A Randomized Controlled Trial of Weight-Bearing Versus Non-Weight-Bearing Exercise For Improving Physical Ability After Usual Care For Hip Fracture
A Randomized Controlled Trial of Weight-Bearing Versus Non-Weight-Bearing Exercise For Improving Physical Ability After Usual Care For Hip Fracture
A Randomized Controlled Trial of Weight-Bearing Versus Non-Weight-Bearing Exercise For Improving Physical Ability After Usual Care For Hip Fracture
2
2
10.15, P.006). At 4 months, more people in the WBE
group became able to walk unaided (WBE, 36%; NWBE,
6%; control, 14%,
2
2
20.02, P.001).
Effect of Interventions on the Self-Reported Measures
No differences between the groups were found for self-rated
fall risk, balance, health, quality of night-time sleep, pain,
activity levels, Katz Activities of Daily Living Scale, or Func-
tional Ambulation Categories performance at either 1- or
4-month assessments.
DISCUSSION
This study found between-group differences for the domains
of balance and functional ability but not for strength and gait,
with the weight-bearing exercise group showing the greatest
improvement. For the balance domain, the most important
contributors to this effect were improved functional reach and
step test abilities. This indicates that these subjects gained
better control of their center of mass while reaching and while
stepping, presumably because the exercises they undertook
provided a greater challenge to the postural control system. No
between-group differences were evident for improvements in
postural sway, which has been shown to be an important risk
factor for falling.
19
However, performance on this test is vari-
able, so improvements may be more difcult to demonstrate
than on other balance measures used. Previous exercise pro-
grams that have led to improved postural sway have been
supervised and of longer duration.
20
This program involved
few visits to subjects and was also conservative in its chal-
lenges to the postural control system. Because the exercises
Fig 1. Flow of subjects through the study.
713 EXERCISE AFTER HIP FRACTURE, Sherrington
Arch Phys Med Rehabil Vol 85, May 2004
were carried out at home, often while the person was alone,
safety was a prime consideration in exercise prescription.
The greatest contribution to the between-group difference in
functional abilities resulted from improved sit-to-stand perfor-
mance. The weight-bearing group improved the most on timed
sit-to-stand. This indicates the potential of this exercise pro-
gram to improve functional abilities that may have implications
for an older persons ability to continue to live independently
in the community. Each subcomponent of the PPME is mea-
sured on a 3-point scale, therefore, the lack of marked changes
in the PPME score may indicate the poor sensitivity of the scale
to smaller changes.
Multivariate analysis of the strength domain did not reveal
signicant between-group differences. However, the WBE
group did show a greater improvement in knee extension
strength and lateral step-up ability. Greater improvements in
muscle strength may have resulted from programs that specif-
ically targeted strength by overloading muscles in a more
intense and structured manner. There was also a correlation
between improvements in sit-to-stand ability and in knee ex-
tension strength for both the affected (r.28, P.005) and
nonaffected (r.23, P.02) leg.
Although the multivariate analysis of the gait domain found
no signicant between-group differences, when compared with
the other groups, more people in the WBE group were able to
walk unaided at the 4-month retest. This suggests better walking
ability and greater condence while walking, despite no change in
gait speed or stepping rate. It is possible that greater between-
group differences in these gait parameters could have resulted if
the WBE program had specically targeted these factors. A more
extensive WBE program could also include activities to prepare
participants to deal with real-life environmental challenges, such
as practice on ramps, stairs, and various surfaces.
The lack of between-group differences in the extent of
improvement in self-reported measures of functional ability,
general health, or activity levels indicates that the between-
group differences discussed above were not perceived to have
resulted in measurable effects on ability to perform everyday
activities. This may reect that self-reported functional out-
comes may be difcult to change with exercise alone, because
they are likely to be affected by psychosocial and environmen-
tal factors as well as by physical ability.
21
Although weight-bearing exercise is less commonly used in
current clinical practice than nonweight-bearing exercise, it
was not associated with adverse effects in this study. No falls
were reported while doing the exercises, and subjects did not
report more pain while doing the weight-bearing exercise pro-
gram than what was reported by subjects doing the non
weight-bearing program. Subjects in the exercise groups also
had a comparable level of compliance with the prescribed
exercise program, suggesting a similar acceptance of the exer-
cises. Subjects in the weight-bearing group found the exercises
moderately more difcult, which probably reects the use of
greater muscle forces and more muscle groups to gain and
maintain the upright position required for the weight-bearing
exercises. It is possible that the weight-bearing exercises had a
greater effect on the physical outcome measures purely as a
result of this greater level of difculty.
