8`

Aminoglycosides

Under supervision of :

Dr. Sara Mohamed Hesham

Prepared by :

Hanan Yosry Mohamed

 1-Gentamicin 2-neomycin
Generic name Gentamicin sulfate neomycin sulfate

Trade name Apigent -biogentacin-cidomycin – mycifradin _neofradin

gental –garamycin -farcocin-genmycin- _neo tab
gentamycin-refobacin-rigaminol

Dosage form In topical preparations as (ointment- Tablets and oral solution.

cream)
- IV injection
-eye drops
concentration In topical preparation: ( 0.1 – 0.3%) 500 mg. 350 mg
-injection (20-40-80 mg/ml )
Use Used for (bacteremia _kidney infection 1_for treatment of hepatic
_plaque _cystic fibrosis _bacterial encephalopathy by inhibiting
ammonia forming bacteria in
endocarditis prevention bone infection
GI tract.
And In multi ingredients medication 2_perioperative prophylaxis.
with prednisolone ophthalmic used in adjunct to mechanical
blepharitis. Conjunctivitis cleansing of the large
intestine in patients
undergoing Colorectal
surgery.
3_Hypercholesterolemia. its
therapeutic value may be due
in part to reduction in GI
absorption of cholesterol.
Dose Adult : For hepatic encephalopathy :
Conventional dosing Adult 4_12g daily in four
3-5 mg/kg/day intravenously/intramuscularly divided dose.
(IV/IM) divided every 8 hours Children 100 mg /kg daily in
Extended dosing interval (every 24 hours or more)
four divided doses.
Initial: 4-7 mg/kg/dose IV once/day
For preoperative
Base dose on lean body weight
Subsequent doses: Consult pharmacist prophylaxis.for 8am surgery
Pediatric give one gram neomycin
Children 5 years and older: 2-2.5 mg/kg/dose sulfate and one gram
intravenously/intramuscularly (IV/IM) every 8 erythromycin at 1pm.
hours For hyper cholesterolemia
Children under 5 years: 2.5 mg/kg/dose IV/IM 0.5_2g not use for long term.
every 8 hours
Ointment : Apply to affected area 3 to 4 times per day
 3- kanamycin 4- amikacin
Generic name kanamycin sulfate amikacin sulfate
Trade name kantrex amikin_amiglyde
__amikacin.)
Dosage form intravenous and intravenous and
intramuscular injection intramuscular injection
solution. solution
Concentration 333 mg /ml 50 mg/ml _250 mg/ml
_1g/4ml _500 mg /2ml
Use for bacterial infection For short-term treatment of
caused by E.coli serious infections due to
susceptible strains of Gram-
_Klebsiella pneumonia
negative bacteria, including
_Proteus species Pseudomonas species,
_serratia marcescens. Escherichia coli, species of
indole-positive and indole-
negative Proteus, Providencia
species, Klebsiella-
Enterobacter-Serratia species,
and Acinetobacter (Mima-
Herellea) species. Amikacin
may also be used to treat
Mycobacterium avium and
Mycobacterium tuberculosis
infections.

Dose for intramuscular route 15 mg/kg IM or IV (over 30 to

15 Mg/kg daily in two 60 minutes) per day, given in
2 to 3 equal doses at equally
equally divided dose
divided intervals
For intravenous route 15 Maximum dose: 15
mg /kg daily must be mg/kg/day
administered slowly Duration of therapy: 7 to 10
days
 5- Tobramycin 6- Streptomycin
Generic name tobramycin Streptomycin sulfate
Trade name Tobrin. Tobradex.Torbrex streptomycin
Dosage form Ophthalmic ointment. injection, powder,
Ophthalmic drop. lyophilized, for solution
Nebulizer solution for
inhalation
Concentration ointment contains 0.3 Reconstitute vial containing 1
%of tobramycin. g streptomycin powder with
4.2, 3.2, or 1.8 mL of sterile
Nebulizer solution :each
water for injection to provide
single dose 5ml ampoule a solution containing
contains 300 mg approximately 200, 250, or
tobramycin 400 mg/mL, respectively.1
Use treatment of 1_for treatment of tuberculosis
caused by(mycobacterium
Pseudomonus tuberculosis)
aeruginosa. Lung 2_non tuberculosis infections as
infection. Also being Pasteurella pestis (plague),
investigated for use in Francisella tularensis (tularemia),
Brucella,
treatment of sinus Calymmatobacterium
infection. granulomatis (donovanosis,
granuloma inguinale),
H. ducreyi (chancroid),
H. influenzae (in respiratory,
endocardial, and meningeal
infections - concomitantly with
another antibacterial agent),
K. pneumoniae pneumonia
(concomitantly with another
antibacterial agent),

Dose Eye Infection Moderate-Severe Infections

Mild/moderate 1-2 g/day IM divided q6-12hr;
no more than 2 g/day
Ointment: Apply ½ in. (1.25
cm) to affected eye(s) q8-12hr Tuberculosis
Solution: 1-2 drops q4-6hr; Daily therapy: 15 mg/kg IM
may be increased to q1-2hr qDay; no more than 1 g/day
during initial 24-48 hours
Severe Twice weekly therapy: 25-30
mg/kg IM 2 times/week; no
Ointment: Apply ½ in. (1.25 more than 1.5 g/day
cm) to affected eye(s) q3-4hr
Solution: 2 drops q30-60min, Tularemia
then less frequently after 1-2 g IM in divided doses for
improvement; for 7-10 days or until patient is
Pseudomonas aeruginosa, 2 afebrile for 5-7 days
drops q5min for 1 hour
Plague
15 mg/kg IM q12hr for
minimum 10 days