Syllabus (Pharmacy) With Old Version New Credit

Department of Pharmacy
Course Curriculum & Syllabus

Bachelor of Pharmacy (Honors)
Khwaja Yunus Ali University

Enayetpur, Sirajgonj
Khwaja Yunus Ali University
Department of Pharmacy
Curriculum and Syllabus For
Bachelor of Pharmacy (Honors) Program
Preamble:
The Department of Pharmacy provides undergraduate program to offer the
Bachelor of Pharmacy (Honors) [B. Pharm. (Hons.)] degree. It is a four year
undergraduate degree curriculum, which contains theoretical courses, practical
sessions, project works and predetermined industrial and hospital trainings.
The Bachelor of Pharmacy (Hons.) program in Khwaja Yunus Ali University aims
to introduce the students to pharmacy as a profession: to provide knowledge on the
responsibilities and uniqueness of the pharmacists in pharmaceutical industry,
hospital & community pharmacy and to help them to acquire knowledge in their
coursework for the real benefits of patients and the people. The core topics provide
the roles required for the modern pharmacists; legal and ethical aspects, pharmacy
service quality and standards: improving the public’s health and medicines
management.
The first year introduces the profession and scientific basis of Pharmacy and the
principles of drug design and disease management. It is projected to equip the
students with the wide range of skills required for further studies and practices.
Courses cover physiology and pharmaceutical chemistry and will be studied along
with core aspects of formulation, drug discovery and use.
Students will study the more complex aspects of Pharmacy in the second year,
including aspects of human physiology, pathology, pharmacology and
microbiology. Pharmaceutics and formulation of dosage forms will also be
covered.
The emphasis of the third year is the development of skills in pharmaceutical
industry on manufacturing & formulation technology, drug analysis, medicinal
chemistry, pharmaceutical biotechnology together with further aspects of the law
and ethical issues in Pharmacy. This will also encompass relevant topics of
toxicology and therapeutics, hospital and community practices.
The fourth/final year is primarily designed to carry out advanced studies on

medicinal chemistry, pharmaceutical analysis, pharmaceutical technology, bio-
pharmaceutics & pharmacokinetics. Topics and key developments in professional
practice and the wider role of pharmacists in patient care, identifying and
responding to symptoms, the monitoring of disease and appropriate drug
interventions, cosmetology, agro-vet pharmacy, food & nutrition will be covered.
The students will be given extended research projects to prepare themselves for
employment and further studies.
Entry Requirements
Students who have passed Secondary School Certificate and Higher Secondary
Certificate or equivalent Examinations in Science (Group with Chemistry, Biology,
Physics and Mathematics with a GPA of at least 2.5 in each level or have passed
GCE, O and A-level examinations with science subjects including those four, of
which at least two must be at the A-Level examination and secured B grade in at
least three of them at any level are eligible for admission in the B. Pharm. (Hons)
course.
Number of Courses and Credits

The curriculum of Bachelor of Pharmacy (Hons) program comprises of 72 courses
containing l54 credits, of which 147 credits are on pharmacy core courses and 7
credits are assigned to the relevant non-pharmacy courses.
Academic Period & Semesters

The B. Pharm. (Hons.) program is offered in 4 (four) academic years consisting of
8 (eight) six monthly semesters. Each semester consists of l8 weeks of class
lectures and practical sessions, 2 weeks of preparatory leave and 4 weeks for Mid
Term and Semester Final examinations. There will be two semesters- spring
(January-July) and fall (October to March) in an academic year.
During any semester, students according to their needs may take additional courses
either to make up deficiencies in credits and/or grade point average (GPA)
requirements, or to fulfill the make-up deficiencies in credits requirements for a B.
Pharm. (Hons.) degree and thus spending less time than the normal durations of 4
years.
ASSIGNMENT OF CREDITS AND COURSES

The program is offered through a set of theoretical and laboratory courses,
fieldwork, project and thesis work.
1. Theoretical Courses:
A one hour lecture per week per semester will be equivalent to one credit. Thus, a
three credit hours course will have three lectures of 60 minutes duration or 2
lectures of 90 minutes duration per week throughout the semester.
2. Practical / Training / Project Work:

Each practical course will be counted as one credit.
Project titles will be provided by the supervisor of the student. The supervisor will
be in overall charge of the management of the project and will also ensure that the
student adheres to the project regulations and requirements. At the end of the
project each student will submit a dissertation and give an oral presentation of his
or her findings.
Grading System:
The total performance of a student in a given course is based on a scheme of
continuous assessment. For a theoretical course, this continuous assessment is
made through homework, assignment, attendance, quizzes, a mid semester (mid-
term) examination of 90 minutes duration and a semester final examination of 150
minutes duration. The distribution of marks for a given course is as follows:
i. Class Assessments (Class test 10%, Class assignment 10%, Class attendance 5%): 20%
ii. Mid Semester (mid-term) examination: 30%
iii. Semester final examination: 50%
Total 100%
The assessment in practical/ course/ field work is made through observation of the
student at work in class, viva voce, during practical hours and quizzes.
The grading system as prescribed by the University Grants Commission (UGC),
Bangladesh is followed in grading students aptitude in examinations. The system is
given below:
Numerical Grade Letter Grade Grade Point
80% and above A+ (A plus) 4.00
75% to less than 80% A (A regular) 3.75
70% to less than 75% A- (A minus) 3.50
65% to less than 70% B+ (B plus) 3.25
60% to less than 65% B (B regular) 3.00
55% to less than 60% B- (B minus) 2.75
50% to less than 55% C+ (C plus) 2.50
45% to less than 50% C (C regular) 2.25
40% to less than 45% D 2.00
Less than 40% F 0.00
Incomplete I
Withdrawal W
Award of Degree:
To obtain Bachelor of Pharmacy (Honors) Degree from the department of
Pharmacy, a student must successfully complete a total of 154.0 Credits and will
require scoring a CGPA of 2.50 or higher.
In addition to those a student has to complete assigned industrial and hospital
training and project work before the graduation.
SUMMARY OF COURSE DISTRIBUTION
The duration of Bachelor of Pharmacy (honors.) program is divided into 4 (four) periods that are
designated as Yeas I (First year), Year II (Second year), Year III (Third year) and Year IV (Fourth year). The
courses and credits are listed below:
No. of Pharmacy No. of Ancillary Total Total

Year Semester
core courses courses Courses Credits
Semester I 04 03 07 18
Year I
Semester II 10 - 10 20
Semester I 09 - 09 19
Year II
Year III
Year IV
Total= 69 03 72 159
Pharmacy core courses = 152 Credits
Non-pharmacy courses = 07 Credits
Total = 154 Credits

Semester-wise Courses of B. Pharm. (Hons.) Program
Year I, Semester I
Sl. No. Code No. Title of Courses Credit/s
01. CCT 1101 Computer & Communication Techniques 2.0
02. BSM 1102 Biostatistics & Mathematics 3.0
03. ENG 1103 Communicative English 2.0
04. BPH 1101 Pharmacognosy 3.0
05. BPH 1102 Inorganic Pharmacy- I 3.0
06. SOC 101 Emergence of Bangladesh 3.0
07. BPH 1103 Pharmacognosy Practical 1.0
08. BPH 1104 Inorganic Pharmacy-I Practical 1.0
09. ETC 111 Introduction to Ethics 0.0
Total =18.0 Credits
Year I, Semester II
Sl. No. Code No. Title of Courses Credit/s Prerequisite
01. BPH 1201 Inorganic Pharmacy-II 3.0 BPH 1102
02. BPH 1202 Physiology & Anatomy-I 3.0
03. BPH 1203 Physical Pharmacy-I 3.0
04. BPH 1204 Pharmacognosy & Phytochemistry 3.0 BPH 1101
05. BPH 1205 Herbal Medicines & Nutraceuticals 3.0 BPH 1101
06. BPH 1206 Inorganic Pharmacy-II Practical 1.0 BPH 1201

07. BPH 1207 Physiology & Anatomy-I Practical 1.0
08. BPH 1208 Physical Pharmacy-I Practical 1.0
Pharmacognosy & Phytochemistry

09. BPH 1209 1.0
Practical
10. BPH 1210 Oral Assessment-I 1.0
11. MATH 201 Fundamental Mathematics 0.0
Total =20.0 Credits
Year II, Semester I
01. BPH 2101 Organic Pharmacy 3.0
02. BPH 2102 Physical Pharmacy-II 3.0 BPH 1203
03. BPH 2103 Pharmacology-I 3.0 BPH 1202
04. BPH 2104 Physiology & Anatomy-II 3.0 BPH 1202
05. BPH 2105 Pharmaceutics-I 3.0 BPH 1203
06. BPH 2106 Organic Pharmacy Practical 1.0 BPH 2101
07. BPH 2107 Physical Pharmacy-II Practical 1.0 BPH 2102
08. BPH 2108 Pharmacology-I Practical 1.0 BPH 2103
09. BPH 2109 Physiology & Anatomy-II Practical 1.0 BPH 2104
Total =19 .0 Credits

Year II, Semester II
01. BPH 2201 Pharmaceutics-II 3.0 BPH 2105
02. BPH 2202 Pharmacology-II 3.0 BPH 2103
03. BPH 2203 Bio-molecular Pharmacy 3.0
04. BPH 2204 Clinical Pathology 3.0
05. BPH 2205 Pharmaceutical Microbiology 3.0
06. BPH 2206 Pharmaceutics-II Practical 1.0
07. BPH 2207 Pharmacology-II Practical 1.0
Pharmaceutical Microbiology
08. BPH 2208 1.0
Practical
09. BPH 2209 Oral Assessment-II 1.0
Total =19.0 Credits
Year III, Semester I
01. BPH 3101 Medicinal Chemistry-I 3.0 BPH 2101
02. BPH 3102 Pharmaceutical Technology-I 3.0 BPH 2105/2201
03. BPH 3103 Bio-molecular Genetics 3.0 BPH 2205
Pharmaceutical Analysis &

04. BPH 3104 3.0 BPH 2102
Quality Control-I
05. BPH 3105 Pharmacology-III 3.0 BPH 2202
06. BPH 3106 Hospital & Community Pharmacy 3.0

07. BPH 3107 Medicinal Chemistry-I Practical 1.0
Pharmaceutical Technology-I
08. BPH 3108 1.0 BPH 3102
Practical
Total =20.0 Credits

Year III, Semester II
01. BPH 3201 Medicinal Chemistry-II 3.0 BPH 3101
02. BPH 3202 Pharmacoeconomics & Policy 2.0
03. BPH 3203 Pharmaceutical Technology-II 3.0 BPH 3102
04. BPH 3204 Pharmaceutical Biotechnology 2.0 BPH 3103

05. BPH 3205 3.0 BPH 3104
Quality Control-II
Biopharmaceutics &
06. BPH 3206 3.0
Pharmacokinetics-I
07. BPH 3207 Medicinal Chemistry-II Practical 1.0
Pharmaceutical Technology-II
08. BPH 3208 1.0
Practical

09. BPH 3209 1.0
Quality Control-II Practical
Biopharmaceutics &
10. BPH 3210 1.0
Pharmacokinetics-I Practical
11. BPH 3211 Oral Assessment-III 1.0
Total =21.0 Credits

Year IV, Semester I
01. BPH 4101 Advanced Medicinal Chemistry 3.0 BPH 3201
02. BPH 4102 Clinical Pharmacy 3.0
Advanced Pharmaceutical
03. BPH 4103 3.0 BPH 3205
Analysis-I
04. BPH 4104 Pharmaceutical Sales & Marketing 3.0
05. BPH 4105 Pharmaceutical Engineering 3.0
06. BPH 4106 Pharmaceutical Law & Ethics 2.0
07. BPH 4107 Clinical Pharmacy Practical 1.0
08. BPH 4108 Project & Dissertation 2.0
Total =20.0 Credits
Year IV, Semester II
01. BPH 4201 Cosmetology 3.0 BPH 3201
02. BPH 4202 Pharmaceutical Technology-III 3.0
Advanced Pharmaceutical Analysis-

03. BPH 4203 3.0 BPH 3205
II
Biopharmaceutics &
04. BPH 4204 3.0
Pharmacokinetics-II
05. BPH 4205 Pharmaceutical Management 3.0
06. BPH 4206 Cosmetology Practical 1.0

Pharmaceutical Technology-III
07. BPH 4207 1.0
Practical
Advance Pharmaceutical Analysis-

08. BPH 4208 1.0
II Practical
09. BPH 4209 Oral Assessment-IV 1.0
Professional Training (Industrial &

10. BPH 4210 3.0
Hospital)
Total =22.0 Credits
Discipline wise course distribution
A: Pharmacy Core Courses

Pharmaceutical Chemistry
01. BPH 1101 Pharmacognosy 3.0
02. BPH 1102 Inorganic Pharmacy-I 3.0
03. BPH 1103 Pharmacognosy-I Practical 1.0
04. BPH 1104 Inorganic Pharmacy-I Practical 1.0
05. BPH 1201 Inorganic Pharmacy-II 3.0
06. BPH 1203 Physical Pharmacy-I 3.0
08. BPH 1204 Pharmacognosy & Phytochemistry 3.0
09. BPH 1205 Herbal Medicines& Nutraceuticals 3.0
10. BPH 1206 Inorganic Pharmacy-II Practical 1.0
11. BPH 1207 Physical Pharmacy-I Practical 1.0

12. BPH 1208 Pharmacognosy & Phytochemistry Practical 1.0
13. BPH 2101 Organic Pharmacy 3.0
14. BPH 2102 Physical Pharmacy-II 3.0
15. BPH-2106 Organic Pharmacy Practical 1.0
16. BPH 2107 Physical Pharmacy-II Practical 1.0
17. BPH 2203 Bio-molecular Pharmacy 3.0
18. BPH 3101 Medicinal Chemistry-I 3.0
19. BPH 3103 Bio-molecular Genetics 3.0
20. BPH 3104 Pharmaceutical Analysis & Quality Control-I 3.0
21. BPH 3107 Medicinal Chemistry-I Practical 1.0
22. BPH 3201 Medicinal Chemistry-II 3.0
23. BPH 3204 Pharmaceutical Biotechnology 2.0
24. BPH 3205 Pharmaceutical Analysis & Quality Control-II 3.0
25. BPH 4101 Advanced Medicinal Chemistry 3.0
26. BPH 4103 Advanced Pharmaceutical Analysis-I 3.0
27. BPH 4203 Advanced Pharmaceutical Analysis-II 3.0
28. BPH 4210 Advanced Pharmaceutical Analysis-II Practical 1.0
Total= 64.0 Credits

