Chief editor: Tareq Kousher (SOMC)

Editor:
Muhammad Ripon (KuMC)
Farzana Islam Shaila (MMC)
Tonusree Chakraborti (BGC Trust Medical College)

IT Expert:
Tanvir Ahmed Yeamin (CMC)
Waresh Hossain Rahat (AFMC)
GENERAL
PHARMACOLOGY
 PHARMACOKINETICS

1. Define Pharmacokinetics.
2. What do you mean by Pharmacokinetics?
3. What are the processes of Pharmacokinetics?
4. What are the emergency routes of drug administration?
5. What are the routes used in prolonged action?
6. Bio-availability of- oral/IV/rectal
7. Name some drugs having high first pass metabolism.
8. Why insulin is not given orally?
9. Why Streptomycin/Benzyl penicillin/Suxamethonium is not preferred in oral route?
10. Define absorption of drug.
11. 2 important sites of drug administration.
12. Name 2 important physiological barrier.
13. Name 2 water soluble drugs.
14. Name some lipid soluble drugs.
15. Special characteristics of Blood Brain Barrier.
16. What are the main processes of drug absorption?
17. What are the carrier mediated transports?
18. Name diff sites of active transport.
19. What is the relation between degree of ionization and drug absorption?
20. Drug interaction of autacoid with dairy products.
21. What are the acidic drugs?
22. What are the basic drugs?
23. Name some highly lipid soluble drugs.
24. Name some factors modifying absorption.
25. Define Bio-availability.
26. 500 mg NSAIDS is given orally. In which 400 mg of tablets reach to the circulation? Calculate its bio-
availability.
27. Factors affecting bio-availability.
28. Significance of bio-availability
29. Name the routs that bypass first pass metabolism.
30. Sites of first pass metabolism.
31. Differences between Bio-availability & Bio-equivalence.
32. Define drug distribution.
33. Factors modifying drug distribution.
34. Name some drugs having special affinity for special tissue.
35. Significance of plasma protein binding drugs.
36. What happens in poisoning in case of high Plasma protein binding drugs?
37. Name some drugs having high plasma protein binding.
38. What is the concept of Volume of Distribution?
39. What do you mean by redistribution of drugs?
40. Define Bio-transformation.
41. What are the principal organs of B.D.?
42. What are the consequences of B.D.?
43. Name some drugs that possess phase-1 reaction.
44. Name some microsomal & non-microsomal enzymes.
45. What do you mean by non-synthetic reaction?
46. Name some important isoenzyme.
47. Factors modifying biotransformation.
48. Name some drugs that possess enzyme induction.
49. What do you mean by auto-induction?
50. Drug interaction of Rifampicin+OCP/Warfarin.
51. Significance of enzyme inhibition.
52. Name some drugs that inhibits Hepatic Microsomal Drug.
53. What do you mean by enterohepatic recycling?
54. Name some drugs excreted through Breast milk.
55. Define Drug Excretion.
56. Name some factors modifying Drug Excretion.
57. Name some processes of Drug Excretion.
58. Name some enzyme inducing drugs.
59. What is enzyme induction?
60. Why Diazepam is cautiously in lactating mother?
61. Factors modifying plasma half-life.
62. Name some drug having long half-life.
63. What do you mean by first order kinetics?
64. What do you mean by Zero Order Kinetics?
65. Which one is more significant between First & Zero order kinetics?
66. Name some drugs follows Zero order kinetics/First order kinetics.
67. What do you mean by law of mass action?
68. Which kinetics follows Law of Mass Action?

69.How urinary pH influences Drug Excretion?

70.Drugs that follow Enterohepatic recycling .

