MATERIAL SAFETY DATA SHEET

TITANIUM DIOXIDE, SOLID

1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

Brenntag Canada Inc. WHMIS#: 00060859

43 Jutland Rd. Index: GCD3174/16A
Toronto, ON
Effective Date: 2016 February 22
M8Z 2G6
(416) 259-8231 Date of Revision: 2016 February 22

Website: http://www.brenntag.ca

EMERGENCY TELEPHONE NUMBER (For Emergencies Involving Chemical Spills or Releases)

1 855 273 6824

PRODUCT IDENTIFICATION
Product Name: Titanium Dioxide, Solid.

Chemical Name: Titanium Dioxide.

Synonyms: Titanic Acid Anhydride; C.I. Pigment White 6; C.I. 77891; Titania; Titanium (IV) Oxide; Titanium
Peroxide; Titanium White.

Trade names include:

BSI Titanium Dioxide 323 ; BSI Titanium Dioxide 325 ; BSI Titanium Dioxide 3328 ; BSI Titanium
Dioxide 3330 ; BSI Titanium Dioxide 3333 ; Kemox RC 808 ; Kemox RC 822. Kronos 1000 ; Kronos
2020 ; Kronos 2044 ; Kronos 2047 ; Kronos 2063 ; Kronos 2064 ; Kronos 2073 ; Kronos 2090 ; Kronos
2101 ; Kronos 2160 ; Kronos 2190; Kronos 2210 ; Kronos 2211 ; Kronos 2220 ; Kronos 2230 ; Kronos
2300 ; Kronos 2310.
Chemical Family: Inorganic Oxide.
Molecular Formula: TiO2.
Product Use: Pigmentation. Chemical intermediate.
WHMIS Classification / Symbol:
D-2A: Very Toxic (carcinogen)

READ THE ENTIRE MSDS FOR THE COMPLETE HAZARD EVALUATION OF THIS PRODUCT.

2. COMPOSITION, INFORMATION ON INGREDIENTS (Not Intended As Specifications)

Ingredient CAS# ACGIH TLV (TWA) % Concentration

Titanium Dioxide (TiO2) 13463-67-7 10 mg/m³ *A4 80 - 100

Some grades may contain:

Aluminum Hydroxide 21645-51-2 --- 0-5
Silica gel 112926-00-8 --- 0 - 10

A4 = Not classifiable as a human carcinogen. (ACGIH-A4).

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3. HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW: Suspect cancer hazard. Dust may cause mechanical irritation to skin, eyes and respiratory tract. May
cause pulmonary fibrosis and pneumoconiosis. Can decompose at high temperatures forming toxic
gases. See "Other Health Effects" Section.
POTENTIAL HEALTH EFFECTS
Inhalation: Product may be mildly irritating to the nose, throat and respiratory tract and may cause coughing and
sneezing. Excessive contact with powder may cause drying of mucous membranes of nose and throat
due to absorption of moisture and oils. See "Other Health Effects" Section.
Skin Contact: This product may cause irritation due to abrasive action. Excessive contact with powder may cause
drying of the skin due to absorption of moisture and oils. Avoid handling when the skin is moist, wet or
abraded.
Skin Absorption: Not likely to be absorbed through the skin.
Eye Contact: This product may cause irritation, redness and possible damage due to abrasiveness. Excessive contact
with powder may cause drying of mucous membranes of the eyes due to absorption of moisture and oils.
Ingestion: This product may cause mild gastrointestinal discomfort. Ingestion of large amounts may cause nausea,
gastrointestinal upset and abdominal pain.
Other Health Effects: Effects (irritancy) on the skin and eyes may be delayed, and damage may occur without the sensation or
onset of pain. Strict adherence to first aid measures following any exposure is essential.

May cause shortness of breath, lung damage, pulmonary fibrosis and pneumoconiosis. Pneumoconiosis
is the deposition of dust in the lungs and the tissue's reaction to its presence. When exposure to the
dust is severe or prolonged, the lungs' defenses are overwhelmed.