Pharmaceutics & Pharmaceutical Technology
01. BPH 2105 Pharmaceutics-I 3.0
02. BPH 2205 Pharmaceutical Microbiology 3.0
03. BPH 2208 Pharmaceutical Microbiology Practical 1.0
04. BPH 2201 Pharmaceutics-II 3.0
05. BPH 2206 Pharmaceutics-II Practical 1.0
06. BPH 3102 Pharmaceutical Technology-I 3.0
07. BPH 3106 Hospital & Community Pharmacy 3.0
08. BPH 3107 Pharmaceutical Technology-I Practical 1.0
09. BPH 3202 Pharmacoeconomics & Policy 2.0
10. BPH 3203 Pharmaceutical Technology-II 3.0
11. BPH 3206 Biopharmaceutics & Pharmacokinetic-I 3.0
12. BPH 3209 Pharmaceutical Technology-II Practical 1.0
13. BPH 3210 Biopharmaceutics & Pharmacokinetic-I Practical 1.0
14. BPH 4104 Pharmaceutical Sales & Marketing 3.0
15. BPH 4105 Pharmaceutical Engineering 3.0
16. BPH 4106 Pharmacy Law & Ethics 2.0
17. BPH 4201 Cosmetology 3.0

18. BPH 4202 Pharmaceutical Technology-III 3.0
19. BPH 4204 Biopharmaceutics & Pharmacokinetic-II 3.0
20. BPH 4205 Pharmaceutical Management 2.0
21. BPH 4206 Cosmetology Practical 1.0
22. BPH 4207 Pharmaceutical Technology-III Practical 1.0
Total= 49.0 Credits
Physiology & Pharmacology
01. BPH 1202 Physiology & Anatomy-I 3.0
02. BPH 1209 Physiology & Anatomy-I Practical 1.0
03. BPH 2103 Pharmacology-I 3.0
04. BPH 2104 Physiology & Anatomy-II 3.0
05. BPH 2108 Pharmacology-I Practical 1.0
06. BPH 2109 Physiology & Anatomy-II Practical 1.0
07. BPH 2202 Pharmacology-II 3.0
08. BPH 2204 Clinical Pathology 3.0
09. BPH 2207 Pharmacology-II Practical 1.0
10. BPH 3105 Pharmacology-III 3.0
11. BPH 4102 Clinical Pharmacy 3.0
12 BPH 4106 Clinical Pharmacy Practical 1.0
Total= 26 Credits
B: Pharmacy Oral Assessments, Projects and Industrial Training
01. BPH 1210 Oral Assessment-I 1.0
02. BPH 2209 Oral Assessment-II 1.0
03. BPH 3211 Oral Assessment-III 1.0
04. BPH 4211 Oral Assessment-IV 1.0
05. BPH 4108 Project & Dissertation 2.0
06. BPH 4209 Professional Training (Industrial & Hospital) 2.0
Total= 8.0 Credits
C: Ancillary Courses
01. CCT 1101 Computer & Communication Techniques 2.0
02. BSM 1102 Biostatistics & Mathematics 3.0
03. ENG 1103 Communicative English 2.0

Total= 7.0 Credits
Detailed description and course contents of Four year
Bachelor of Pharmacy (Hons.) Program
Year I, Semester I
CCT 1101 Computer & Communication Techniques (Credit 2.0)
1. Computer fundamentals: Some basic concepts about computer, classification

of computers, organization and functional parts of central processing unit, memory
and memory organizations, input/ output media and devices, storage devices,
hardware and software.
2. Application software packages: MS word, MS Excel, presentation tools (MS

power point), graphics management (Adobe Photoshop), specialized applications –
Chem Draw and other chemistry related softwares.
3. Software engineering (For Software Project Management).
4. Basic ideas of networking internet/E-commerce/Efficient browsing/Searching

for academic information.
5. Web page creation: Front page, macromedia software.
6. Introduction to computer graphics: Adobe software.
7. Computer applications in pharmacy: Drug discovery and development,

formulation and dosage form research and development, hospital management,
prescription and patient management, Pre-clinical and clinical trials,
biopharmaceutical data analysis, industrial management, quality control and
analysis, chemo-informatics and bioinformatics, Drug information system etc.
Recommended books:
1. Gordon B. Davis and M. H. Olson (1984), “Management Information Systems".

McGraw Hill Book Company.
2. Manuals of relevant software packages.
3. Burstein. J. “Computers and Information Systems”, Holt, Rinehart and Winston.

New York, USA.
BSM 1102 Mathematics & Biostatistics (Credit 3.0)
A. Mathematics:
1. Introduction to mathematics: Variables, constant and parameter, co-ordination

system with graph.
2. Straight lines: Equation of straight lines, slope of straight line, equation of

slope intercept.
3. Functions: Odd function, even function, one-one function, onto function,

variable substitution in function, composition of functions.
4. Limit of function: Limit, graphical representation of limit, evaluation of

different types of limit.
5. Differentiation of functions: Physical meaning of differentiation, basic rules of

differentiation, differentiation of different functions. "
6. Integration: Physical meaning of integration, rules of integration, integration of

different functions.
B. Biostatistics:
1. Introduction to biostatistics: Scope and application of statistics in

pharmaceutical sciences, collection, tabulation and graphical representation of
data.
2. Measures of central tendency: Arithmetic mean, geometric mean, harmonic

mean, weighted mean, median and mode, their applications in pharmacy.
3. Measures of dispersion: Range, mean deviation, standard deviation, variation,

coefficient of variation, and their application in pharmaceutical preparations.
4. Probability: Laws of addition and multiplication.

5. Tests of significance: Basic concepts of tests of significance, tests of means and
variances based on normal, t, χ2 and F distributions, tests of independence in a
contingency table.
6. Analysis of variance: One-way and two-way classifications, completely

randomized design, randomized block design.
7. Regression and correlation analysis: Estimation of regression line and

parameter, correlation analysis (simple, partial and multiple).
8. Sampling: Different techniques and their suitability in pharmaceutical fields.
9. Application of statistics in pharmacy: Studies of rates of chemical and

biological reactions, samplings, test for uniformity of tables, qualitative test on
samples, limits of content of active ingredient of tables, probability of batch
passing or falling to pass a test, dispensing error, dispensing of liquids, dispensing
of solids, analysis of variance in studying the results obtained in the development
of bioassays, threshold dose assay, toxicity tests, bacteriological counts.
Recommended books:
l. Statistics- J. M. Tanur et. al.
2. Computer Applications in Pharmacy- Fassett.
3. Methods of Statistics- M. G. Mostafa.
4. Statistical Methods- J. S. Milton & J. O. Tsokos.
5. Calculus- by Howard Anton.
6. Calculus- Sehum's outlines series.
ENG 1103 Communicative English (Credit 2.0)
1. Listening & Speaking: Listening for specific information, listening for main
idea/gist, listening for key words and listening for note taking.
2. Content area: Conversation, interview, short description of the people, &
places, receiving and making phone calls, likes & dislike complaining, asking for
and giving information.
3. Vocabulary: Vocabulary items are presented and new words tare explained to
show how to use them. Students learn to find out contextual meanings, they learn
to build on and expand existing vocabulary, dictionary work.
4. Grammar: Review of tenses, subject-verb agreement, sentence patterns,

conditionals. modals, sentence fragment, run-on, punctuation, misplaced, dangling
modifiers, faulty parallelism.
5. Reading: Applications of reading skills, skimming, scanning and intensive

reading: reading for general comprehension, reading for information and reading
for pleasure.
6. Text types: Short texts, extracts, short conversations, advertisements,

instructions and stimulated newspaper articles.
7. Writing: Planning & writing paragraphs, short passage, topic sentence,

developing topic sentences, organizing detail logically. Writing paragraphs:
descriptive, narrative, compare & contrast, cause & effect, process and
argumentative, writing summaries.
8. Basic idea about the popular English language testing systems like IELTS,
TOEFL as well as GRE.
Recommended books:
1. Murphy, R essential English Grammar. l99l. Cambridge:cup
2. John and Liz Soars. New Headway English Course: intermediate Level,
Student’s Book 2000 Oxford '
3. lmhoof. Hudson and H. From Paragraph to Essay, I : Longman, 2002.
4. Langan. John. English Skills.

BPH 1101 Pharmacognosy (Credit 3.0)
1. Introduction: Scopes and historical development of Pharmacognosy; drug

literature and publications: Pharmacopoeia, Codex, National Formulary; official,
non-official, un-official drugs.
2. Crude drugs: A general view of their origin, distribution, cultivation,

collection, drying, storage. Commerce and quality control, classification of drugs,
preparation of drugs for commercial market, evaluation of crude drugs, drug
adulteration.
3. Drugs of animal origin: Cod liver oil, Shark liver oil, Hilsha fish oil,
Cochineal, Spermaceti, Lard and Honey.
4. Phytochemistry and pharmaceutical uses of:
Fats and Lipids: Castor oil, Olive oil, Peanut oil, Chaulmoogra oil and Bees wax.
Carbohydrate and related compounds: Biosynthesis of carbohydrates, sugar and

sugar containing drugs: Sucrose, dextrose, glucose, fructose etc.
Polysaccharide and polysaccharide containing drugs: Starches, dextrose and

cellulose etc.
Gums and mucilage: Acacia, tragacanth, sSterculia, sodium algenate, agar, resin
and resin combination.
5. Surgical dressings and fibers used in the treatment and management of

wounds, abrasion.
6. Plant analysis: Introduction to general structure of morphological parts of

plants, types of plant constituents, extraction of drugs, solvents used in extraction
of drugs, application of concept of Henry's distribution law, partition co efficient
and dielectric constant in extraction process, various types of extraction process
e.g. infusion, maceration, percolation etc. Separation techniques, comparative
phytochemistry and chemotaxonomy.
Recommended books:
1. Pharmacognosy - Tyler and brady.

2. Pharmacognosy - Trease and evans.
3. Pharmacognosy - Claus and Tyler.
4. Textbook of Pharmacognosy - Wilallis.
5. Practical Pharmacognosy - Zafar & Gandhi.
6. Textbook of Pharmacognosy-Mohammed Ali
7. Text book of Pharmacognosy- Abdul Ghani
8. Medicinal Plants of Bangladesh- Abdul Ghani
9. Traditional Medicine- Abdul Ghani
10. Pharrnacognosy Practical- Abdul Ghani
BPH 1102 Inorganic Pharmacy-I (Credit 3.0)
1. Atomic structure: Basic concepts of atomic structure, fundamental particles,

classical atomic models and their limitations, quantum numbers and their
significance, de Broglie relation, wave function and atomic orbitals, origin of
spectral lines, origin of hydrogen spectrum, electronic configuration of atoms,
Pauli’s exclusion principle, Aufbau principles, Hund’s rule.
2. Chemical bonding and molecular structure: Electronic concept of valence,

different types of chemical bonds e.g. ionic, covalent, co-ordinate covalent,
metallic, dipole, hydrogen bond etc., bond length, bond angle and bond energy,
shapes of molecules, valence bond theory, hybrid orbital, multiple bonding,
molecular orbital theory, bonding and anti-bonding molecular orbitals and
delocalized orbitals.
3. Periodic table: Periodic law, atomic radius, ionization energy, variation of

properties with in periods and groups, usefulness and limitation of periodic table.
4. Chemistry of co-ordination compounds: Ligands or coordinating groups,

mono-dentate or uni-dentate ligands, polydentate ligands, co-ordination number,
co-ordination sphere, chelation, factors affecting the stability of metal complexes,
application of chelate formation, isomerism of co-ordination compounds, Warner's
co-ordination theory, Sidgwick’s electronic concept of co-ordinate bond in co-
ordination compounds, valence bond theory, pharmaceutical importance of
chelation.
5. Inert or noble gases: Source, electronic configuration and inertness, isolation of

inert gases from dry air (chemical method) and liquid air (physical method),
physical & chemical properties and uses of noble gases, conditions and types of
compounds formed by inert gases.
6. Medicinal gases: Official medical gases and their properties, uses, container and
fittings, handling and storages.
Recommended books:
l. Introduction to Modern Inorganic Chemistry- S. Z. Haider.
2. Modern Inorganic Chemistry- Madan, S. Chand & Company Ltd.
3. Introduction to Modern Inorganic Chemistry- J. D Lee, Blackwells.
4. Bentley and Driver's Textbook of Pharmaceutical Chemistry- Bently, Arthur

Owen, Oxford University Press.
5. Modern Inorganic Pharmaceutical Chemistry- Clarence A. Discher, Leonard C.

Bailey. Thomas Medwick, Waveland Pr Inc.
6. Rogers Inorganic Pharmaceutical Chemistry- Rogers, Charles Herbert, Taito 0.

Some and Charles 0. Wilson. Philadelphia. Lea & Febiger.
7. Inorganic Medicinal & Pharmaceutical Chemistry- Block, John H., Roche,

Edward B. Some, Taito O., Wilson, Charles O, Lea and Febiger, Philadelphia.
BPH 1103 Pharmacognosy practical (Credit 1.0)
l. Cell, cell contents and cell types.
Cell - (a) some cellular organism, chalk & diatomite.
(b) Fungi- Mucor or rhizopus, aspergillus, pencillium, ergot and yeast.
Cell contents — Starches and derivatives, calcium carbonate, silica.

