Measles

Anbar Medical College
Department of Family and Community Medicine

Epidemiology of Communicable Diseases
Dr. Ahmed Al-Delaimy MBChB, MSc, PhD
Measles (Rubeola)
The measles virus (RNA Virus) is a paramyxovirus, genus

Morbillivirus. The World Health Organization estimates there
were 145,700 deaths globally from measles in 2013.
Incubation period: Average 14 days (range 6-21 days).
Measles transmission is primarily person to person via

respiratory droplets.
Measles is characterized by a prodromal stage (2-4 days) of
fever and malaise, cough, and conjunctivitis, followed by an
erythematous maculopapular rash. Koplik’s spots, occurs 1-2
days before the rash to 1-2 days after the rash, Koplik’s spots
are small, red, irregularly-shaped spots with blue-white
centers found on the mucosal surface of the oral cavity.
Lymphadenopathy and diarrhea are common.
Common complications include middle ear infection (7%–9%),

and pneumonia (1%–6%). Encephalitis, which can result in
permanent brain damage, occurs in approximately 1 per
1,000–2,000 cases of measles.
Subacute sclerosing panencephalitis
(SSPE), a rare complication and might
occur 7 years after the infection, it is
serious degenerative central nervous
system disease caused by a persistent infection with a
defective measles virus, is estimated to occur in 4–11 per
100,000 cases.
Skin of a patient after 3 days of measles

infection.
1
Infection may occur among College students, Persons

working in medical facilities, and International travelers are
at risk of having measles. In temperate areas, measles
disease occurs primarily in late winter and spring.
MMR Vaccine
 First dose of MMR at 12-15 months
 Second dose of MMR at 4-6 years
 Second dose may be given any time at least 4 weeks
after the first dose
 For the first dose of measles, mumps, rubella, and
varicella vaccines either MMR and varicella vaccines or
MMRV vaccine can be used
 For the second dose at any age, use of MMRV vaccine
generally is preferred.
 Fever 5-15%
 Rash 5%
 Thrombocytopenia, Lymphadenopathy, and allergic are
rare.
Host factors:
o Nutrition: measles tend to be sever in
malnourished children.
o Infant: are usually immune during the first few
months of life through the transplacental
transmission of passive immunity from the
mothers.
o Large epidemic waves occur on alternative years
in densely populated urban areas, but at longer
interval in rural areas.
o The explosive outbreak seems to occur only when
there has been a sufficient accumulation of
susceptible children.
Lab. Diagnosis:
2
o Increase antibodies titres of haemagglutination-

inhabiting (HI), and neutralizing (N) antibodies.
o Capture antibodies for measles IgM antibodies in
serum.
o Urine specimen to detect the virus through
polymerase chain reaction (PCR).
Control:
1- Isolation of children for 4 weeks who have measles is of
limited value in the control of infection because it’s
highly infectious in the prodromal phase before the
characteristic rash appears.
2- Quarantine to contacts for 15 days.
3- Active immunization: the best means of reducing the
incidence of measles is by having an immune
population, children should be vaccinated at 12 months,
with one dose of live attenuated measles virus vaccine,
gives about 12 years protection. vaccine must be kept in
a temperature between 2 and 8 C, and protected from
light.
4- Passive immunization: artificial passive immunization
using immune gamma globulin (0.25 ml/ kg) is given
early within 3 days of exposure regardless of
vaccination status, the infection will be prevented.
-----
Antibiotics can be used for bacterial complication
Supportive treatment: ( to prevent complication)
Vitamin A is administered once a day for 2 days at the
following doses:
50,000 IU for infants aged <6 months
100,000 IU for infants aged 6–11 months
200,000 IU for children aged ≥12 months
3
German Measles (Rubella)
This disease is often mild of low grade fever and sore throat.
The disease can last one to five days. Children recover more
quickly than adults. Rash may start 2 weeks after exposure
and lasts for 3 days (itchy and less bright than measles).
Is an acute viral infection (Rubella Virus) which presents with
fever, mild upper respiratory symptoms, lymphadenopathy
affecting post-cervical and sub-occipital. During the first
trimester of pregnancy is associated with abortion and high
risk (up to 20%) of congenital abnormalities in the fetus. the
child may be born with congenital rubella syndrome (CRS).
Deafness, congenital heart abnormality, cataract. More
serious in the first 2 months of gestation.
I.P: 2-3 weeks
Aetiological agent is the rubella virus.
Epidemiology: world wide, humans are the reservoir of
infection, transmission by droplets or by direct or indirect
contact.
Lab. Diagnosis:
Specific IgM antibodies and M-antibodies.
Clinical differentiation from other mild infection difficult.
Control:
- Vaccination of prepubertal girls with a single dose.
- Any pregnant women who has in contact with the
disease should be protected with human
immunoglobulin.
Chicken pox (Varicella) (varicella-zoster virus).
Acute febrile
illness with
characteristic
skin rash appears
4
first in abdomen,back, face and then spread all over the body.
incubation period usually from 10 -21 days.
Common infection all over the world.
Mode of transmission is directly through droplet infection
from respiratory tract. Or indirectly from soiled articles.
Infectious remains from 1-2 days before the rash appears and
until the blisters (itchy) have formed scabs.
In most cases its mild, self-limiting disease. More sever in
adults. One attack usually gives lifelong immunity.
Lab. Dx: virus cultured or identified immunologically from the
early skin lesions or from throat.
Control: first exclude small pox. Patient are isolated from
susceptible persons.
Antiviral drug such as acyclovir.

Immunization: in some developed countries a live attenuated
virus (Oka strain) vaccine. Given to non-immune child 12
months to 12 years
Small pox (Variola virus)

Eradication?? 1979
Biological weapon??
Epidemiological Surveillance powerful measure through
systemic tracing of foci of infection. + vaccine improvement.

Measles

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Anbar Medical College

Department of Family and Community Medicine

The measles virus (RNA Virus) is a paramyxovirus, genus

Measles transmission is primarily person to person via

Common complications include middle ear infection (7%–9%),

Skin of a patient after 3 days of measles

Infection may occur among College students, Persons

o Increase antibodies titres of haemagglutination-

German Measles (Rubella)

Chicken pox (Varicella) (varicella-zoster virus).

Antiviral drug such as acyclovir.

Small pox (Variola virus)

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