This exercise program was conducted in the home, with little
supervision from the physical therapists, so it was not possible
to gather reliable information about the actual intensity of
training, that is, the number of repetitions completed or the
duration of exercise sessions. As a result, we cannot provide
information about the amount of practice required to produce
the improvements in motor function that were found.
Table 2: Strength Between-Group Comparisons
Outcome by Group Preintervention 1 Month 4 Months
Hip abduction affected leg
WBE 47.829.8 55.728.1 57.927.9
NWBE 49.925.7 54.126.0 56.324.3
Control 46.126.0 52.425.4 53.028.0
Hip abduction nonaffected leg
WBE 63.128.5 66.625.0 72.231.3
NWBE 61.429.1 65.927.0 68.827.2
Control 60.831.3 62.930.9 64.830.1
Hip exion affected leg
WBE 39.823.6 47.625.3 50.428.3
NWBE 38.821.2 45.824.8 49.323.1
Control 38.222.1 41.522.4 43.326.4
Hip exion nonaffected leg
WBE 52.923.9 57.924.9 60.829.4
NWBE 56.424.1 60.425.5 62.925.3
Control 53.426.2 59.126.5 55.326.7
Knee extension affected leg
WBE 124.562.7 141.056.3 152.975.9*
NWBE 108.848.1 119.647.3 125.647.2
Control 106.453.8 113.461.0 112.973.0
Knee extension nonaffected leg
WBE 146.671.2 162.970.0 172.079.6*
NWBE 146.961.4 153.368.5 152.260.3
Control 139.864.5 145.580.2 139.278.9
NOTE. Values are mean SD (N). Subject numbers at 1 month: WBE, n33; NWBE, n37; control, n36; 4 months: WBE, n32; NWBE, n34;
control, n36. At 4 months, post hoc tests revealed differences between the control and WBE groups for knee extension strength for both the
affected leg (mean difference, 31.8N; 95% condence interval [CI], 9.554.0; P.02) and the nonaffected leg (mean difference, 27.2N; 95% CI,
5.648.7; P.04).
714 EXERCISE AFTER HIP FRACTURE, Sherrington
Arch Phys Med Rehabil Vol 85, May 2004
Nineteen percent of subjects in the exercise groups who
underwent the nal assessment were not doing the prescribed
exercises at that time. This compliance rate is consistent with
other exercise intervention studies
22
and is not surprising, be-
cause no contact was made with the subjects between the 1-
and 4-month assessments. A program that incorporated more
visits or follow-up phone calls might have produced a higher
compliance rate. A more intense program might also have led
to greater between-group differences in the outcome measures.
The WBE program was designed to reect the way muscles
work during daily weight-bearing tasks, such as standing up,
walking, reaching, and stair-climbing. Larger improvements
for the WBE group were found for the measures that reected
daily task requirements (functional reach, step test, sit-to-stand
ability, walking aid use, and step-up ability); there were no
measures in which the NWBE group improved more than the
weight-bearing group. It therefore appears that exercises that
more closely approximate daily functional tasks are a better
choice for this population.
The external validity of this study is likely to be high.
Subjects were representative of those with fractured hips, peo-
ple with a wide range of ages (5795y) were included, and
Table 3: Balance Between-Group Comparisons
Outcome by Group Preintervention 1 Month 4 Months
Step test affected leg (steps)
WBE 7.05.4 10.06.4* 11.06.3*
NWBE 7.77.1 8.37.3 9.46.7
Control 8.36.5 9.47.0 9.07.3
Step test nonaffected leg (steps)
WBE 7.85.2 11.46.0* 11.75.9*
NWBE 7.65.8 8.76.5 9.15.8
Control 8.96.3 10.36.4 9.97.2
Functional reach (cm)
WBE 17.56.8 21.09.0 24.88.8*
NWBE 18.49.1 18.77.4 19.98.1
Control 17.88.7 19.99.0 19.410.0
Sway distance oor (mm)
WBE 76.445.8 78.847.7 79.046.0
NWBE 75.953.6 81.353.1 70.052.8
Control 90.350.3 89.254.4 89.859.9
Sway distance foam (mm)
WBE 136.681.2 128.580.5 115.773.3
NWBE 146.3108.1 142.5111.2 122.084.1
Control 143.595.6 128.885.2 129.079.4
NOTE. Values are mean SD. Subject numbers at 1 month: WBE, n33; NWBE, n37; control, n36; 4 months: WBE, n33; NWBE, n35;
control, n36.
