Nizatidin

Nizatidin
(IUPAC) ime
	N-(2-[(2-[(dimetilamino)metil]tiazol-4-il)metiltio]etil)-N-metil-2-nitroeten-1,1-diamin
Klinički podaci
Robne marke	Aksid
AHFS/Drugs.com	Monografija
MedlinePlus	a694030
Identifikatori
CAS broj	76963-41-2
ATC kod	A02BA04
PubChem	3033637
DrugBank	DB00585
ChemSpider	2298266
UNII	P41PML4GHR
KEGG	D00440
ChEMBL	CHEMBL653
Hemijski podaci
Formula	C12H21N5O2S2
Mol. masa	331,46 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+ ; Key: SGXXNSQHWDMGGP-IZZDOVSWSA-N
Farmakokinetički podaci
Bioraspoloživost	>70%
Vezivanje za proteine plazme	35%
Metabolizam	Hepatički
Poluvreme eliminacije	1-2 sata
Izlučivanje	Renalno
Farmakoinformacioni podaci
Licenca	US FDA:link
Trudnoća	B3(AU)
Pravni status	Samo na recept (S4) (AU) POM (UK) OTC (SAD)
Način primene	Oralno

Nizatidin je histaminski antagonist H₂ receptora koji inhibira produkciju želudačne kiseline, i često se koristi za tretiranje želudačnih čireva i gastroezofagealne refluksne bolesti. Ovaj lek je razvila kompanija Eli Lili. U prodaji je pod imenima Tazak i Aksid.

Klinička upotreba

Glavni članak: Antagonist H2-receptora

Pojedini preparati nizatidina su dostupni na slobodno u raznim zemljama. Nizatidina je eksperimentalno korišćen za kontrolu dodatne telesne težine stečene upotrebom pojedinih antipsihotičkih lekova.^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Atmaca M, Kuloglu M, Tezcan E, Ustundag B, Kilic N (January 2004). „Nizatidine for the treatment of patients with quetiapine-induced weight gain”. Hum Psychopharmacol 19 (1): 37–40. DOI:10.1002/hup.477. PMID 14716710.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Nizatidin
Axid @ FDA
Aksid oralni rastvor Arhivirano 2008-05-26 na Wayback Machine-u

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid14716710-6] Atmaca M, Kuloglu M, Tezcan E, Ustundag B, Kilic N (January 2004). „Nizatidine for the treatment of patients with quetiapine-induced weight gain”. Hum Psychopharmacol 19 (1): 37–40. DOI:10.1002/hup.477. PMID 14716710.

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Klinička upotreba

Reference

Spoljašnje veze

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