 Pharmacodynamics

1. What do you mean by Pharmacodynamics?

2. Define Pharmacodynamics.
3. Molecular target of drug action.
4. Protein targets of drug action.
5. Name 2 drugs with carrier molecules.
6. Define receptor.
7. What are the properties of Receptors?
8. Name some drug receptor bond.
9. Classification of drug receptors(according to location/m/a/onset of action).
10. Give some examples of classical receptors.
11. Give some examples of non-classical receptors.
12. Define spare receptors.
13. What is drug receptor interaction?
14. Hoe receptor action is regulated?
15. Mechanism of drug regulation/Adaptation/Refractoriness/Desensitization.
16. Mechanism of up regulation of receptor.
17. What are the causes of down regulation?
18. Give some examples of up regulation & down regulation.
19. What is internalization?
20. What is agonist? Give some examples of agonists.
21. Define antagonists. Give some examples of antagonists.
22. What is partial agonists?
23. Give examples of partial agonists.
24. Define inverse agonist.
25. Diff b/w antagonist & partial agonists.
26. Diff b/w agonist & partial agonist.
27. Diff b/w Agonists & Antagonists.
28. Define-Affinity/Efficacy/Potency.
29. Criteria of Potency.
30. Examples of Ligand gated ion channels receptors.
31. Clinical importance of ion channels.
32. Mechanism of G-protein coupled receptors.
33. Define 2nd messengers.
34. Examples of second messengers.
35. Why they are called G-protein coupled receptors?
36. Examples of Tyrosine kinase receptors.
37. Mechanism of DNA coupled receptors.
38. Location of DNA receptors.
39. Examples of DNA coupled receptors.
40. Give examples of non-classical receptors.
41. Factors modifying the prolongation of drug action.
42. Factors modifying drug actions.
43. Response variation of drug action.
 44. What are the factors for response variation?
45. Types of Dose-Response Relationship.
46. Diff b/w Potency & Efficacy.
47. What are the information we get from the Quantal Dose Response curve?
48. Define Therapeutic Index.
49. What are the information we get from Therapeutic Index?
50. Low Therapeutic Index drugs.
51. Name some drugs having High Therapeutic Index.
52. Define Drug Interaction.
53. Sites of Drug Interaction.
54. What do you mean by Synergism?
55. Examples of Drug Interaction at absorption level/distribution level/Bio-transformation level/Excretion
level.
56. What is Pharmacological Antagonism?
57. Competitive antagonism- a) Definition.

b) Characteristics.

c)Examples.

58. Non-competitive antagonism- a) Definition.

b) Characteristics.

c)Examples.

59. Define Physiologic Antagonism.

60. Define Functional Antagonism.

61. Examples of Functional Antagonism.

62 . Examples of Chemical Antagonism.

63. Diff b/w Pharmacological & Physiological antagonism.

64. What are the drugs that produce Teratogenicity?

65. What are the drugs safe in pregnancy?

66. 3 drugs that should be used in essential drug list.

67. What is tachyphylaxis? Give examples.

68.What is tolerance? Give examples.

69. Diff b/w Tachyphylaxis & Tolerance.

70.Another name of Type-A /Type-B adverse drug reaction.

71.Name some drugs producing withdrawal symptoms.

72.Diff b/w Type-A &Type- B Adverse Drug Reactions.

SYSTEMIC
PHARMACOLOGY
 Autonomic Nervous System
1. Somatic nervous system & Autonomic nervous system এর মধ্যে পার্থক্ে কক্? Somatic

কক্ার্ায় supply কেয়? Autonomic কক্ার্ায় supply কেয়?

4. Cholinergic neuron কক্ যরধ্ের NT secretes ক্ধ্র?

Name of Cholinergic Neuron.

5. Source of Adrenaline.

6. Adrenergic Neuron কক্ কক্ আধ্ে এবং site.

7. Sympathetic nerve এর outflow

Parasympathetic nerve এর outflow

কক্ান কক্ান Cranial nerve act as parasympathetic?

8. Symp. & parasymp এর functions on eyes & lungs.

9. Pure excitatory & inhibitory NT.

10. Adrenaline nerve ending এ synthesis হয় কক্না,কক্ভাধ্ব nerve ending কর্ধ্ক্ adrenaline release হয়?

11. Auto receptor কক্ কক্ আধ্ে, Nature of auto receptors.

12. কক্ান enzyme কেধ্য় Ach synthesis হয়?

কক্ান enzyme কেধ্য় Ach breakdown হয়?

