Citikolin

Citikolin
(IUPAC) ime
	5'-O-[hidroksi({hidroksi[2-(trimetilamonio)etoksi]; fosforil}oksi)fosforil]citidin
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	987-78-0
ATC kod	N06BX06
PubChem	13805
ChemSpider	16736209
UNII	536BQ2JVC7
KEGG	D00057
ChEMBL	CHEMBL1618340
Hemijski podaci
Formula	C14H27N4O11P2+
Mol. masa	489,332 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C12H22N4O11P2/c1-16(2,3)26-29(22,23)27-28(20,21)24-6-7-9(17)10(18)11(25-7)15-5-4-8(13)14-12(15)19/h4-5,7,9-11,17-18H,6H2,1-3H3,(H3-,13,14,19,20,21,22,23)/t7-,9-,10-,11-/m1/s1 ; Key: OPDHNBAEGPICKZ-QCNRFFRDSA-N
Sinonimi	Cytidine diphosphate choline
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Citikolin (citidin difosfat-holin, CDP-holin, citidin 5'-difosfoholin) je psihostimulans/nutropik. On je intermedijar u generaciji fosfatidilholina iz holina.

Ispitivanja sugerišu da CDP-holin suplementi povećavaju gustine dopaminskog receptora,^[6] i da pomažu u sprečavanju gubljenja memorije uzrokovanog lošim uslovima životne sredine.^[7] Preliminarna ispitivanja su utvrdila da citikolinski suplementi pomažu u poboljšanju fokusa i mentalne energije, te da potencijalno mogu da budu korisni u tretmanu deficita koncentracije.^[8]^[9] Citikolin isto tako povišava nivo ACTH-a nezavisno od nivoa CRH.^[10]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Giménez R, Raïch J, Aguilar J (November 1991). „Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice”. British Journal of Pharmacology 104 (3): 575–8. PMC 1908237. PMID 1839138.
↑ Teather LA, Wurtman RJ (2005). „Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats”. Learning & Memory 12 (1): 39–43. DOI:10.1101/lm.83905. PMC 548494. PMID 15647594.
↑ „Supplement naturally boosts ageing brain power”. Sydney Morning Herald. 25. 02. 2008.. Pristupljeno 28. 07. 2009.
↑ Silveri MM, Dikan J, Ross AJ, et al. (November 2008). „Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy”. NMR in Biomedicine 21 (10): 1066–75. DOI:10.1002/nbm.1281. PMID 18816480.
↑ Cavun S, Savci V (October 2004). „CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement”. Fundamental & Clinical Pharmacology 18 (5): 513–23. DOI:10.1111/j.1472-8206.2004.00272.x. PMID 15482372.

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	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Giménez R, Raïch J, Aguilar J (November 1991). „Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice”. British Journal of Pharmacology 104 (3): 575–8. PMC 1908237. PMID 1839138.

[7] Teather LA, Wurtman RJ (2005). „Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats”. Learning & Memory 12 (1): 39–43. DOI:10.1101/lm.83905. PMC 548494. PMID 15647594.

[8] „Supplement naturally boosts ageing brain power”. Sydney Morning Herald. 25. 02. 2008.. Pristupljeno 28. 07. 2009.

[9] Silveri MM, Dikan J, Ross AJ, et al. (November 2008). „Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy”. NMR in Biomedicine 21 (10): 1066–75. DOI:10.1002/nbm.1281. PMID 18816480.

[10] Cavun S, Savci V (October 2004). „CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement”. Fundamental & Clinical Pharmacology 18 (5): 513–23. DOI:10.1111/j.1472-8206.2004.00272.x. PMID 15482372.

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Reference

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