A-84,543

A-84,543
(IUPAC) ime
	3-(1-metil-2-(S)-pirolidinilmetokdi)piridin
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	9794141
ChemSpider	10739566
ChEMBL	CHEMBLCHEMBL84149
Hemijski podaci
Formula	C11H16N2O
Mol. masa	192,257
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C11H16N2O/c1-13-7-3-4-10(13)9-14-11-5-2-6-12-8-11/h2,5-6,8,10H,3-4,7,9H2,1H3/t10-/m0/s1 ; Key: MVLJPWPLDPHKST-JTQLQIEISA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

A-84543 je lek koji je razvilo preduzeće Abbott. Ovaj molekul je agonist neuronskog nikotinskog acetilholinskog receptora koji je visoko selektivan za α4β2 receptor. On nalazi široku primenu u naučnim israživanjima strukture i funkcije tog receptora. Ovaj ligand je bio polazno jedinjenje u razvoji velike familije srodnih derivata.^[5]^[6]^[7]^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Abreo, M.; Lin, N.; Garvey, D.; Gunn, D.; Hettinger, A.; Wasicak, J.; Pavlik, P.; Martin, Y. i dr.. (1996). „Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors”. Journal of Medical Chemistry 39 (4): 817–825. DOI:10.1021/jm9506884. PMID 8632405.
↑ Lin, N. H.; Gunn, D. E.; Li, Y.; He, Y.; Bai, H.; Ryther, K. B.; Kuntzweiler, T.; Donnelly-Roberts, D. L. i dr.. (1998). „Synthesis and structure-activity relationships of pyridine-modified analogs of 3-2-((S)-pyrrolidinyl)methoxypyridine, A-84543, a potent nicotinic acetylcholine receptor agonist”. Bioorganic & Medicinal Chemistry Letters 8 (3): 249–254. DOI:10.1016/S0960-894X(98)00019-5. PMID 9871663.
↑ Wei, Z.; Xiao, Y.; Yuan, H.; Baydyuk, M.; Petukhov, P.; Musachio, J.; Kellar, K.; Kozikowski, A. (2005). „Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits”. Journal of Medicinal Chemistry 48 (6): 1721–1724. DOI:10.1021/jm0492406. PMID 15771418.
↑ Carreras, J.; Avenoza, A.; Busto, J.; Peregrina, J. (2007). „Synthesis of azabicyclo2.2.nalkane systems as analogues of 3-1-methyl-2-(S)-pyrrolidinyl- methoxypyridine (A-84543)”. The Journal of Organic Chemistry 72 (8): 3112–3115. DOI:10.1021/jo0700732. PMID 17371077.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Abreo, M.; Lin, N.; Garvey, D.; Gunn, D.; Hettinger, A.; Wasicak, J.; Pavlik, P.; Martin, Y. i dr.. (1996). „Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors”. Journal of Medical Chemistry 39 (4): 817–825. DOI:10.1021/jm9506884. PMID 8632405.

[autogenerated1-6] Lin, N. H.; Gunn, D. E.; Li, Y.; He, Y.; Bai, H.; Ryther, K. B.; Kuntzweiler, T.; Donnelly-Roberts, D. L. i dr.. (1998). „Synthesis and structure-activity relationships of pyridine-modified analogs of 3-2-((S)-pyrrolidinyl)methoxypyridine, A-84543, a potent nicotinic acetylcholine receptor agonist”. Bioorganic & Medicinal Chemistry Letters 8 (3): 249–254. DOI:10.1016/S0960-894X(98)00019-5. PMID 9871663.

[7] Wei, Z.; Xiao, Y.; Yuan, H.; Baydyuk, M.; Petukhov, P.; Musachio, J.; Kellar, K.; Kozikowski, A. (2005). „Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits”. Journal of Medicinal Chemistry 48 (6): 1721–1724. DOI:10.1021/jm0492406. PMID 15771418.

[8] Carreras, J.; Avenoza, A.; Busto, J.; Peregrina, J. (2007). „Synthesis of azabicyclo2.2.nalkane systems as analogues of 3-1-methyl-2-(S)-pyrrolidinyl- methoxypyridine (A-84543)”. The Journal of Organic Chemistry 72 (8): 3112–3115. DOI:10.1021/jo0700732. PMID 17371077.

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Reference

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