*P .05. Univariate tests of between-group differences on change scores. At 4 months, post hoc tests revealed differences between the WBE
and control groups for the step test on both the affected leg (mean difference, 2.8 steps; 95% CI, 0.94.8; P.01) and the nonaffected leg (mean
difference, 2.6 steps; 95% CI, 0.94.7; P.008) and for the functional reach (mean difference, 5.9cm; 95% CI, 2.19.6; P.004) and between the
WBE and NWBE groups for the step test on both the affected (mean difference, 2.9 steps; 95% CI, 0.94.8; P.01) and nonaffected legs (mean
difference, 3.1 steps; 95% CI, 1.34.8; P.003) and for the functional reach (mean difference, 7.1cm; 95% CI, 3.410.9; P.001).
Table 4: Gait Between-Group Comparisons
Outcome by Group Preintervention 1 Month 4 Months
Time to walk 6m at comfortable pace (s)
WBE 14.310.0 12.39.0 11.89.2
NWBE 15.913.2 14.211.4 13.212.9
Control 14.210.9 13.312.1 13.211.7
No. of steps taken in 6m at comfortable pace
WBE 19.310.1 18.710.8 18.311.0
NWBE 17.66.4 17.05.2 17.37.1
Control 17.18.8 17.711.1 17.29.4
Time to walk 6m at fast pace (s)
WBE 10.48.6 9.28.4 9.29.1
NWBE 12.310.8 11.010.0 9.910.8
Control 11.210.2 11.915.7 11.011.6
No. of steps taken in 6m fast pace
WBE 17.19.8 16.210.3 16.310.7
NWBE 16.15.8 15.65.3 15.76.0
Control 15.98.3 16.712.8 16.39.9
NOTE. Values are mean SD. Subject numbers at 1 month: WBE, n33; NWBE, n37; control, n37; 4 months: WBE, n33; NWBE, n36;
control, n36.
715 EXERCISE AFTER HIP FRACTURE, Sherrington
Arch Phys Med Rehabil Vol 85, May 2004
there were few exclusion criteria. In addition, subjects were
recruited from several hospitals, both public and private care,
and from several different settings (orthopedic wards, rehabil-
itation wards, physical therapy departments). The subjects had
received several different treatment approaches before entering
the study and represented a range of socioeconomic and ethnic
backgrounds.
CONCLUSIONS
This study indicates that a home-exercise program with
limited supervision can be of benet after hip fracture. Weight-
bearing exercise produced greater improvements than non
weight-bearing exercise or no exercise, particularly in balance
and functional performance. All participants had completed the
usual postfracture care, so it is evident that they had the
potential for further improvements in physical functioning,
particularly with a weight-bearing exercise program.
Acknowledgments: This study is part of the National Health and
Medical Research Councils Prevention of Injuries in Older People
Health Partnership research program. Staff at 6 Sydney hospitals
(Bankstown-Lidcombe, Liverpool, War Memorial, Balmain, Green-
wich, Hunters Hill Private) assisted with the recruitment of subjects.
Jenny Jacka assisted with nancial management. Pat Pamphlett and
Pernille Jensen assisted with exercise prescription and data collection.
Dr. Hylton Menz made useful comments on an earlier draft of this
manuscript.
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Supplier
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Table 5: Functional Performance Between-Group Comparisons
Outcome by Group Preintervention 1 Month 4 Months
Timed sit-to-stand 5 (s)
WBE 25.418.5 20.014.1 18.012.4*
NWBE 28.120.4 24.920.3 20.312.7
Control 21.712.8 22.521.8 23.215.4
Timed supine-to-sit (s)
WBE 4.63.9 3.83.6 3.43.5
NWBE 6.88.7 5.45.5 5.59.2
Control 4.53.6 3.73.4 4.13.5
PPME total score
WBE 9.42.1 10.22.3 10.32.3
NWBE 9.52.0 9.91.8 10.51.5
Control 9.81.8 10.21.7 10.11.8
NOTE. Values are mean SD. Subject numbers at 1 month: WBE,
n33; NWBE, n37; control, n34; 4 months: WBE, n33; NWBE,
n36; control, n36.
*P.05. Univariate tests of between-group differences on change
scores. At 4 months, post hoc tests revealed differences for timed
sit-to-stand between the WBE and control groups (mean difference,
8.1s; 95% CI, 3.412.8; P.001) and between the NWBE and control
groups (mean difference, 5.8s; 95% CI, 1.210.5; P.02).
716 EXERCISE AFTER HIP FRACTURE, Sherrington
Arch Phys Med Rehabil Vol 85, May 2004