Climate change is disrupting the natural, economic, and social systems we rely on, which is shifting our ability to ensure human health and well-being – especially of the most vulnerable populations. While global-scale commitments are critical to a just transition away from fossil fuels, there is a need for solutions that are tailored to local and cultural contexts, drawing on deep historical and area knowledge. MacMillan elevates inquiry and action that reflect the urgency of one of the most daunting social challenges of our time – offering particularly critical regional insights.