Titanium dioxide dust is considered possibly carcinogenic to humans based on animal evidence, which
shows that high concentrations of pigment-grade (powdered) and ultrafine titanium dioxide dust causes
respiratory tract cancer in rats exposed by inhalation and intratracheal instillation. (4) See Section 11,
"Other Studies Relevant to Material".

4. FIRST AID MEASURES

FIRST AID PROCEDURES
Inhalation: If respiratory problems arise, move the victim to fresh air. Give artificial respiration ONLY if breathing
has stopped. Give cardiopulmonary resuscitation (CPR) if there is no breathing AND no pulse. Obtain
medical advice IMMEDIATELY.
Skin Contact: Start flushing while removing contaminated clothing. Wash affected areas thoroughly with soap and
water. If irritation, redness, or a burning sensation develops and persists, repeat flushing and obtain
medical attention.
Eye Contact: Immediately flush eyes with running water for a minimum of 20 minutes. Hold eyelids open during
flushing. Take care not to rinse contaminated water into the unaffected eye or onto the face. If irritation
persists, repeat flushing. Obtain medical attention IMMEDIATELY.
Ingestion: Do not attempt to give anything by mouth to an unconscious person. If victim is alert and not convulsing,
rinse mouth out and give 1/2 to 1 glass of water to dilute material. DO NOT induce vomiting. If
spontaneous vomiting occurs, have victim lean forward with head down to avoid breathing in of vomitus,
rinse mouth and administer more water. Obtain medical attention IMMEDIATELY.
Note to Physicians: Treat symptomatically. Medical conditions that may be aggravated by exposure to this product include
diseases of the skin, eyes or respiratory tract.

5. FIRE-FIGHTING MEASURES

Flammability Limits in Air (%):

AutoIgnition
Flashpoint (°C) Temperature (°C) LEL UEL

Non-combustible (does not Not applicable. Not applicable. Not applicable.

burn).
Flammability Class (WHMIS): Not regulated.
Hazardous Combustion Thermal decomposition products are toxic and may include oxides of silicon and oxides of titanium.
Products:
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Unusual Fire or Explosion Minimize air borne spreading of dust. Spilled material may cause floors and contact surfaces to become
Hazards: slippery.
Sensitivity to Mechanical Impact: Not expected to be sensitive to mechanical impact.
Rate of Burning: Not available.
Explosive Power: Not available.
Sensitivity to Static Discharge: Not expected to be sensitive to static discharge.
EXTINGUISHING MEDIA
Fire Extinguishing Media: Foam. Dry chemical, carbon dioxide or water spray.
FIRE FIGHTING
INSTRUCTIONS
Instructions to the Fire Fighters: Use water spray to cool fire-exposed containers or structures. Use water spray to disperse vapours.
Spilled material may cause floors and contact surfaces to become slippery.
Fire Fighting Protective Use self-contained breathing apparatus and protective clothing.
Equipment:

6. ACCIDENTAL RELEASE MEASURES

Information in this section is for responding to spills, leaks or releases in order to prevent or minimize the adverse effects on persons,
property and the environment. There may be specific reporting requirements associated with spills, leaks or releases, which change from
region to region.
Containment and Clean-Up In all cases of leak or spill contact vendor at Emergency Number shown on the front page of this MSDS.
Procedures: Minimize air borne spreading of dust. Wear respirator, protective clothing and gloves. Avoid dry
sweeping. Do not use compressed air to clean surfaces. Vacuuming is preferred. Do not allow to enter
sewers or watercourses. Collect product and contaminated soil for re-use or disposal. Ventilate
enclosed spaces. Notify applicable government authority if release is reportable or could adversely
affect the environment. Where a package (drum or bag) is damaged and / or leaking, repair it, or place it
into an over-pack drum immediately so as to avoid or minimize material loss and contamination of
surrounding environment.