13. Ach. Synthesis এর rate limiting step কক্

14. Muscarinic & Nicotinic receptor কক্ান যরধ্ের receptor?

15. Name some OPC.Antidotes of OPC poisoning.

16. Which drug act directly or indirectly?

17. COPD কে কক্ন cholinergic drug কেয়া যাধ্ব না

PUD কে কক্ন cholinergic drug কেয়া যাধ্ব না

18. What is Cyclopsam & Cycloplegia?

19. Diff b/w Physostigmine & Neostigmine

 20. Rule of Pralidoxime in OPC poisoning

21. Aging process কক্?

22. কক্ধ্না mydriatics atropine এর কেধ্য়

Tropicamide কবকি use ক্রা হয়?

23. Rule of Atropine in MI.

24. Non depolarizing & depolarizing drug এর পার্থক্ে

25. Suxamethasone apnoea কক্?

26. Metabolism of adrenaline (MAO & COMT).

27. Metabolic end product of Catecholamine.

28. Natural Catecholamine কক্ কক্ আধ্ে?

29. Biphasic response of adrenaline.

30. Vasomotor reversal of date কক্?

31. Treatment of anaphylactic shock.

32. Cardiogenic shock এ কক্ধ্না adrenaline কেয় না?

33. Name some nasal decongestants.

34. Male young patient with HTN-োধ্ক্ কক্ধ্না Alpha blocker কেয়া হয় না?

35. BPH এ কক্ান Drug use ক্রা হয়?

36 Masking effects of Beta-blocker.

37. Orthostatic Hypotension কক্?

DRUGS USED IN GLAUCOMA

1.Open, Close angle Glaucoma কক্?

2.Name of intra ocular muscle.

3.কক্ান যরধ্ের Diuretic's use ক্রা হয় Glaucoma কে?

4.Name some PG used in Glaucoma.

 CNS
1.Name of central NT

2.Types of sleep.

3.Define sedation & hypnosis.

4.Sedation vs Hypnosis.

5.Stage of CNS depression.

6.Name of some “Z-Compound”.

7.Purely Anxiolytic drugs name.

8.M/A of Barbiturates'.

M/A of BDZ.

9.BDZ & Barbiturate এর মধ্যে কক্ানটা ভাধ্ া?

10.Antidote of BDZ.

11.Kernicterus' এ Phenobarbitone এর role কক্?

12.Hangover effect কক্?

13.Barbiturate+Atropine=Effect?

Barbiturates+warfarin=effect?

14.Fast & Slow pain এর nerve fiber.

15.Nociceptors কক্?

16.Source of Opioid.

17.Endogenous Opioid Peptides.

18.Functions of µ, Δ & k receptors.

19.Opioid vs NSAIDS.

20.Opioid কক্ার্ায় ক্াজ ক্ধ্র?

NSAIDS কক্ার্ায় ক্াজ ক্ধ্র?

21.Crude Opium এ কক্ কক্ আধ্ে?

22.Name of natural Morphine.

23.Opioid poisoning কক্ভাধ্ব বু ঝধ্বা?

24.Anti-tussive Morphine কক্ কক্ আধ্ে ?

25.Head injury কে কক্ধ্না Morphine কেয়া যাধ্ব না?

26.Undiagnosed acute abdomen এ Morphine কেধ্বা কক্ না?

27.Labour এ Pethidine কক্ধ্না use ক্রা হয়?

 Why not morphine?

28.Any pain with CKD কে কক্ান যরধ্ের Analgesic use ক্রধ্বা?

29.Antidote of Morphine poisoning.

30.Analgesic Ladder কক্?

31.Examples of co-analgesics.

32.Hypothesis of depression.

33.TCA vs SSRI.Which one is best?

34.Psychosis vs Neurosis.

35.Hypothesis of psychosis.

36.Tyoical & atypical Neuroleptic analgesics এর পার্থক্ে.

37.EPS কক্ কক্ আধ্ে?

38.Name of Dopaminergic pathway.

39.Tx of Neuroleptic malignant syndrome.

40.Clozapine+Procyclidine এর Combination effect কক্?

41.Pathophysiology of Convulsion.

42.Safe anti-convulsant drug in pregnancy.

43.Treatment of status epilepticus.

44.Foetal hydantoid syndrome (Phenytoin) কক্ কক্ আধ্ে?

