This study is testing whether a single dose of psilocybin, a compound found in certain mushrooms, is safe, tolerable, and helpful for adults struggling with symptoms like anxiety, depression, or trauma that interfere with daily life.

Participants will take one dose of psilocybin and attend follow-up visits over six weeks to see if their symptoms improve and how they function day-to-day. The study is open to adults with a wide range of symptoms, even those who don’t have formal diagnosis, and will take place at Yale University in New Haven, CT.