7. HANDLING AND STORAGE

HANDLING
Handling Practices: Use normal "good" industrial hygiene and housekeeping practices. Minimize air borne spreading of dust.
Clean up immediately to eliminate slipping hazard.
Ventilation Requirements: See Section 8, "Engineering Controls".
Other Precautions: Use only with adequate ventilation and avoid breathing dusts. Avoid contact with eyes, skin or clothing.
Wash thoroughly with soap and water after handling. Wash contaminated clothing thoroughly before re-
use.

Titanium dioxide product may be packaged at temperatures of approximately 100 to 120 °C and stay hot
for a long time depending on ambient temperatures and inventory storage practices. (3)
STORAGE
Storage Temperature (°C): See below.
Ventilation Requirements: General exhaust is acceptable. Local exhaust ventilation preferred.
Storage Requirements: Store in a cool, dry and well-ventilated area. Keep away from heat, sparks and flames. Keep containers
closed. Avoid moisture contamination. Prolonged storage may result in lumping or caking.
Special Materials to be Used for Confirm suitability of any material before using.
Packaging or Containers:

8. EXPOSURE CONTROLS / PERSONAL PROTECTION

Recommendations listed in this section indicate the type of equipment, which will provide protection against overexposure to this product.
Conditions of use, adequacy of engineering or other control measures, and actual exposures will dictate the need for specific protective
devices at your workplace.
ENGINEERING CONTROLS
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Engineering Controls: Local exhaust ventilation required. Make up air should be supplied to balance air that is removed by local
or general exhaust ventilation. Ventilate low lying areas such as sumps or pits where dense dust may
collect.
PERSONAL PROTECTIVE
EQUIPMENT (PPE)
Eye Protection: Safety glasses with side shields are recommended to prevent eye contact. Use chemical safety goggles
when there is potential for eye contact. Contact lenses should not be worn when working with this
material.
Skin Protection: Gloves and protective clothing made from cotton, canvas or rubber should be impervious under
conditions of use. Prior to use, user should confirm impermeability. Discard contaminated gloves.
Respiratory Protection: No specific guidelines available. A NIOSH/MSHA-approved air-purifying respirator equipped with dust,
mist, fume cartridges for concentrations up to 100 mg/m³. An air-supplied respirator if concentrations are
higher or unknown.
Other Personal Protective Wear regular work clothing. The use of coveralls is recommended. Locate safety shower and eyewash
Equipment: station close to chemical handling area. Take all precautions to avoid personal contact.
EXPOSURE GUIDELINES

SUBSTANCE ACGIH TLV OSHA PEL NIOSH REL

(STEL) (TWA) (STEL) (TWA) (STEL)

Titanium Dioxide (TiO2) — 15 mg/m³ (Total --- --- ---

Dust)

9. PHYSICAL AND CHEMICAL PROPERTIES (Not intended as Specifications)

Physical State: Solid.
Appearance: Dry, white granules: fine sized, beads, pucks, or powder.
Odour: Odourless.
Odour Threshold (ppm): Not applicable.
Boiling Range (°C): Not available.
Melting/Freezing Point (°C): > 1000.
Vapour Pressure (mm Hg at 20° C): Not applicable.
Vapour Density (Air = 1.0): Not applicable.
Relative Density (g/cc): 3.7 - 4.2.
Bulk Density: Not available.
Viscosity: Not applicable.
Evaporation Rate (Butyl Acetate = 1.0): Not applicable.
Solubility: Not soluble in water.
% Volatile by Volume: Not available.
pH: 8 - 10.5 (slurry).
Coefficient of Water/Oil Distribution: Not available.
Volatile Organic Compounds (VOC): Not applicable.
Flashpoint (°C): Non-combustible (does not burn).

10. STABILITY AND REACTIVITY

CHEMICAL STABILITY
Under Normal Conditions: Stable.
Under Fire Conditions: Not flammable.
Hazardous Polymerization: Will not occur.
Conditions to Avoid: High temperatures, sparks, open flames and all other sources of ignition. Minimize air borne spreading of
dust. Clean up immediately to eliminate slipping hazard. Combines with most metallic oxides at elevated
temperatures to form "glass".
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Materials to Avoid: Lewis or mineral acids.