Cell types — Parenchyma and modifications — colocynth, nux-vomica,
endosperm, cinnamon powder, tea, labiatae stem, parenchyma-pericyclic fibres
jute, xylem fibres and vessels-liquorice, tracheids-pinus wood.
2. Epidermal cells and associated structures (trichomes stomata etc.), leaves of

belladonna, mentha, rosemary, senna, Indian hemp, digitalis etc.
Seed trichomes- cotton and nux-vomica seeds, cork cells- cascara sagrada.
3. Study of some groups of unorganized white and of-white powder and whole
drugs:
(a) General tests for carbohydrates.
(b) Preparation and examination of starches and related products.
(c) Examination of gums: Acacia, tragacanth, sterculia agar and alginates.
4. Study of some medical plants of Bangladesh.
5. Extraction and tests of alkaloids, lipids etc.
BPH 1104 Inorganic Pharmacy-I Practical (Credit 1.0)
Qualitative analysis ofinorganic ions and radicals:
Na+, K+, Ca+, Al3+, Mg2+, Fe2+, Fe3+, Mn2+, Ag2+, Cu+, Cu2+, Cl- , Br-, I- , and CO32-,
SO42-, NO3-,PO43- etc.
Year I, Semester II
BPH 1201 Inorganic Pharmacy-II (Credit 3.0)
1. Environmental chemistry and environmental sciences: Causes of

environmental pollution, types of pollutants: Gases (SO 2, SO3, CO2, CO, NO2),
hydrocarbons, smokes, suspended particulates, pesticides, gasoline and industrial
wastes, pharmaceutical food additives.
Heavy metal toxicity: Poisoning caused by mercury, arsenic, lead, iron, copper;
their adverse effects on human life cycle and study of antidotes used in these
poisoning cases; quantitative and qualitative analysis of heavy metals.
2. Radioactivity and nuclear sciences: Nature of elements, types of elements that

possess radioactive properties, their uses in pharmaceutical and medical sciences.
3. Electrolytes: Intra and extra cellular electrolytes (Na, K, Ca and Cl ions),

electrolytes used in acid-base therapy, essential and traces ions: their preparations
(Fe, Cu, Zn, Mn, Sn, I, Cr) and application is in pharmaceutical sciences.
4. Gastrointestinal agents: Antacids (Al and Mg preparations with applications),

preparation and application of adsorbents, saline cathartics and laxatives.
5. Dental preparations: Dental plaque and antiplaque agents, dental caries,

fluorides and other anticaries agents (preparation and application), dentifrices.
6. Topical agents: Classification of topical agents, preparations and applications of

different antimicrobial, astringent and protective agents, preparations and uses of
zinc, iodine, sulfur, boric acid, selenium, cadmium sulphites, silver sulphadiazine.
7. Water: Hardness of water, treatment of natural water, distilled water,

demineralized water and official water.
Recommended books:
1. Introduction to Modern Inorganic Chemistry- S. Z. Haider.
2. Modern Inorganic Chemistry- Madan, S. Chand & Company Ltd.
3. Introduction to Modern Inorganic Chemistry- J. D Lee, Blackwells.

4. Bentley and Driver's Textbook of Pharmaceutical Chemistry- Bently, Arthur
Owen, Oxford University Press.
5. Modern Inorganic Pharmaceutical Chemistry- Clarence A. Discher, Leonard C.

Bailey. Thomas Medwick, Waveland Pr Inc.
6. Rogers Inorganic Pharmaceutical Chemistry- Rogers, Charles Herbert, Taito 0.

Some and Charles 0. Wilson. Philadelphia. Lea & Febiger.
7. Inorganic Medicinal & Pharmaceutical Chemistry- Block, John H., Roche,

Edward B. Some, Taito O., Wilson, Charles O, Lea and Febiger, Philadelphia.
BPH 1202 Physiology & Anatomy-I (Credit 3.0)
1. General physiology: Physiology of cell and body fluids, composition of body

fluids, membrane physiology, transport through cell membrane, membrane
potential, action potential, neuromuscular transmission and muscle contraction,
introduction to various body tissues and systems with their definition, classification
and functions.
2. Blood: Composition and function.
Plasma: Electrolytes, proteins and other organic constituents.
Blood Cell: Their formation and destruction, cell count function of different blood
Cells.
Hemoglobin: Structure, properties and functions.
Anemia: Causes and classifications.
Blood coagulation, blood groups and blood transfusion.
Lymph: Composition, formation, circulation and function, lymph nodes and

lymphatics.
3. Circulatory system:
Heart: Structure, heart muscles, conductions system of heart, origin and

transmission of cardiac impulse, cardiac cycle, cardiac output, nervous regulation
of heart, cardiac refluxes, ECG, cardiac arrhythmia.
Blood pressure: Measurement and regulation of blood pressure and nervous

control.
Arterial pulse: Definition, clinical study and recording of arterial pulse.
Capillary circulation: Importance and function.
Regional blood circulation: Pulmonary, hepatic, renal, cerebral circulation.
4. Alimentary system: Structure of different parts of alimentary system,

movement and control of different parts of alimentary tract, swallowing, gastric
contractions, intestinal contraction, defecation, secretion of digestive juices: saliva,
gastric juice, pancreatic juice, intestinal juice and bile; mechanism and control of
various secretions and their functions, digestion of food stuff, absorption of
different digested materials.
5. Liver: Structure and function of liver, formation of bile and it's concentration in
the gall balder, circulation of bile salts, and bile pigments.
6. Histological structure of various organs of body, muscles, liver, spleen and

kidney. Anatomy of heart and alimentary tract.
Recommended books:
1. Human Physiology (vol. I & II) - C.C. Chatterjee.
2. Medical Physiology- Guyton.
3. Medical Physiology- Ganon.
4. Practical Physiology- C. L. Ghai.

BPH 1203 Physical Pharmacy-I (Credit 3.0)
1. Acids and bases: Arrhenius concept, Bronsted-Lowry Concept, Lewis concept,

relative strengths of acids and bases.
2. lonic equilibrium and buffer capacity: pH, determination of pH, preparation

of buffers and isotonic systems, methods for adjusting tonicity of solutions, buffers
in biological system.
3. States of matter:
The gaseous state: Gas laws; ideal gas law, Gas density, Molecular weight, gas
mixture, Laws of partial pressure.
Ideal gases; Kinetic molecular theory, Postulates of kinetic theory of gases,

derivation of kinetic equation, ideal gas law from kinetic theory, molecular speeds:
Diffusion and effusion.
Real Gases: Amagat's curves, van der Waal's equation of state, significance and
limitation of van der waal's equation.
Change of state: Gas- Liquid- Andrew's experiments, critical temperature, critical

pressure, critical volume, Liquefaction of gases.
The liquid state: Vapour pressure of liquids, boling point of liquids, surface
tension and viscosity, dipole- dipole forces, London (Dispersion) forces, hydrogen
bonding.
Solid state: Types of intermolecular forces in solids, melting point and structure,
hardness and structure, electrical conductivity and structure, crystalline solids,
crystal lattice, unit cell, crystal defects.
4. Solutions: Types of solutions, solubility and the solution process, effect of

temperature and pressure on solubility.
Colligative properties: Expression of concentrations, molarity, mass percentage

of solute, molality, molefraction, normality.
Vapour pressure of solution: Raoult's law of lowering of vapour pressure,

elevation of boiling point, depression of freezing point, osmosis-osmotic pressure.
Colloids: Tyndall effect, types of collids, coagulation.
5. Chemical equilibrium: Laws of mass action, determination of equilibrium

constant, heterogeneous and homogeneous equilibrium, the Le Chatelier Principle,
Vant Hoff’s equation.
6. Chemical thermodynamics: Introduction, the first law of thermodynamics,

work of expansion, internal energy and determination of internal energy, heat
changes at constant volume and pressure. Thermo-dynamic reversibility, work of
isothermal reversible expansion of gases, maximum works under the isothermal
expansion of a gases, the second law of thermodynamics, Camot's cycle and
efficiency of a perfect engine, the concept of entropy and entropy changes for an
ideal gas expansion, entropy changes of materials under various conditions, free
energy and work functions, Gibbs Helmholthz equation, free energy changes under
equilibrium, the Clausius-Claperon equation.
7. Phase equilibrium: Phase, component and degree of freedom, phase rules and
thermodynamic deviation, phase diagrams of water, partially miscible liquid pairs:
phenol and water, nicotine- water system, completely miscible liquid pairs and
their separation by fractional distillation.
Recommended books:
1. Physical Pharmacy- Martin.
2. Principle of Physical Chemistry- Haque & Nawab.
3. Elements of Physical Chemistry- Lewis & Glasstone.
4. Physical Chemistry-Atkins.
5. Physical Chemistry- Bahl & Tuli.

BPH 1204 Pharmacognosy & Phytochemistry (Credit 3.0)
1. Phytochemistry and pharmaceutical uses:
Glycosides and glycoside-containing drugs: Definition and classification of

glycosides, biosynthesis of glycosides. The details of the following:
Cyanogenic: Wild Cherry
Isothiocyantate: Mustard (Black and white mustard)
Cardiac: Digitalis, Stophanthus, Squill, Nerium.
Anthraquinone: Cascara sagrada, Aloe, Senna, Rhubarb.
Other glycosides and neutral principles: Vanilla, Gentian Quasslia, Saffron.
2. Alkaloid: Distribution, properties, tests, extraction, classification of alkaloids.

The details of the following:
Tropane: Belladona, Strmonium, Hyoscyamus , coca or coca leaves.
Quinoline: Cinchona, Cusparia bark.
Isoqulnoline: lpecac, Opium, Sanguinaraia, Curare.
Indole: Rauwolfia, Nux vomica, Ergot, Catharanthus.
Imidazole: Pilocarpine.
Steroidal: Vertrum viride, Aconite.
Purine base: Coffee, Tea.
Alkaloidal amines: Ephedrine, colchicine.
3. Volatile oils and related terpenoids: Methods of obtaining of volatile oils,

chemistry, medicinal and commercial uses, biosynthesis of some important volatile
constituents used as drug. The details of the following:
Terpenes and sesquiterpenes: Pinus, Juniper, Cade
Alcohols: Coriander, Sandalwood.

Ester: Peppermint, Lavender, Rosemary.
Aldehydes: Cinnamon bark, Eucalyptus, Lemon peel, Lemon grass, Spearmint,

Caraway, camphor.
Phenols: Clove, Cinnamon leaf, Ajowan.
Ethers: Fennel, Nutmeg, Eucalyptus, Anise, Cajunut.
Peroxides: Chenopodium. .
Others: Mustard, Wintergreen, Bitter almond, Cardamon.
4. Phenolic compounds and tannins: Chemical nature and tests for tannins,
studies of some tannin containing drugs like Nutgall, Catechu etc.
5. Herb and health foods: Alfa alfa, Apricot, Garlic, Onion, Gingeng, Spirulina,
Honey, Evening Primrose oil etc.
6. Study of some poisonous plants and riatural pesticides: Dutura, Helmok,

Foxglove, Tobbaco, Red Squill, Nux vomica, Nerium
Recommended books:
1. Pharmacognosy - Tyler and Brady.
2. Pharmacognosy - Trease and Evans.
3. Pharmacognosy - Claus and Tyler.
4. Textbook of Pharmacognosy- Wilallis.
5. Practical Pharmacognosy — Zafar & Gandhi.
6. Textbook of Pharmacognosy-Mohammed Ali
7. Text book of Pharmacognosy- Abdul Ghani
8. Medicinal Plants of Bangladesh- Abdul Ghani
9. Traditional Medicine— Abdul Ghani
10. Pharmacognosy Practical- Abdul Ghani

BPH 1205 Herbal Medicines & Neutraceuticals (Credit 3.0)
1. Medicinal plants: Occurrence, distributing, chemical constituents and uses of

some selected medicinal plants of Bangladesh. .
2. Indigenous system: Herbalism, folk medicine, etc. Their methods of diagnosis,

treatment, types, composition of medicinal preparations, merits and demerits.
3. Scientiric validation and impact: Impact on the overall health management

programs, Socio-economic aspects of the country, in vitro studies, animal studies,
clinical studies etc.
4. Pharmacological aspects of herbal medicines: Indications, dosage,

pharmacological action, side effects, toxicity, contraindications, precautions,
adverse effects of traditional medicaments. T
5. Formulation and dosage forms of herbal medicines: Types and methods, use
of modern technology and pharmaceutical knowledge.
6. Fundamental principles of the science of human nutrition: Nutritional intake

and effects on health, contemporary issues in nutrition and recognizing reliable
sources of nutrition.
7. Modified diets used for treating diseases: Diabetes, obesity, anorexia and
diseases of the gastrointestinal tract.
8. Foods for special diets used in various diseases: Cardiovascular, liver and
kidney diseases, trauma and cystic fibrosis.
9. Nutritional needs: Infant, maternal and gerontological nutrition, nutritional menu

for a special care home.
Recommended books:
1. Herbal Medicine for Human Health- Chowdhury, B.R. (WHO Publication)
2. Medicinal Plants of Bangladesh (2nd edition)- Abdul Ghani
3. The Use of Traditional medicine in Primary Healthcare- WHO Publication

4. Healing Power of Herbs- M. T. Murray
5. Traditional Medicine- Abdul Ghani c
6. Medicinal Plants Traditional medicine in Africa- A. Sofowora.
7. Medicinal Herbal - H. M. Said (Hamdard Publication)
8. Medicinal Botany: Plants affecting Man's Health- W.H:7 Levis & Elvin-Lewis.
9. Natural Products as Medicinal agents- Beal & Reinhard
10. Hamdard Pharmacopoeia
11. Unani and Ayurvedic Formularies of Bangladesh
12. Dietary Supplements and functional Foods- G P Webb
13. Prevention Foreign Material Contamination of Foods-Doug Peariso.
14. Herbal Drug Technology- S S. Agrawal & M. Paridhavi.
BPH 1206 Inorganic Pharmacy-II Practical (Credit 1.0)
1. Identification of inorganic ions from pharmaceutical formulations: Ca2+,

Fe2+, Al3+, Mg2+, K+ and Na+ ions from supplied preparations.
2. Preparation of inorganic drugs:
a. Preparation of aluminium hydroxide gel.
b. Preparation of magnesium hydroxide.
c. Preparation of haematinics: ferrous sulphate, ferrous gluconate and ferrous

fumerate.
3. Conversion of different Water insoluble or sparingly soluble drugs into Water

soluble form:
a. Na/K-salicylate from salicylic acid.
b. Na/K-benzoate from benzoic acid.

c. Na/K—citrate from citric acid.
BPH 1207 Physiology & Anatomy-I Practical (Credit 1.0)
l. Study of compound microscope.
2. Histology of muscles, liver, spleen, kidney, large and small intestine, pancreas,
Lungs and skin.
3. Estimation of hemoglobin and ESR
4. Determination of clotting and bleeding time.
5. Blood cell count (TC, DC)
6. Blood grouping and Rh typing
BPH 1208 Physical Pharmacy-I Practical (Credit 1.0)
l. Standardization of acids and bases.
2. Determination of pKa and pKb values.
3. Preparation of solutions of different pHs and buffer capacities.
4. Determination of phase diagram of binary systems.
5. Determination of distribution co-efficients.
6. Determination of molecular weiglit by Victor Meyer's method.
7. Determination of heats of solutions by measuring solubility as a function of

temperature (Van't Hoff equation).
BPH 1209 Pharmacognosy & Phytochemistry Practical (Credit 1.0)
1. Study of volatile oils and volatile oils containing drugs: Caraway, Clove,
Cinnamon, Peppermint.
2. Extraction and identification of alkaloids from Coffee, Tea, Belladonna, Nux

vomica.
3. Isolation of lactose from cow's milk.

