GPR18
| G protein-spregnuti receptor 18 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | GPR18; | ||||||||||
| Vanjski ID | OMIM: 602042 MGI: 107859 HomoloGene: 18814 IUPHAR: GPR18 GeneCards: GPR18 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2841 | 110168 | |||||||||
| Ensembl | ENSG00000125245 | ENSMUSG00000050350 | |||||||||
| UniProt | Q14330 | n/a | |||||||||
| RefSeq (mRNA) | NM_005292 | NM_182806 | |||||||||
| RefSeq (protein) | NP_005283 | NP_877958 | |||||||||
| Lokacija (UCSC) |
Chr 13: 98.7 - 98.71 Mb |
Chr 14: 121.05 - 121.05 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
GPR18, N-arahidonil glicinski receptor, je protein koji je kod čoveka kodiran GPR18 genom.[1][2] Zajedno sa drugim „orfanskim“ receptorima GPR55 i GPR119, za GPR18 je utvrđeno da je receptor za endogene lipidne neurotransmitere, nekoliko od kojih se takođe vezuju za kanabinoidne receptore.[3][4][5] Nedavna istraživanja daju snažnu podršku hipotezi da GPR18 predstavlja abnormalni kanabidiolni receptor, i sugerišu da N-arahidonoil glicin, endogeni lipidni metabolit anandamida, inicira usmerenu mikroglijalnu migraciju u CNS-u putem GPR18 aktivacije.[6]
Ligandi
[уреди | уреди извор]Ligandi za koje je utvrđeno da vezuju GPR18 su:[6]
- Abnormalni kanabidiol
- N-arahidonoil glicine
Literatura
[уреди | уреди извор]- ^ Gantz I, Muraoka A, Yang YK, Samuelson LC, Zimmerman EM, Cook H, Yamada T (1997). „Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis”. Genomics. 42 (3): 462—6. PMID 9205118. doi:10.1006/geno.1997.4752.
- ^ „Entrez Gene: GPR18 G protein-coupled receptor 18”.
- ^ Kohno M, Hasegawa H, Inoue A, Muraoka M, Miyazaki T, Oka K, Yasukawa M (2006). „Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18”. Biochemical and Biophysical Research Communications. 347 (3): 827—32. PMID 16844083. doi:10.1016/j.bbrc.2006.06.175.
- ^ Burstein S (2008). „The elmiric acids: biologically active anandamide analogs”. Neuropharmacology. 55 (8): 1259—64. PMC 2621443
. PMID 18187165. doi:10.1016/j.neuropharm.2007.11.011.
- ^ Bradshaw HB, Lee SH, McHugh D (2009). „Orphan endogenous lipids and orphan GPCRs: a good match”. Prostaglandins & Other Lipid Mediators. 89 (3-4): 131—4. PMC 2740803 . PMID 19379823. doi:10.1016/j.prostaglandins.2009.04.006.
- ^ а б McHugh D, Hu SS, Rimmerman N, Juknat A, Vogil Z, Walker JM, Bradshaw HB (2010). „N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor”. BMC Neuroscience. 11 (1): 44. PMC 2865488 . PMID 20346144. doi:10.1186/1471-2202-11-44.
Dodatna literatura
[уреди | уреди извор]- Christian SL; McDonough J; Liu Cy CY; et al. (2002). „An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia.”. Genomics. 79 (5): 635—56. PMID 11991713. doi:10.1006/geno.2002.6765.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Dunham A; Matthews LH; Burton J; et al. (2004). „The DNA sequence and analysis of human chromosome 13.”. Nature. 428 (6982): 522—8. PMC 2665288 . PMID 15057823. doi:10.1038/nature02379.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Kohno M; Hasegawa H; Inoue A; et al. (2006). „Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.”. Biochem. Biophys. Res. Commun. 347 (3): 827—32. PMID 16844083. doi:10.1016/j.bbrc.2006.06.175.