Metals (e.g. aluminum powder, lithium, magnesium and zinc) - reduction of titanium dioxide on heating is
accompanied by incandescence and temperature rise; the reactions are violently exothermic and rapid.
(4)

Potassium perchlorate, Aluminum powder and Titanium dioxide - A mixture of the 3 compounds
exploded violently during mixing. The mixture has also been accidentally ignited by a spark. (4)
Decomposition or Combustion Thermal decomposition products are toxic and may include oxides of silicon and oxides of titanium.
Products:

11. TOXICOLOGICAL INFORMATION

TOXICOLOGICAL DATA:

SUBSTANCE LD50 (Oral, Rat) LD50 (Dermal, Rabbit) LC50 (Inhalation, Rat, 4h)

Titanium Dioxide (TiO2) > 25 000 mg/kg (4) > 10 000 mg/kg (4) > 6820 mg/m3 (4)

Carcinogenicity Data: Titanium Dioxide: Possibly carcinogenic to humans. (IARC-2B)

Reproductive Data: No adverse reproductive effects are anticipated.
Mutagenicity Data: No adverse mutagenic effects are anticipated.
Teratogenicity Data: No adverse teratogenic effects are anticipated.
Respiratory / Skin Sensitization None known.
Data:
Synergistic Materials: None known.
Other Studies Relevant to The International Agency for Research on Cancer (IARC) has determined that titanium dioxide is
Material: possibly carcinogenic to humans (Group 2B) based on inadequate evidence in humans and sufficient
evidence in experimental animals. This conclusion relates to long-term inhalation exposure to high
concentrations of pigmentary (powdered) or ultrafine titanium dioxide.

Long-term inhalation of high concentrations of titanium dioxide dust has caused lung tumours in rats but
not in hamsters or mice. The tumours are believed to be related to the inflammation resulting from dust
overloading of the lungs. Ultrafine titanium dioxide has increased the incidence of lung tumours at much
lower exposure concentrations than are required with the larger sized pigment grade particles. The
effects are more closely related to lung burden in terms of the surface area rather than the mass of the
particles. (4)

Female rats were exposed whole-body to filtered air or to an aerosol of ultrafine titanium dioxide (primary
particle size, 15-40 nm; MMAD of aerosol particles: 0.80 micrometres) for up to 2 years (18 hr/d, 5 d/wk).
The concentrations of titanium dioxide used were 7.2 mg/m3 for the first 4 months, 14.8 mg/m3 for the
next four months and 9.4 mg/m3 for the remaining 16 months. There was a significant decrease in
survival, body weight and lung clearance and a significant increase in lung weight of exposed rats. The
number of rats with lung tumours was 32/100 compared to 1/217 for unexposed controls. Female mice
similarly exposed for 13.5 months had no increase in lung tumours. Tumours in the airways and lungs
were observed in rats following inhalation of 250 mg/m3 titanium dioxide dust (MMAD of aerosol
particles: 1.5-1.7 micrometres; 84% respirable) for 2 years (6 hr/d, 5 d/wk). (4)

12. ECOLOGICAL INFORMATION

Ecotoxicity: Not available. Low acute toxicity to aquatic organisms.
Environmental Fate: Not available. May be harmful if allowed to enter drinking water intakes. Do not contaminate domestic or
irrigation water supplies, lakes, streams, ponds, or rivers.

13. DISPOSAL CONSIDERATIONS

Deactivating Chemicals: None required.
Waste Disposal Methods: This information applies to the material as manufactured. Reevaluation of the product may be required
by the user at the time of disposal since the product uses, transformations, mixtures and processes may
influence waste classification. Dispose of waste material at an approved (hazardous) waste
treatment/disposal facility in accordance with applicable local, provincial and federal regulations. Do not
dispose of waste with normal garbage, or to sewer systems.
Titanium Dioxide, Solid Brenntag Canada Inc.
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Safe Handling of Residues: See "Waste Disposal Methods".

Disposal of Packaging: Empty containers retain product residue. Treat package in the same manner as the product.