4. Physical and chemical tests for honey.
5. Distillation method for obtaining volatile axis.
BPH 1210 Oral Assessment-I (Credit 1.0)
Year II, Semester I
BPH 2101 Organic Pharmacy (Credit 3.0)
1. Principles of various reactions:
Electrophilic, nucleophilic and free radical addition.
Aliphatic, aromatic and free radical substitution.
Elimination reaction.
Rearrangement reaction.
2. Aldehydes and ketones: Chemistry, properties, synthesis, uses, phannacertical

importance of such compounds and their derivatives.
3. Carboxylic acids: Chemistry, properties, synthesis, uses, pharmaceutical

importance of such compounds and tl§eir derivatives.
4. Aliphatic and aromatic amines and related nitrogen containing compounds:

Properties, synthesis, reactions and reaction mechanisms, pharmaceuticals and/or
biological importance.
5. Some name reactions: Grignard reaction, Perkin reaction, Reformatsky

reaction, Witting reaction, Diels-Alder reaction, Oppenauer reaction, Kolb
reaction, Meerwin-Pondroff reaction, Clemension reaction, Baklelite reaction,
Birch reaction, Darzens condensation reaction, Friedel-Crafts reaction,
Gattermann-Koch and Sandmeyer reaction, Hofmann reaction, Mannich reaction,
Michael reaction, Reimer-Tiemami reaction- their principles, mechanisms and
pharmaceutical applications.
6. Heterocyclic compounds:
5-memebered compounds: Preparations, reactions and pharmaceuticals

importance.
6-membered compounds: Preparations, reactions and pharmaceuticals importance

of pyridine, pyrimidine, pyradazine, pyrazine and triazine.
7. Introduction to common essential drugs: Preparation and uses of salicylic acid,

aspirin, phenacetin, paracetamol, benzoic acid, benzyl benzoate, sulfa-drugs,
PASA, PABA, isoniazide, halothen, enflurage methoxyfiureane.
Recommended books:
1. Organic Chemistry- Robert Thornton Morrison and Robert Neilson Boyd,

Prentice- Hall of India. Private Limited.
2. A Textbook of Organic Chemistry- Arun Bahl and B. S. Bahl, S. Chand &

Company Ltd.
3. Organic Chemistry- Louis Felser and Mary Feiser, Asia Publishing House,
India.
4. Organic Chemistry, vol. I & II, L. Final, Long man, London.
5. Advanced Organic Chemistry- B. S. Bahl and Arun Bahl, S. Chand & Company
Ltd.
6. Introduction to Organic Laboratory Techniques- d Donald L, Pavia, Gary M.

Lampman, George S. Kriz, Randall G. Engel, Thomson Brooks Cole. .
7. Advanced Organic Chemistry- Reactions, Mechanisms and Structure, Jerry

March, John Willey & Sons.
8. Heterocyclic Chemistry- J. A. Joule and G. F. Smith, English Language book

Society.
BPH 2102 Physical Pharmacy-II (Credit 3.0)
1. Chemical kinetics: Rates and orders of reactions, methods for determination of

orders of reactions, influences of temperature on rate of reactions, theories of
reaction rates, decomposition of pharmaceutical products, accelerated test for
physical, chemical and photochemical stability, stability aspects of formulations,
marketed products and clinical supplies, shelf-life determination.
2. Adsorption and interfacial phenomena: Adsorption and Interface, Freundlich

and Langmuir isotherm, BET equation, electrical properties of interfaces, electrical
double layer, Nernst and zeta potential, Gibbs equation, spreading, surface active
agents, emulsifiers, detergents and antifoaming agents, surfactants and drug
activity, surfactants and pharmaceutical products.
3. Rheology: Newtonian liquids, Non-Newtonian materials, yield value, plastic &

pseudo-plastic flow, dilatant and thixotropic flow, viscosity of suspending agents.
4. Electrochemistry: Electrical units and their interrelation, Faradays laws of

electrolysis and electrochemical equivalents, electrolytic conduction, equivalent
conductance and the related facts, conductometric titrations, transference numbers
and their determination.
5. Electrochemical cell: Electrode and cell potentials, energies involved in

electrode processes, reference electrodes, buffer solutions and measurement of PH;
potentiometric titrations and oxidation- reduction systems, concentration cells.
Recommended books:
1. Principle of Physical Chemistry- M. Mahbubul Haque & M. Ali Nawab.
2. Physical Pharmacy- Alfred N. Martin.
3. Physical Chemistry- P. W. Atkins, Peter Atkins, Julio De Paula, W. H Freeman.
4. Essentials of Physical Chemistry- B. S. Bahl, G. D. Tuli and Arun Bahl, S.

Chand.
5. Physicochernical Principles of Pharmacy- A. T. Florence and D. Attwood,

Macmillan.
BPH 2103 Pharmacology-I (Credit 3.0)
1. General principle: Drug source, routes of administration and

pharmacogenetics.
2. Introduction to pharmacokinetics: Drug absorption, factors affecting drug

absorption, distribution, metabolism and excretion.
3. Introduction to pharmacodynamics: Basic principle, receptors, agonists,

antagonists, potentiation, synergism, drug-receptor interaction, factors modifying
drug action, drug tolerances, dependence etc.
4. Mechanism of drug action: Basic concepts of drug action, drug receptors,

receptor and non-receptor mechanisms of drug action, relationship between drug
and receptor binding, signaling mechanism of drug action, relation between drug
dose and clinical response.
5. Therapy for some diseased conditions:
Histamine and antihistamines (H1 and H2 blockers).
Local and general anesthetics.
6. Study of analgesic and antipyretic drugs: Concept of pain and fever, causes of
pain and fever, narcotic analgesic, non narcoltic analgesics, concept of
inflammation, drugs used in the treatment of gout.
Recommended books:
l. Pharmacological Basis of Therapeutics- Goodaman & Gillman.
2. Basic and Clinical Pharmacology- Katzung.
3. Medical Pharmacology- Meyer.
4. Medical Pharmacology- A. Goth.
5. Pharmacology & Pharmacotherapeutics- R. S. Satosker

BPH 2104 Physiology & Anatomy-II (Credit 3.0)
1. Respiratory system: Mechanism of respiration, pulmonary ventilation,

ventilation volumes, gaseous interchange through lungs, carriage of O2 and CO2,
regulation of respiration, Nervous and chemical respiration. Hypoxia: Causes and
classification.
2. Nervous system:
Nerve cell: Properties, classification and function.
Nerve fibers: Types of nerve fibers, origin and propagation of verve impulse across
nerve fiber, action potential, units for measurement of nerve excitability.
Synapse: Classification and properties of synapses and their functions.
Reflex action: Definition, classification and properties, principal division of

nervous system, CNS, PNS, different parts of CNS, principal motor and sensory
paths of the CNS, upper motor neurone and lower motor neurone. "
Sensory nerve ending: Different types of sensation.
Muscle tone: Definition and regulation.
Posture and postural reflex: Autonomic nervous system and its principal division,
sympathetic and parasympathetic functions served by the sympathetic and para
sympathetic nerves, neurotransmitters.
3. Metabolism: Fats, carbohydrates, proteins and nucleoproteins metabolism.

Metabolic pathways of fats, carbohydrates and proteins. Enzymes, hormones,
vitamins regulating the metabolic pathways, vitamin and minerals their
physiological properties and functions.
4. Endocrine system: Structure and functions of pituitary, thyroid, parathyroid,

adrenal glands and pancreatic islets. Hormones secreted by the different endocrine
glands and hypothalamus. Normal and disordered functions of the different
hormones. Regulation the secretion of different hormones.
Recommended books:
1. Human Physiology (vol. I & II)- C.C. Chatterjee.
2. Medical Physiology- Guyton.
3. Medical Physiology- Ganon.
4. Practical Physiology- C. L. Ghai.
BPH 2105 Pharmaceutics-I (Credit 3.0)
1. History and principle of pharmacy practices: History, code of ethics,

pharmacopoeias, formularies, and codex officially recognized in Bangladesh.
2. Micromeritics: Importance of particle size determination, different means of

expressing particle size, methods of particle size determination, optical and
electronic microscope studies, Coulter counter methods, laser beam technique,
Sieve analysis, sedimentation methods, particle shape and surface area,
measurement of surface area.
3. Solubility and dissolution rate: Methods of expressing solubility, solubility of

gases in liquids, solubility of liquids in liquids, solubility of solids in solids,
solubility of solids in liquids, factor affecting solubility, dissolution rate of solids
in liquids.
4. Dispersed systems: The colloidal state, classification of colloids, preparation

and properties of colloidal solutions, electric double layer, origin of the charge,
stability of colloids, sedimentation, Stock's law, viscosity of colloids, coacervation,
dialysls, properties of gels, protective colloid, sensitization, Donnan membrane
equilibrium, application and uses of colloidal preparation in pharmacy.
5. Pharmaceutical calculation: Dosage calculation, statisticai methods used in

pharmaceuticals, ANOVA, logarithm calculation, percentage calcuiation, ratio
strength, and concentration measurements, calculation for preparation of
percentage solution, isotonic solution etc.
6. Norms of Good Manufacturing Practices (GMP)

Recommended books:
1. Dispensing for Pharmaceutical Students- Cooper & Gunn
2. American Pharmacy- Sprowl’s.
3. Remington's Pharmaceutical Sciences.
4. Dispensing of medication- Husa & Martin.
5. Pharmaceutical Practice- Aulton.
6. An Introduction to Pharmaceutical Formulations- Fishburn.
7. An Introduction to Pharmaceutical Productions- Polderman.
8. The Extra Pharmacopoeia- Martindale.
9. Bentley's Textbook of Pharmaceutics.
10. Tutorial Pharmacy- Cooper & Gunn.
BPH 2106 Organic Pharmacy Practical (Credit 1.0)
Synthesis and tests of the following drugs and drug intermediates:
1. Paracetamol.
2. Aspirin.
3. PABA (Para amino benzoic acid).
4. Ethyl para hydroxyl benzoate.
5. Methyl salicylate.
BPH 2107 Physical Pharmacy-II Practical (Credit 1.0)
1. Determination of viscosity of liquid pharmaceutical preparations- Syrup,

emulsion, suspension.
2. Study of variation of viscosity of liquids with temperature using Ostwald and/or

Engler's viscometer.
3. Determination of adsorption isotherm of oxalic or acetic acid from aqueous

solution by charcoal and calculation of the constant in Freundlich's equation.
4. Determination of equilibrium constant of the reaction, KI + I2 = KI3
5. Determination of velocity constant of hydrolysis of an ester in the basic medium

by conductance measurements.
6. Determination of iron content in supplied solution of Mohr's salt by titration

with KMnO4.
BPH 2108 Pharmacology-I Practical (Credit 1.0)
l. Study of drugs acting on CNS.
a. CNS stimulant drugs (strychnine, ephedrine, amphetamine)
b. CNS depressant drugs (barbiturates)
2. Effect of local anesthetics on rat-tail.
3. Effect of pilocarpine or atropine on rats eye.
BPH 2109 Physiology & Anatomy-II Practical (Credit 1.0)
1. Recording of normal heart beat in toad.
2. Determination of effect of temperature aviation on toad heart.
3. Determination of the effects of electrolytes (Na+, K+) on toad heart.

4. Recording of respiration with spectrograph. Effect of physical exercise on
breathing.
5. Measurement of blood pressure (B.P) with sphygmomanometer. Effect of

physical exercise on B.P. and heartbeat.
6. Estimation of blood sugar.
Year II, Semester II
BPH 2201 Pharmaceutics-II (Credit 3.0)
1. Preformulation considerations: Preliminary evaluation and molecular

optimization, bulk characterization, material crystallinity, polymorphism, thermal
properties, hygroscopicity, particle characterization, bulk density, powder flow
properties, solubility analysis, pKa determination, pH, solubility profile, effect of
temperature, solubilization, partition coefficient, dissolution, stability analysis,
solution stability and solid state stability.
2. Polymer science for pharmaceuticals: Pharmaceutical applications, physical,

chemical and mechanical properties, molecular weight and distribution, polymer
solution properties, plasticization, and elastomers.
3. Pharmaceutical excipients: Chemistry, physical properties and uses of the

following excipients: Acidifying agents, air displacement agents, alkalizing agents,
antifoaming agents, antimicrobial agents, preservatives, antioxidants, buffering
agents, chelating agents. Colors complexing agents, emulsifying agents, flavoring
agents and perfumes, humectants, ointment bases, solvents, stiffening agents,
wetting and solubilizing agents.
4. Basic principles of compounding and dispensing: Weights, measures and

units calculation for compounding and dispensing, fundamental operation of
compounding, good pharmaceutical practices in compounding and dispensing,
containers and closures for dispensed products, responding to prescription, labeling
of dispensed medications.
5. General approach to drug development: Drug approval process, pre-clinical

testings, animal models, manufacturing issues, clinical trial design.
Recommended books:
1. The Theory and practice of industrial Pharmacy- Lachmann.
2. Dispensing for Pharmaceutical Students- Cooper & Gunn
3. American Pharmacy- Sprowl’s.
4. Remington’s Pharmaceutical Sciences.
5. Dispensing of medication- Husa & Martin.
6. Pharmaceutical Practice- Aulton
7. An Introduction of Pharmaceutical Formulations- Fishburn
8. An Introduction to Pharmaceutical Productions- Polderman
9. The Extra Pharmacopoeia- Martindale
10. Bentley's Textbook of Pharmaceutics
11. Tutorial Pharmacy- Cooper & Gunn
BPH 2202 Pharmacology-II (Credit 3.0)
1. Antibacterial and antifungal agents: Introduction, classification, chemistry,

mode of action, SAR, pharmacokinetics, indications, contraindications dose,
adverse effect and drug interaction of the following individual class of drugs:
a. Sulfonamide and trimethroprime.
b. β-lactam antiliotics: Penicillins, cephalosporins, carbapenems, monolactams.
c. Drugs affect on bacterial protein synthesis: Tetracycline, chloramphanicol.

amoglycosides, microclides.
d. Fluroquinolones.
e. Glycopeptides antibiotics: Polymixin antibiotics, bacitricin and nitrofurantoin.

f. Anti-tubercular agents: Streptomycin, isoniazid, rifampicin, ethambutol, pyra
zinamide, caprc on. vcin, tharacetazone.
g. Anti-leprosy drug: Damson, rifampicin, clofazimine.
h. Anti-fungal agents.
2. Drugs used in tropical diseases: Introduction, classification, chemistry, mode

of action, SAR- pharmacokinetics, indications, contraindications, dose, adverse
effects and drug interaction of the following individual class of drugs:
a. Anti-amoebic drugs
b. Anti-malarial drugs.
c. Anthelmentic drugs.
d. Drugs used in enteric fever.
e. Drugs used in diarrhea and cholera.
3. Pharmacology of drugs affecting cardio-vascular system: General

considerations, pharmacological actions, mechanism of action, therapeutic uses,
side effects and structure activity relationships of the following drugs:
a. Diuretics and anti -diuretics
b. Drugs used in angina and myocardial infarction.
c. Anti-hypertensive drugs.
d. Drugs used in heart failure.
Recommended books:
1. Pharmacological Basis of Therapeutics- Goodman & Giliman.
2. Basic and Clinical Pharmacology- Katzung.
3. Medical Pharmacology- Meyer.
4. Medical Pharmacology- A. Goth.

