ6Vδ1 TCR, and produced interleukin (IL)-17A upon stimulation. Nonetheless, contrasting with earlier reports, uterine γδ T cells were not obviously intraepithelial, being more akin to sub-epithelial Vγ6Vδ1+ T cells at several other anatomical sites. By contrast to other tissues however, the uterine compartment also included non-Vγ6+, IFN-γ-producing cells; was strikingly enriched in young mice; expressed genes hitherto associated with the uterus, including the progesterone receptor; and did not require microbes for development and/or maintenance. This notwithstanding, γδ T-cell deficiency severely impaired resistance to reproductive tract infection by Candida albicans, associated with decreased responses of IL-17-dependent neutrophils. These findings emphasise tissue-specific complexi...
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Papers by Yasunobu Yoshikai