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Cell Junction

The document discusses five types of cell junctions: tight junctions, adherens junctions, desmosomes, hemidesmosomes, and gap junctions. Tight junctions prevent leakage between cells. Adherens junctions attach to microfilaments. Desmosomes and hemidesmosomes attach cells through intermediate filaments. Gap junctions connect cells through connexions.

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9 views

Cell Junction

The document discusses five types of cell junctions: tight junctions, adherens junctions, desmosomes, hemidesmosomes, and gap junctions. Tight junctions prevent leakage between cells. Adherens junctions attach to microfilaments. Desmosomes and hemidesmosomes attach cells through intermediate filaments. Gap junctions connect cells through connexions.

Uploaded by

gsvssuma
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPSX, PDF, TXT or read online on Scribd
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CELL JUNCTION

SAURABH MARU
A S S I S TA N T P R O F E S S O R
SCHOOL OF PHARMACY & TECHNOLOGY
M A N A G E M E N T,
SVKM’S NMIMS, SHIRPUR
• Cells are tightly joined into functional units
• Cell junctions are contact points between the plasma
membranes of tissue cells
• Following are the five most important types of cell junctions:
• Tight Junctions
• Adherens Junctions
• Desmosomes
• Hemidesmosomes
• Gap Junctions

2
TIGHT JUNCTIONS

• Consist of web like strands of


transmembrane proteins that fuse together
the outer surfaces of adjacent plasma
membranes to seal off passageways between
adjacent cells
• Epithelial tissues that line the stomach,
intestines, urinary bladder
• Prevent the contents of organs from leaking
into blood or surrounding tissues
ADHERENS JUNCTIONS

• Contain plaque, a dense layer of


proteins on inside of plasma membrane
that attaches both to membrane
proteins and to microfilaments of
cytoskeleton

• Transmembrane glycoproteins called


cadherins join the cells

• Adherens junctions help epithelial


surfaces resist separation during
various contractile activities
4
DESMOSOMES
• Contain plaque and have transmembrane glycoproteins (cadherins) that extend
into intercellular space between adjacent cell membranes and attach cells to
one another
• Plaque of desmosomes does not attach to microfilaments
• It attaches to elements of the cytoskeleton –intermediate filaments, which
consist of protein keratin
• Intermediate filaments extend from desmosomes on one side to desmosomes
on opposite side of cell
• This structural arrangement contributes to stability of cells and tissue.
• Eg up the epidermis (the outermost layer of the skin) and among cardiac
muscle cells in the heart.
• Prevent epidermal cells from separating under tension and cardiac muscle cells
from pulling apart during contraction.
HEMI-DESMOSOMES

• (hemi- half) resemble desmosomes, but they do not link adjacent cells. look
like half of a desmosome
• transmembrane glycoproteins in hemidesmosomes are integrins rather than
cadherins.
• Inside of plasma membrane, integrins attach to intermediate filaments made
of protein keratin.
• outside of plasma membrane, integrins attach to protein laminin, which is
present in the basement membrane
• It anchor cells not to each other but to the basement membrane
GAP JUNCTIONS

• Membrane proteins connexins form tiny fluid-filled tunnels called


connexions- connect neighboring cells
• Ions and small molecules can diffuse from the cytosol of one cell to
another,
• large molecules as vital intracellular proteins is prevented
• Plasma membranes of gap junctions -separated by a very narrow
intercellular gap.
• Transfer of nutrients, wastes, in avascular tissues as lens, cornea of eye
• In developing embryo, some chemical and electrical signals that regulate
growth and cell differentiation travel via gap junctions.
• Nerve conduction and muscle contraction in heart, git tract, and uterus

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