5. Pharmacology & Pharmacotherapeutics- R.S. Satosker
BPH 2203 Bimolecular Pharmacy (Credit 3.0)
1. Carbohydrates: Introduction, classification, isomerism, stero-chemistry,

aldoses, ketoses, oxidation, effect of alkali, configuration of aldoses and ketones,
epimers and anomers of sugars, derivatives of monosaccharides, glycoproteins,
physiologically important glycosides, reducing and non-reducing sugars, optical
activity, hemiacital and acital form of glucose, ring size determination,
disaccharides, structure of polysaccharides, starch, cellulose, glycogen, some
pharmaceutically important carbohydrates.
2. Amino acids and proteins: Introduction, classification, essential and non-

essential amino acids, structure of amino acids, acidity and basicity of amino acids,
properties of amino acids, iso electric point, zwitterions, reactions of amino acids,
amino acid sequence determination of proteins, racimization, etc. Denaturation and
purification of proteins, proteins as enzymes, proteins as drugs, biologically
important peptides.
3. Enzymes and coenzymes: Chemistry, classification, catalytic properties,

enzyme specificity, mechanism of enzyme action, enzyme catalyzed reactions,
chemotherapy, co-enzymes, thiamine pyrophosphate, flavin coenzyme,
tetrahydrofolate, pantothanic acid, NAD+, NADH, pyridoxal pyrophosphate, biotin,
vitamin B12, etc.
4. Lipids: Introduction, acylglycerols; saturated, unsaturated and essential fatty

acids, isomerism in fatty acids, phosphoglycerides, steroids, bile salts, lipoproteins,
etc.
5. Nucleic acids: Chemistry of nucleic acids, bases, nucleosides, nucleotides,

polynucleotides, nucleoproteins, RNA, DNA, double-helix theory, replication of
DNA, codons, anti-codons.
Recommended books:
1. Biochemistry, J.M. Berg, J. L. Tymoczko and L. Stryer. Freeman.
2. Molecular Cell Biology, Lodish. H. et at.
3. Essential Cell Biology, B. Alberts et al. Pub. Gariand.
4. Amazing Schemes within your Genes, Balkwill and Rolph. Colllins.
5. Instant Notes in Biochemistry, hames, Hooper and Houghton, Bios Scientific

Publishers
6. Biochemistry- Lehninger.
BPH 2204 Clinical Pathology (Credit 3.0)
1. General considerations and scopes of clinical pathology: Introduction and

basic concepts.
2. Cellular injury and adaptation: Morphology of injured cells, intracellular

accumulation, sub-cellular alteration, adaptation, neuralgia.
3. Inflammation and repair: Morphological patterns and changes in vascular flow

and permeability, phagocytosis, chemical mediators, mechanisms of regeneration
and repairing. gastritis, ulceration, pleuritis, cervicitis.
4. Neoplasia: Characters, grading and stages of cancer, metastasis, karyo type

changes in tumor, carcinogenic and their cellular interactions, oncogenes and
cancer. sarcomas.
5. Diseases of blood vessels: Arteriosclerosis, hypersensitivity, thrombophelibitis,

varicose veins.
6. Thyroid diseases: Cretinism, myxedema, graves disease, goiter,

hypetithyroidism.
7. Miscellaneous: Spleenomegaly, pyloric stenosis, endometrial hyperplasia,

cholelithiasis, cholecysitis, diseases of the nervous system, gestational and
placental disorders, diseases of stomach and intestine.
Recommended books:
1. Robins Pathologic Basis of Diseases
2. Pathology Illustrated- A.D.T. Govan
3. General Pathology- J. B Walter & M. S Israel.
BPH 2205 Pharmaceutical Microbiology (Credit 3.0)
1. Introduction to microbiology: Microbiology as a field of biology, place of

micro-organism in the living field, Prokaryotic and Eukaryotic protest groups of
micro-organism, area and application of microbiology.
2. Microscopic observations of microorganisms: Bright field, dark field,

fluorescence and phase contrast microscopy. Electronic microscopy preparations of
microscopic examinations, wet mount and hanging drop techniques, fixed and
stained smears, microbiological stains, simple and differential staining methods.
3. Bacteria: Nomenclature of bacteria, morphology and fine structures, nutritional

requirements. bacteriological media, growth and reproduction, quantitative
measurement of bacterial growth, maintenance and preservation of pure culture of
bacteria.
4. Microorganisms other than bacteria:
Yeasts-types: Morphology, reproduction and physiology, pathogenic yeasts.
Rickettsiae: Introduction, Characteristics of rickttsiae, Pathogenic rickettsiae,

laboratory diagnosis of rikettsial diseases.
Viruses: History, classification, characteristics, reproduction, cultivation of virus,

virus inhibition, control of viral infection, bacteriophages, morphology,
composition, cultivation, reproduction of bacterial viruses.
5. Sterilization techniques: Sterilization by heat, gas, filtration, radiation, etc.
6. Aseptic techniques: Sources of contamination, design of laboratories, aseptic

room ventilation, provision of bacteriological clean air, mechanical filtration, types
of filter, electrostatic precipitation, UV light, chemicals, evaluation of filters,
bacteriological testing, methylene blue test, sodium flame test, bubble pressure
technique, laminar flow of air.
7. Sterility testing: Significance, factors influencing the design of sterility test;

sampling, control test, inactivation of antibacterials, filtration techniques in sterility
testing, mechanisms, advantage and disadvantages of filtration, tests on aqueous
solution. LAL Test.
8. Evaluation techniques in microbiology: Methods of evaluation,

microbiological assay of disinfectants and antibiotics- principles, methodology and
features of the assay.
9. Microbiological contamination of pharmaceutical products: Sources,

evaluation, prevention, control etc.
10. Immunology: Infection, resistance, immunity, antigens and antibodies,

antigen-antibody reactions, primary & secondary defensive mechanism of body,
microbial resistance, interferon, basic principles of immunity, active and passive
immunity.
Recommended books:
l. Microbiology- Pelczar, Kreig and chan.
2. Microbiology: An Introduction- Tortora, Funkee and Case.
3. Biology of Microorganisms- T. D. Brock.
4. Industrial Microbiology- Prescott and Dunn.
5. Pharmaceutical Microbiology- Harris.
6. Fundamental Principles of Bacteriology- Salle.
7. Dispensing for Pharmaceutical Students- Cooper and Gunn.
8. Microbiology- Lachman and Whistriche.

BPH 2206 Pharmaceutics-II Practical (Credit 1.0)
Experiments to illustrate the preparation, problems encountered during preparation,

physical evaluation of: pH determination, isotonicity & soluility determination and
adjustments.
BPH 2207 Pharmacology-II Practical (Credit 1.0)
1. Estimation of salicylic acid in blood after administration of aspirin tablet.
2. Estimation of paracetamol in blood after administration.
3. Test of local anesthesia.
4. Estimation of antihistamine in blood after administration.
BPH 2208 Pharmaceutical Microbiology Practical (Credit 1.0)
1. Identification and characterization of bacteria
2. Staining of bacterial cells and spores.
3. Preparation of pure culture and its identification.
4. Bacterial counts.
BPH 2209 Oral Assessment-II (Credit 1.0)

Year III, Semester I
BPH 3101 Medicinal Chemistry-I (Credit 3.0)
1. Drug targets: Various types of drug targets, identification and validation,

receptors as drug targets, general principles of designing and developing various
receptor agonists and antagonists, receptors sensitization and desensitization,
tolerance and dependence, enzymes as drug targets, designing enzyme inhibitors,
nucleic acids as drug targets.
2. Signal transduction and its role in designing drugs.
3. Structure activity relationship and quantitative structure activity

relationship: Their importance in designing drug molecules.
4. Stereochemistry and drug design.
5. Structure activity relationship (SAR), physicochemical properties,

biochemical approaches to drug design of the following group of drugs:
(a) Antimetabolites
(b) Anticancer drugs
6. Chemotherapeutic agents: Agents used in bacterial, protozoal and other

parasitic infections, resistance and the development of new chemotherapeutic
agents.
Recommended books:
l. A Textbook of Organic Medicinal & Pharmaceutical Chemistry - Wilson &

Gisvold.
2. Medicinal Chemistry- Burger.
3. Organic Chemistry (Vol. 1 & 2) - Finar.
4. Organic Chemistry- Morrison & Boyd.

BPH 3102 Pharmaceutical Technology-I (Credits 3.0)
1. Dosages forms: Introduction, definition and classification of different

pharmaceutical dosages forms.
2. Liquid dosages forms: Solution and elixirs, theory of solution, different factors
affection solution process, packaging of liquids, preservation and stability, quality
control system of liquids.
3. Suspensions: Advantages and disadvantages of suspension, theoretical

considerations, aggregated and dispersed systems, formulation, manufacturing,
stability, evaluation and quality control, rheological considerations, illustrative
example.
4. Emulsions: Definitions, applications. advantages, disadvantages, theory,

formation, classification of emulsifying agents, formulation, manufacturing,
stability, evolution and quality system, rheological considerations, illustrative
examples.
5. Semisolids (ointment, paste, gel): Structure of skin, percutaneous absorption of

drugs, definition, classification of semisolid. Classification of ointment bases,
formulation, manufacturing of ointment, rheological considerations, evaluation and
quality system.
6. Suppositories: Drug absorption from colon, classification, formulation,

manufacturing, quality control, suppository bases.
Recommended books:
1. The Theory and Practice of Industrial Pharmacy-Lachmann
2. American Pharmacy- Sprowl.
3. Pharmaceutics- Aulton.
4. Remington's Pharmaceutical Sciences.
5. Dispensing of Medication- Husa & Martin

7. An introduction of Pharmaceutical Formulations- Fishburn.
8. An introduction of Pharmaceutical Formulations Polderman.
9. The Extra Pharmacopoeia- Maitindale.
BPH 3103 Bimolecular Generics (Credit 3.0)
1. Prokaryotic and eukaryotic ribosomes, amino acid activation, initiation,

elongation, termination, inhibition by antibiotics, genetic engineering and its
applications in pharmaceutical industries.
2. Metabolism of Carbohydrates: Glycolysis with all related reactions. Kreb’s

cycle with all related reactions, glycogenesis, glycogenolysis, gluconeogenesis,
hexose monophosphate shunt, uronic acid pathway, biological oxidation, electron
transport chain, oxidative phosphorylation, free radicals and antioxidants.
3. Metabolism of lipids: An overview of lipid metabolism, beta-oxidation of fatty

acids, energy of fatty acid oxidation, oxidation of unsaturated fatty acids, ketone
bodies, over production of ketone bodies, regulation of ketogenesis, ketoacidosis,
lipoproteins, fatty liver, lipotropic factors, obesity, atherosclerosis.
4. Metabolism of ammonia and nitrogen containing compounds: Biosynthesis

of amino acids, catabloism of amino acids, deamination, transamination, ammonia
formation and transport, one carbon metabolism, fate of carbon skeleton of amino
acids, inborn errors of amino acid metabolism, conversion of amino acids to
specialized products, urea cycle, metabolic disorders of urea cycle, metabolism of
sulfur containing amino acids, porphyrin biosynthesis, formation of bile pigments,
hyperbilirubinemia, purine biosynthesis, purine nucleotide inter conversion,
pyrimidine biosynthesis and formation of deoxyriboneucleotides.
5. Nucleic acids and protein biosynthesis: Brief introduction of the genetic

organization of the mammalian genome, alteration and rearrangements of genetic
materials, biosynthesis of DNA and its replication, mutation, physical and
chemical mutagenesis, carcinogenesis, DNA repair mechanism, biosynthesis of
RNA, genetic code, components of protein synthesis and inhibition of protein
synthesis, regulation of gene expression.
6. DNA replication, RNA and transcription: Genetic code in DNA replication,
mRNA, tRNA, rRNA, ribosome structure, RNA synthesis and post-transcriptional
modifications.
Recommended books:
BPH 3104 Pharmaceutical Analysis & Quality Control-I (Credit 3.0)
1. Introduction and techniques of pharmaceutical analysis: Selection of

samples, selection of chemicals, choosing tools, identification of containers,
filtration, ignition of precipitates, drying of samples, recording of results.
2. Aqueous acid-base titration: Definitions, distribution of acid-base species with

pH of the medium, acid base titrimetric for determination of weakly acidic and
basic pharmaceuticals, indicators (theories), their selection and applications.
3. Oxidation reduction titration: Principles and concepts, determination

involving potassium permanganate, potassium dichromate and potassium '
bromate, iodometric titration, miscellaneous oxidation-reduction titrations,
indicators and applications.
4. Complexometric titration: Introduction to complexometric titration, complexes

and chelates, stability of complexions, titration based on complex formation, types
of complexometric titrations, techniques employed in complexometric titrations,
methods of end point detection, titration selectivity and masking agents.
5. Aquametric titration: Concept, physical methods of water determination,

chemical methods of water determination and pharmaceutical importance.
6. Non-aqueous titration: Concept, different methods and pharmaceutical

importance.
7. Principles of microbiological assay of antibiotics and vitamins.
Recommended books:
1. A Textbook of Pharmaceutical Analysis- K .A. Connors
2. Quantitative Pharmaceutical Analysis- Chatten