45.Pathophysiology of Parkinsons Disease.

46.Levodopa+carbidopa=Combination result কক্?

47.Dopamine কক্ধ্না Parkinson disease এর treatment কহধ্েধ্ব বোবহার ক্রা হয় না?

48.Source of Dopamine.

49.Step of G/A.

50.What is MAC?

51.Why Propofol is called Milk Anaesthesia?

52.Dissociative anaesthesia কক্?ক্ারা ক্ধ্র?

53.Name some Long-acting local anaesthetics.

54.Adrenaline + Lignocaine = Combination effect কক্?

55.Name some end artery.

56.circumcision এ কক্ধ্না Adrenaline use ক্রা হয় না?

57.Name Muscle relaxant.

 CVS

1.HTN Type কক্ কক্ আধ্ে?

2. Pregnancy এর োধ্র্ related HTN.

3.Risk factors of HTN.

4.types of Blood pressure.

5.Isolated systolic HTN কক্?

6.What is Hypertensive emergency & Hypertensive urgency?

7.Drugs used in Hypertensive emergency.

8.Dry cough এ কক্ধ্না ACEi কেয়া যাধ্ব না?

9.Drugs used in gestational hypertension.

10.What is first dose effect?

11.Type of Ca++ channel & location.

12.CCB-কে কক্ধ্না ankle oedema হয়?

13.Drugs used in Raynaud's phenomenon.

14.Amlodipine + Atenolol=Combination effect কক্?

15.Function of Angiotensin II.

16.First dose hypotension কক্?

17.ACEi,ARB=>Hyperkalaemia ক্ধ্র কক্ধ্না?

18.ACEi + Frusemide = Combination effect কক্?

19.ACEi,ARB= which one is preferable for patient with COPD/Asthma?

20.IHD কক্ কক্ আধ্ে?

21.What is preload & afterload?

22.Routes of GTN.

23.GTN কক্ধ্না lying position এ কনয়া হয়?

24.Organic nitrate vs inorganic nitrate.

25.Drugs used in acute MI.

26.Ionotropic effect কক্?

27Source of Cardiac Glycosides.

28.Hypokalaemia কে কক্ধ্না Digoxin toxicity দ্রুে develop ক্ধ্র?

29.Digoxin + ACEi =combination effect কক্?

30.Anti-malarial drug used in arrythmia.

31.L/A used in arrythmia.

DIURETICS
1.Name of emergency diuretics.

2.Name some physiologic diuretics.

3.Aquaretic কক্?

Natriuretic কক্?

4.Loop, Thiazides both causes hypokalaemia, but which one causes more hypokalaemia?

5.Diabetes insipidus এ কক্ান যরধ্ের Diuretics use ক্রা হয়?

6.Metabolic effect of Thiazide diuretics.

7.Indication of spironolactone.

8.Hirsutism, PCOC =>Diuretics.

9.Function of CA Enzyme.

10.Name diuretics causing Metabolic Alkalosis.

11.Indication of osmotic diuretics.

12.Classify diuretics according to site of action.

ANTI-MICROBIAL DRUG

1.Antibiotic vs Chemotherapeutics.

2.Empirical therapy basis.

3.Classification of antimicrobial drugs according to mode of action.

4.Example of bactericidal drugs.

5.Examples of bacteriostatic drugs.

6.Which anti-tubercular drug is bacteriostatic?

7.MIC, MBC কক্?MIC,MBC এর মধ্যে কক্ানটি superior?

8.Superinfection কক্?

Opportunistic infection ক্খন হয়?

9.Chemoprophylaxis কক্?Example োও।

10.β-lactamase inhibitors কক্ কক্ আধ্ে?

11.Transposons কক্?

12.Transfer of resistance gene.

13.Acid resistance penicillin. (Orally can be given)

14.Long-acting penicillin.

15.Anti-staphylococcal penicillin.

16.Prolongation of duration of penicillin.

17.Penicillin vs Cephalosporin.

18.Anti-pseudomonal antibiotics.

19.Drugs causing Disulfiram like action.

20.Name some non-beta lactam cell wall synthesis inhibitors.

21.Natural vs synthetic penicillin.

