Biopharmaceutics and Pharmacokinetics (Sem VIII CBSGS) Question Bank Mock Test

Biopharmaceutics and Pharmacokinetics (Sem VIII CBSGS)
Question Bank Mock test

1. Paddle over disc apparatus is used for dissolution testing of
a. Tablets
b. Capsules
c. Transdermal drug delivery systems
d. All types of formulation
2. Glucose is transported by
a. Simple diffusion
b. Pinocytosis
c. Facilitated transport
d. Pore transport
3. Water soluble drugs of molecules of small molecular size are transported by

a. Active transport
b. Endocytosis
c. Pore transport
d. Passive diffusion
4. Identify the equation for first order pharmacokinetics after IV drug administration
a. h h
b. h h
c. h h
d. h
5. Identify the correct order

a. Absorption, metabolism, distribution, excretion
b. Distribution, metabolism, absorption, excretion
c. Absorption, distribution, metabolism, excretion
d. Absorption, excretion, metabolism, distribution
6. Identify the factors affecting drug absorption

a. Environmental factors: temperature and humidity of the surroundings
b. Biological membrane properties, route of drug administration, mechanism of
drug transport
c. The height and weight of the patient
d. Posture of the patient
7. If the volume of distribution of a drug in 33L it indicates that the drug is
a. Distributed throughout the body
b. Is confined to the blood
c. It distributed to the brain and lipophilic tissues
d. Is metabolized by the liver
8. Identify the correct formula for volume of distribution

th
a.
t
b.
th
c.
d. th
9. In hypoalbuminemia, protein binding may be reduced and result in

a. lipid binding
b. high concentrations of free drug in blood
c. make the drug long acting
d. the drug will cross the blood brain barrier
10. The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting
30 microgram/mL instantaneous concentration in plasma shall be
a. 100 L
b. 1.0 L
c. 0.1 L
d. 10 L
11. The characteristic of non-linear pharmacokinetics include :
(A) Area under the curve is proportional to the dose
(B) Elimination half-life remains constant
(C) Area under the curve is not proportional to the dose
(D) Amount of drug excreted remains constant
12. Drugs following one compartment open model pharmacokinetics are eliminated
a. Bi- exponentially
b. Tri-exponentially
c. Mono exponentially
d. Non-exponentially
13. The Area under the plasma level time curve indicates
a. Amount of drug excreted in Urine
b. Amount of drug absorbed
c. Amount of drug filtered by the kidney
d. Biological half-life of the drug
14. The volume of distribution of a drug is ___________

a. A relationship between total amount of drug in the body and concentration of
drug in the blood
b. A measure of total body fluid
c. Proportional to the bioavailability of the drug
d. An expression of total body volume
15. The rate and extent of drug reaching the systemic circulation is called
a. Absorption
b. Distribution
c. Bioavailability
d. Clearance
16. The time required for a drug to start producing a pharmacological action is called
a. Duration of action
b. Onset of action
c. Therapeutic index
d. Tmax
17. Primary route of drug excretion of drugs and their metabolites is

a. Bile
b. Saliva
c. Urine
d. Sweat
18. The therapeutic index of a drug is related to its

a. Safety and Efficacy
b. Onset of action and lag time
c. Dose and dosage form
d. Elimination rate constant and clearance
19. _____________ drugs are easily excreted by the kidneys.

a. Water soluble
b. Volatile
c. Lipid soluble
d. Drugs with large molecular size
20. Indian Pharmacopoeia describes ___________types of dissolution apparati.

a. 2
b. 4
c. 6
d. 7
21. Identify the wrong statement:
The peak time (tmax) can be used:
a.to determine comparative bioavailability and/or bioequivalence
b.to determine the preferred route of drug administration and the desired dosage
form for the patient
c.to assess the onset of action
d.is affected by the dose
22. The biopharmaceutical classification of the drugs classifies the drugs into four classes
according to their solubility and permeability. BCS Class III drugs can be described as
those having
a. High solubility and high permeability
b. Low solubility and high permeability
c. High solubility and low permeability
d. Low solubility and high permeability
23. Absorption rate constant for a drug after extravascular administration can be
determined by
a. Phase II reactions
b. Residual method
c. Michelis menten equation
d. Noyes Whitney equation
24. The primary site of drug metabolism in the body is

a. Kidney
b. Adipose tissue
c. Liver
d. Blood
25. A drug has a volume of distribution V = 8 L and a clearance Cl = 875

mL/h. The drug's half-life t1/2 will be
a. 1h
b. 6.34 h
c. 63.4 h
d. 0.634 h

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Biopharmaceutics and Pharmacokinetics (Sem VIII CBSGS)

Question Bank Mock test

3. Water soluble drugs of molecules of small molecular size are transported by

5. Identify the correct order

6. Identify the factors affecting drug absorption

8. Identify the correct formula for volume of distribution

9. In hypoalbuminemia, protein binding may be reduced and result in

14. The volume of distribution of a drug is ___________

17. Primary route of drug excretion of drugs and their metabolites is

18. The therapeutic index of a drug is related to its

19. _____________ drugs are easily excreted by the kidneys.

20. Indian Pharmacopoeia describes ___________types of dissolution apparati.

24. The primary site of drug metabolism in the body is

25. A drug has a volume of distribution V = 8 L and a clearance Cl = 875

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