3. Quantitative inorganic Analysis (Vol. I & II) - Vogel
4. United State Pharmacopoeia.
5. British Pharmacopoeia.
6. Quality Control in Pharmaceutical Industry- M. S. Cooper
7. Quality Control in Pharmaceutical Industry- Bekkect and Stenlake.
BPH 3105 Pharmacology-III (Credit 3.0)
1. Drugs acting on CNS:
a. CNS stimulating drugs.
b. Cholinergic and anti-cholinergic drugs.
c. Adrenergic and anti-adrenergic drugs.
d. Sedatives & hypnotics, psychotropic and anti-depressant drugs.
2. Anti-diabetic drugs: Introduction and classification of diabetics, hyperglycemia

and hypoglycemia, introduction, classification, chemistry, mode of action, SAR,
pharmacokinetics, indications, and contraindications; dose, adverse effects and
drug interactions of oral hypoglycemic agents (sulfonylurea and bigunides),
management of diabetes mellitus, hormone preparation: insulin.
3. Toxicology: Principles, LD50, LD10, ED50, therapeutic index, evaluation of

toxicology in animals, factors affecting poisoning: interventions by pharmacists in
the prevention, diagnosis and management of poisoning, types of arsenic
poisoning, ground water and arsenic poisoning, geographical distribution in
Bangladesh, detection of arsenic: symptoms, diagnosis, prevention and treatment
of arsenic poisoning; arsenic mitigation programs in Bangladesh.
4. Drug abuse: General considerations in drug abuse, characteristics and treatment

of drug abuse, consequences of drug abuse, control of drug abuse etc.
BPH 3106 Hospital & Community Pharmacy (Credit 3.0)
1. Introduction: Abilities required of a hospital pharmacist, hospital as an

institution, registration requirements, general functions, classification,
organizational patterns, management and administration, role of a pharmacist in
the hospital, hospital pharmacy, organizational and administration, supportive
personnel, pharmacy education.
2. Pharmacy and therapeutics committee: Description and purposes,

organization, scopes and functions, hospital formulary, guiding principles, legal
basis. Principles for admission of deletion of drugs, investigational use of drugs,
description and principle involved, classification, control, identification, advisory
committee, hospital formulary system.
3. Purchasing and drug distribution: Purchasing system, control on purchases,

storage, physical inventory, perpetual inventory, drug distribution and control
system in hospitals, floor sock drugs, inspection of nursing station medication area.
4. Control of special classes of drugs: Narcotics distribution and control,

procurement and execution of order forms, dispensing, hospital narcotic
regulations.
5. Dispensing to in and out patients: Dispensing of charged non floor stock

drugs, unit dose dispensing, dispensing to out-door patients, record keeping,
dispensing during off hours, emergency boxes and night drug cabinets, pharmacist
on call, drug charges in hospitals, pricing, breakeven point pricing.
6. Drug information center and library: Physical facilities, selection of contents,

methods of dissemination of drug information, external educational programs.
7. Community pharmacy: Concept of community health care, health needs of the

community, different levels of health care, elements of primary health care, and
principles of primary health care, community pharmacy in dealing with
communicable diseases problem, nutritional problems, environmental sanitation
problems and indigenous systems of medicine, development of community
pharmacy infrastructure.
8. Rational use of drugs: Background of rational use of drugs, definition, factors
underlying irrational use of drugs,‘ factors affecting drug use, strategies to improve
prescribing, strengths and weakness of different interventions to change drug use
patterns, international network for rational use of drugs.
9. Forensic pharmacy: Definition, epidemiology of poisoning, influential factors,

substances most frequently involved in accidental ingestions among children, first-
aid treatment of poisoning, antidotes: locally acting and systemic, prevention of
poisoning, poison control, poison control act, schedules, poison treatment centre,
poison prevention packaging, national and community awareness, centralization of
poison information, responsibilities of pharmacists.
Recommended books:
l. Clinical Pharmacy and Therapeutics by Herfinadal, Gourly & Hort
2. Therapeutic basis of Clinical Pharmacy in the tropics by Aguwa
3. Hospital Pharmacy by William Hasan
4. Textbook of Hospital Pharmacy by Allwood
BPH 3107 Medicinal Chemistry-I Practical (Credit 1.0)
Experiments involving the synthesis, design of synthetic process of different

generic group of pharmaceuticals and allied raw materials covered in the
theoretical section of the medicinal chemistry curriculum.
BPH 3108 Pharmaceutical Technology-I Practical (Credit 1.0)
1. Preparation of paracetamol suspension.
2. Preparation of benzyl benzoate ointment.
3. Preparation of chlorpromazine hydrochloride syrup.
4. Preparation of dry syrups and suspensions.

5. Preparation of effervescent powders.
6. Preparation of ORS.
Year III, Semester II
BPH 3201 Medicinal Chemistry-II (Credit 3.0)
1. Target oriented drug design: Optimization of drug target interactions, getting

from hit to lead to clinic.
2. Pharmacokinetic drug design: Optimization of pharmacokinetic parameters.
3. Combinational synthesis: Role in lead generation and lead optimization.
4. Computer aided drug design: Design via structure and computer modeling.
5. Synthetic procedures and SAR of the following drugs:
a. Drugs affecting cholinergic neurotransmission.
b. Drugs affecting adrenergic neurotransmission.
c. Drugs affecting serotonergic neurotransmission.
d. Local anesthetics.
e. Neuromuscular blockers, anti-parkinson and spasmolytic agents.
f. Antipsychotic agents.
Recommended books:
l. A Textbook of Organic Medicinal & Pharmaceutical Chemistry- Wilson and

Gisvold.
3. Organic Chemistry (vol. 1 & 2) - Finar.
4. Organic Chemistry- Morrison and Boyd.

5. Essentials of Medicinal chemistry- Andrejus Korolkovas.
6. Foye’s Principles of Medicinal Chemistry- David A. Williams and Thomas L.

Lemke, Lippincott Williams & Wilkins.
7. An Introduction to Medicinal Chemistry- Graham L. Patrick.
BPH 3202 Pharmacoeconomics & Policy (Credit 2.0)
1. Basic of pharmacoeconomics and policy: Understandings of how the market

for pharmaceuticals works and why it is often the focus of much regulation, flow of
funds, demand, contracting.
2. Managed care, risk, capital and competition, insurance.
3. Economic and policy problems: Managing pharmaceutical markets and how to

evaluate the impact of alternative policy approaches, basic features of
pharmaceutical markets, approaches to regulate the market, critical evaluation of
the impact of policy on market outcomes.
4. Analyses of pharmaceutical markets from the perspectives of several main

factors: Governments, third party payers, pharmaceutical industry, doctors,
patients, pharmacists and wholesalers. Literature from health economics, industrial
organization and health policy.
5. Fundamentals to decision making of pharmaceutical economic agents:

Business firms, macroeconomics, consumers and government. ’
Recommended books:
l. Health Economics: Fundamentals and Flow of Funds- Thomas E. Getzen.
2. E Mossialos, M Mraqzek & T Walley (Eds). Regulating Pharmaceuticals in

Europe. Striving for Feeiciency, Equity and Quality, Buckingham, Open
University Press (2004).
3. S O Schweitzer, Pharmaceutical Economics and Policy, OUP (1997); P M

Danzon, Pharmaceutical Price Regulation, AEI Press (1997).
4. W S Comanor, ‘The Political Economy of the Pharmaceutical Industry’, Journal
of Economic Literature, XXIV (September): 1178-1217 (1986).
5. F M Scherer ‘The Pharmaceutical Industry', Chapter 25, in: A J Culyer & J P

New house (Eds), Handbook of Health Economics, vol. 1, Amsterdam, Oxford,
Elsevier.
BPH 3203 Pharmaceutical Technology-II (Credit 3.0)
1. Powder and granules: Reasons for granulation, properties of granules, size,

shape, surface area, density, strength and friability. Pharmaceutical granulation
equipment: Wet and dry granulators. Granulation methods: wet and dry granulation
methods, direct compression methods, effect of granulation method on granules
structure.
2. Tablet formulation: Definition and classification, advantages and

disadvantages, properties of tablets, formation of tablets, modem tableting
recipients, directly compressible vehicles, manufacturing of tablets, effervescent
tablets, compression coated tablets, chewable tablets, common problems in
tabulating process. Evaluation of tablets: hardness measurement, weight variation
tests, thickness and diameter, friability, disintegration time, dissolution time,
mechanism of tablet disintegration and dissolution in-process quality control.
3. Tablet compression machines and tooling: Types of tablet tooling, steel

selection, maintenance and storage of tooling.
4. Tablet coating: Definition and classification of coating methods, advantages of

coating methods, different methods of coating, sugar coating, film coating, enteric
coating.
5. Hard gelatin capsules: Definition, classification advantages and limitations of

capsule dosages form, gelatin and its manufacturing, manufacturing of hard gelatin
capsule shell, properties and formulation of capsules, capsule filling machines,
tooling, accessories, manufacturing problems, quality control and packaging.
6. Soft gelatin capsule: Definition, classification, advantages and limitations of
capsules, manufacturing of soft capsule, properties and formulation of capsule,
manufacturing problems, quality control and packaging.
7. Sustained release drug delivery systems: Principles, advantages, limitations

and type of SR dosages forms, methods of obtaining SR effect of drugs.
Formulation and manufacturing of SR matrix tablets, drug release from SR dosage
forms, evaluation of SR dosage forms, excipients used in SR dosage forms, dose
calculation.
8. Micro encapsulation technology: Purpose, method of preparation and

evaluation.
BPH 3204 Pharmaceutical Biotechnology (Credit 2.0)
1. Introduction: Pharmacist and biotechnology, approved biotechnological

products and vaccines, GMP compliance and biopharmaceutical facilities.
2. Immobilization of enzymes: Surface immobilization by covalent coupling,

adsorption, complexation and chelation, within support immobilization and cell
immobilization.
3. Fermentation technology: Fermentation process and optimization,

improvement of microbial strain, structure and types of fermenters, fermented
pharmaceutical products (antibiotics and vitamins).
4. Recombinant DNA technology: Introduction, cutting and rejoining of DNA,

mutagenesis, polymerase chain reaction (PCR) in gene amplification,
pharmaceutical applications of recombinant DNA technology, drug delivery
system, gene therapy, basic molecular mechanism of gene transfer, prerequisites of
human gene therapy, gene therapy for cancer and HIV, various problems in gene
therapy.
5. Basic immunology: Natural and acquired immunity, innate immune system,

adapted, acquired immunity, specific immunity and antibody clonal selection, cells
of immune system, antibody and immunoglobulin, monoclonal antibody and its
applications, current trends in vaccines, delivery considerations of
biopharmaceutical products, molecular principles of drug category.
6. Antisense therapy: Antisense therapy, basic concept, mechanism of antisense

therapy and examples of antisense therapy for the treatment of different diseases.
7. Bioinformatics: Definition and concepts, importance of bioinformatics,

biological database, primary sequence database, protein sequence database, DNA
sequence database, and genome resources web address, multiple sequence
alignment, importance of multiple sequences alignment of drug design, importance
of coiled coil peptides for drug design.
8. Dispensing biotechnological products: Storage and maintenance, handling and
transportation requirements, preparation and administration, reimbursement.
Recommended books:
1. Biotechnology and its application in Pharmacy- Giriraj Kulkarni.
2. Introduction to Bioinformatics- T. Attwood, D. J. Parry- Smith.
3. Pharmaceutical Biotechnology- D. Commelin.
4. Pharmaceutical Biotechnology- Vyas.
BPH 3205 Pharmaceutical Analysis & Quality Control-II (Credit 3.0)
1. Quality assurance: Theory and concepts of cGMP, ISO 9001, TQM, quality
review and documentation, regulatory control, regulatory drug analysis and
interpretation of analytical data, process and equipment validation and quality,
validation of analytical instruments.
2. Absorption spectrophotometry:
a. UV-visible: Introduction, electromagnetic radiations, units, electromagnetic

spectra and absorption of radiation, Lambert's and Beer's laws, deviations from
Lambert's Beer's law, Chromopheres and auxochromes, analyses of mixtures,
absorption and intensity shifts, applications of UV-visible spectroscopy in
quantitative analysis of drugs.
b. IR spectrophotometry: Introduction, principle, instrumentation and applications

of IR spectrophotometry in pharmaceutics analyses.
3. Flourometry: Theoretical principle, fluorescence and chemical structures,

instrumentation, factors influencing intensitgy of fluorescence, comparison of
fluorometry and spectrophotometry, applications of fluorometry in pharmaceutical
analysis.
4. Polarimetry: Introduction, origin of optical rotation, molecular requirements for

optical rotation, methods used in polarimetry, instrumentation and applications of
polarimentry.
5. Chromatographc techniques: Column, paper, thin layer, gas, ion exchange,

HPLC, size exclusion and their applications in pharmaceutical analysis.
Recommended books:
1. A Textbook of Pharmaceutical Analysis- K.E. Connors
2. Quantitative Pharmaceutical Analysis- Chatten
3. Quantitative Inorganic Analysis (vol. I & II)- Vogel
4. United State Pharmacopoeia.
6. Quality Control in Phannaceutical Industry- M.S. Cooper.
BPH 3206 Biopharmaceutics & Pharmacokinetics-I (Credit 3.0)
1. Introduction to pharmacokinetics: Basic aspects of biopharmaceutical and

clinical pharmacokinetics and their roles in formulation development and clinical
setting.
2. Fate of drug after administration: Drug absorption; physiological, physic-

chemical and biopharmaceutical considerations; apparent volume of distribution of
drugs, zero order absorption model, first order model, determination of rate
constant from oral absorption data.
3. Pro-drug concept: Methods of modifying drug delivery systems.
4. Drug-protein interaction: Theoretical aspect of protein-drug interaction,

methods used for protein binding, identification of drug binding sites, kinetics of
protein binding, determination of binding sites and association constant, factors
affecting protein binding, effects of protein binding on drug distribution,
elimination and pharmacological effects of drugs.
5. Bioavailability and bioequivalence: Definition of different parameters relative

to bioavailability; purpose of bioavailability, relative and absolute bioavailability,
methods of assaying bioavailability, criteria for bioequivalence studies.
6. Drug clearance and metabolism:
(a) Theoretic aspects of drug elimination, excretion and biotransformation.
(b) Renal elimination: Glomerular filtration, active tubular secretion, tubular

reabsorption, determination of renal clearance.
(c) Hepatic elimination: Biotransformation of drugs in the liver, drug

biotransformation reactions, pharmacokinetics of drugs and metabolites (Michelis
Menten Equation), first pass effect, liver excretion ratio, relation between absolute
bioavailability and liver excretion, hepatic clearance- relationship between blood
flow, intrinsic clearance and hepatic clearance, hepatic clearance of a protein
bound drug (effect of protein binding on hepatic clearance).
(d) Biliary excretion of drugs.
Recommended books:
l. Biopharmaceutics and Clinical Pharmacokinetics- M. Gibaldi
2. Biopharmaceutics and Clinical Pharmacokinetics- Notari.
3. Biopharmaceutics and Relevant Pharmacokinetics- T. G. Wagner.
4. Biopharmaceutics and Drug Interactions- Cadwallader.

