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    Jurnal Kistik Fibrosis

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    Alie Anwar Sutisna
    Cystic fibrosis is a genetic disease that affects many organs but primarily the lungs. Lung disease in cystic fibrosis begins early in life and is characterized by inflammation, impaired mucus clearance, and chronic infections in the airways. This leads to progressive lung function decline and periodic acute worsening of respiratory symptoms known as pulmonary exacerbations. Pulmonary exacerbations negatively impact patients' quality of life and healthcare costs. The Cystic Fibrosis Foundation established guidelines to define key questions about treating pulmonary exacerbations and make evidence-based treatment recommendations to help clinicians.

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    Jurnal Kistik Fibrosis

    Uploaded by

    Alie Anwar Sutisna
    886 views2 pages
    Cystic fibrosis is a genetic disease that affects many organs but primarily the lungs. Lung disease in cystic fibrosis begins early in life and is characterized by inflammation, impaired mucus clearance, and chronic infections in the airways. This leads to progressive lung function decline and periodic acute worsening of respiratory symptoms known as pulmonary exacerbations. Pulmonary exacerbations negatively impact patients' quality of life and healthcare costs. The Cystic Fibrosis Foundation established guidelines to define key questions about treating pulmonary exacerbations and make evidence-based treatment recommendations to help clinicians.

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    Jurnal kistik fibrosis

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    Jurnal kistik fibrosis

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    Cystic fibrosis is a genetic disease that affects many organs but primarily the lungs. Lung disease in cystic fibrosis begins early in life and is characterized by inflammation, impaired mucus clearance, and chronic infections in the airways. This leads to progressive lung function decline and periodic acute worsening of respiratory symptoms known as pulmonary exacerbations. Pulmonary exacerbations negatively impact patients' quality of life and healthcare costs. The Cystic Fibrosis Foundation established guidelines to define key questions about treating pulmonary exacerbations and make evidence-based treatment recommendations to help clinicians.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
    886 views2 pages

    Jurnal Kistik Fibrosis

    Uploaded by

    Alie Anwar Sutisna
    Cystic fibrosis is a genetic disease that affects many organs but primarily the lungs. Lung disease in cystic fibrosis begins early in life and is characterized by inflammation, impaired mucus clearance, and chronic infections in the airways. This leads to progressive lung function decline and periodic acute worsening of respiratory symptoms known as pulmonary exacerbations. Pulmonary exacerbations negatively impact patients' quality of life and healthcare costs. The Cystic Fibrosis Foundation established guidelines to define key questions about treating pulmonary exacerbations and make evidence-based treatment recommendations to help clinicians.

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    Pulmonary Perspective

    Cystic Fibrosis Pulmonary Guidelines


    Treatment of Pulmonary Exacerbations

    Perspektif paru
    Pedoman paru Fibrosis kistik
    Pengobatan Paru Eksaserbasi

    The natural history of cystic fibrosis lung disease is one of


    chronic
    progression with intermittent episodes of acute worsening of
    symptoms frequently called acute pulmonary exacerbations
    These
    exacerbations typically warrant medical intervention. It is
    important
    that appropriate therapies are recommended on the basis of
    available
    evidence of efficacy and safety. The Cystic Fibrosis
    Foundation
    therefore established a committee to define the key questions
    related to pulmonary exacerbations, review the clinical
    evidence
    using an evidence-based methodology, and provide
    recommendations
    to clinicians. It is hoped that these guidelines will be helpful to
    clinicians in the treatment of individuals with cystic fibrosis.

    Riwayat alami penyakit fibrosis paru cystic adalah salah satu


    kronis
    perkembangan dengan episode intermiten akut memburuknya
    Gejala yang sering disebut paru akut eksaserbasi ini
    eksaserbasi biasanya menjamin intervensi medis. Itu penting
    bahwa terapi yang tepat direkomendasikan atas dasar tersedia
    bukti efikasi dan keamanan. Cystic Fibrosis Foundation
    Oleh karena itu membentuk komite untuk menentukan
    pertanyaan kunci
    terkait dengan eksaserbasi paru, meninjau bukti klinis
    menggunakan metodologi berbasis bukti, dan memberikan
    rekomendasi
    untuk dokter. Diharapkan panduan ini akan membantu untuk
    dokter dalam pengobatan individu dengan fibrosis kistik.

    Cystic fibrosis (CF) is a complex genetic disease affecting


    many
    organs, although 85% of the mortality is a result of lung
    disease
    (1). CF lung disease begins early in life with inflammation and
    impaired mucociliary clearance and consequent chronic
    infection
    of the airways (2). There is progressive decline of lung
    function with episodes of acute worsening of respiratory
    symptoms, often referred to as pulmonary exacerbations.
    Although a generally applicable prospective definition of a
    pulmonary
    exacerbation has not been developed, clinical features
    of an exacerbation may include increased cough, increased
    sputum production, shortness of breath, chest pain, loss of
    appetite, loss of weight, and lung function decline (3).
    Pulmonary exacerbations have an adverse impact on patients
    qualityof life and a major impact on the overall cost of care
    (4).Identifying optimal treatment methods for these events
    couldproduce significant improvements in quality and length

    Cystic fibrosis (CF) adalah penyakit genetik kompleks yang


    mempengaruhi banyak
    organ, meskipun 85% dari kematian adalah akibat dari penyakit
    paru-paru
    (1). Penyakit CF paru-paru dimulai sejak awal kehidupan
    dengan peradangan dan
    gangguan pembersihan mukosiliar dan infeksi kronis akibat
    dari saluran udara (2). Ada penurunan progresif dari paru-paru
    fungsi dengan episode akut memburuk pernafasan
    gejala, sering disebut sebagai '' eksaserbasi paru. ''
    Meskipun calon definisi umum yang berlaku dari paru a
    eksaserbasi belum dikembangkan, fitur klinis
    eksaserbasi dapat mencakup peningkatan batuk, peningkatan
    produksi sputum, sesak napas, nyeri dada, kehilangan
    nafsu makan, kehilangan berat badan, dan fungsi paru-paru
    menurun (3). Paru eksaserbasi berdampak buruk pada kualitas
    pasien ' hidup dan dampak yang besar pada biaya keseluruhan
    perawatan (4).Mengidentifikasi metode pengobatan yang
    optimal untuk peristiwa ini bias menghasilkan perbaikan yang
    signifikan dalam kualitas dan panjang hidup

    of life for patients with CF.

    untuk pasien dengan CF.

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