22.Aminoglycosides vs Tetracycline.

23.Topical aminoglycosides.

24.Adverse effects of tetracycline.

25.Drugs causing Gray Baby Syndrome.

26.Justify once daily dosing of Azithromycin.

27.Name anti-folate drugs.

28.M/A of cotrimoxazole.

29.How to prevent crystalluria in using Sulfonamide.

30.Respirator quinolones.

31.Ciprofloxacin কক্ধ্না children কের কেধ্বা না?

32.Quinolone vs Fluoroquinolone.

33.Drugs used in Enteric Fever.

34.Drugs used in UTI.

35.1st line vs 2nd line anti TB drugs.

36.Adverse effects of INH.

37.Which anti TB drug is enzyme inducer?

38.Parenteral route এ কক্ান anti TB drug কেয়া হয়?

39.How to avoid adverse effects of INH?

40.Advice during prescribing Rifampicin.

41.Tx regimen of PTB.

42.FDC কক্?

43.DOTS কক্?

44.Tx of MDR_TB.
45.XDR-TB কক্?

46.drugs used in Leprosy.

47.Types of Leprosy.

48.Classify anti-malarial drugs.

49.Drugs used in causal prophylaxis.

50.Drugs used in radical cure.

51.Tx of severe malaria.

52.Drugs used in Kala-azar.

53.Anti-amoebic drugs.

54.ADR of Metronidazole.

55.Drugs producing metalic taste.

56.Name some anti-helminthic drugs.

57.Topical anti-fungal.

58.Imidazole vs Triazole.

59.Name of anti-viral drugs.

60.HAART কক্?

AUTACOIDS
1.Classification of autacoids.

2.Storage site of Histamine.

3.Drugs causing release of Histamine.

4.Distribution of Histamine receptor.

5.Agonist of Histamine.

6.Triple response of histamine.

7.Clinical use of Histamine.

8.3rd generation of anti-histamine.

9.1st generation vs 2nd generation of anti-histamine.

10.বাচ্চাধ্ের কক্ান generation কেধ্বা? (anti-histamine)

11.Driver কক্ কক্ান generation কেধ্বা? ( anti-histamine)

12.drugs used in morning sickness.

13.Triple response of Lewis (Serotonin).

14.PG synthesis inhibitor.

15.PG analogue and their uses.

16.COX-1 vs COX-2.

17.drugs used in migraine.

NSAIDS
1.Why COXIB is better than non-selective NSAIDS.

2.COX এর inhibitors.

3.LOX এর inhibitors.

4.Patho-physiology of fever.

5.Aspirin কক্ন surgery এর one weak before stop ক্রধ্ে হয়?

6.Different dose of aspirin & their mechanism of action.

7.Reyes syndrome কক্?

8.dengue কে কক্ধ্না aspirin কেয়া যাধ্ব না?

9.pharmacological effects of paracetamol.

10.Aspirin vs Paracetamol.

11.Name DMARD.

12.Name some biologics.

13.Drugs causing gout.

 DISEASE OF BLOOD
1.What is haemostasis?

2.Steps of haemostasis.

3.Coagulation vs thrombosis.

4.Aspirin যারা কনধ্ে পাধ্র না োধ্ের কক্ কেয়া হয়?

5.Loading and maintenance dose of aspirin.

6.Ticlopidine vs Clopidogrel (কক্ানটি best?).

7.MI patient with PUD কক্ানটি কেধ্বা? Aspirin নাকক্ Clopidogrel?

8.Blood vessel এ কক্ধ্না blood clot হয় না?

9.Test tube এ কক্ান anti-coagulant use ক্রা হয়?

10.Blood bag এ কক্ান anti-coagulant use ক্রা হয়?

11.Heparin কক্ধ্না orally কেয়া হয় না?

12.Heparin কক্ন I/M কেয়া হয় না?

13.Source of heparin.

14.How heparin therapy is monitored?

15.Vit k dependent clotting factor.

16.Dicumarol কক্ান enzyme কক্ inhibit ক্ধ্র?

17.Pregnancy কে Heparin/Warfarin কক্ানটি use ক্রধ্বা?

18.Monitoring of warfarin therapy.