5. Biopharmaceutics- M. Gibaldi & D. Perrier. ,
BPH 3207 Medicinal Chemistry II Practical (Credit 1.0)
1. Synthesis of organic compounds of medicinal uses.
2. Studies of drug design.
3. Extraction of metabolic enzymes from liver and their effects.
4. Exercise on stereochemistry and drug receptor interactions.
BPH 3208 Pharmaceutical Technology-II Practical (Credit 1.0)
l. Preparation of granules by wet granulation methods.
2. Formulation of emulsions, suspensions, syrups, ointments, suppositories.
3. Preparations, problems encountered during preparation, physical evolution of

the different dosage forms:
a. Tablets including coated tablets
b. Capsules.
c. Suppositories
4. Physical tests (hardness, weight variation, thickness, friability) for tablet.
S. Disintegration and dissolution study of tablet and hard gelatin capsule.

BPH 3209 Pharmaceutical Analysis & Quality Control-II Practical (Credit 1.0)
l. Assay of salicylic acid in tablets.
2. Determination of calcium gluconate in tablets by EDTA methods.
3. Non aqueous assay of diclofenac sodium in suppositories.
4. Determination of saponification value, iodine value and acid value of fixed oils.
5. Microbial assay of antibiotics and vitamins.
BPH 3210 Biopharmaceutics & Pharmacokinetics-I Practical (Credit 1.0)
1. Study of hardness variation, disintegration time of tablet dosage form.
2. Dissolution study of theophylline tablet (conventional tablet)
3. Dissolution study of sustain release theophylline tablet.
4. Dissolution of study of diclofenac sodium (enteric coated) tablet.
BPH 3211 Oral Assessment-III (Credit 1.0)
Year IV, Semester I
BPH 4101 Advanced Medicinal Chemistry (Credit 3.0)
1. Drug design and discovery: Sources of drugs, cost and place of development of
drugs, search for new drugs, genesis of drugs.
2. Drug metabolism: Pathways of drug metabolism, metabolism of various groups

of drugs, factors affecting drug metabolism, methods of studying drug metabolism,
new aspects of drug metabolism. metabolic products of some common drugs.
3. Chemistry, synthesis, SAR and physics-chemical properties of the following

group of drugs:
a. Sedatives and hypnotics
b. Autacoids.
c. Analgesics, antipyretics and anti-inflammatory drugs.
d. Tranquilizing agents.
e. Membrane acting drugs: Drugs acting on Ca+ , Na+ and Ka+ channels.
4. Case history of specific drug design:
a. Antihypertensive (β- blockers)
b. H2 receptor blockers.
c. Anti-diabetic drugs.
Recommended books:
1. A Textbook of Medicinal Chemistry- Wilson and Gisvold.
3. Organic Chemistry (vol. 1 & 2)- Finar.
4. Organic Chemistry- Morrison and Boyd.
5. Essentials of Medicinal chemistry- Andrejus Korolkovas.
6. Foye’s Principles of Medicinal Chemistry- David A. Williams and Thomas L.

Lemke, Lippincott Williams & Wilkins.
7. An Introduction to Medicinal Chemistry- Graham L. Patrick.
BPH 4102 Clinical Pharmacy (Credit 3.0)
1. Introduction of clinical pharmacy: Role of clinical pharmacists, skills and

abilities of clinical pharmacists.
2. Basic concepts of pharmacotherapy:
a. Clinical pharmacokinetics and individualization of dosage regimen.
b. Drug: induced diseases.
c. Adverse drug interaction.
d. Clinical toxicology.
3. Interpretation of common clinical laboratory tests: Hb test, ESR test, SGPT,

SGOT, LDL. HDL, creatinine, liver function tests etc.
4. Disorder of organ systems and their management:
(a) Cardiovascular disorders: Hypertension, congestive cardiac failure (CCF),

myocardial infarction (Ml), angina, arrhythmias.
(b) CNE disorder: Epilepsy, parkinsonism, schizophrenia, depression.
(c) Asthma.
(d) Ulcer, hepatitis, cirrhosis of the liver.
(e) Diabetes and thyroid disorders.
(f) Anemia.
(g) Tuberculosis, urinary tract infection, enteric infection, upper respiratory tract
infection etc.
(h) Neoplastic diseases.
Recommended books:
1. The Pharmacological Basis of Therapeutics- A.G. Gillman, L. S. Goodman.
2. Text Book of Pharmacology and Therapeutics- S.S. Bhattacharya (ed.), BB. N.

Ghosh's
3. Atlas of Drug Reactions- R. D. Colins.
4. British National Formulary, Royal Pharmaceutical Society of Great Britain,

London.
5. Clinical Pharmacy and Therapeutics Williams & Wilkins.
6. Therapeutic Basis of Clinical Pharmacy in the Tropics- Aguwa
BPH 4103 Advanced Pharmaceutical Analysis-I (Credit 3.0)
1. Polarography: Introduction, theoretical considerations, instrumentation, general
Polarographic analysis.
2. Conductrometry: Introduction, theoretical considerations, instrumentation,
general conductometric analysis.
3. Electrogravimetry and coulometry: Introduction," instrumentation,

polarization effect, contrast with potentiometer, potentiostatic electrolysis, uses in
pharmaceutical sciences.
4. X-ray crystallography: Introduction, instrumentation and application of X-ray
crystallography in pharmaceutical sciences.
5. Potentiometry: Introduction, theory and principles, electrochemical cells and

half-cells, electrodes, measurement of potential, application of potentiometric
titrations in pharmacy.
6. Amperometry: Introduction, theoretical considerations, instrumentation,

general amperometric titrations using one and two electrodes.
7. Bioassay of antibiotics with statistical evaluation: Introduction, principle,

methodologies, advantages and limitations, statistical analysis, applications.
Recommended books:
1. A Textbook of Pharmaceutical Analysis- K.E. Connors.
2. Pharmaceutical Chemistry- Lasie G. Chatten, Marcel Dekker Inc.
3. Quantitative Inorganic Analysis (Vol. I & II) - Vogel
4. Untied State Pharmacopoeia.
6. Quality Control in Pharmaceutical Industry- Cooper.
BPH 4104 Pharmaceutical Sales & Marketing (Credit 3.0)
1. Basic of marketing: Needs, wants and demands; products, value, cost,

satisfaction, exchange, transaction and relationship; markets, marketing and
marketers.
2. Production, product, selling and marketing concepts: Marketing prices-
selection of marketing opportunities, targeting the market, product positioning,
formulating marketing strategy and plans, organizing, implementing and
controlling marketing efforts.
3. Pharmaceutical marketing environment: Patents- disease incidence,

economic factors, demographic factors. Physicians- different classes, hospitals and
clinics, retail and wholesale pharmacy, competitive factors, social and cultural
factors, technology, government and legal aspects.
4. Identification of marketing opportunity: Marketing information system,

prescription audit, prescription behavior analysis, doctors database, purchase
invoice audit, prevalence of diseases, identifying competitors, strategy, objectives,
strengths and weakness reactions.
5. Demand analysis: Market potential, estimation of market share, forecasting

techniques- expert opinion, seasonal variation, statistical techniques, trend
extrapolation, survey of prescribers opinions.
6. Market segmentation: Necessity of market segmentation, prescription, market-

group of doctors, therapeutic market, OTC market, wholesale market and
govemmert market, clinics, NGOs, foreign market.
7. Code of pharmaceutical marketing: Future of pharmaceutical marketing,

effects of GATT, change in drug policy, development of genetic engineering,
changes in health habit and awareness, introduction of health insurance.
8. Formulation of marketing strategies: Establishing competitive edge, product

differentiation, service differentiating, product positioning, medical treatment
problems.
Recommended books:
l. Marketing Management- Kotler, Philip; Prentice- Hall Inc.
2. Organizational Behavior- Robbins, Stephens P. Prentice Haa Inc.
3. Management- A Global Perspective- Weiriech, Heinz & Koontz
4. Principals and Methods of Pharmacy Mangament- H.A. Smith

BPH 4105 Pharmaceutical Engineering (Credit 3.0)
1. Drying: Theory of drying, methods of drying of wet solids; convective,

conductive and radiation drying; dryers for dilute solutions and suspensions, freeze
drying, solute migration during drying.
2. Mixing: Theory and type of mixing, degree of mixing, mixing of powdered

materials and miscible liquids and suspension, mixing of semisolids, factors
affecting mixing processes, types of semisolid mixers.
3. Clarification and filtration: Definition and theory of filtration, factors affecting

filtration rate. mechanism of filtration, industrial filters and filtration techniques.
4. Lay out plan of pharmaceutical manufacturing plant: Guidelines for

selecting new plant sites.
5. Water treatment plant in pharmaceutical industry: Sources of raw water,

natural impurities in raw water and their removal, purification methods, definition
and classification of pharmaceutical water, manufacturing and storage of
pharmaceutical water, distillation of water, ion-exchange process, reverse osmosis,
microbiological quality and analysis of pharmaceutical water.
6. Humidity control and air conditioning: Importance of humidity control in

pharmaceutical industry, methods of humidity control, psychometric chart and
measurement of humidity in pharmacy.
7. Milling and size separation: Theoretical aspects of milling, influence of

material properties on milling, crack propagation and toughness, surface hardness,
energy requirements, influence of size reduction on size distribution, factors
affection milling, industrial size reduction methods, selection of particle size
reduction methods.
8. Safety methods in pharmaceutical industry: Fire protection, handling of

dangerous and toxic chemicals, waste disposal, animal handling in pharmaceutical
industry.
9. Material handling system:
(a) Liquid handling: Different types of pumps.

(b) Gas handling: Various types of fans, blowers & compressors.
(c) Solid handling: Bins, bunkers, conveyors and air transport.
10. Automated process control systems: Process variables, temperature, pressure,

flow level and vacuum and their measurements, elements of automatic process
control, introduction to automatic process control systems, elements of computer
aided manufacturing (CAM).
11. Industrial hazards & safety precautions: mechanical, chemical, electrical,

fire and dust hazards, industrial dermatitis, accident records etc. t
Recommended books:
l. The Theory and Practice of Industrial Pharmacy- lachmann.
2. American Pharmacy-Sprowl.
4. Remington’s Pharmaceutical Scineces.
5. Dispensing of Medication- Husa & Martin.
7. An introduction to Pharmaceutical Formulations- Fishbum.
8. An introduction to Pharmaceutical Formulations- Polderman
9. The Extra Pharmacopoeia- Martindale.
BPH 4106 Pharmacy Law & Ethics (Credit 2.0)
1. Scope opportunities in government and the armed forces.
2. Drug administration and pharmacy council of Bangladesh: Their scopes and

functions.
3. Regulations and laws governing the practices of pharmacy: The pharmacy

ordinance 1976, control of drug advertisements, prices, patented and trade market
medicine, proprietary medicines, schedules of drugs and poisons, regulation of
cosmetics and poison control.
4. Policies, sales, regulation and laws concerning to the manufacture,

possession, distribution sale of drugs and poisons: The drug policy 1982,
Essential drug list. The drug act 1940. The Drug Control Ordinance 1982, The
Narcotics Control Act 1990, The Poisons Act 1919 and related amendments.
5. Professional characteristic and ethical norms: Relationship of trust, ethical

considerations during pharmacy practice, deficiencies of self-regulation, adherence
of self-regulation.
6. The pharmacists code of ethics as per the Pharmacy Council of Bangladesh.
7. Government health and drug policies.
Recommended books:
1. The Pharmacy Ordinance, 1976, Ministry of Law and Parliamentary affairs,

Government of Bangladesh, Dhaka.
2. The Drugs (control) Ordinance, 1982, Ministry of Law and Land Reforms
Government of Bangladesh, Dhaka.
3. Drug Policy of Bangladesh, Ministry of Health and Population Control, health

Division. Dhaka A Textbook of Forensic Pharmacy- B m. Mithal .
4. Pharmacists Code of Ethics, Pharmacy Council of Bangladesh.
BPH 4107 Clinical Pharmacy Practical (Credit 1.0)
1. Estimation of blood glucose levels in different stages and after receiving oral
xylose, galactose.
2. Estimation of maltose or pharmaceuticals that may contain these substances.
e. Estimation of serum electrolytes and trace elements.
4. Estimation of serum bilirubin.
5. Preparation of total parenteral nutrients (TPN).