14. TRANSPORTATION INFORMATION

CANADIAN TDG ACT SHIPPING DESCRIPTION:
This product is not regulated by TDG.
Label(s): Not applicable. Placard: Not applicable.
ERAP Index: -----. Exemptions: None known.

US DOT CLASSIFICATION (49CFR 172.101, 172.102):

This product is not regulated by DOT.
Label(s): Not applicable. Placard: Not applicable.
CERCLA-RQ: Not available. Exemptions: None known.

15. REGULATORY INFORMATION

CANADA
CEPA - NSNR: All components of this product are included on the DSL.
CEPA - NPRI: Titanium (and its compounds).
Controlled Products Regulations Classification (WHMIS):
D-2A: Very Toxic (carcinogen)

USA
Environmental Protection Act: All components of this product are included on the TSCA inventory.
OSHA HCS (29CFR 1910.1200): Carcinogenic.
Text22:
NFPA: Health, Fire, Reactivity (Not available.)
HMIS: 2 Health, 0 Fire, 0 Reactivity (6)
Text22:

INTERNATIONAL
Titanium Dioxide is found on the following inventories: EINECS (European Inventory of Existing Commercial Chemical Substances),
Australia (ACOIN), Japan (MITI) and Korea (ECL).

16. OTHER INFORMATION

REFERENCES

1. RTECS-Registry of Toxic Effects of Chemical Substances, Canadian Centre for Occupational Health and Safety RTECS
database.
2. Clayton, G.D. and Clayton, F.E., Eds., Patty's Industrial Hygiene and Toxicology, 3rd ed., Vol. IIA,B,C, John Wiley and Sons, New
York, 1981.
3. Supplier's Material Safety Data Sheet(s).
4. CHEMINFO chemical profile, Canadian Centre for Occupational Health and Safety, Hamilton, Ontario, Canada.
5. Guide to Occupational Exposure Values, 2011, American Conference of Governmental Industrial Hygienists, Cincinnati, 2011.
6. Regulatory Affairs Group, Brenntag Canada Inc.
7. The British Columbia Drug and Poison Information Centre, Poison Managements Manual, Canadian Pharmaceutical Association,
Ottawa, 1981.
8. Lewis, Sr., Richard J., Carcinogenically Active Chemicals, Van Nostrand Reinhold, 1991, ISBN 0-442-31875-8.
____________________________________________________________________________________________________________

The information contained herein is offered only as a guide to the handling of this specific material and has been prepared in good faith by
technically knowledgeable personnel. It is not intended to be all-inclusive and the manner and conditions of use and handling may involve
other and additional considerations. No warranty of any kind is given or implied and Brenntag Canada Inc. will not be liable for any
damages, losses, injuries or consequential damages which may result from the use of or reliance on any information contained herein.
Titanium Dioxide, Solid Brenntag Canada Inc.
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This Material Safety Data Sheet is valid for three years.

____________________________________________________________________________________________________________

To obtain revised copies of this or other Material Safety Data Sheets, contact your nearest Brenntag Canada Regional office.

British Columbia: 20333-102B Avenue, Langley, BC, V1M 3H1

Phone: (604) 513-9009 Facsimile: (604) 513-9010

Alberta: 6628 - 45 th. Street, Leduc, AB, T9E 7C9

Phone: (780) 986-4544 Facsimile: (780) 986-1070

Manitoba: 681 Plinquet Street, Winnipeg, MB, R2J 2X2

Phone: (204) 233-3416 Facsimile: (204) 233-7005

Ontario: 43 Jutland Road, Toronto, ON, M8Z 2G6

Phone: (416) 259-8231 Facsimile: (416) 259-5333

Quebec: 2900 Jean Baptiste Des., Lachine, PQ, H8T 1C8

Phone: (514) 636-9230 Facsimile: (514) 636-0877

Atlantic: A-105 Akerley Boulevard, Dartmouth, NS, B3B 1R7

Phone: (902) 468-9690 Facsimile: (902) 468-3085
____________________________________________________________________________________________________________

Prepared By: Regulatory Affairs Group, Brenntag Canada Inc., (416) 259-8231.