19.Normal time of aPTT,PT,BT,CT,TT.

20.Sources of Streptokinase.

21.12 hours পর কক্ধ্না streptokinase কেয়া যাধ্ব না?

22.Drugs used to stop bleeding.

23.কক্ান কক্ান vitamins act as lipid lowering agents.

24.কক্ান vit iron absorption এ োহাযে ক্ধ্র?

25.storage form of iron.

26.how transport of iron occurs?

27.Iron form in foods

28.Pernicious anaemia কে IDA হধ্ে পাধ্র কক্ না?

29.Iron dextran কক্ান কক্ান route এ কেয়া হয়?

30.Iron profile এ কক্ কক্ আধ্ে?

31.Folic acid & vit B12 deficiency,কক্ানটি common?

32.Vit B12 deficiency কে FA কেয়া যাধ্ব কক্ না?

33.CKD কে কক্ধ্না IDA হয়?

34.Iron absorbable form কক্?

35.FeSO4 এর dose কক্?

36.Iron supplement কক্ধ্না 6 months পযথন্ত কেয়া হয়?

GIT
1.Acid-peptic disease কক্ কক্ আধ্ে?

2.Common sites of PUD.

3.Pathophysiology of PUD.

4.Properties of H. Pylori.

5.Systemic antacid.

6.drug interaction with antacid.

7.H2 blocker vs PPI.

8.Cimetidine এর adverse effects কক্ কক্ আধ্ে?(Endocrine)

9.PPI এর active drug এর নাম কক্?

10.Burn, Stroke এ কক্ান যরধ্ের ulcer হয়?

11.What is Zollinger-Ellison syndrome?

12.Rescue therapy কক্?

13.Rule of Clarithromycin in PUD.

14.Rule of Amoxicillin in PUD.

15.Triple therapy complete হওয়ার পর PPI ক্ে কেন পযথন্ত use ক্রধ্বা and why?

16.NSAID induced PUD কে কক্ use ক্রধ্বা?

17.Adverse effects of Misoprostol.

18.Advice during prescribing NSAIDS.

19.Advice to a PUD patient.

20.Indication of enema.

21.Bulk forming laxatives কক্ কক্ আধ্ে?

22.Ispaglula hush কক্ভাধ্ব বেবহার ক্রধ্ে হয়?

23.Prokinetic agents কক্ কক্ আধ্ে?

24.Vomitting center name.

25.Gynaecomastia ক্ারা ক্ধ্র?

26.Domperidone vs Metoclopramide.

27.Diarrhoea কক্ saline কেয়া হয়?

28.Diarrhoea হধ্ কক্ান ion cautiously use ক্রধ্ে হধ্ব?

29.ক্ে ঘন্টা পর ORS use ক্রা যায় না?

30.Steps of preparing home made ORS.

31.Composition of ORS.
32.IBS & IBD.
33.Smooth muscle relaxants.

34.Skeletal muscle relaxant.

BRONCHIAL ASTHMA
1.C/F of asthma.

2.Steroids used n inhalation.

3.Management of status asthmaaticus.

4.During inhalation,pt এর position কক্মন হধ্ব?

5.Advice the pt who use inhaler.

6.Inhalation কক্ভাধ্ব কনয়?process কেখাও।

7.Natural sources of Methixanthine.

8.Rule of steroid in asthma.

9.Drugs used in asthma as prophylaxis.

10.Inhaler vs Nebulizer.

11.Anti-tussive drugs.
 ENDOCRINE PHARMACOLOGY
1.Classify DM.

2.Type-I vs Type –II.

3.Sources of insulin.

4.Management of hypoglycemic shock.

5.Adrenal steroids.

6.Topical steroids.

7.Permissive action কক্?

8.Steroid েক্াধ্ কেয়া হয় না কক্ধ্না?

9.Tapering dose.

10.Indication of steroids.

11.Cushing syndrome features.

12.Steroid's vs NSAIDS.

13.Hormone used in HRT.

14.Anti-thyroid drugs used in pregnancy.

15.Blood এ T3 & T4 এর মধ্যে কক্ানটা কবকি র্াধ্ক্?

16.Active form of thyroid hormone.