6. New specimen labels and labeling.
7. Urine analysis: dipstick and microscopic examination.
8. Coagulation test: prothrombin time (PT).
9. Assay of triglycerides and LDL.
10. Opiate and related drugs testing in urine.
11. Testing for amphetamines, benzodiazepines, THC and barbiturates in urine,
12. Culture and sensitivity of different specimens.
BPH 4108 Project and Dissertation (Credit 2.0)
Year IV, Semester II
BPH 4201 Cosmetology (Credit 3.0)
1. Introduction: Prospect of cosmetics in health care and hygienic practices.
2. The skin: Introduction, epidermis & keratinizing systems, pigmentary system,

Langerhans cell, dermis, nerve and sense organs, blood vessels, exocrine sweat
glands, hair follicles, sebaceous glands, apocrine glands, common disorders of the
skin.
3. Product ingredients: Commonly used surface active agents, humectants,

antiseptics, preservatives, antioxidants.
4. The manufacture of cosmetics: Introduction, mixing and manufacture of bulk

cosmetic products, solid-solid mixing. Manufacture of pigmented power products.
Mixing processes involving fluid, general principles of fluid mixing. Mixing
equipment for fluids, solid- liquid mixing, suspension of solids in agitated tanks,
liquid-liquid mixing, miscible liquids.
5. Skin creams: Introduction, classification of skin creams, cold creams, cleansing
creams, night and massage creams; moisturizing, vanishing and foundation creams;
pigmented foundation creams, hand creams, hand-and body creams, all-purpose
creams.
6. Shaving preparations: Introduction, lather shaving cream, brushless or non-

lathering cream, aerosol shaving foams, after-shave preparations.
7. Dental products: Introduction, formulation and manufacture of toothpastes,

tooth powders, mouth washes.
8. Shampoos: Introduction, hair setting lotions, hair tonics and conditioners,

formulation and manufacture of different types of shampoos.
Recommended books:
1. Cosmetics, Science and Technology (Vol. I & II) - Balsam and Sagarin.
2. Preparation and Distribution of Drugs and Cosmetics- Sahn.
BPH 4202 Pharmaceutical Technology-III (Credit 3.0)
1. Design and operation of clean room: Source of contamination, air flow

system: conventional, unidirectional, laminar air flow unit. Air filtration-
mechanisms, fibrous and HEPA filters; temperature and humidity control, building
design, construction and use; personnel, protective clothing, cleaning and
disinfecting, commissioning test of clean and aseptic rooms, routine monitoring
tests, the operation of clean and aseptic rooms, key factors in clean room
operations.
2. Parenteral products: Definitions, classifications; formulation considerations:

vehicles and additives, containers; manufacturing considerations. Environmental
tests, manufacturing techniques, raw materials and machines, quality control,
sterility tests, pyrogen test, clarity test. leak test for ampoules and packaging of
potential products.
3. Ophthalmic products: Anatomy of eye and adnexa, absorption of drugs in the

eye, classification of ophthalmic products, safety considerations, formulation
considerations, environment, manufacturing techniques, raw materials and
machines, quality control, quality control and packaging of ophthalmic products.
4. Packaging technology: Purpose of packaging, properties of packaging

materials, factors influencing choice of packaging, advantages and disadvantages
of packing materials, glass and glass containers, metal and metal containers, plastic
and plastic containers; films, foils laminates, rubber based materials, closures,
tamper resistant packaging, testing and assurance of packaging materials different
packing machines and accessories, organization of packaging line, labeling.
5. Compaction and compression: Physics of tablet compression, mechanism of

tablet formation, bonding in tablets, the effect of compressional force on tablet
properties, effect of lubricants on tablet compression, binding, tablet machines and
tooling, problems associated with large scale manufacturing of tablets.
6. Aerosol science and technology: Definitions, classifications, propellants for

aerosol manufacturing components of aerosol formulation, containers and valves
for aerosols, metered dose delivery of aerosols, manufacturing and evaluation of
aerosol.
7. Drug delivery to lungs: Drug administration to respiratory tract, mechanism

and factors affecting depositions of drugs in the respiratory tract, quality control in
manufacturing of dose inhalers.
Recommended books:
1. Theory and Practice of Industrial Pharmacy- Lachmann.
2. American Pharmacy- Sprowl.
4. Remington’s Pharmaceutical Science.
5. Cooper & Gunn’s dispensing for Pharmaceutical Students.
6. Dispensing of Medication- Husa and Martin.
7. Bentley’s Textbook of Pharmaceutics.
8. Tutorial Pharmacy- Cooper & Gunn.

9. An Introduction to Pharmaceutical Formulations- Fishburn.
4203 Advanced Pharmaceutical Analysis-II (Credit 3.0)
1. UV and IR spectrophotometry: Ultraviolet and Infrared spectrophotometry in

structural analysis of organic compounds. -
2. NMR spectroscopy:
1
H NMR Spectroscopy: Introduction and theory, relaxation process,
instrumentation, shift. factors affecting chemical shift, spin-spin coupling, different
spin systems, coupling constants, factors affecting coupling constants, spin-spin
decoupling, long range coupling, nuclear over Hauser effect (nOe).
C Spectroscopy: Theoretical consideration, broad band and DEPT spectra,

13
application of 13C NMR in structural analysis.
Two-dimensional NMR spectroscopy: Correlated spectroscopy (COSY), 2D

nuclear over Hauser enhancement spectroscopy (NOESY), HOHAHA, HMBC,
HMQC.
3. Mass spectroscopy: Introduction, theory, mass spectrum, determination of

molecular formula, ionization techniques, recognition of molecular ion,
fragmentation process, application of mass spectroscopy.
4. Atomic absorption spectroscopy: Theory, instrumentation, application in

quantitative analysis. i
Recommended books:
1. Organic Structure for Spectra- L. D. Field, S. Sternhell, J. R. Kalman, John

Willey & Sons, New York, Singapore.
2. Introduction to Spectroscopy- Donald L. Pavia., Gary M. Lampman, George S.

Kriz, Books/ Cole, Thomson Learning. Dudley H. Williams, Ian.
3. Spectroscopic Methods in Organic Chemistry, Flemming, Tata McGraw-Hill

Publishing Company Limited.
4. Interpretation of NMR Spectra: An Empirical Approach, Roy H. Bible, Plenum
Press, New York.
5. One and Two Dimensional NMR Spectroscopy - Alta-Uv Rahman, Elsevier,

Amsterdem, Oxford, Newyork, Tokyo.
5. Introduction to Mass Spectrometry, H.C.Hill, Heyden & Son Limited.
6. Interpretation of Mass Spectra, Fred W. McLafferly,, W.A Benjamin Inc., New

York.
BPH 4204 Biopharmaceutics & Pharmacokinetics-II (Credits 3.0)
1. Introduction to compartment:
a. One-compartment open model: Determination of plasma concentration from

one compartment open model, elimination rate constant, apparent volume of
distribution, calculation of K from urinary data.
b. Multiple compartment models:
(i) Two-compartment open model, method of residuals, apparent volumes of

distributions, drug in tissue compartment, elimination rate constant.
(ii) Three compartment open model, method of residuals, determination of area

under curve, apparent volumes of distribution, elimination rate constant.
2. Pharmacokinetics of drug absorption: Zero-order absorption model, first-

order absorption model, determination of absorption rates constant from oral
absorption data.
3. Multiple dosage regimens (MDR): Drug accumulation, repetitive intravenous

injection, multiple oral dosage regimens, loading dose and determination of
bioavailability and bioequivalence from MDR.
4. Intravenous infusion: One-compartment model drugs, Two-compartment

model drugs, infusion plus loading dose.
5. Dosage Adjustment in renal and hepatic disease:
a. Pharmacokinetic considerations, general approaches for dose adjustment in renal

disease, dose adjustment based on drug clearance, dose adjustment based on the
elimination rate constant, measurement of glomerular filtration rate (GFR),
calculation of creatinine, clearance from serum creatinine concentration, dose
adjustment based on monogram Giust-Hayton method, Wegner method.
b. Extracorporeal removal of drugs.
6. Non-Compartmental analysis: Physiologic-pharmacokinetic model, statistical

moment, mean residence time.
7. Relationship between pharmacokinetic and pharmacologic responses:

Introduction, basic concepts, relationship etc.
Recommended books:
1. Biopharmaceutics and Clinical Pharmacokinetics- M. Gibaldi.
2. Biopharmaceutics and Clinical Pharmacokinetics- Notari.
3. Biopharmaceutics and Relevant Pharmacokinetics- T. G. Wagner.
4. Biopharmaceutics and Drug Interactions- Casdwallade.
5. Biopharmaceutics- M. Gibaldi & D. Perrier.
BPH 4205 Pharmaceutical Management (Credit 2.0)
1. Nature and principles of management: Style of management, the MBO

system and improving decision making.
2. Organization Structures: Social organization and legal organization, the sole

proprietor ship, the general partnership, private and public limited companies, their
relative advantages and disadvantages.
3. Personal management: Importance, principles, methods, motivation, staff

requirements.
4. Planning, organizing, staffing, landing & controlling.
5. Managerial role of pharmacists: Pharmacists in different services of health

and pharmaceutical industry, marketing & sales, regulatory affair research &
development, hospital pharmacy, community pharmacy etc.
6. Inventory control: Methods; Intuitive, systematic want book, perpetual

inventory, open-to-buy, stock record card, economic order quality, selection of
optimum methods, effect of inventory control.
7. Purchasing: Formulating Effective buying policies, needs and desires, selecting

the sources of supply, determination terms of purchase, receiving, marketing and
stocking of goods.
Recommended Books:
1. Principles of management- Davis
2. Principles and Methods of Pharmacy Management- H.A. Smith
3. Management: A Global Perspective- Weirich Heinz & Koontz.
4. Personnel Management- Mamoria.
5. Purchasing & Store keeping- D.R. Gupta, R. K. Rajput.
6. Materials Management- Gopal Krisnan and R. K. Rajput.
7. Marketing Management- Philips Kottler, Printice Hall of India Pvt. Ltd.
8. Marketing Strategy: A Global Perspective- Vernon R. Stuable, The Dryden

Press.
BPH 4206 Cosmetology Practical (Credit 1.0)
1. Laboratory Scale preparation of cold cream, vanishing cream, transparent

shampoo, egg shampoo, hand and body lotion, shaving cream, tooth paste, tooth
powder, after shave lotion etc.
2. Quality control of cosmetic preparations, determination of pH, checking the
viscosity, and related rheological properties, stability and microbial aspects.
BPH 4207 Pharmaceutical Technology-III Practical (Credit 1.0)
Preparation, problem encountered during preparation, physical evaluation of

different dosage forms:
a. Parenteral products.
b. Ophthalmic products.
c. Sustained release products.
BPH 4208 Advanced Pharmaceutical Analysis-II Practical (Credit 1.0)
1. Determination of potency of different drugs by spectrophotometry.
2. Flurometric determination of Vitamin B1 and B2.
3. Assay of different drugs by conductometric, potentiometric, amperometric and

electro-gravimetric analysis.
4. Separation of compounds by different chromatographic techniques.
BPH 4209 Oral Assessment (Credit 1.0)
BPH 4210 Training (Industrial and Hospital Pharmacy) (Credit 1.0)
At the end of fourth academic year, the students for the degree of Bachelor of
Pharmacy (Honors) have to undergo training program for duration of four to six
weeks. After the completion of the training program(s), students have to submit
individualized report on their activities to the department. Such report will be
examined by the department.

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Department of Pharmacy

Course Curriculum & Syllabus

Khwaja Yunus Ali University

Curriculum and Syllabus For

Bachelor of Pharmacy (Honors) Program

The fourth/ﬁnal year is primarily designed to carry out advanced studies on

Number of Courses and Credits

Academic Period & Semesters

ASSIGNMENT OF CREDITS AND COURSES

2. Practical / Training / Project Work:

ii. Mid Semester (mid-term) examination: 30%

iii. Semester final examination: 50%

80% and above A+ (A plus) 4.00

75% to less than 80% A (A regular) 3.75

70% to less than 75% A- (A minus) 3.50

65% to less than 70% B+ (B plus) 3.25

60% to less than 65% B (B regular) 3.00

55% to less than 60% B- (B minus) 2.75

50% to less than 55% C+ (C plus) 2.50

45% to less than 50% C (C regular) 2.25

40% to less than 45% D 2.00

Less than 40% F 0.00

No. of Pharmacy No. of Ancillary Total Total

Pharmacy core courses = 152 Credits

Non-pharmacy courses = 07 Credits

Total = 154 Credits

Sl. No. Code No. Title of Courses Credit/s

01. CCT 1101 Computer & Communication Techniques 2.0

02. BSM 1102 Biostatistics & Mathematics 3.0

03. ENG 1103 Communicative English 2.0

04. BPH 1101 Pharmacognosy 3.0

05. BPH 1102 Inorganic Pharmacy- I 3.0

06. SOC 101 Emergence of Bangladesh 3.0

07. BPH 1103 Pharmacognosy Practical 1.0

08. BPH 1104 Inorganic Pharmacy-I Practical 1.0

09. ETC 111 Introduction to Ethics 0.0

Total =18.0 Credits

Sl. No. Code No. Title of Courses Credit/s Prerequisite

01. BPH 1201 Inorganic Pharmacy-II 3.0 BPH 1102

02. BPH 1202 Physiology & Anatomy-I 3.0

03. BPH 1203 Physical Pharmacy-I 3.0

04. BPH 1204 Pharmacognosy & Phytochemistry 3.0 BPH 1101

06. BPH 1206 Inorganic Pharmacy-II Practical 1.0 BPH 1201

08. BPH 1208 Physical Pharmacy-I Practical 1.0

Pharmacognosy & Phytochemistry

10. BPH 1210 Oral Assessment-I 1.0

11. MATH 201 Fundamental Mathematics 0.0

Total =20.0 Credits

Year II, Semester I

Sl. No. Code No. Title of Courses Credit/s Prerequisite

01. BPH 2101 Organic Pharmacy 3.0

02. BPH 2102 Physical Pharmacy-II 3.0 BPH 1203

03. BPH 2103 Pharmacology-I 3.0 BPH 1202

04. BPH 2104 Physiology & Anatomy-II 3.0 BPH 1202

05. BPH 2105 Pharmaceutics-I 3.0 BPH 1203

06. BPH 2106 Organic Pharmacy Practical 1.0 BPH 2101

07. BPH 2107 Physical Pharmacy-II Practical 1.0 BPH 2102

08. BPH 2108 Pharmacology-I Practical 1.0 BPH 2103

Total =19 .0 Credits

Sl. No. Code No. Title of Courses Credit/s Prerequisite